Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome DOI Creative Commons
Jing Shi, Kai-Lun Hu, Xiaoxue Li

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 10, 2024

Abstract Background Bisphenol A (BPA) levels are high in women with polycystic ovary syndrome (PCOS). The mechanism by which BPA induces abnormal glucose metabolism PCOS patients is largely unknown. Methods Serum and urine samples were collected from without (control) at the reproductive medicine center informed consent. Non-PCOS who received vitro fertilization recruited for collection of ovarian follicular fluid granular cells. Wild-type C57BL/6 AhR −/− mice used to verify effects on PCOS. Real-time PCR, western blotting, ELISA conducted analyze function BPA. Chip-qPCR verified role GLUT4 transcription. Flow cytometry was performed determine uptake. Results positive correlation observed between concentration serum patients. aggravated changes metabolism, impaired fertility, increased body fat. Mechanistically, we showed that activated led decreased transport via downregulation Therefore, use inhibitors or knockout could effectively rescue BPA-induced metabolic disorders mice. Conclusions Our results revealed suppressed expression induced activating AhR, causing insulin resistance, thus a potential contributor development be new therapeutic target

Language: Английский

Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review DOI Open Access
Saira Amir, Syed Tahir Abbas Shah, Charalampos Mamoulakis

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(4), P. 1464 - 1464

Published: Feb. 4, 2021

Increasing contamination of the environment by toxic compounds such as endocrine disrupting chemicals (EDCs) is one major causes reproductive defects in both sexes. Estrogen/androgen pathways are utmost importance gonadal development, determination secondary sex characteristics and gametogenesis. Most EDCs mediate their action through respective receptors and/or downstream signaling. The purpose this review to highlight mechanism which can trigger antagonistic or agonistic response, acting estrogen/androgen causing that lead infertility. In vitro, vivo silico studies focusing on impact related proteins published last decade were considered for review. PUBMED PUBCHEM used literature search. bind estrogen (ERα ERβ) androgen activate alternative G protein-coupled (GPCR), GPR30, estrogen-related receptor (ERRγ) signaling via kinases. Bisphenol A, dichlorodiphenyltrichloroethane, dichlorodiphenyldichloroethylene, polychlorinated biphenyls phthalates toxicants interfere with normal leading infertility sexes many ways, including DNA damage spermatozoids, altered methylation pattern, histone modifications miRNA expression.

Language: Английский

Citations

125
A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence DOI Creative Commons
Nadeem Khan G, Jacinta Correia, Divya Adiga

et al.

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 28(16), P. 19643 - 19663

Published: March 5, 2021

Bisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances human exposure predisposing individuals at extremely low doses diseases, including cancer. enters body via oral, inhaled, dermal routes leach-out products. BPA may be anticipated probable carcinogen. Studies using in vitro cell lines, rodent models, epidemiological analysis have convincingly shown increasing susceptibility cancer below oral reference dose set by Environmental Protection Agency BPA. Furthermore, exerts toxicological effects genetic epigenetic levels, influencing various signaling pathways. The present review summarizes available data on potential impact clinical outcome.

Language: Английский

Citations

113
Human health risk assessment of bisphenol A (BPA) through meat products DOI Creative Commons
Xin Wang, Rajat Nag, Nigel P. Brunton

et al.

Environmental Research, Journal Year: 2022, Volume and Issue: 213, P. 113734 - 113734

Published: June 22, 2022

Meat and meat products are often consumed in our daily diet, providing essential nutrients. Contamination by chemical hazards, including bisphenol A (BPA) products, is a concern continuously monitored. BPA well-known for its endocrine-disrupting properties, which may cause potential toxicological effects on reproductive, nervous, immune systems. Dietary consumption the main route of exposure, major contributor. exposure from focus this review. This review found that has been widely detected canned non-canned products. assumed to be predominantly migration can coatings. Relatively low levels observed source contamination these yet definitively identified. recent European Food Safety Authority (EFSA) draft opinion proposed lower tolerable intake 4 μg kg body weight (bw)-1 day-1 0.04 ng day-1, therefore health risks need addressed. investigated at farm, industrial processes, retail levels. Data gaps literature also identified improve future food safety industry. Also, unified risk assessment strategy proposed. Further understanding needed as part reduce risk, more data dose-response relationship will help comprehend adverse humans. research inform public, producers processing industry, policymakers reduction measures, thus, ensuring safety.

