Processes,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2938 - 2938
Published: Dec. 23, 2024
Plant-derived
extracellular
vesicles
(PDEVs)
are
lipid
bilayer
nanoparticles,
naturally
produced
by
plant
cells,
with
sizes
ranging
from
50
to
500
nm.
Recent
studies
have
highlighted
their
great
potential
in
the
biotechnological
and
medical
fields,
due
natural
origin,
high
biocompatibility
intrinsic
therapeutic
properties.
PDEVs
contain
a
complex
biological
cargo
of
proteins,
lipids,
nucleic
acids
secondary
metabolites,
including
antioxidants
anti-inflammatory
molecules,
making
them
ideal
for
biomedical
applications
such
as
drug
delivery.
These
play
key
role
intercellular
communication
gene
regulation,
proving
be
particularly
promising
personalized
medicine.
ability
improve
stability
bioavailability,
optimizing
targeted
release
minimizing
side
effects.
Despite
some
challenges,
compositional
variability
need
standardized
protocols,
at
gunsight
innovative
research
aimed
improving
loading
capacity
specificity.
This
review
aims
provide
comprehensive
overview
PDEVs,
exploring
structure,
isolation
methods,
functional
characteristics,
applications,
highlighting
advantages
over
synthetic
nanoparticles
animal-derived
vesicles,
leading
an
sustainable
solution
development
new
approaches.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 25, 2024
Abstract
The
innate
immune
pathway
is
receiving
increasing
attention
in
cancer
therapy.
This
ubiquitous
across
various
cell
types,
not
only
cells
but
also
adaptive
cells,
tumor
and
stromal
cells.
Agonists
targeting
the
have
shown
profound
changes
microenvironment
(TME)
improved
prognosis
preclinical
studies.
However,
to
date,
clinical
success
of
drugs
remains
limited.
Interestingly,
recent
studies
that
activation
can
paradoxically
promote
progression.
uncertainty
surrounding
therapeutic
effectiveness
targeted
for
a
critical
issue
needs
immediate
investigation.
In
this
review,
we
observe
role
demonstrates
heterogeneity,
linked
development
stage,
status,
specific
types.
We
propose
within
TME,
exhibits
multidimensional
diversity.
diversity
fundamentally
rooted
cellular
heterogeneity
manifested
as
variety
signaling
networks.
pro-tumor
effect
essentially
reflects
suppression
classical
pathways
potential
alternative
pathways.
Refining
our
understanding
tumor’s
network
employing
appropriate
strategies
enhance
ability
harness
anti-tumor
ultimately
bridge
gap
from
application.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 4751 - 4778
Published: Aug. 1, 2023
Abstract:
Exosomes,
as
natural
nanocarriers,
characterized
with
low
immunogenicity,
non-cytotoxicity
and
targeted
delivery
capability,
which
have
advantages
over
synthetic
nanocarriers.
Recently,
exosomes
shown
great
potential
diagnostic
markers
for
diseases
are
also
considered
a
promising
cell-free
therapy.
Engineered
significantly
enhanced
the
efficacy
precision
of
delivering
therapeutic
agents,
currently
being
extensively
employed
in
investigations
various
ailments,
including
oncology,
inflammatory
disorders,
degenerative
conditions.
Particularly,
engineered
enable
agent
loading,
modification,
evasion
MPS
phagocytosis,
intelligent
control,
bioimaging,
been
developed
multifunctional
nano-delivery
platforms
recent
years.
The
utilization
bioactive
scaffolds
that
loaded
exosome
has
to
substantially
augment
retention,
extend
release,
enhance
efficacy.
This
approach
advanced
from
conventional
hydrogels
nanocomposite
hydrogels,
nanofiber
3D
printing,
resulting
superior
physical
biological
properties
effectively
address
limitations
scaffolds.
Additionally,
plant-derived
exosomes,
can
participate
gut
flora
remodeling
via
oral
administration,
an
ideal
platform
treatment
intestinal
diseases.
Consequently,
there
is
interest
nanocarriers
applications.
comprehensive
review
provides
overview
biogenesis,
composition,
isolation
methods
exosomes.
it
examines
pathological
mechanisms
diseases,
tumors,
Furthermore,
this
highlights
significance
microbial-derived
Strategies
specific
applications
scaffold-loaded
further
summarized,
especially
some
new
techniques
such
large-scale
loading
technique,
macromolecular
development
nano-scaffold-loaded
delivery.
benefits
using
gut-related
discussed.
challenges,
opportunities,
prospects
exosome-based
disease
diagnosis
summarized
both
preclinical
clinical
viewpoints.
Keywords:
diagnosis,
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116543 - 116543
Published: April 11, 2024
In
recent
years,
there
has
been
an
increasing
number
of
related
studies
on
exosomes.
Most
have
focused
exosomes
derived
from
mammals,
confirming
the
important
role
that
play
in
cell
communication.
