Nanoscale, Journal Year: 2024, Volume and Issue: 16(35), P. 16329 - 16343
Published: Jan. 1, 2024
Ultrasonic nanotechnology is a groundbreaking, non-invasive approach for treating Staphylococcus aureus skin infections, effectively addressing antibiotic resistance and biofilm formation.
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117177 - 117177
Published: July 24, 2024
Cytokines regulate immune responses essential for maintaining homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge promising therapeutic agents because they mitigate oxidative stress and modulate pathways. Antioxidants potentially ameliorate inflammation-related disorders by counteracting excessive cytokine-mediated responses. A comprehensive understanding of pathways the interplay with is paramount developing natural targeting helping improve clinical outcomes enhance quality life patients. Among these antioxidants, curcumin, vitamin C, D, propolis, allicin, cinnamaldehyde have garnered attention their anti-inflammatory properties potential benefits. This review highlights interrelationship between cytokines-mediated in various diseases approaches involving antioxidants.
Language: Английский
Citations
83
Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899
Published: July 9, 2024
This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.
Language: Английский
Citations
73
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)
Published: Nov. 6, 2024
Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.
Language: Английский
Citations
13
Beilstein Journal of Nanotechnology, Journal Year: 2025, Volume and Issue: 16, P. 195 - 215
Published: Feb. 17, 2025
The human eye, with its remarkable resolution of up to 576 million pixels, grants us the ability perceive world astonishing accuracy. Despite this, over 2 billion people globally suffer from visual impairments or blindness, primarily because limitations current ophthalmic treatment technologies. This underscores an urgent need for more advanced therapeutic approaches effectively halt even reverse progression eye diseases. rapid advancement nanotechnology offers promising pathways development novel therapies. Notably, photothermal nanomaterials, particularly well-suited transparent tissues have emerged as a potential game changer. These materials enable precise and controllable therapy by manipulating distribution thermal field. Moreover, they extend beyond conventional boundaries therapy, achieving unparalleled effects through their diverse composite structures demonstrating enormous in promoting retinal drug delivery photoacoustic imaging. paper provides comprehensive summary structure-activity relationship between properties these nanomaterials innovative mechanisms. We review latest research on nanomaterial-based treatments various Additionally, we discuss challenges future perspectives this field, focus enhancing global health.
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 5, 2025
Photoacoustic brain imaging (PABI) has emerged as a promising biomedical modality, combining high contrast of optical with deep tissue penetration ultrasound imaging. This review explores the application photoacoustic in tumor imaging, highlighting synergy between nanomaterials and state art techniques to achieve high-resolution deeper tissues. PABI leverages effect, where absorbed light energy causes thermoelastic expansion, generating waves that are detected converted into images. technique enables precise diagnosis, therapy monitoring, enhanced clinical screening, specifically management complex diseases such breast cancer, lymphatic disorder, neurological conditions. Despite integration agents radiation, providing comprehensive overview current methodologies, major obstacles treatment, future directions for improving diagnostic therapeutic outcomes. The underscores significance robust research tool medical method, potential revolutionize disease diagnosis treatment.
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101028 - 101028
Published: March 24, 2024
The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.
Language: Английский
Citations
8
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9549 - 9574
Published: Sept. 1, 2024
Molecular imaging is an advanced technology that utilizes specific probes or markers in conjunction with cutting-edge techniques to observe and analyze the localization, distribution, activity, interactions of biomolecules within living organisms. Tumor molecular imaging, by enabling visualization quantification characteristics tumor cells, facilitates a deeper more comprehensive understanding tumors, providing valuable insights for early diagnosis, treatment monitoring, cancer biology research. However, image quality still requires improvement, nanotechnology has significantly propelled advancement imaging. Currently, nanoparticle-based technologies encompass radionuclide fluorescence magnetic resonance ultrasound photoacoustic multimodal among others. As our microenvironment deepens, design nanoparticle also evolved, offering new perspectives expanding applications Beyond diagnostics, there marked trend towards integrated diagnosis therapy, image-guided playing pivotal role. This includes surgery, photodynamic chemodynamic therapy. Despite continuous advancements innovative developments many these remain experimental stage require breakthroughs before they can be fully into clinical practice.
Language: Английский
Citations
8
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 10, 2024
Abstract Background Properly designed second near-infrared (NIR-II) nanoplatform that is responsive tumor microenvironment can intelligently distinguish between normal and cancerous tissues to achieve better targeting efficiency. Conventional photoacoustic nanoprobes are always “on”, microenvironment-responsive nanoprobe minimize the influence of endogenous chromophore background signals. Therefore, development respond internal external stimulus shows great application potential for diagnosis tumor. Results In this work, a low-pH-triggered thermal-responsive volume phase transition nanogel gold nanorod@poly(n-isopropylacrylamide)-vinyl acetic acid (AuNR@PNIPAM-VAA) was constructed detection Via an photothermal switch, absorption AuNR@PNIPAM-VAA in be dynamically regulated, so produces switchable signals NIR-II window tumor-specific enhanced imaging. vitro results show at pH 5.8, signal amplitude increases up obviously after modulating, while they remain slightly change 7.4. Quantitative calculation presents 1064 nm has ~ 1.6 folds enhancement as temperature from 37.5 °C 45 simulative microenvironment. vivo prepared imaging selective through responding thermal field, which precisely controlled by light. Conclusions This work will offer viable strategy using NIR light regulate field target low microenvironment, expected realize accurate dynamic monitoring treatment.
Language: Английский
Citations
7
Current Drug Targets, Journal Year: 2024, Volume and Issue: 25(4), P. 241 - 260
Published: Jan. 29, 2024
Cancer is the most widely studied disorder in humans, but proper treatment has not yet been developed for it. Conventional therapies, like chemotherapy, radiation therapy, and surgery, have employed. Such therapies target only cancerous cells also harm normal cells. therapy does result specific targeting hence leads to severe side effects. The main objective of this study explore QDs. QDs are used as nanocarriers diagnosis at same time. They based on principle theranostic approach. can be conjugated with antibodies
Language: Английский
Citations
4
Archives of Gastroenterology Research, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 10
Published: Jan. 1, 2024
Background: Liver fibrosis staging is critical for patient selection and management prior to transplantation, but biopsy invasive serum biomarkers lack accuracy. Near-infrared spectroscopy (NIRS) an emerging non-invasive technology that can detect liver via changes in tissue composition. Machine learning (ML) enables analysis of NIRS data diagnostic modeling. Purpose: To review the potential NIRS-ML approaches rapid, point-of-care detection, including technological principles, promising applications, current limitations, future directions. Main body abstract: leverages unique near-infrared absorbance patterns reflecting collagen accumulation, lipid reduction, other chemical alterations fibrotic liver. Handheld/hyperspectral systems acquire spectroscopic minutes. Multiple human studies correlate with histological scores. ML techniques like partial least squares regression, neural networks, support vector machines, random forests analyze spectra develop optimized algorithms. Initial models differentiate mild versus advanced stage cirrhosis high accuracy, outperforming traditional biomarkers. Recent advances include smartphone-based scanning, cloud computing, integrated user-friendly platforms. However, further large validation trials, standardization, assessment confounding factors, improved methodology, cost-effectiveness are required before widespread clinical implementation. Conclusion: With ongoing research address remaining barriers, hold great disruptive quantification fibrosis, optimizing transplant surgery planning management.
Language: Английский
Citations
4