Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(20)
Published: July 5, 2024
Abstract
Amphiphilic
peptides
have
garnered
significant
attention
due
to
their
highly
designable
and
self‐assembling
behaviors.
Self‐assembled
hold
excellent
potential
in
various
fields
such
as
biosensing,
environmental
monitoring,
drug
delivery,
owing
remarkable
biological,
physical,
chemical
properties.
While
nanomaterials
formed
by
peptide
self‐assembly
found
widespread
use
biomedical
applications,
the
development
of
2D
nanosheets
based
on
amphiphilic
remains
challenging
terms
rational
design
morphology
modulation.
In
this
study,
rationally
designed
molecules
are
self‐assembled
into
(PNS)
under
specific
conditions
encapsulate
gold
nanoparticles
(AuNPs),
resulting
formation
AuNPs/PNS
hybrid
materials
with
high
photothermal
conversion
efficiency.
The
findings
demonstrate
that
PNS
enhances
overall
therapy
effect
nanohybrid
larger
hosting
area
for
AuNPs
higher
biocompatibility.
well‐designed
study
offer
insights
structural
functional
modulation
molecules.
addition,
constructed
biomimetic‐functional
inorganic/organic
applications
engineering.
Biomedical
materials
are
of
great
significance
for
preventing
and
treating
major
diseases
protecting
human
health.
At
present,
more
stringent
requirements
have
been
put
forward
the
preparation
methods
dimension
control
biomedical
based
on
urgent
demand
high-performance
materials,
especially
existence
various
physiological
size
thresholds
in
vitro/in
vivo.
Microfluidic
platforms
break
limitations
traditional
micro-/nanomaterial
synthesis,
which
provide
a
miniaturized
highly
controlled
environment
size-dependent
biomaterials.
In
this
review,
basic
conceptions
technical
characteristics
microfluidics
first
described.
Then
syntheses
with
different
dimensions
(0D,
1D,
2D,
3D)
driven
by
systematically
summarized.
Meanwhile,
applications
microfluidics-driven
including
diagnosis,
anti-inflammatory,
drug
delivery,
antibacterial,
disease
therapy,
discussed.
Furthermore,
challenges
developments
research
field
further
proposed.
This
work
is
expected
to
facilitate
convergence
between
bioscience
engineering
communities
continue
contribute
emerging
field.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: April 6, 2023
As
an
interdisciplinary
field,
drug
delivery
relies
on
the
developments
of
modern
science
and
technology.
Correspondingly,
how
to
upgrade
traditional
dosage
forms
for
a
more
efficacious,
safer,
convenient
poses
continuous
challenge
researchers.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: July 2, 2023
Abstract
Natural
materials
and
bioprocesses
provide
abundant
inspirations
for
the
design
synthesis
of
high‐performance
nanomaterials.
In
past
several
decades,
bioinspired
nanomaterials
have
shown
great
potential
in
application
biomedical
fields,
such
as
tissue
engineering,
drug
delivery,
cancer
therapy,
so
on.
this
review,
three
types
strategies
nanomaterials,
that
is,
inspired
by
natural
structures,
biomolecules,
bioprocesses,
are
mainly
introduced.
We
summarize
discuss
concepts
approaches
various
along
with
their
specific
roles
applications.
Additionally,
we
challenges
development
mechanical
failure
wet
environment,
limitation
scale‐up
fabrication,
lack
deep
understanding
biological
properties.
It
is
expected
clinical
translation
will
be
further
promoted
under
cooperation
interdisciplinary
subjects
future.
This
article
categorized
under:
Implantable
Materials
Surgical
Technologies
>
Nanomaterials
Implants
Therapeutic
Approaches
Drug
Discovery
Emerging
Cancers,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3836 - 3836
Published: July 28, 2023
Cancer
is
an
impending
bottleneck
in
the
advanced
scientific
workflow
to
achieve
diagnostic,
prognostic,
and
therapeutic
success.
Most
cancers
are
refractory
conventional
diagnostic
chemotherapeutics
due
their
limited
targetability,
specificity,
solubility,
side
effects.
The
inherent
ability
of
each
cancer
evolve
through
various
genetic
epigenetic
transformations
metabolic
reprogramming
underlies
limitations.
