Sensors,
Journal Year:
2025,
Volume and Issue:
25(2), P. 450 - 450
Published: Jan. 14, 2025
Fluorescence
imaging
has
been
widely
used
in
fields
like
(pre)clinical
and
other
domains.
With
advancements
technology
new
fluorescent
labels,
fluorescence
lifetime
is
gradually
gaining
recognition.
Our
research
department
developing
the
tauCAMTM,
based
on
Current-Assisted
Photonic
Sampler,
to
achieve
real-time
NIR
(700–900
nm)
region.
Incorporating
into
endoscopy
could
further
improve
differentiation
of
malignant
benign
cells
their
distinct
lifetimes.
In
this
work,
capabilities
an
endoscopic
system
are
demonstrated
using
a
rigid
endoscope
involving
various
phantoms
IRF-free
deep
learning-based
method
with
only
6-time
points.
The
results
show
that
application’s
image
better
uniformity
precision
points
than
conventional
methods.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(6), P. 2932 - 2971
Published: Jan. 1, 2024
Silver
and
gold
nanoparticles
have
found
extensive
biomedical
applications
due
to
their
strong
localized
surface
plasmon
resonance
(LSPR)
intriguing
plasmonic
properties.
This
review
article
focuses
on
the
correlation
among
particle
geometry,
properties
applications.
It
discusses
how
shape
size
are
tailored
Life Sciences,
Journal Year:
2024,
Volume and Issue:
352, P. 122899 - 122899
Published: July 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(7), P. 4021 - 4078
Published: March 22, 2024
Fluorescence
imaging
is
one
of
the
most
promising
approaches
to
achieve
intraoperative
assessment
tumor/normal
tissue
margins
during
cancer
surgery.
This
critical
improve
patients'
prognosis,
and
therefore
various
molecular
fluorescence
probes
have
been
developed
for
identification
lesions
Among
them,
"activatable"
that
react
with
cancer-specific
biomarker
enzymes
generate
signals
great
potential
high-contrast
due
their
low
background
high
signal
amplification
by
enzymatic
turnover.
Over
past
two
decades,
activatable
employing
control
mechanisms
worldwide
this
purpose.
Furthermore,
new
activities
specific
types
cancers
identified,
enabling
visualization
sensitivity
specificity.
Review
focuses
on
recent
advances
in
design,
function
characteristics
target
also
discusses
future
prospects
field
activity-based
diagnostics
cancer.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: March 5, 2024
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II)
is
burgeoning
because
of
its
higher
fidelity
monitoring
physiological
and
pathological
processes
than
clinical
visible/the
fluorescence
imaging.
Notably,
heavily
dependent
on
agents.
So
far,
indocyanine
green,
one
polymethine
dyes,
with
good
biocompatibility
renal
clearance
only
dye
approved
by
Food
Drug
Administration,
but
it
shows
relatively
low
NIR-II
brightness.
Importantly,
tremendous
efforts
are
devoted
to
synthesizing
dyes
for
preclinically
clinically.
They
have
shown
feasibility
customization
structure
properties
fulfill
various
needs
therapy.
Herein,
a
timely
update
special
focus
molecular
design
strategies
fluorescent,
photoacoustic,
multimodal
imaging,
offered.
Furthermore,
progress
sensing
biomarkers
even
reporting
drug
release
illustrated.
Moreover,
imaging-guided
therapies
summarized
regarding
chemo-,
photothermal,
photodynamic,
approaches.
In
addition,
artificial
intelligence
pointed
out
potential
expedite
development.
This
comprehensive
review
will
inspire
interest
among
wide
audience
offer
handbook
people
an
dyes.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(13), P. 1085 - 1085
Published: June 25, 2024
Carbon-based
nanomaterials,
such
as
carbon
quantum
dots
(CQDs)
and
2D
nanosheets
(graphene,
graphene
oxide,
graphdiyne),
have
shown
remarkable
potential
in
various
biological
applications.
CQDs
offer
tunable
photoluminescence
excellent
biocompatibility,
making
them
suitable
for
bioimaging,
drug
delivery,
biosensing,
photodynamic
therapy.
Additionally,
CQDs'
unique
properties
enable
bioimaging-guided
therapy
targeted
imaging
of
biomolecules.
On
the
other
hand,
exhibit
exceptional
physicochemical
attributes,
with
excelling
biosensing
also
delivery
antimicrobial
applications,
graphdiyne
tissue
engineering.
Their
properties,
porosity
high
surface
area,
contribute
to
controlled
release
enhanced
regeneration.
However,
challenges,
including
long-term
biocompatibility
large-scale
synthesis,
necessitate
further
research.
Potential
future
directions
encompass
theranostics,
immunomodulation,
neural
interfaces,
bioelectronic
medicine,
expanding
bioimaging
capabilities.
