Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Sept. 21, 2023
Language: Английский
Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)
Published: April 18, 2024
Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose eventually falling out. Timely identification has crucial role preventing controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is hunt for alternative diagnostic monitoring methods due progress technology. Various biomarkers have been assessed using multiple bodily fluids sample sources. Furthermore, conventional categorization factors do not provide significant insights into present disease activity, severity amount tissue damage, future development, responsiveness treatment. In recent times, growing utilization nanoparticle (NP)-based detection strategies create quick efficient assays. Every single one these platforms leverages distinct characteristics NPs identify Plasmonic include metal NPs, quantum dots (QDs), carbon base nanozymes, exceptionally potent light absorbers scatterers. These find application labeling, surface-enhanced spectroscopy, color-changing sensors. Fluorescent function photostable sensitive instruments capable labeling various biological targets. article presents comprehensive summary latest developments effective detect
Language: Английский
Citations
27
Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)
Published: March 25, 2024
Cellular lipid membranes serve as the primary barrier preventing viral infection of host cell and provide viruses with a critical initial point contact. Occasionally, can utilize lipids receptors. Viruses depend significantly on rafts for at virtually every stage their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) promoting its lysosomal degradation, has garnered increasing interest. Conversely, using therapeutic, fully humanized antibodies to block PCSK9 leads significant reduction high LDL (LDL-C) levels. Food Drug Administration (FDA) approved inhibitors, including inclisiran (Leqvio®), alirocumab (Praluent), evolocumab (Repatha). At present, active immunization strategies targeting present compelling substitute passive through administration antibodies. In addition current inquiry into potential therapeutic application inhibition human immunodeficiency virus (HIV)-infected patients hyperlipidemia associated HIV antiretroviral therapy (ART), preclinical research suggests may also play inhibiting hepatitis C (HCV) replication. Furthermore, been suggested protect against dengue (DENV) potentially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses. Recent evidence regarding impact variety infections, HCV, HIV, DENV, SARS-CoV-2, is examined this article. As result, inhibitors vaccines viable therapies our indicates involved pathogenesis infections.
Language: Английский
Citations
14
Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)
Published: Jan. 12, 2024
Primary liver cancer, which is scientifically referred to as hepatocellular carcinoma (HCC), a significant concern in the field of global health. It has been demonstrated that conventional chemotherapy, chemo-hormonal therapy, and conformal radiotherapy are ineffective against HCC. New therapeutic approaches thus urgently required. Identifying single or multiple mutations genes associated with invasion, metastasis, apoptosis, growth regulation resulted more comprehensive comprehension molecular genetic underpinnings malignant transformation, tumor advancement, host interaction. This enhanced notably propelled development novel agents. Therefore, gene therapy (GT) holds great promise for addressing urgent need innovative treatments However, complexity HCC demands precise effective approaches. The adeno-associated virus (AAV) distinctive life cycle ability persistently infect dividing nondividing cells have rendered it an alluring vector. Another appealing characteristic wild-type its evident absence pathogenicity. As result, AAV, vector lacks envelope can be modified transport DNA specific cells, garnered considerable interest scientific community, particularly experimental strategies still clinical stage. AAV vectors emerge promising tools due their non-immunogenic nature, efficient cell entry, prolonged expression. While AAV-mediated GT demonstrates across diverse diseases, current ongoing trials targeting underscores untapped potential this context. Furthermore, transfer through hepatic frequently facilitated by research, several congenital anomalies affecting liver. Notwithstanding enthusiasm notion, recent discoveries expose integration genome at double-strand breaks give rise apprehensions regarding enduring safety effectiveness. review explores versatile targeted In summation, we encapsulate multifaceted exploration GT, underlining transformative within landscape oncology human
Language: Английский
Citations
10
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: Nov. 20, 2023
Abstract Carcinoma of the lung is among most common types cancer globally. Concerning its histology, it categorized as a non-small cell carcinoma (NSCLC) and small (SCLC) subtype. MicroRNAs (miRNAs) are member non-coding RNA whose nucleotides range from 19 to 25. They known be critical regulators via epigenetic control oncogenes expression by regulating tumor suppressor genes. miRNAs have an essential function in tumorous microenvironment modulating growth, metastasis, angiogenesis, metabolism, apoptosis. Moreover, wide information produced several investigations indicates their tumor-suppressing, oncogenic, diagnostic assessment, predictive marker functions different malignancy. miRNA mimics or anti-miRNAs can transferred into cell, with possible curative implications. As result, hold promise targets for treatment detection. In this study, we investigate various malignancy, which been achieved recent years that show cancer-associated regulation expression, concerning beginning, development, resistance chemotherapy, also probability utilize biomarkers therapy reaction. Graphical abstract
Language: Английский
Citations
21
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Nov. 9, 2023
