Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

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Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(28), P. 12825 - 12833

Published: July 5, 2022

The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through assembly aggregation-induced emission-active four-arm ligand 90° Pt acceptors Pt(PEt3)2(OTf)2. held longest maximum wavelength (1005 nm) compared those previously reported SCCs up to now exhibited both high photothermal conversion efficiency (39.3%) superior reactive oxygen species generation behavior precursor ligand. vitro vivo assessments demonstrated that metallacage-loaded nanoparticles excellent biocompatibility stability were capable simultaneously affording precise tumor diagnosis complete elimination by means NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.

Language: Английский

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)

Published: July 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Language: Английский

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Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4392 - 4442

Published: Jan. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Language: Английский

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Potential of nonporous adaptive crystals for hydrocarbon separation

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6075 - 6119

Published: Jan. 1, 2023

The adsorptive separation based on nonporous adaptive crystals (NACs) is an attractive green technology. Herein, we comprehensively summarize recent advances in various supramolecular hosts-based NACs for hydrocarbon separation.

Language: Английский

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Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(13), P. 8991 - 9003

Published: March 21, 2024

Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λem = 1105 nm), as first example Ru(II) supramolecular ICD inducer. synergistically potentiates immunomodulatory and reduces adverse through multiple regulated approaches, including NIR-light excitation, increased reactive oxygen species (ROS) generation, selective targeting tumor cells, precision organelle localization, improved penetration/retention capabilities. Specifically, demonstrates excellent depth-activated ROS production (∼1 cm), resistance to diffusion, anti-ROS quenching. Moreover, exhibits promising results cellular uptake generation cancer cells multicellular spheroids. Importantly, induces more efficient an ultralow dose (10 μM) compared conventional agent, oxaliplatin (300 μM). In vivo experiments further confirm Ru1105's potency inducer, eliciting CD8+ T depleting Foxp3+ effects. Our research lays foundation for design secure exceptionally potent metal-based agents immunotherapy.

Language: Английский

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Recent Advances of Platinum‐Based Anticancer Complexes in Combinational Multimodal Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(22)

Published: April 25, 2023

Abstract Platinum drugs with manifest therapeutic effects are widely used, but their systemic toxicity and the drug resistance acquired by cancer cells limit clinical applications. Thus, exploration on appropriate methods strategies to overcome limitations of traditional platinum becomes extremely necessary. Combination therapy can inhibit tumor growth metastasis in an additive or synergistic manner, potentially reduce platinum‐resistance. This review summarizes various modalities current progress platinum‐based combination therapy. The synthetic some anticancer complexes gene editing, ROS‐based therapy, thermal immunotherapy, biological modelling, photoactivation, supramolecular self‐assembly imaging modality briefly described. Their potential challenges prospects also discussed. It is hoped that this will inspire researchers have more ideas for future development highly effective anti‐cancer complexes.

Language: Английский

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Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(6), P. 3167 - 3204

Published: Jan. 1, 2024

We report strategies employed by metallacycle/metallacage-based supramolecular coordination complexes to enhance water solubility and biostability reduce potential toxicity side effects for biomedical applications.

Language: Английский

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Supramolecular Coordination Complexes for Synergistic Cancer Therapy

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(8), P. 1174 - 1187

Published: April 1, 2024

ConspectusSupramolecular coordination complexes (SCCs) are predictable and size-tunable supramolecular self-assemblies constructed through directional bonds between readily available organic ligands metallic receptors. Based on planar 3D structures, SCCs can be mainly divided into two categories: metallacycles (e.g., rhomboidal, triangular, rectangular, hexagonal) metallacages tetrahedral, hexahedral, dodecahedral). The enable the efficient formation of with well-defined architectures geometries. exhibit several advantages, including good directionality, strong interaction force, tunable modularity, solution processability, making them highly attractive for biomedical applications, especially in cellular imaging cancer therapy. Compared their molecular precursors, demonstrate enhanced uptake a strengthened tumor accumulation effect, owing to inherently charged structures. These properties chemotherapeutic potential inherent platinum have promoted widespread application antitumor Furthermore, defined structures SCCs, achieved via design modification assembly elements introduction different functional groups, combat malignant tumors multipronged treatment modalities. Because development cancer-treatment methodologies integrated clinics has evolved from single-modality chemotherapy synergistic multimodal therapy, therapy is crucial. While some pioneering reviews explored bioapplications often categorized by specific function or focusing metal ligand types, comprehensive exploration multifunctionality critical gap current literature.In this Account, we focus platinum-based applications other metals, such as Pd-, Rh-, Ru-, Ir-based been Therrien Casini et al., garnered significant interest, unique advantages which enhance efficacy, considered prominent candidates therapies desirable properties, potent activity, exceptionally low systemic toxicity, active tumor-targeting ability, uptake. diverse diagnostic therapeutic modalities chemotherapy, photothermal photodynamic therapy) single platform based Consequently, herein, summarize our recent research particular emphasis cooperative interplay methods. In Conclusions section, present key advancements basis findings propose future directions that may significantly impact field.

Language: Английский

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Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: April 11, 2024

Drug delivery is a key component of nanomedicine, and conventional relies on the adsorption or encapsulation drug molecules to nanomaterial. Many vehicles contain metal ions, such as metal-organic frameworks, oxides, transition dichalcogenides, MXene, noble nanoparticles. These materials have high content pose potential long-term toxicity concerns leading difficulties for clinical approval. In this review, recent developments are summarized in use ligands coordination forming various nanomaterials soft materials. these cases, drug-to-metal ratio much higher than adsorption-based strategies. The divided into small-molecule drugs, nucleic acids, proteins. formed hybrid mainly include nanoparticles hydrogels, upon which targeting can be grafted improve efficacy further decrease toxicity. application addressing cancer, viral infection, bacterial infection inflammatory bowel disease, bone diseases reviewed. end, some future directions discussed from fundamental research, science, medicine.

Language: Английский

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