Association between the systemic immune-inflammation index and metabolic syndrome and its components: results from the multi-ethnic study of atherosclerosis (MESA) DOI Creative Commons
Azra Ramezankhani, Maryam Tohidi, Farzad Hadaegh

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 15, 2025

The Systemic Immune-Inflammation Index (SII) is a novel biomarker of systemic inflammation. We explored the association between SII and metabolic syndrome (MetS) its components in middle-aged older adults. included 2755 participants (1305 men) aged 45–84 years from Multi-Ethnic Study Atherosclerosis (MESA) cohort examination 5 (2010–2012). Logistic regression was employed to assess relationship MetS, as well components. A total 1082 (463 were diagnosed with MetS. On continuous scale, positively associated MetS (odds ratio (OR): 1.23, 95% confidence interval (CI): 1.05–1.46) including hyperglycemia (1.23: 1.05–1.44) elevated blood pressure (BP) (1.47: 1.14–1.89). When analyzed on quartile 4 had 32% 63% higher prevalence BP, respectively, compared those 1 (P for trend: 0.021 < 0.001, respectively). Additionally, we identified 40% low HDL-C 2 (1.40; 1.07–1.83) trend = 0.454). In subgroup analysis, general obesity status modified abdominal obesity, showing positive obese individuals (1.72: 1.00-2.95) negative (0.80: 0.66–0.97) non-obese interaction 0.009). Higher scores an increased likelihood hyperglycemia, high BP among Longitudinal studies are needed determine causal relationships development potential role screening tool clinical practice.

Language: Английский

Associations of ω-3, ω-6 polyunsaturated fatty acids intake and ω-6: ω-3 ratio with systemic immune and inflammatory biomarkers: NHANES 1999-2020 DOI Creative Commons

Yifan Li,

Hao Tang,

Xiaotong Yang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 7, 2024

Background In recent years, diseases caused by abnormal immune-inflammatory responses have become increasingly severe. Dietary intervention involving omega-3 polyunsaturated fatty acids (ω-3 PUFAs) has emerged as a potential treatment. However, research investigating the relationship between ω-3, ω-6 PUFAs, and to ω-3 ratio with inflammatory biomarkers remains controversial. Methods To investigate correlation intake of PUFAs ω-6: inflammation, National Health Nutrition Examination Survey (NHANES) data (1999 2020) was utilized. The systemic immune-inflammation index (SII), platelet-lymphocyte (PLR), neutrophil-lymphocyte (NLR), white blood cell (WBC) were selected study subjects. for collected via two 24-h dietary recall interviews. SII other indicators obtained from routine data. multiple linear regression restricted cubic spline models utilized evaluate association intake, secondary measures. Results This involved total 43,155 American adults. exhibited negative correlations SII, PLR, NLR, WBC. WBC not significant. Furthermore, dose–response showed that an “L” pattern. Conclusion Intake reduces levels several in body exerts immunomodulatory effects.

Language: Английский

Citations

7
The relationship between complete blood cell count-derived inflammatory biomarkers and benign prostatic hyperplasia in middle-aged and elderly individuals in the United States: Evidence from NHANES 2001–2008 DOI Creative Commons

Chengdong Shi,

Hongliang Cao,

Guoqiang Zeng

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(7), P. e0306860 - e0306860

Published: July 9, 2024

Benign prostatic hyperplasia (BPH) is a common health disorder of the male genitourinary system with high prevalence, especially among middle-aged and older adults, which seriously affects men's quality life. Inflammatory markers derived from complete blood cell count (CBC) have previously been considered prognostic indicator for various diseases, but little known about their relationship BPH. This study evaluated between (CBC)-derived inflammatory biomarkers

Language: Английский

Citations

7
Depression heightened the association of the systemic immune-inflammation index with all-cause mortality among osteoarthritis patient DOI
Sen Wang, Wenyu Xiao,

Zhengwei Duan

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 355, P. 239 - 246

Published: March 27, 2024

Language: Английский

Citations

6
Prognostic value of pretreatment systemic immune-inflammation index in patients with endometrial cancer: a meta-analysis DOI

Pengtian Ji,

Junjun He

Biomarkers in Medicine, Journal Year: 2024, Volume and Issue: 18(7), P. 345 - 356

Published: April 2, 2024

Background: The present work focused on evaluating the systemic immune-inflammation index (SII) for its role in predicting endometrial cancer (EC) patient prognosis by meta-analysis. Methods: SII's of EC patients was analyzed calculating combined hazard ratios (HRs) and 95% CIs. Results: As revealed analysis, an increased SII predicted poor overall survival (HR = 2.01; CI 1.58–2.57; p < 0.001) as well inferior progression-free 1.87; 1.36–2.58; EC. Conclusion: An score significantly subjects with is suitable short- long-term prognoses

Language: Английский

Citations

6
The predictive value of systemic immune-inflammation index for vascular access survival in chronic hemodialysis patients DOI Creative Commons

