Prediction of Persistent Tumor Status in Nasopharyngeal Carcinoma Post-Radiotherapy-Related Treatment: A Machine Learning Approach DOI Open Access
Hsien‐Chun Tseng, Chao‐Yu Shen,

Pan‐Fu Kao

et al.

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 96 - 96

Published: Dec. 31, 2024

Background/Objectives: The duration of the response to radiotherapy-related treatment is a critical prognostic indicator for patients with nasopharyngeal carcinoma (NPC). Persistent tumor status, including residual presence and early recurrence, associated poorer survival outcomes. To address this, we developed prediction model identify at high risk persistent status prior initiating treatment. Methods: This retrospective study included 104 NPC receiving who had completed 3-year follow-up period; 29 were classified into group 75 disease-free group. Radiomic features extracted from pretreatment positron emission tomography (PET) images used construct by employing machine learning algorithms. model’s diagnostic performance was assessed using area under receiver operating characteristic curve (AUC), whereas SHapley Additive exPlanations (SHAP) analysis conducted determine contribution individual model. Results: AdaBoost algorithm validated through five-fold cross-validation achieved highest AUC 0.934. Its sensitivity, specificity, positive predictive value, negative accuracy 89.66%, 86.67%, 72.22%, 95.59%, 87.5%, respectively. SHAP revealed that feature dependence low metabolic uptake emphasis50 greatest impact on predictions. Furthermore, as exhibited markedly higher overall rates compared those status. Conclusions: In conclusion, proposed efficiently identified radiomic PET images.

Language: Английский

The multi-target mechanism of action of Selaginella doederleinii Hieron in the treatment of nasopharyngeal carcinoma: a network pharmacology and multi-omics analysis DOI Creative Commons

Huaguo Liang,

Caifu Fang,

Meng Qiu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Nasopharyngeal carcinoma (NPC) presents significant treatment challenges due to its complex etiology and late-stage diagnosis. The traditional Chinese medicine Selaginella doederleinii Hieron (S. doederleinii) has shown potentiality in NPC multi-target, multi-pathway anti-cancer mechanisms. First, we identified related target genes from databases like GeneCards, OMIM, DisGeNET, performed WGCNA analysis on the GSE53819 dataset identify several important gene modules NPC. Active components their targets S. were screened TCMSP other databases, identifying 32 overlapping genes. Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) pathway revealed that these are primarily involved critical biological processes protein phosphorylation cell cycle regulation. A protein–protein interaction network was constructed, cytoHubba six key (BCL2, MAPK14, ABCB1, PLK1, ATM, HMOX1). Kaplan–Meier immune infiltration further showed closely prognosis microenvironment patients. Single-cell RNA sequencing expression distribution across different types explored roles differentiation process malignant cells through pseudotime trajectory analysis. Molecular docking dynamics simulation results indicated Berberine-MAPK14 Matairesinol-PLK1 complexes have high binding affinity stability. Binding free energy calculations confirmed stability complexes. Based our comprehensive multi-level analysis, active may play a role multi-target synergistic effects.

Language: Английский

Citations

2
Role of infectious agents in Cancer pathogenesis and therapy DOI Creative Commons

Ezichi F. Ofoezie,

C Ogbonna,

Sandra C. Olisakwe

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100284 - 100284

Published: March 1, 2025

Language: Английский

Citations

1
Impact of UV radiation on Mxene-mediated tubulin dissociation and mitochondrial apoptosis in breast cancer cells DOI
Ee Wern Tan, Samson Eugin Simon, Arshid Numan

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113793 - 113793

Published: Feb. 9, 2024

Language: Английский

Citations

6
Optimizing Radiotherapy Timing for Nasopharyngeal Carcinoma: The Impact of Radiation Scheduling on Survival DOI
Ying Li,

Youliang Weng,

Zongwei Huang

et al.

