Secretome of Stromal Cancer-Associated Fibroblasts (CAFs): Relevance in Cancer DOI Creative Commons
Deepshikha Mishra, Debabrata Banerjee

Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 628 - 628

Published: Feb. 15, 2023

The cancer secretome reflects the assortment of proteins released by cells. Investigating cell secretomes not only provides a deeper knowledge healthy and transformed state but also helps in discovery novel biomarkers. Secretomes cells have been studied past, however, contribution stromal needs to be studied. Cancer-associated fibroblasts (CAFs) are one predominantly present populations tumor microenvironment (TME). CAFs play key role functions associated with matrix deposition remodeling, reciprocal exchange nutrients, molecular interactions signaling neighboring TME. or CAFs-secreted factors would help identifying CAF-specific biomarkers, unique druggable targets, an improved understanding for personalized diagnosis prognosis. In this review, we tried include all studies available PubMed keywords "CAFs Secretome". We aim provide comprehensive summary investigating CAF on development, progression, therapeutic outcome. However, challenges process addressed later sections. highlighted clinical relevance analysis CAF-rich types. This review specifically discusses cancers. A components their will identification biomarkers more precise treatment plan.

Language: Английский

Extracellular vesicles as personalized medicine DOI Creative Commons
Danielle J. Beetler, Damian N. Di Florio, Katelyn A. Bruno

et al.

Molecular Aspects of Medicine, Journal Year: 2022, Volume and Issue: 91, P. 101155 - 101155

Published: Nov. 28, 2022

Extracellular vesicles (EVs) are released from all cells in the body, forming an important intercellular communication network that contributes to health and disease. The contents of EVs cell source-specific, inducing distinct signaling responses recipient cells. specificity their accumulation fluid spaces accessible for liquid biopsies make them highly attractive as potential biomarkers therapies duality favorable (therapeutic) or unfavorable (pathological) messengers is context dependent remains be fully determined homeostasis various disease states. This review describes use biomarkers, drug delivery vehicles, regenerative therapeutics, highlighting examples involving viral infections, cancer, neurological diseases. There growing interest provide personalized therapy based on individual patient characteristics. Increasing evidence suggests EV therapeutic approaches ideal medicine due diversity multifunctionality EVs.

Language: Английский

Citations

56
Multifaceted role of chemokines in solid tumors: From biology to therapy DOI

Sana Raza,

Sangam Rajak,

Archana Tewari

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 1105 - 1121

Published: Jan. 1, 2022

Language: Английский

Citations

52
Targeting HIF-2α in the Tumor Microenvironment: Redefining the Role of HIF-2α for Solid Cancer Therapy DOI Open Access
Leah Davis, Matthias Recktenwald,

Evan Hutt

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(5), P. 1259 - 1259

Published: Feb. 28, 2022

Inadequate oxygen supply, or hypoxia, is characteristic of the tumor microenvironment and correlates with poor prognosis therapeutic resistance. Hypoxia leads to activation hypoxia-inducible factor (HIF) signaling pathway stabilization HIF-α subunit, driving progression. The homologous alpha subunits, HIF-1α HIF-2α, are responsible for mediating transcription a multitude critical proteins that control proliferation, angiogenic signaling, metastasis, other oncogenic factors, both differentially sequentially regulating hypoxic response. Post-translational modifications HIF play central role in its behavior as mediator transcription, well temporal transition from HIF-2α occurs response chronic hypoxia. While it evident highly dynamic, remains vastly under-considered. can intensify behaviors most aggressive tumors by adapting cell oxidative stress, thereby promoting tissue remodeling, angiogenesis, upregulating cancer stem factors. structure, function, response, spatiotemporal dynamics, roles progression persistence this molecule

Language: Английский

Citations

52
Intratumor microbiome in cancer progression: current developments, challenges and future trends DOI Creative Commons

Jinyan Liu,

Yi Zhang

Biomarker Research, Journal Year: 2022, Volume and Issue: 10(1)

Published: May 31, 2022

Abstract Cancer is a complicated disease attributed to multifactorial changes, which causes difficulties with treatment strategies. Various factors have been regarded as the main contributors, and infectious etiological recently attracted interest. Several microbiomes contribute carcinogenesis, cancer progression, modulating by inducing cancerous epithelial cells chronic inflammation. Most of our knowledge on role microbiota in tumor oncogenesis clinical efficiency associated intestinal microbiome. However, compelling evidence has also confirmed contribution intratumor microbiome cancer. Indeed, findings samples, animal models, studies vitro revealed that many promote tumorigenesis immune evasion. In addition, participates regulating response even affects outcomes treatment. This review summarizes interplay between cancer, focusing mechanism initiation, potential applications therapy.