Ren Song,

Chuan Xv,

Wang Dongqing

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 17, 2024

Objective To examine the prognostic values of systemic immune-inflammation indices hemodialysis (HD) vascular access failure and develop a prediction model for based on most pertinent index. Study design A prospective cohort study. Setting &amp; participants Patients undergoing autogenous HD surgeries or arteriovenous graft as permanent in tertiary center southwest China from January 2020 to June 2022. Predictors Systemic indices, including NLR, dNLR, AAPR, SIRI, SII, PNI, PLR, LIPI, clinical variables. Outcomes The outcome was defined survival access, with both occluded stenotic being considered instances failure. Analytical approach Cox proportional hazard regression model. Results 2690 patients were included study population, whom 658 experienced during follow-up period. median duration 18 months. increased are predictive failure, SII demonstrating strongest value. simple SII-based developed, achieving C-indexes 0.6314 (95% CI: 0.6249 – 0.6589) 0.6441 0.6212 0.6670) predicting 6- 12-month survival, respectively. Conclusions significantly negatively associated survival. developed anticipates further improvement through larger validation diverse centers.

Language: Английский

Citations

6
Comparison of PIV and Other Immune Inflammation Markers of Oncological and Survival Outcomes in Patients Undergoing Radical Cystectomy DOI Open Access
Pierluigi Russo, Giuseppe Palermo, Roberto Iacovelli

et al.

Published: Jan. 4, 2024

Inflammation is widely acknowledged as a significant characteristic of cancer, playing substantial function in both the initiation and advancement cancers. In this research, we planned to investigate comparison among pan-immune inflammation markers other well-known (systemic immune index neutrophil lymphocyte ratio) predict prognosis individuals treated with radical cystectomy for bladder cancer. Methods: retrospective analysis, focused on preoperative PIV, systemic (SII), neutrophil-lymphocyte ratio (NLR) 193 managed cancer between January 2016 November 2022. Multivariable logistic regression assessments were perfomred assess predictive capabilities SII, NLR infiltration lymph nodes (N), aggressive tumor stage (pT3/pT4), any non-organ limited disease at time RC. Cox analyses conducted impact PIV Relapse-free survival (RFS), Cancer-specific (CSS), Overall (OS). Results: Our divided into high low cohorts using optimal cut-off value (340.96 x 109/ L) based receiver operating curve analysis relapse-free survival. multivariable models, only SII correlated nodes, disease, confined disease. models considering presurgical clinicopathological variables, an higher was associated diminished RFS (p = 0.017) OS 0.029). addition, postoperative outcomes, ( p 0.034) p= 0.048). Conclusions: study suggests that are two very similar may serve independent predictor worse impacts undergoing neoplasm.

Language: Английский

Citations

5
Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011–2016 DOI

Xiaoya Sun,

Yujie Deng,

Lanlan Fang

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(7), P. 3005 - 3017

Published: Oct. 10, 2023

Language: Английский

Citations

13
Association between preoperative systemic immune inflammation index and postoperative sepsis in patients with intestinal obstruction: A retrospective observational cohort study DOI Creative Commons
Jirong Yang, Taojia Ran, Xiaoyu Lin

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(2)

Published: Feb. 1, 2024

Sepsis is a severe complication that results in increased morbidity and mortality after intestinal obstruction surgery. This study examined the role of preoperative systemic immune inflammation index (SII) for postoperative sepsis patients.

Language: Английский

Citations

4
Prognostic Value of the Baseline Systemic Immune-Inflammation Index in HER2-Positive Metastatic Breast Cancer: Exploratory Analysis of Two Prospective Trials DOI

Jian Pang,

Nianhua Ding, Xuan Liu

et al.

Annals of Surgical Oncology, Journal Year: 2024, Volume and Issue: 32(2), P. 750 - 759

Published: Nov. 20, 2024

Language: Английский

Citations

4
Association between the Systemic Immune-Inflammation Index and Thyroid Function in U.S. Adults DOI Creative Commons
Xinyu Hu,

Ying-Chao Liang,

Huan-Huan Zhang

et al.

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 12

Published: Nov. 16, 2023

The systemic immune-inflammation index (SII) is used as an indicator of prognosis for a wide range diseases. Thyroid function has been found to be strongly associated with inflammation. purpose this investigation was analyze the correlation between SII and various thyroid functions.This study utilized data from National Health Nutrition Examination Survey (NHANES) 2007-2012. association analyzed using weighted univariate multivariate linear regression analyses. Subgroup analyses, interaction tests, restricted cubic spline (RCS) analyses were also employed test correlation.Of 6,875 participants (age ≥ 20 years), mean age 46.87 ± 0.40 years. adjusted model showed that lnSII negatively correlated FT3 (β = -0.0559, 95% CI -0.1060 -0.0059,) FT3/FT4 -0.0920, -0.1667 -0.0173,). There positive TT4 0.1499, 0.0722-0.2276,). In subgroup still independently affected functions. Weighted RCS analysis nonlinear relationship lnSII.Close relationships exist variety can predict dysfunction. Control inflammatory activity may protective measure against More large-scale prospective studies are necessary further explore role obesity in this.

Language: Английский

Citations

10