JCO Precision Oncology, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

PURPOSE Chronoradiobiology has emerged as a potential field of study with therapeutic implications for cancer treatment. We aimed to investigate the association between radiation chronotherapy and efficacy toxicity patients nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS Patients nonmetastatic NPC treated intensity-modulated radiotherapy in Fujian Cancer Hospital January 2017 December 2019 were included. Propensity score matching (PSM) 1:1:1 was used account selection bias. Cox regression analysis performed explore impact timing on patient survival. Sensitivity implemented determine size directional stability. RESULTS One thousand forty met inclusion criteria 332 included PSM cohort. In unmatched cohort analysis, morning exhibited significantly superior overall survival (OS) outcome (hazard ratio [HR], 0.60 [95% CI, 0.40 0.91], adjusted log-rank P = .028) than afternoon one. After it observed that individuals undergoing group (HR, 5.88 2.55 13.58], .004) night 4.81 1.91 12.11], .018) displayed tendency toward shorter OS compared group. No significant differences acute treatment-related adverse effects among three groups. Morning demonstrated consistent robustness multivariable thereby establishing an higher OS. The directionality effect across sensitivity analysis. CONCLUSION These results underscore benefits scheduling management, although prospective studies are needed confirm these findings.

Language: Английский

Citations

0
MB based RT-qPCR increase the clinical application of cfEBV DNA for NPC in non-endemic area of China DOI Creative Commons
Qiao He,

Y. L. Tuo,

Yi Zhou

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

To compare the performance of magnetic bead (MB) and concentrated precipitation (CP) based RT-qPCR to qualify cell free EBV DNA (cfEBV DNA) for nasopharyngeal carcinoma (NPC) in non-endemic area China. From January 2014 June 2024, a retrospective analysis 2 cohort studies on cfEBV NPC patients was conducted assess diagnostic value, positive detection rate clinical application. with CP 1 MB method 2. The quantitative measurement load higher than same plasma samples from (P < 0.001). measured 1405 244 healthy controls 40.8% sensitivity (AUC = 0.704, 95% CI: 0.676-0.731). In 2(683 naive 303 controls), had 75.84% 0.879, 0.86-0.90). There were no significant differences TNM stage among between two cohorts > 0.05). considerably increased NPCs at stages III-IV, T2-T4, N1-N3, M0 At end treatment, 97.51% detectable just 2.49% DNA. Those who received ≤ or ≥ 3 cycles NAC median t1/2 clearance 9.8 days 12.6 days, respectively. quantity demonstrated superior rates can be more positively noticed, value broader variety applications areas.

Language: Английский

Citations

0
Deciphering the role of ELAVL1: Insights from pan-cancer multiomics analyses with emphasis on nasopharyngeal carcinoma DOI
Jindong Xie, Yi Xie,

Wencheng Tan

et al.

Journal of Translational Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Background and Objectives Cancer continues to be a predominant cause of mortality worldwide, underscoring the critical need identify develop novel biomarkers improve prognostic accuracy therapeutic approaches. The dysregulation ELAVL1 is linked various diseases, including cancer. Nevertheless, its role across different cancer types remains insufficiently investigated. Methods We conducted systematic investigation into expression patterns, significance, genomic alterations, modifications, functional implications in pan-cancer types. Besides, we performed vitro vivo experiments confirm nasopharyngeal carcinoma (NPC). Results By utilizing multi-omics datasets, found obvious overexpression at both mRNA protein levels, with malignant cells. Survival analysis revealed that increased was unfavorable outcomes certain cancers; however, effect difers among Additionally, alterations modifications were related tumor progression. discovered elevated NPC tissues. In addition, survival indicated patients higher had worse prognoses. Functional assays demonstrated suppression led decreased proliferation migration cell lines. Moreover, knockdown effectively inhibited progression lymph node lung metastasis models. Conclusions summary, exhibits diverse complex involvement Targeting it might inhibit progression, making promising biomarker target for enhancing treatment outcomes.

