Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116921 - 116921
Published: June 12, 2024
Pulp
therapy
has
been
emerged
as
a
one
of
the
efficient
therapies
in
field
endodontics.
Among
different
types
new
endodontic
materials,
pulpotec
materialized
recognized
material
for
vital
pulp
therapy.
However,
its
efficacy
challenged
due
to
lack
information
about
cellular
biocompatibility.
This
study
evaluates
mechanistic
biocompatibility
cement
with
macrophage
cells
(RAW
264.7)
at
and
molecular
level.
The
was
evaluated
using
experimental
computational
techniques
like
MTT
assay,
oxidative
stress
analysis
apoptosis
through
flow
cytometry
fluorescent
microscopy.
results
showed
concentration-dependent
cytotoxicity
extract
RAW
264.7
an
LC
50
X/10-X/20.
depicted
interaction
components
metabolic
proteins
Sod1
p53.
revealed
effects
Pulpotec
cement's
extract,
showing
induction
apoptosis.
These
were
influential
structural
functional
abnormalities
p53
proteins,
caused
by
their
internalized
cement.
provided
detailed
view
on
utility
applications,
highlighting
biomedical
aspects.
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(9), P. 105904 - 105904
Published: July 9, 2024
Owing
to
its
capacity
damage
the
endocrine
system,
bisphenol
A
(BPA)
is
being
substituted
in
common
consumer
products
by
chemically
related
compounds,
including
F
(BPF)
and
S
(BPS).
Although
BPF
BPS
body
fluids
are
comparable
concentration
frequency
BPA,
toxicity
of
these
analogs
female
reproduction
remains
largely
unknown.
Using
a
nontargeted
metabolomics
technique,
this
study
aimed
examine
effect
exposure
on
metabolism
human
ovarian
granulosa
(KGN)
cells.
Analysis
differentially
expressed
metabolites
(DEMs)
identified
991
609
DEMs
KGN
cells
exposed
BPS,
respectively,
at
three
various
concentrations
(0.1,
1,
10
µM),
with
having
greater
interfering
than
BPS.
Specifically,
low
(0.1
µM)
both
bisphenols
more
greatly
affected
cellular
higher
concentrations.
Metabolic
pathway
enrichment
analysis
using
KEGG
database
revealed
that
mechanisms
which
induced
were
different:
significantly
altered
purine
metabolism,
autophagy-related
pathways,
ferroptosis,
whereas
mainly
interfered
one-carbon
(vitamin
B6,
riboflavin,
folate).
These
results
demonstrated
differences
cell
dysfunction.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 15, 2024
Recently,
the
area
devoted
to
fractional
calculus
has
given
much
attention
by
researchers.
The
reason
behind
such
huge
is
significant
applications
of
mentioned
in
various
disciplines.
Different
problems
real
world
processes
have
been
investigated
using
concepts
and
important
applicable
outcomes
were
obtained.
Because,
there
a
lot
interest
differential
equations.
It
brought
on
both
extensive
development
theory
its
applications.
use
linear
quadratic
perturbations
nonlinear
equations
mathematical
models
variety
real-world
received
interest.
Therefore,
motivated
importance,
this
research
work
analyze
detailed,
class
fractal
hybrid
equation
under
Atangana-
Baleanu-
Caputo
ABC
derivative.
qualitative
problem
examined
tools
non-linear
functional
analysis.
Ulam-Hyer's
(U-H)
type
stability
criteria
also
applied
consider
problem.
Further,
numerical
solution
model
developed
powerful
technique.
Lastly,
Wazewska-Czyzewska
Lasota
Model,
well-known
biological
model,
verifies
results.
Several
graphical
representations
different
fractals
orders
values
are
presented.
detailed
discussion
explanations
at
end.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101139 - 101139
Published: June 24, 2024
The
prevalence
of
polymer
usage
in
everyday
activities
has
emerged
as
a
detriment
to
both
human
life
and
the
environment.
A
large
number
studies
describe
severe
impacts
micropolymers
(MP)
nanopolymers
(NP)
on
various
organ
systems,
including
endocrine
system.
Additionally,
plasticizers
utilized
additives
have
been
identified
endocrine-disrupting
chemicals
(EDCs).
MP/NP,
along
with
associated
plasticizers,
affect
principal
signalling
pathways
glands
such
pituitary,
thyroid,
adrenal,
gonads,
thereby
disrupting
hormone
function
metabolic
processes
crucial
for
maintaining
homeostasis,
fertility,
neural
development,
fetal
growth.
This
review
delves
into
sources,
distribution,
effects
micropolymers,
nanopolymers,
acting
EDCs.
Furthermore,
it
provides
detailed
mechanisms
underlying
disruption
relation
different
types
MP/NP.