Abstract According to a paper released and submitted WHO by IARC scientists, there would be 905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths expected as direct result. Hepatitis B virus (HBV) hepatitis C (HCV), D (HDV) all play critical roles the pathogenesis hepatocellular carcinoma (HCC), despite rising prevalence HCC due non-infectious causes. Liver cirrhosis are devastating consequences HBV HCV infections, which widespread worldwide. Associated high mortality rate, these infections cause about 1.3 million annually primary globally. In addition causing insertional mutations viral gene integration, epigenetic alterations inducing chronic immunological dysfunction methods viruses turn hepatocytes into cancerous ones. While expanding our knowledge illness, identifying pathways also give possibilities for novel diagnostic treatment methods. Nuclear factor erythroid 2-related 2 (NRF2) activation is gaining popularity option oxidative stress (OS), inflammation, metabolic abnormalities. Numerous studies have shown that elevated Nrf2 expression linked HCC, providing more evidence HCC. This aberrant signaling drives cell proliferation, initiates angiogenesis invasion, imparts drug resistance. As result, this master regulator may promising target addition, common effect contributes pathogenesis, development, chronicity infection. However, certain suppress activity, helpful maintaining cellular homeostasis. paper, we discussed influence deregulation on life cycle associated HCV. We summed up mechanisms modulation deregulated viruses. Moreover, describe molecular mechanism modulated cancer, stem cells (LCSCs), caused
Language: Английский
Citations
18
Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 97, P. 101279 - 101279
Published: May 20, 2024
Language: Английский
Citations
7
Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)
Published: June 26, 2024
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, affects large regions of Asia, Southwestern Southeastern Europe, Africa. CCHFV can produce symptoms, including no specific clinical mild to severe or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, cheap technology, biosensors, must be designed developed detect The goal this article offer overview modern laboratory available as well other innovative detection methods such biosensors CCHFV, the benefits limits assays. confirmed cases CCHF managed with symptomatic assistance general supportive care. This study examined various treatment modalities, their respective limitations developments, immunotherapy antivirals. Recent biotechnology advancements availability suitable animal models have accelerated development vaccines by substantial margin. We range potential in research, comprising nucleic acid, viral particles, inactivated, multi-epitope vaccines, present obstacles developments field. Thus, purpose review comprehensive summary endeavors dedicated advancing diagnostic, therapeutic, preventive strategies infection anticipation forthcoming hazards.
Language: Английский
Citations
7
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Dec. 14, 2023
Abstract Viruses communicate with their hosts through interactions proteins, lipids, and carbohydrate moieties on the plasma membrane (PM), often resulting in viral absorption via receptor-mediated endocytosis. Many viruses cannot multiply unless host’s cholesterol level remains steady. The large endo/lysosomal protein (MP) Niemann-Pick C1 (NPC1), which is involved cellular transport, a crucial intracellular receptor for infection. NPC1 ubiquitous housekeeping essential controlled efflux from lysosomes. Its human absence results type C disease, deadly lysosomal storage disorder. an host component filovirus entrance, infection, pathogenesis. For NPC1’s function unnecessary. Furthermore, blocking limits entry replication of African swine fever virus by disrupting homeostasis. Cell entrance quasi-enveloped variants hepatitis A E has also been linked to NPC1. By controlling levels, necessary effective release reovirus cores into cytoplasm. Drugs that limit activity are against several viruses, including SARS-CoV Type I Feline Coronavirus (F-CoV). These findings reveal as potential therapeutic target treating illnesses demonstrate its significance infections. This article provides synopsis infections review inhibitors may be used counteract Graphical
Language: Английский
Citations
15
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: Oct. 25, 2023
Cancer Stem Cells (CSCs) are the main "seeds" for initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including human papillomaviruses, hepatitis B virus, Epstein-Barr C promote aggressiveness cancer by encouraging development CSC features. Therefore, a better method targeted elimination CSCs knowledge their regulatory mechanisms in carcinogenesis may lead future tool management treatment cancer. Oncolytic viruses (OVs), which include herpes adenovirus, vaccinia, reovirus, also new class therapeutics that have favorable properties such as selective replication tumor cells, delivery numerous eukaryotic transgene payloads, induction immunogenic cell death promotion antitumor immunity, well tolerable safety profile essentially differs from other therapeutics. The effects infection on suppression OV therapy were examined this paper. purpose review is investigate dual role (oncolytic virotherapy oncogenes).
Language: Английский
Citations
13
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Multidrug resistance (MDR) facilitates tumor recurrence and metastasis, which has become a main cause of chemotherapy failure in clinical. However, the current therapeutic effects against MDR remain unsatisfactory, mainly hampered by rigid structure drug-resistant cell membranes uncontrolled drug release. In this study, based on sequential release strategy, we engineered core–shell nanoparticle (DOX-M@CaP@ATV@HA) depleting cholesterol for reverse MDR. DOX-M@CaP@ATV@HA could accurately target cells due to active targetability hyaluronic acid (HA) toward CD44 receptors. The calcium phosphate (CaP) shell was cleaved lysosomal acidic environment so that cholesterol-lowering atorvastatin (ATV) rapidly released diminish P-glycoprotein (P-gp) level membrane, thereby boosting uptake. Next, doxorubicin (DOX) gradually from hydrophobic core mPEG-DSPE micelle, inflicting irreversible DNA damage triggering apoptosis. nanosystem proven both vitro vivo effectively exhibited remarkable efficacy tumors with high biosafety. conclusion, reverses via depletion, provides an innovative strategy treatment.
Language: Английский
Citations
0