Deoxyvasicinone hybrids in the management of Alzheimer's disease: Recent advances on manmade derivatives, pharmacological activities, and structure–activity relationship DOI Open Access

A Gaur,

Yash Pal Singh, Rajiv Sharma

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 358(1)

Published: Dec. 27, 2024

Alzheimer's disease (AD) is a prevalent neurological illness that affects over 80% of aged adults globally in cases dementia. Although the exact pathophysiological causes AD remain unclear, its pathogenesis primarily driven by several distinct biochemical alterations: (i) accumulation toxic Aβ plaques, (ii) hyperphosphorylation tau proteins, (iii) oxidative stress resulting cell death, and (iv) an imbalance between two main neurotransmitters, glutamate acetylcholine (ACh). Currently, there are very few medications available no treatment. Presently marketed include memantine, N-methyl-d-aspartate receptor (NMDA) antagonist, acetylcholinesterase (AChE) inhibitors: rivastigmine, donepezil, galantamine. Unfortunately, these only useful initial stages AD. The mentioned provide symptomatic relief do not slow down progression advanced stages. Therefore, urgent need to develop potential candidates treat AD, symptomatically therapeutically. Many research groups focus on natural products due their diverse therapeutic profiles easy availability. One such product deoxyvasicinone, isolated from Adhatoda vasica. Given broad pharmacological profile, various researchers have developed semisynthetic hybrids deoxyvasicinone address multifaceted diseases like In this review article, we tried summarize past decade (2014-2024) for managing We design, activity, structure-activity relationship (SAR) analysis. hope enhances reader's understanding future exploratory options management.

Language: Английский

Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases DOI Creative Commons
Andrea Stoccoro

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 98 - 98

Published: Jan. 19, 2025

Neurodegenerative diseases are characterized by profound differences between females and males in terms of incidence, clinical presentation, disease progression. Furthermore, there is evidence suggesting that sensitivity to medical treatments may exist the two sexes. Although role sex hormones chromosomes driving differential susceptibility these well-established, molecular alterations underlying remain poorly understood. Epigenetic mechanisms, including DNA methylation, histone tail modifications, activity non-coding RNAs, strongly implicated pathogenesis neurodegenerative diseases. While it known epigenetic mechanisms play a crucial sexual differentiation distinct patterns characterize males, sex-specific have been largely overlooked studies aiming identify associated with This review aims provide an overview processes central nervous system, main three diseases, Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis. Understanding sex-related essential for developing personalized interventions account unique landscapes each sex.

Language: Английский

Citations

1
Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease DOI Open Access
Mona Abdelhamid, Scott Counts, Chunyu Zhou

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

Citations

1
Role of Tau and Amyloid-beta in autophagy gene dysregulation through oxidative stress DOI

Mehrnaz Haghi,

Raheleh Masoudi, Fatemeh Ataellahi

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102765 - 102765

Published: Jan. 1, 2025

Language: Английский

Citations

0
Elevated CSF GAP-43 in Mild Cognitive Impairment Linked to Cognitive Impairment Through Increased Amyloid-β Accumulation, with a Shift to Reduced Amyloid-β Accumulation in Alzheimer’s Disease DOI
Ali Azargoonjahromi,

Mortaza Eivazi,

Hamide Nasiri

et al.

Journal of Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 75(2)

Published: March 20, 2025

Language: Английский

Citations

0
Unveiling the role of Na⁺/K⁺-ATPase pump: neurodegenerative mechanisms and therapeutic horizons DOI

Ramandeep Kaur Sidhu,

Kousik Maparu,

Shamsher Singh

et al.

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
A multiscale model to explain the spatiotemporal progression of amyloid beta and tau pathology in Alzheimer's disease DOI Creative Commons
Chunrui Xu, Enze Xu, Yang Xiao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142887 - 142887

Published: April 1, 2025

Amyloid-beta (Aβ) and tubulin-associated unit (tau) proteins are key biomarkers of Alzheimer's disease (AD), detectable by Positron Emission Tomography (PET) imaging Cerebrospinal Fluid (CSF) assays. They reflect insoluble fibrils in the brain soluble monomers cerebrospinal fluid, respectively. PET CSF have been utilized diagnosing AD; however, their incomplete agreement significantly confounds early detection. Additionally, molecular mechanisms underlying dynamics AD remain elusive yet to be quantitatively revealed. To answer these questions, we develop a multiscale mathematical model that characterizes various forms biomarkers, including molecules diffusive across regions, brain. Mathematical modeling enables explanation asynchronous trajectory biomarkers. Our captures spatiotemporal Aβ tau with neurodegeneration AD. Simulation results demonstrate PET-CSF discordance is typical stage natural history protein aggregation, becoming abnormal before onset abnormality. Furthermore, correlation analysis reveals more strongly associated tau-PET than Aβ-PET. These findings suggest recognized as biomarker at AD, while suitable for assessment. The proposed explains neurobiological factors contributing offers valuable tool improving detection treatment strategies clinical trials.

Language: Английский

Citations

0
The potential link between the development of Alzheimer’s disease and osteoporosis DOI Creative Commons

Fariha Nasme,

Jyotirmaya Behera,

Prisha Tyagi

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

0
Psychedelics in neuroinflammation: Mechanisms and therapeutic potential DOI

Júnia L. de Deus,

Juliana Marino Maia, Renato Nery Soriano

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111278 - 111278

Published: Jan. 1, 2025

Language: Английский

Citations

0
Changes in the pH value of the human brain in Alzheimer’s disease pathology correlated with CD68-positive microglia: a community-based autopsy study in Beijing, China DOI Creative Commons
Xue Wang,

Xiangqi Shao,

Liang Yu

et al.

Molecular Brain, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 10, 2025

Abstract The microenvironment of the central nervous system is highly complex and plays a crucial role in maintaining function neurons, which influences Alzheimer’s disease (AD) progression. pH value brain critical aspect regulating various physiological processes. However, specific mechanisms this mechanism are not yet fully understood. To better understand relationship between AD, we analyzed frontal lobe AD pathology scores postmortem samples from 368 donors National Human Brain Bank for Development Function, 96 whom were diagnosed with pathology. Analysis revealed significant decrease patients, was strongly correlated β-amyloid plaques phosphorylated tau proteins. Here, elucidated differential protein expression level CD68-positive microglia control groups (t = 3.198, df 20, P 0.0045), its negatively (F 26.93, p 0.0006). Our findings that increased activation disrupted lysosomal homeostasis pathological tissue individuals may lead to pH.

Language: Английский

Citations

0
Plasma tryptophan levels are linked to hippocampal integrity and cognitive function in individuals with mild cognitive impairment DOI
Ali Azargoonjahromi

Brain Imaging and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0