Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(6), P. 2475 - 2504
Published: March 20, 2024
Resistance
to
cancer
immunotherapy
is
mainly
attributed
poor
tumor
immunogenicity
as
well
the
immunosuppressive
microenvironment
(TME)
leading
failure
of
immune
response.
Numerous
therapeutic
strategies
including
chemotherapy,
radiotherapy,
photodynamic,
photothermal,
magnetic,
chemodynamic,
sonodynamic
and
oncolytic
therapy,
have
been
developed
induce
immunogenic
cell
death
(ICD)
cells
thereby
elicit
boost
antitumor
However,
many
challenges
hamper
clinical
application
ICD
inducers
resulting
in
modest
Here,
we
outline
current
state
using
nanomedicines
for
boosting
cells.
Moreover,
synergistic
approaches
used
combination
with
inducing
remodeling
TME
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(2)
Published: Nov. 27, 2022
Cancer
immunotherapy
effect
can
be
greatly
enhanced
by
other
methods
to
induce
immunogenic
cell
death
(ICD),
which
has
profoundly
affected
as
a
highly
efficient
paradigm.
However,
these
treatments
have
significant
limitations,
either
causing
damage
of
the
immune
system
or
limited
superficial
tumors.
Sonodynamic
therapy
(SDT)
ICD
promote
without
affecting
because
its
excellent
spatiotemporal
selectivity
and
low
side
effects.
Nevertheless,
SDT
is
still
reactive
oxygen
species
yield
complex
tumor
microenvironment.
Recently,
some
emerging
SDT-based
nanomedicines
made
numerous
attractive
encouraging
achievements
in
field
cancer
due
high
immunotherapeutic
efficiency.
this
cross-cutting
research
far
from
being
widely
explored
huge
professional
barriers.
Herein,
characteristics
microenvironment
mechanisms
are
firstly
systematically
summarized.
Subsequently,
therapeutic
mechanism
fully
summarized,
advantages
limitations
discussed.
The
representative
advances
for
further
highlighted.
Finally,
application
prospects
challenges
future
clinical
translation
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Drug Resistance Updates,
Journal Year:
2023,
Volume and Issue:
72, P. 101018 - 101018
Published: Nov. 11, 2023
Cuproptosis
is
a
newly
identified
form
of
cell
death
driven
by
copper.
Recently,
the
role
copper
and
triggered
in
pathogenesis
cancers
have
attracted
attentions.
has
garnered
enormous
interest
cancer
research
communities
because
its
great
potential
for
therapy.
Copper-based
treatment
exerts
an
inhibiting
tumor
growth
may
open
door
chemotherapy-insensitive
tumors.
In
this
review,
we
provide
critical
analysis
on
homeostasis
dysregulation
development
progression
cancers.
Then
core
molecular
mechanisms
cuproptosis
discussed,
followed
summarizing
current
understanding
copper-based
agents
(copper
chelators,
ionophores,
complexes-based
dynamic
therapy)
treatment.
Additionally,
summarize
emerging
data
ionophores
to
subdue
chemotherapy
resistance
different
types
We
also
review
small-molecule
compounds
nanoparticles
(NPs)
that
kill
cells
inducing
cuproptosis,
which
will
shed
new
light
anticancer
drugs
through
future.
Finally,
important
concepts
pressing
questions
future
should
be
focused
were
discussed.
This
article
suggests
targeting
could
novel
antitumor
therapy
strategy
overcome
drug
resistance.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(51)
Published: June 1, 2023
Sonodynamic
therapy
(SDT)
is
a
promising
non-invasive
therapeutic
modality
to
treat
deep-seated
tumors
owing
the
good
tissue
penetration
ability
and
spatiotemporal
controllability
of
ultrasound
(US);
however,
low
sonodynamic
activity
potential
side
effects
greatly
limit
its
clinical
translation.
Cancer
immunotherapy
that
leverages
immune
system
fight
against
cancer
has
great
synergize
with
SDT
for
treatment
high
efficiency
safety.
In
this
review,
convergence
exert
their
merits
break
through
limitations
combination
sono-immunotherapy
are
discussed.
The
focus
on
development
construction
organic
materials
immunotherapeutic
efficiency.
These
not
only
induce
immunogenic
cell
death
improve
tumor
immunogenicity
via
but
also
activate
antitumor
immunity
immuno-oncology
drug-mediated
pathway
modulation.
various
drugs
sonosensitizers
categorized
discussed
along
prospects
challenges
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Small Methods,
Journal Year:
2023,
Volume and Issue:
7(5)
Published: Feb. 21, 2023
Abstract
In
cancer
treatment,
traditional
radiotherapy
(RT)
is
routinely
conducted
in
local
tumors
and
limited
by
radioresistance,
while
recently
emerged
immunotherapy
confronted
with
low
response
rate,
high
cost,
cytokine
release
syndrome.
Logically,
the
combination
of
two
therapeutic
modalities
into
radioimmunotherapy
promising
to
complement
each
other
for
systemic
elimination
cells
specificity,
efficiency,
safety.
Especially,
RT‐induced
immunogenic
cell
death
(ICD)
plays
an
imperative
role
evoke
immune
against
cancer,
including
elevating
immunity
tumor
antigens,
recruiting
activating
antigen‐presenting
cells,
priming
cytotoxic
T
lymphocytes
tumoral
infiltration
eradication.
This
review
first
retrospects
origin
concept
ICD,
summarizes
major
damage‐associated
molecular
patterns
signaling
pathways,
highlights
characteristics
ICD.