Plants,
as
a
natural
ingredient,
plant-derived
confirmed
to
similar
structures
and
functions
mammalian-derived
Plant-derived
exosome-like
nanoparticles
(PELNs)
are
lipid
bilayer
membrane
nanovesicles
containing
bioactive
constituents
such
miRNA,
mRNA,
protein,
lipids
obtained
plant
cells,
can
participate
intercellular
communication
mediate
transboundary
communication,
high
bioavailability
low
immunogenicity,
relatively
safe,
shown
maintaining
homeostasis
preventing,
treating
variety
diseases.
this
review,
we
describe
biogenesis,
isolation
purification
methods,
structural
composition,
stability,
safety,
function
PELNs
challenges.
The
anti-inflammatory,
antioxidant,
antitumor
drug
delivery
mainly
described,
status
research
exosome
Chinese
herbal
medicines
is
outlined.
Overall,
summarized
importance
latest
results
field
provided
theoretical
basis
for
future
clinical
application
PELNs.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
200, P. 107062 - 107062
Published: Jan. 9, 2024
Extracellular
vesicles
(EVs)
are
tiny
lipid
bilayer-enclosed
membrane
particles
released
from
a
variety
of
cell
types
into
the
surrounding
environment.
These
EVs
have
massive
participated
in
cell-to-cell
communication
and
interspecies
communication.
In
recent
years,
plant-derived
extracellular
(PDEVs)
"exosome-like"
populations
found
distinct
plants
attracted
widespread
attention.
Especially,
research
on
medicinal
(MPDEVs)
increasing,
which
considered
kind
promising
natural
compound.
This
review
summarizes
current
knowledge
MPDEVs
terms
bioactive
compounds,
including
small
RNA,
protein,
lipid,
metabolite,
been
surface
and/or
lumen
MPDEVs.
Moreover,
both
vitro
vivo
experiments
shown
that
exert
broad
biomedical
functions,
such
as
anti-inflammatory,
anticancer,
antioxidant,
modulate
microbiota,
etc.
may
be
better
substitute
than
animal-derived
(ADEVs)
because
safety
biocompatibility
future.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1189 - 1204
Published: Feb. 1, 2024
Abstract:
Tissue
engineering
holds
great
potential
for
tissue
repair
and
rejuvenation.
Plant-derived
exosome-like
nanoparticles
(ELNs)
have
recently
emerged
as
a
promising
avenue
in
engineering.
However,
there
is
an
urgent
need
to
understand
how
plant
ELNs
can
be
therapeutically
applied
clinical
disease
management,
especially
regeneration.
In
this
review,
we
comprehensively
examine
the
properties,
characteristics,
isolation
techniques
of
ELNs.
We
also
discuss
their
impact
on
immune
system,
compatibility
with
human
body,
role
To
ensure
suitability
engineering,
explore
various
modification
strategies.
Additionally,
provide
insights
into
progress
commercialization
industrial
perspectives
This
review
aims
highlight
regenerative
medicine
by
exploring
current
research
landscape
key
findings.
Keywords:
plant,
nanoparticles,
nanomedicine,
cartilage,
wound,
bone
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3834 - 3854
Published: June 3, 2024
Immunotherapy
is
an
important
cancer
treatment
method
that
offers
hope
for
curing
patients.
While
immunotherapy
has
achieved
initial
success,
a
major
obstacle
to
its
widespread
adoption
the
inability
benefit
majority
of
The
success
or
failure
closely
linked
tumor's
immune
microenvironment.
Recently,
there
been
significant
attention
on
strategies
regulate
tumor
microenvironment
in
order
stimulate
anti-tumor
responses
immunotherapy.
distinctive
physical
properties
and
design
flexibility
nanomedicines
have
extensively
utilized
target
cells
(including
tumor-associated
macrophages
(TAMs),
T
cells,
myeloid-derived
suppressor
(MDSCs),
fibroblasts
(TAFs)),
offering
promising
advancements
In
this
article,
we
reviewed
aimed
at
targeting
various
focus
models
are
based
nanomedicines,
with
goal
inducing
enhancing
improve
It
worth
noting
combining
other
treatments,
such
as
chemotherapy,
radiotherapy,
photodynamic
therapy,
can
maximize
therapeutic
effects.
Finally,
identified
challenges
nanotechnology-mediated
needs
overcome
more
effective
nanosystems.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 9, 2024
Abstract
Tumor
cells
primarily
employ
the
PD-1/PD-L1
pathway
to
thwart
anti-tumor
capabilities
of
T
lymphocytes,
inducing
immunosuppression.
This
occurs
through
direct
interaction
PD-L1
with
PD-1
on
lymphocyte
surfaces.
Recent
research
focusing
tumor
microenvironment
has
illuminated
pivotal
role
immune
cells,
particularly
tumor-associated
macrophages
(TAMs),
in
facilitating
PD-L1-mediated
Exosomes,
characterized
by
their
ability
convey
information
and
be
engulfed
significantly
contribute
promoting
TAM
involvement
establishing
immunosuppression
within
microenvironment.
In
addition
receiving
signals
from
tumor-derived
exosomes
that
promote
expression,
TAMs
also
exert
control
over
expression
release
exosomes.
paper
aims
summarize
mechanisms
which
participate
this
process,
identify
crucial
factors
influence
these
mechanisms,
explore
innovative
strategies
for
inhibiting
or
reversing
tumor-promoting
effects
targeting
