Cited by GRP78: A New Promising Candidate in Colorectal Cancer Pathogenesis and Therapy

Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance DOI

Yanhong Xiao, M Hassani,

Melina Barahouei Moghaddam

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 14, 2025

Language: Английский

Citations

Nanotechnology-based biomedical devices in the cancer diagnostics and therapy DOI

Junaid Tantray, Akhilesh Patel,

Hiba Parveen

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(2)

Published: Jan. 20, 2025

Language: Английский

Citations

Overcoming Obstacles: The Role of Lipid Nanocarriers in Therapeutic Approaches for Pancreatic Cancer DOI

Md Sadique Hussain, Bhupendra G. Prajapati, Sonu Gandhi

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 11, 2025

Language: Английский

Citations

Using New Technologies to Analyze Gut Microbiota and Predict Cancer Risk DOI

Mohammad Amin Hemmati, Marzieh Monemi,

Shima Asli

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1987 - 1987

Published: Dec. 1, 2024

The gut microbiota significantly impacts human health, influencing metabolism, immunological responses, and disease prevention. Dysbiosis, or microbial imbalance, is linked to various diseases, including cancer. It crucial preserve a healthy microbiome since pathogenic bacteria, such as

Language: Английский

Citations

A new quantum-enhanced approach to AI-driven medical imaging system DOI

Seyed‐Sajad Ahmadpour,

Danial Bakhshayeshi Avval,

Mehdi Darbandi

et al.

Cluster Computing, Journal Year: 2025, Volume and Issue: 28(3)

Published: Jan. 28, 2025

Language: Английский

Citations

Green Synthesis of Copper Nanoparticles Using Panchagavya: Nanomaterials for Antibacterial, Anticancer, and Environmental Applications DOI

Samuthirapandi Muniasamy, Marissa Angelina, Ponnirul Ponmanickam

et al.

Luminescence, Journal Year: 2025, Volume and Issue: 40(2)

Published: Feb. 1, 2025

ABSTRACT This study explores the green synthesis of copper nanoparticles (Cu‐NPs) using Panchagavya, a traditional organic substance composed five cow‐derived components, as reducing and stabilizing agent. Cu‐NPs were characterized UV–Vis, FT‐IR, XRD, SEM‐EDS, TEM, DLS, zeta potential analysis, which revealed their size, shape, elemental properties. They exhibited strong antibacterial activity against Bacillus cereus Pseudomonas aeruginosa . Biofilm inhibition was observed at various concentrations, with 38.98% ½ MIC, 67.48% 84.03% 2× MIC. SEM analysis confirmed that disrupted bacterial cell membrane, causing leakage cellular contents. Antioxidant assays (DPPH, FRAP) high scavenging activity, percentages 88.50% 92.54%, respectively. showed anticancer on MCF7 cells, an IC 50 38.18 μg/mL. Additionally, significantly reduced nitric oxide (NO) production in RAW 264.7 macrophage cells dose‐dependent manner. The also larvicidal efficacy, 99.12% mortality Aedes aegypti 95.26% Culex quinquefasciatus , LC values 29.40 μg/mL 93.55 μg/mL, Morphological changes treated larvae included body shrinkage degeneration tracheal tube ventral brush noticed compared to control. Histopathological examinations Cu‐NP‐treated several structural damages, including damage gut epithelial dissipation muscle layer, loss goblet cells. GC–MS Panchagavya its for biological applications. These findings highlight eco‐friendly multifunctional nature Panchagavya‐mediated Cu‐NPs, demonstrating antimicrobial, antioxidant, anticancer, applications, could contribute sustainable pest disease management strategies.

Language: Английский

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An interdisciplinary approach to assessing the toxicity reduction of cerium oxide nanoparticles coated with polyethylene glycol and polyvinylpyrrolidone polymers: An in vitro study DOI

Mohadeseh Soltani,

Motahareh Soltani,

Somayyeh Karami‐Mohajeri

et al.

Toxicology in Vitro, Journal Year: 2025, Volume and Issue: unknown, P. 106022 - 106022

Published: Feb. 1, 2025

Language: Английский

Citations

Cerium‐Decorated Reduced Graphene Oxide Nanostructure for Enhanced Biomedical Applications DOI

Manoj Jayan,

Anjumol Joy,

Jitesh Kumar

et al.

Luminescence, Journal Year: 2025, Volume and Issue: 40(2)

Published: Feb. 1, 2025

The development of multifunctional biomaterials holds paramount importance in advancing biomedical research and applications. This investigation focuses on synthesizing cerium/reduced graphene oxide (Ce/RGO) nanocomposites using a hydrothermal approach. Structural evaluations via XRD Raman spectroscopy confirm the successful conversion (GO) to rGO integration cerium nanoparticles onto surface. FTIR further validates structural alterations adhesion nanoparticles. Morphological elemental analyses performed FE-SEM EDAX demonstrate attachment sheets. Enhanced hardness Ce/rGO samples, compared with pure rGO, as indicated by Vickers testing, suggests improved mechanical properties because existence Measurements water contact angle show reduced hydrophobicity Ce-rGO implying enhanced wettability upon nanoparticle integration. Additionally, porosity analysis reveals increased facilitating nutrient transfer within system. Biocompatibility assessments, including hemolytic activity testing Vero cell viability tests favorable biocompatibility samples rGO. Antibacterial studies unveil efficacy against S. aureus E. coli attributed synergistic effects rGO's antimicrobial nanoparticles' activity. study highlights encouraging potential nanostructures for applications, offering distinct properties, hydrophilicity, biological interactions, antibacterial performance.

Language: Английский

Citations

Tumor microenvironment: recent advances in understanding and its role in modulating cancer therapies DOI

Disha D. Shah, Mehul R. Chorawala, Neha R. Raghani

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 18, 2025

Language: Английский

Citations

The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials DOI

Chen Zhang,

Shu Xu,

Chuanzheng Yin

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 29, 2025

Breast cancer remains the most frequently diagnosed globally, exerting a profound impact on women's health and healthcare systems. Central to its pathogenesis therapeutic resistance are breast stem cells (BCSCs), which possess unique properties such as self-renewal, differentiation, conventional therapies, contributing tumor initiation, metastasis, recurrence. This comprehensive review elucidates pivotal role of mechanistic target rapamycin (mTOR) pathway in regulating BCSCs implications for progression treatment resistance. We explore cellular mechanisms by mTOR influences metabolism, autophagy, ferroptosis BCSCs, highlighting contribution epithelial-to-mesenchymal transition (EMT), metabolic reprogramming, survival under stress. On molecular level, interacts with key signaling pathways including PI3K/Akt, Notch, IGF-1R, AMPK, TGF-β, well regulatory proteins non-coding RNAs, orchestrating complex network that sustains BCSC mediates chemoresistance radioresistance. The further examines various strategies targeting encompassing selective PI3K/Akt/mTOR inhibitors, monoclonal antibodies, natural products, innovative approaches nanoparticle-mediated drug delivery. Clinical trials investigating inhibitors like sirolimus combination therapies agents everolimus trastuzumab discussed, underscoring their potential eradicating improving patient outcomes. Additionally, compounds repurposed drugs offer promising adjunctive modulating activity BCSC-specific vulnerabilities. In conclusion, presents viable avenue enhancing efficacy effectively eliminating reducing recurrence, overall survival. Continued research clinical validation mTOR-targeted essential translate these insights into effective interventions, ultimately advancing personalized management outcomes patients.

Language: Английский

Citations