Subsequently,
strategies
enhancing
ICD
are
reviewed
from
perspectives
RT
itself,
treatments,
stimulating
holistic
system.
On
basis
these
published
research
underlying
mechanism,
this
work
attempts
forecast
possible
directions
enhancement
promote
clinical
applications.
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 94 - 114
Published: Aug. 7, 2023
Immunogenic
cell
death
(ICD)
is
a
unique
mode
of
death,
which
can
release
immunogenic
damage-associated
molecular
patterns
(DAMPs)
and
tumor-associated
antigens
to
trigger
long-term
protective
antitumor
immune
responses.
Thus,
amplifying
"eat
me
signal"
during
tumor
ICD
cascade
critical
for
cancer
immunotherapy.
Some
therapies
(radiotherapy,
photodynamic
therapy
(PDT),
photothermal
(PTT),
etc.)
inducers
(chemotherapeutic
agents,
have
enabled
initiate
and/or
facilitate
activate
Recently,
nanostructure-based
drug
delivery
systems
been
synthesized
inducing
through
combining
treatment
chemotherapeutic
photosensitizers
PDT,
transformation
agents
PTT,
radiosensitizers
radiotherapy,
etc.,
loaded
at
an
appropriate
dosage
in
the
designated
place
time,
contributing
higher
efficiency
lower
toxicity.
Also,
immunotherapeutic
combination
with
produce
synergetic
effects,
thus
potentiating
Overall,
our
review
outlines
emerging
inducers,
nanostructure
loading
diverse
evoke
chemoradiotherapy,
PTT
or
agents.
Moreover,
we
discuss
prospects
challenges
harnessing
induction-based
immunotherapy,
highlight
significance
multidisciplinary
interprofessional
collaboration
promote
optimal
translation
this
strategy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(18)
Published: Jan. 15, 2024
Abstract
Mitochondria,
widely
known
as
the
energy
factories
of
eukaryotic
cells,
have
a
myriad
vital
functions
across
diverse
cellular
processes.
Dysfunctions
within
mitochondria
serve
catalysts
for
various
diseases,
prompting
widespread
demise.
Mounting
research
on
remedying
damaged
indicates
that
constitute
valuable
target
therapeutic
intervention
against
diseases.
But
less
clinical
practice
and
lower
recovery
rate
imply
limitation
traditional
drugs,
which
need
further
breakthrough.
Nanotechnology
has
approached
favorable
regiospecific
biodistribution
high
efficacy
by
capitalizing
excellent
nanomaterials
targeting
drug
delivery.
Mitochondria‐remedying
nanodrugs
achieved
ideal
effects.
This
review
elucidates
significance
in
cells
organs,
while
also
compiling
mortality
data
related
Correspondingly,
nanodrug‐mediate
strategies
applicable
mitochondria‐remedying
disease
are
detailed,
with
full
understanding
roles
dysfunction
advantages
nanodrugs.
In
addition,
future
challenges
directions
discussed.
conclusion,
this
provides
comprehensive
insights
into
design
development
nanodrugs,
aiming
to
help
scientists
who
desire
extend
their
fields
engage
interdisciplinary
subject.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: Feb. 19, 2024
Abstract
Sonodynamic
therapy
(SDT)
has
been
explored
for
cancer
therapy,
especially
deep
tumors
due
to
its
low
tissue
penetration
restriction.
The
therapeutic
efficacy
of
SDT
is
limited
the
complicated
tumor
microenvironment.
This
study
reports
construction
oxygen‐carrying
semiconducting
polymer
nanoprodrugs
(OSPN
pro
)
treatment
via
combining
amplified
with
pyroptosis.
An
oxygen
carrier
perfluorohexane,
sonodynamic
as
sonosensitizer,
and
reactive
species
(ROS)‐responsive
prodrug
are
co‐loaded
into
a
nanoparticle
system,
leading
formation
these
nanoprodrugs.
Such
OSPN
show
an
effective
accumulation
in
tissues
after
systemic
administration,
which
they
deliver
relieve
hypoxia
microenvironment
thus
mediate
producing
ROS
under
ultrasound
(US)
irradiation,
even
when
covered
2‐cm
chicken
breast
tissue.
In
addition,
ROS‐responsive
prodrugs
activated
by
generated
trigger
pyroptosis
cells.
sono‐pyroptosis
induces
strong
antitumor
immunity
obviously
higher
level
infiltrations
effector
immune
cells
tumors.
Therefore,
‐based
combinational
can
greatly
inhibit
growth
tissue‐covered
suppress
metastasis.
offers
nanoplatform
strategy.
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(4)
Published: April 25, 2024
Abstract
Copper
is
a
necessary
micronutrient
for
maintaining
the
well-being
of
human
body.
The
biological
activity
organic
ligands,
especially
their
anticancer
activity,
often
enhanced
when
they
coordinate
with
copper(I)
and
(II)
ions.
its
compounds
are
capable
inducing
tumor
cell
death
through
various
mechanisms
action,
including
activation
apoptosis
signaling
pathways
by
reactive
oxygen
species
(ROS),
inhibition
angiogenesis,
induction
cuproptosis,
paraptosis.
Some
copper
complexes
currently
being
evaluated
in
clinical
trials
ability
to
map
hypoxia
cancers,
locally
advanced
rectal
cancer
bulky
tumors.
Several
studies
have
shown
that
nanoparticles
can
be
used
as
effective
agents
chemodynamic
therapy,
phototherapy,
hyperthermia,
immunotherapy.
Despite
promising
copper-based
compounds,
use
subject
certain
limitations.
Elevated
concentrations
may
promote
growth,
metastasis
affecting
cellular
processes.