Though
tumor
microenvironments
(TMEs)
quite
well
understood
some
cancers,
microenvironment
differs
from
other
internal
perturbations
skew
thereby
impeding
development
appropriate
diagnostics,
drugs,
vaccines,
therapies.
associated
bioenergetics
modulations
regulate
TME,
angiogenesis,
immune
evasion,
generation
resistant
niches
progression,
a
thorough
understanding
crucial
However,
this
remains
missing
element
theranostics,
necessitating
modalities
that
can
be
adapted
for
diagnostics
therapeutics.
In
challenging
scenario,
nanomaterials
modular
platforms
TME
achieving
successful
theranostics.
Several
nanoscale
particles
have
been
successfully
researched
animal
models,
few
reached
clinical
trials,
achieved
Nanoparticles
exhibit
intrinsic
capability
interact
with
diverse
biomolecules
modulate
functions.
Furthermore,
nanoparticles
functionalized
receptors,
modulators,
drugs
facilitate
specific
targeting
reduced
toxicity.
This
review
discusses
current
different
theranostic
nanosystems,
synthesis,
functionalization,
targetability
modulation
bioenergetics,
microenvironment.
We
highlight
potential
nanosystems
enhanced
chemotherapeutic
success
emphasizing
questions
remain
unanswered.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(11), P. e21334 - e21334
Published: Oct. 20, 2023
Colorectal
cancer
(CRC)
is
one
of
the
most
common
malignancies
with
a
high
mortality
rate
worldwide.
While
surgery,
chemotherapy,
and
radiotherapy
have
shown
some
effectiveness
in
improving
survival
rates,
they
come
drawbacks
such
as
side
effects
harm
to
healthy
tissues.
The
theranostic
approach,
which
integrates
processes
diagnosis
treatment,
can
minimize
biological
effects.
Photothermal
therapy
(PTT)
an
emerging
treatment
method
that
usages
light-sensitive
agents
generate
heat
at
tumor
site
induce
thermal
erosion.
development
nanotechnology
for
CRC
using
imaging-guided
PTT
has
garnered
significant.
Nanoparticles
suitable
physical
chemical
properties
enhance
efficiency
PTT.
This
approach
enables
monitoring
progress
safeguards
In
this
article,
we
concisely
introduce
application
metal
nanoparticles,
polymeric
carbon
nanoparticles
colorectal
cancer.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 9, 2024
Abstract
Different
from
most
of
the
conventional
platforms
with
dissatisfactory
theranostic
capabilities,
supramolecular
nanotheranostic
systems
have
unparalleled
advantages
via
artful
combination
chemistry
and
nanotechnology.
Benefiting
tunable
stimuli-responsiveness
compatible
hierarchical
organization,
host–guest
interactions
developed
into
popular
mainstay
for
constructing
nanoplatforms.
Characterized
by
strong
diverse
complexation
property,
cucurbit[8]uril
(CB[8])
shows
great
potential
as
important
building
blocks
systems.
In
this
review,
we
summarize
recent
progress
CB[8]-based
theranostics
regarding
design,
manufacture
mechanism.
Meanwhile,
current
limitations
corresponding
reasonable
solutions
well
future
development
are
also
discussed.
Graphical
APL Materials,
Journal Year:
2024,
Volume and Issue:
12(8)
Published: Aug. 1, 2024
MXenes,
a
novel
class
of
two-dimensional
(2D)
materials,
have
attracted
considerable
attention
in
various
fields,
especially
drug
delivery,
wound
healing,
bone
tissue
engineering,
biosensing,
and
cancer
treatment.
Thanks
to
their
remarkable
physicochemical
properties,
MXenes
hold
great
promise
for
biomedical
applications.
Concurrently,
hydrogels
composed
polymers
been
extensively
utilized
contexts.
The
unique
properties
facilitate
integration
into
bioactive
with
enhanced
functions
thereby
endowing
the
composites
multifunctional
capabilities.
MXene-reinforced
polymer
(MRPHs)
synergistically
combine
advantageous
characteristics
both
hydrogels,
making
them
highly
adaptable
other
theranostic
strategies
medical
In
this
comprehensive
review,
we
demonstrate
recent
advances
design
synthesis
MRPHs
Specifically,
introduce
analyze
methods
tailoring
by
incorporating
active
components,
including
functional
molecules,
2D
metal
ions,
natural
polymers,
drugs/genes.
We
then
discuss
applications
designed
biosensors,
therapy.
hope
that
work
provides
valuable
guidance
inspiration
readers
develop
advanced