Language: Английский

Citations

0
Regulatory role of miRNAs in nasopharyngeal cancer involving PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F signaling pathways: A review DOI
Rabiatul Basria S. M. N. Mydin,

Adam Azlan,

Simon Imakwu Okekpa

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)

Published: Feb. 16, 2024

Abstract MicroRNAs (miRNA) are small and conserved noncoding RNA molecules that regulate gene expression at the posttranscriptional level. These groups of RNAs crucial in various cellular processes, especially mediating disease pathogenesis, particularly cancer. The dysregulation miRNAs was reported many cancer types, including nasopharyngeal (NPC), which is a malignant tumor nasopharynx. In this review, involvement signaling pathways associated with NPC such as PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin pRB‐E2F investigated. could function suppressor‐miR or onco‐miR profoundly influenced cell cycle, apoptosis, proliferation, migration, metastasis. This comprehensive review current literature provided thorough profile their interplay aforementioned NPC. Understanding these molecular interactions remarkably impact diagnosis, prognosis, therapeutic strategies for

Language: Английский

Citations

2
Early recurrence as a pivotal event in nasopharyngeal carcinoma: identifying predictors and key molecular signals for survivors DOI Creative Commons
Ying Li, Zongwei Huang,

Ximing Zeng

et al.

Head & Face Medicine, Journal Year: 2024, Volume and Issue: 20(1)

Published: Sept. 28, 2024

Language: Английский

Citations

2
Epidermal growth factor receptor mutant T790M-L858R-V948R inhibitor from Calophyllum inophyllum L. leaf as potential non-small cell lung cancer drugs DOI Creative Commons

Precella Silvia,

Jeremi Ongko,

Yulanda Antonius

et al.

Journal of Pharmacy & Pharmacognosy Research, Journal Year: 2024, Volume and Issue: 12(5), P. 881 - 891

Published: April 17, 2024

Context: Non-Small Cell Lung Cancer (NSCLC) is the most common lung cancer type, with 80-85% prevalence. Usually, NSCLC treated by chemotherapy and radiotherapy in collaboration gefitinib or other anticancer drugs. Those treatments have many adverse effects, such as shortness of breath, bleeding, fever, hair loss, radiation pneumonitis. Lack treatment options numerous mutations greatly contribute to cancer's shocking death toll. Therefore, potential EGFR mutant inhibitors need be analyzed. Aims: To identify an epidermal growth factor receptor (EGFR) derived from Calophyllum inophyllum L. leaf using silico approach. Methods: In analysis literature study were carried out. Secondary metabolite compounds C. obtained through PubChem database, their biological activity ADMET Molecular docking wild-type (5FED) (5HG7) was out PyRx. Furthermore, amino acid residues analyzed Discovery Studio. Results: Based on overall screening molecular docking, a non-toxic compound low binding affinity protein 4-[2-(4-nitrophenyl)ethylcarbamoyl]benzenesulfonyl. Moreover, interactions hydrogen bonds at Ala743, Gly796, Leu718, Phe856, Leu844, Val726 are known play crucial role ATP inhibition toward tyrosine kinase domain, resulting inhibition. Conclusions: 4-[2-(4-nitrophenyl)ethylcarbamoyl]benzenesulfonyl one candidates However, vitro vivo research needs performed confirm these results.

Language: Английский

Citations

1
The role of tazarotene-induced gene 1 in carcinogenesis: is it a tumor suppressor gene or an oncogene? DOI Open Access
Chunhua Wang,

Leining Wang,

Rong‐Yaun Shyu

et al.

Biocell, Journal Year: 2024, Volume and Issue: 48(9), P. 1285 - 1297

Published: Jan. 1, 2024

Tazarotene-induced gene 1 (TIG1) is induced by a derivative of vitamin A and known to regulate many important biological processes control the development cancer.TIG1 widely expressed in various tissues; yet cancer tissues, it not because methylation its promoter.Additionally, expression TIG1 cells inhibits their growth invasion, suggesting that acts as tumor suppressor gene.However, some cancers, poor prognosis associated with expression, indicating protumor characteristics, especially promoting invasion inflammatory breast cells.This review comprehensively summarizes roles details mechanisms through which regulates development, aim understanding development.Abbreviations 5-aza-dC 5-aza-2'-deoxycytidine AGBL2 ATP/GTP binding protein-like 2 AMPK AMP-activated protein kinase CCP2 Cytoplasmic carboxypeptidase CCPs Cytosolic carboxypeptidases CDK Cyclin-dependent

Language: Английский

Citations

1