International Immunopharmacology, Journal Year: 2023, Volume and Issue: 115, P. 109691 - 109691
Published: Jan. 11, 2023
Language: Английский
Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)
Published: Nov. 27, 2023
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.
Language: Английский
Citations
76
Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)
Published: Jan. 23, 2024
Abstract Ageing is a crucial risk factor for Alzheimer’s disease (AD) and characterised by systemic changes in both intracellular extracellular microenvironments that affect the entire body instead of single organ. Understanding specific mechanisms underlying role ageing development can facilitate treatment ageing-related diseases, such as AD. Signs brain have been observed AD patients animal models. Alleviating pathological caused dramatically ameliorate amyloid beta- tau-induced neuropathological memory impairments, indicating plays pathophysiological process In this review, we summarize impact several age-related factors on propose preventing promising strategy improving cognitive health.
Language: Английский
Citations
30
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 18, 2025
Language: Английский
Citations
8
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: Jan. 13, 2025
Traumatic brain injury (TBI) is characterized by high mortality and disability rates. Disease-associated microglia (DAM) are a newly discovered subtype of microglia. However, their presence function in the acute phase TBI remain unclear. Although glycolysis important for microglial differentiation, its regulatory role DAM transformation during still In this study, we investigated functions DAM-like cells mice, as well relationship between glycolysis. controlled cortical impact model was used to induce adult male wild-type (WT) C57BL/6 mice TREM2 knockout mice. Various techniques were assess effects on cells, including RT‒qPCR, immunofluorescence assays, behavioural tests, extracellular acidification rate (ECAR) Western blot analysis, cell magnetic sorting culture, glucose lactate flow cytometry. observed depended expression. impaired neurological recovery possibly due part clearing debris secreting VEGFa BDNF. Moreover, exhibited significantly increased glycolytic activity. regulated AKT‒mTOR‒HIF-1α pathway TBI. The increase partially contributed Taken together, results our study demonstrated that present might influence modulating Our provide new possible intervening
Language: Английский
Citations
3
npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 3, 2025
Language: Английский
Citations
2
Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(5)
Published: Jan. 24, 2023
Macrophage migration inhibitory factor (MIF) is a multifaced protein that plays important roles in multiple inflammatory conditions. However, the role of MIF endothelial cell (EC) death under condition remains largely unknown. Here we show actively promotes receptor-interacting kinase 1 (RIPK1)-mediated oxygen-glucose deprivation condition. expression induced by surgical trauma peripheral myeloid cells both perioperative humans and mice. We demonstrate MIF-loaded surgery adhere to brain ECs after distal middle cerebral artery occlusion (dMCAO) exacerbate blood–brain barrier (BBB) disruption. Genetic depletion myeloid-derived ischemic stroke (PIS) mice with MCAO following insult leads significant reduction apoptosis necroptosis associated BBB The adoptive transfer blood mononuclear (PBMC) from ΔLyz2 wild-type (WT) also shows reduced compared PBMC f l/f l recipients. genetic inhibition RIPK1 attenuates disruption WT PIS. administration inhibitor (ISO-1) (Nec-1s) can reduce EC neurological deficits conclude through kinase-dependent pathway. above findings may provide insights into mechanism as how inflammation pathology central nervous system.
Language: Английский
Citations
31
Inflammation Research, Journal Year: 2024, Volume and Issue: 73(4), P. 641 - 654
Published: Feb. 27, 2024
Language: Английский
Citations
10
ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15724 - 15741
Published: Aug. 11, 2023
Metabolic reprogramming that senses brain homeostasis imbalances is necessary to drive detrimental microglial polarization, and specific targeting of this process contributes the flexible control pathological inflammatory responses in Alzheimer's disease (AD), displaying distinctive therapeutic benefits. Herein, glutathione-functionalized gold nanocages loaded with immunosuppressant fingolimod hydrochloride are developed as brain-targeted microglia-located immunometabolic nanomodulators (GAF NPs) for AD management. By virtue glutathione-mediated transport properties, nanomodulator can cross blood-brain barrier localize microglia lesions. Through blocking Akt/mTOR/HIF-1α signaling pathways, GAF NPs not only promote dominated metabolic shift from glycolysis oxidative phosphorylation under immune activation but also inhibit transporter-mediated glucose overconsumption by microglia. Correlation analysis based on real-time bioenergetic assessment 18F-labeled fluorodeoxyglucose (FDG) PET reveals utilization metabolism restored NP treatment serve a sensitive effective indicator M1 M2 polarization switching, ultimately alleviating neuroinflammation its derived neurodegeneration well ameliorating cognitive decline mice. This work highlights potential nanomedicine aimed at modifying mTOR-mediated halt energy deprivation-induced progression.
Language: Английский
Citations
21
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 7796 - 7813
Published: March 2, 2024
Language: Английский
Citations
8
Antioxidants, Journal Year: 2022, Volume and Issue: 12(1), P. 94 - 94
Published: Dec. 30, 2022
Neurodegenerative diseases, characterized by progressive loss in selected areas of the nervous system, are becoming increasingly prevalent worldwide due to an aging population. Despite their diverse clinical manifestations, neurodegenerative diseases multifactorial disorders with standard features and mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress inflammation. As there no effective treatments counteract increasing interest has been directed potential neuroprotective activities plant-derived compounds found abundantly food agrifood by-products. Food waste extremely negative impact on environment, recycling is needed promote disposal overcome this problem. Many studies have carried out develop green strategies extract bioactive from by-products, peel, leaves, seeds, bran, kernel, pomace, oil cake, investigate biological activity. In review, we focused activity wastes obtained common products widely produced consumed Italy, grapes, coffee, tomatoes, olives, chestnuts, onions, apples, pomegranates.
Language: Английский
Citations
24