Language: Английский

Citations

86
Astaxanthin: Past, Present, and Future DOI Creative Commons
Yasuhiro Nishida,

Pernilla Berg,

Behnaz Shakersain

et al.

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(10), P. 514 - 514

Published: Sept. 28, 2023

Astaxanthin (AX), a lipid-soluble pigment belonging to the xanthophyll carotenoids family, has recently garnered significant attention due its unique physical properties, biochemical attributes, and physiological effects. Originally recognized primarily for role in imparting characteristic red-pink color various organisms, AX is currently experiencing surge interest research. The growing body of literature this field predominantly focuses on AXs distinctive bioactivities properties. However, potential algae-derived as solution global environmental societal challenges that threaten life our planet not received extensive attention. Furthermore, historical context nature, well significance diverse cultures traditional health practices, have been comprehensively explored previous works. This review article embarks comprehensive journey through history leading up present, offering insights into discovery AX, chemical distribution biosynthesis. Additionally, it delves intricate realm benefits, biofunctional characteristics, current market status AX. By encompassing these multifaceted aspects, aims provide readers with more profound understanding robust foundation future scientific endeavors directed at addressing needs sustainable nutritional medicinal solutions. An updated summary present status, applications are also included well-rounded perspective.

Language: Английский

Citations

50
The adverse role of endocrine disrupting chemicals in the reproductive system DOI Creative Commons

Jing Pan,

Pengfei Liu,

Xiao Yu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 17, 2024

Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.

Language: Английский

Citations

47
Bisphenol A and its structural analogues exhibit differential potential to induce mitochondrial dysfunction and apoptosis in human granulosa cells DOI
Guofeng Xu, Mingquan Huang, Jun Hu

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 188, P. 114713 - 114713

Published: May 1, 2024

Language: Английский

Citations

30
Effects of bisphenol A on cardiovascular disease: An epidemiological study using National Health and Nutrition Examination Survey 2003–2016 and meta-analysis DOI
Shinje Moon, Sung Hoon Yu, Chang Beom Lee

et al.

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 763, P. 142941 - 142941

Published: Oct. 14, 2020

Language: Английский

Citations

110
Endocrine disrupting chemical Bisphenol A and its potential effects on female health DOI

Iram Ashaq Kawa,

Akbar Masood,

Qudsia Fatima

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2021, Volume and Issue: 15(3), P. 803 - 811

Published: March 31, 2021

Language: Английский

Citations

101
Bisphenol A in Africa: A review of environmental and biological levels DOI
Oluwakemi A. Rotimi, Tolulope D. Olawole, Opeyemi C. De Campos

et al.

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 764, P. 142854 - 142854

Published: Oct. 9, 2020

Language: Английский

Citations

76
Childhood obesity and central precocious puberty DOI Creative Commons
Li Shi, Zhiyan Jiang, Li Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 18, 2022

Childhood obesity is a major public health problem worldwide, and the relationship between central precocious puberty has long been confirmed, however, mechanisms underlying this association remain elusive. This review provides an overview of recent progress regarding how childhood impacts on hypothalamic-pituitary-gonadal axis pubertal onset, focusing adipokines (leptin ghrelin), hormone (insulin), lipid (ceramide), as well critical signaling pathways (AMPK/SIRT, mTOR) that integrate peripheral metabolism circuits. Notably, prevention CPP beneficial for adult life children, thus we further summarize potential strategies in treating preventing CPP. The updated understanding metabolic stress pediatric endocrine disease will arise attention society, also contribute to more serious comorbidities later period children.

Language: Английский

Citations

70