Language: Английский

Citations

50
Harnessing cancer stem cell-derived exosomes to improve cancer therapy DOI Creative Commons
Jianqiang Yang, Yong Teng

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: May 23, 2023

Abstract Cancer stem cells (CSCs) are the key “seeds” for tumor initiation and development, metastasis, recurrence. Because of function CSCs in development progression, research this field has intensified viewed as a new therapeutic target. Exosomes carrying wide range DNA, RNA, lipids, metabolites, cytosolic cell-surface proteins released outside originating through fusion multivesicular endosomes or bodies with plasma membrane. It become evident that CSC‐derived exosomes play significant role almost all “hallmarks” cancer. For example, from can maintain steady state self-renewal microenvironment regulate microenvironmental distant to help cancer escape immune surveillance induce tolerance. However, value underlying molecular mechanisms still largely undefined. To provide an overview possible targeting strategies, we summarize relevant progress, highlight potential impact detecting on treatment, discuss opportunities challenges based our experience insights area. A more thorough understanding characteristics may open avenues clinical diagnostic/prognostic tools therapies prevent resistance relapse.

Language: Английский

Citations

26
Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence DOI Creative Commons
Muhammad Tufail, Canhua Jiang, Ning Li

et al.

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Language: Английский

Citations

1
Tumor microenvironment: recent advances in understanding and its role in modulating cancer therapies DOI
Disha D. Shah, Mehul R. Chorawala, Neha R. Raghani

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 18, 2025

Language: Английский

Citations

1
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance DOI Creative Commons
Kalyani Patil, Khan Farheen Badrealam, Sabah Akhtar

et al.

Cancer and Metastasis Reviews, Journal Year: 2021, Volume and Issue: 40(3), P. 691 - 720

Published: Aug. 28, 2021

The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than hardwired defined entity has evolved our understanding the functional and biological plasticity these elusive components in malignancies. Pancreatic (PC), based on its features clinical evolution, is prototypical example CSC-driven disease. Since discovery pancreatic CSCs (PCSCs) 2007, evidence unraveled their control over many facets natural history PC, including primary tumor growth, metastatic progression, disease recurrence, acquired drug resistance. Consequently, current near-ubiquitous treatment regimens for PC using aggressive cytotoxic agents, aimed at ''tumor debulking'' eradication CSCs, have proven ineffective providing clinically convincing improvements patients with this dreadful Herein, we review key hallmarks well intrinsic extrinsic resistance mechanisms that mediate failure enlist potential CSC-targeting 'natural agents' are gaining popularity recent years. A better molecular landscape PCSC-intrinsic evasion chemotherapeutic drugs offers facile opportunity treating an intractable grim prognosis dire need effective therapeutic advances.

Language: Английский

Citations

48
Tumor microenvironment and nanotherapeutics: intruding the tumor fort DOI

Ammu V. V. V. Ravi Kiran,

Garikapati Kusuma Kumari, Praveen Thaggikuppe Krishnamurthy

et al.

Biomaterials Science, Journal Year: 2021, Volume and Issue: 9(23), P. 7667 - 7704

Published: Jan. 1, 2021

Over recent years, advancements in nanomedicine have allowed new approaches to diagnose and treat tumors. Nano drug delivery systems exploit the enhanced permeability retention (EPR) effect enter tumor tissue's interstitial space. However, barriers play a crucial role, cause inefficient EPR or homing effect. Mounting evidence supports hypothesis that components of microenvironment, such as extracellular matrix, cellular physiological collectively cooperatively hinder entry distribution drugs, therefore, limit theragnostic applications cancer nanomedicine. This abnormal microenvironment plays pivotal role was recently recognized promising target for improving nano-drug their therapeutic outcomes. Strategies like passive active targeting, stimuli-triggered nanocarriers, modulation immune shown results achieving anticancer efficacy. The present review focuses on nanoparticle-based strategies (polymeric, inorganic organic nanoparticles) intruding barrier effects.

Language: Английский

Citations

43
Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer DOI

Yonglei Liu,

Li Ma, Fanli Hua

et al.

Oncogene, Journal Year: 2022, Volume and Issue: 41(14), P. 2012 - 2025

Published: Jan. 13, 2022

Language: Английский

Citations

31