In
summary,
both
hold
promise
revolutionize
biomedical
sciences,
offering
innovative
solutions
improved
therapies
diverse
contexts.
Addressing
current
challenges
will
unlock
their
full
can
shape
medicine
biotechnology.
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(5)
Published: Jan. 23, 2024
Surgical
resections
of
solid
tumors
guided
by
visual
inspection
tumor
margins
have
been
performed
for
over
a
century
to
treat
cancer.
Near-infrared
(NIR)
fluorescence
labeling/imaging
in
the
NIR-I
(800
900
nm)
range
with
systemically
administrated
fluorophore/tumor-targeting
antibody
conjugates
introduced
improve
margin
delineation,
removal
accuracy,
and
patient
survival.
Here,
we
show
Au
25
molecular
clusters
functionalized
phosphorylcholine
ligands
(AuPC,
~2
nm
size)
as
preclinical
intratumorally
injectable
agent
NIR-II/SWIR
(1,000
3,000
imaging-guided
resection.
The
AuPC
were
found
be
uniformly
distributed
4T1
murine
breast
cancer
upon
intratumor
(i.t.)
injection.
phosphocholine
coating
afforded
highly
stealth
clusters,
allowing
high
percentage
fill
interstitial
fluid
space
homogeneously.
Intra-operative
surgical
navigation
imaging
NIR-II
allowed
complete
non-excessive
also
employed
photothermal
therapy
(PTT)
heat
up
eradicate
tumors.
Further,
vivo
NIR-IIb
(1,500
1,700
treated
using
quantum
dot-Annexin
V
(QD-P
3
-Anx
V)
conjugate,
revealing
cell
apoptosis
following
PTT.
therapeutic
functionalities
combined
rapid
renal
excretion,
biocompatibility,
safety
make
them
promising
clinical
translation.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 884 - 884
Published: Feb. 14, 2025
Researchers
have
extensively
investigated
photosensitizer
(PS)
derivatives
for
various
applications
due
to
their
superior
photophysical
and
electrochemical
properties.
However,
inherent
problems,
such
as
instability
self-quenching
under
physiological
conditions,
limit
biological
applications.
Metal-organic
frameworks
(MOFs)
covalent
organic
(COFs)
represent
two
relatively
new
material
types.
These
materials
high
surface
areas
permanent
porosity,
they
show
a
tremendous
deal
of
potential
like
these.
This
review
summarizes
key
synthesis
processes
highlights
recent
advancements
in
integrating
PS-based
COF
MOF
nanocarriers
biomedical
while
addressing
obstacles
prospects.
Journal of Biological Engineering,
Journal Year:
2023,
Volume and Issue:
17(1)
Published: Oct. 24, 2023
Abstract
Sensitive
and
minimally
invasive
medical
diagnostics
are
essential
to
the
early
detection
of
diseases,
monitoring
their
progression
response
treatment.
Engineered
bacteria
as
live
sensors
being
developed
a
new
class
biosensors
for
sensitive,
robust,
noninvasive,
in
situ
disease
onset
at
low
cost.
Akin
microrobotic
systems,
combination
simple
genetic
rules,
basic
logic
gates,
complex
synthetic
bioengineering
principles
used
program
bacterial
vectors
living
machines
detecting
biomarkers
some
which
cannot
be
detected
with
other
sensing
technologies.
Bacterial
whole-cell
(BWCBs)
can
have
wide-ranging
functions
from
only,
recording,
closed-loop
detection-regulated
In
this
review
article,
we
first
summarize
unique
benefits
sensors.
We
then
describe
different
bacteria-based
diagnosis
approaches
provide
examples
diagnosing
various
diseases
disorders.
also
discuss
use
imaging
image-guided
surgery.
conclude
by
highlighting
current
challenges
opportunities
further
exploration
toward
clinical
translation
these
systems.
Physical Chemistry Chemical Physics,
Journal Year:
2024,
Volume and Issue:
26(13), P. 9816 - 9847
Published: Jan. 1, 2024
This
review
article
explores
the
fascinating
realm
of
fluorescence
using
organochalcogen
molecules,
with
a
particular
emphasis
on
tellurium
(Te).
The
discussion
encompasses
underlying
mechanisms,
structural
motifs
influencing
fluorescence,
and
applications
these
intriguing
phenomena.
not
only
elucidates
current
state
knowledge
but
also
identifies
avenues
for
future
research,
thereby
serving
as
valuable
resource
researchers
enthusiasts
in
field
chemistry
focus
Te-based
molecules.
By
highlighting
challenges
prospects,
this
sparks
conversation
transformative
potential
Te-containing
compounds
across
different
fields,
ranging
from
environmental
solutions
to
healthcare
materials
science
applications.
aims
provide
comprehensive
understanding
distinct
behaviors
exhibited
by
compounds,
contributing
insights
evolving
landscape
chalcogen-based
research.
