The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development DOI Creative Commons
Baisuo Zhao, Eugenie Nepovimová, Qinghua Wu

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 16, 2025

The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. At the heart of this lies PERIOD proteins (PERs), pivotal to clock, influencing timing behavioral processes impacting oxidative stress, immune functionality, tumorigenesis. PER1 orchestrates cooperation enzyme GPX1, modulating mitochondrial dynamics in sync with daily thus regulating mechanisms managing energy substrates. PERs innate cells modulate temporal patterns NF-κB TNF-α activities, as well response LPS-induced toxic shock, initiating inflammatory responses that escalate into chronic conditions. Crucially, cancer cell behaviors including proliferation, apoptosis, migration by levels cycle stimulating expression oncogenes c-Myc MDM2. PER2/3, antagonists stem biology, play important roles differentiating their stemness. Importantly, Pers serve a significant factor early diagnosis prognosis. This review delves link rhythm regulator PERs, disruptions rhythm, oncogenesis. We examine evidence highlights how dysfunctions activities initiate development, aid tumor growth, modify metabolism through pathways involved stress system. Comprehending these connections opens new development rhythm-based therapeutic strategies, aims boosting enhancing treatments.

Language: Английский

The Role of the Kynurenine/AhR Pathway in Diseases Related to Metabolism and Cancer DOI Open Access
Amir Shadboorestan,

Meriem Koual,

Julien Dairou

et al.

International Journal of Tryptophan Research, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

The Aryl hydrocarbon receptor (AhR) is a xenobiotic and endobiotic receptor, which regulates many cellular processes from contaminant metabolism to immunomodulation. Consequently, it also involved in pathophysiological pathways now represents potential therapeutical target. In this review, we will highlight the ancestral function of protein together with an illustration its ligand’s battery, emphasizing different responses triggered by these high diverse molecules. Among them, several members kynurenine pathway (one key process tryptophan catabolism) are AhR agonists subsequently regulatory functions. We finally display interplay between Tryptophan (Trp) catabolism dysregulation metabolic drawing hypothesis on involvement cancer-related processes.

Language: Английский

Citations

17
The pharmacoepigenetic paradigm in cancer treatment DOI Creative Commons

Belén Ocaña-Paredes,

Sebastián Rivera-Orellana, David Ramírez

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 24, 2024

Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role development and progression of cancer significantly influencing activity cellular function. This insight has led to novel class therapeutic agents, known as epigenetic drugs. These drugs, including histone deacetylase inhibitors, acetyltransferase methyltransferase aim modulate curb growth uniquely landscape cells. Ongoing research clinical trials are rigorously evaluating efficacy these particularly their ability improve outcomes when used combination with other treatments. Such therapies may more effectively target potentially overcome challenge drug resistance, significant hurdle therapy. Additionally, importance nutrition, inflammation control, circadian rhythm regulation modulating responses been increasingly recognized, highlighting critical modifiers thereby effectiveness pharmacological interventions patient outcomes. drugs represent paradigm shift treatment, offering targeted that promise precise approach treating wide spectrum tumors, fewer side effects compared traditional chemotherapy. progress marks step towards personalized interventions, leveraging unique profiles individual tumors optimize treatment strategies.

Language: Английский

Citations

7
Circadian rhythms and breast cancer: unraveling the biological clock’s role in tumor microenvironment and ageing DOI Creative Commons

Yalan Yan,

Lanqian Su,

Shanshan Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved pathogenesis breast cancer. In this paper, we reviewed molecular mechanisms by which dysregulation circadian genes impacts development BC, focusing on critical clock genes, brain muscle ARNT-like protein 1 (BMAL1) locomotor output cycles kaput (CLOCK). We discussed how rhythm disruption (CRD) changes tumor microenvironment (TME), immune responses, inflammation, angiogenesis. The CRD compromises surveillance features activities effectors, including CD8+ T cells tumor-associated macrophages, that are important an effective anti-tumor response. Meanwhile, review, discuss bidirectional interactions: age rhythms, aging further increases risk through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, ability to repair damaged DNA, weakened immunity. These complex interplays open new avenues toward targeted therapies combination drugs with chronotherapy potentiate response while reducing progression for better outcomes. This review tries cover broad area emerging knowledge tumor-immune nexus affected

Language: Английский

Citations

6
A glassy carbon electrode modified with a composite consisting of electrodeposited chitosan and carboxylated multi-walled carbon nanotubes for simultaneous voltammetric determination of dopamine, serotonin and melatonin DOI
Shanshan Tang, Axin Liang, Miao Liu

et al.

Carbon letters, Journal Year: 2023, Volume and Issue: 33(7), P. 2129 - 2139

Published: June 13, 2023

Language: Английский

Citations

15
How Does Chronobiology Contribute to the Development of Diseases in Later Life DOI Creative Commons

Taylor A. Stowe,

Colleen A. McClung

Clinical Interventions in Aging, Journal Year: 2023, Volume and Issue: Volume 18, P. 655 - 666

Published: April 1, 2023

Abstract: An increasingly older population is one of the major social and medical challenges we currently face. Between 2010 2050, it estimated that proportion adults over 65 years age will double from 8% to 16% global population. A concern associated with aging changes in health can lead various diseases such as cancer neurogenerative diseases, which are burdens on individuals societies. Thus, imperative better understand sleep circadian rhythms accompany improve an target aging. Circadian play a role most physiological processes contribute age-related diseases. Interestingly, there relationship between For example, many have shift chronotype, individual's natural inclination certain times day. As age, people tend go earlier while also waking up earlier. Numerous studies suggest disrupted may be indicative developing like neurodegenerative disorders cancer. Better understanding allow us current treatments or develop novel ones commonly Keywords: rhythms, aging, sleep,

Language: Английский

Citations

13
The contribution of circadian clock to the biological processes DOI Creative Commons

Beibei Luo,

Jiangyuan Song, Jiaqi Zhang

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: June 6, 2024

All organisms have various circadian, behavioral, and physiological 24-h periodic rhythms, which are controlled by the circadian clock. The clock controls behavioral rhythms. In mammals, primary is present in suprachiasmatic nucleus of hypothalamus. rhythm interaction between negative positive feedback loops, consisting crucial regulators (including Bmal1 Clock), three cycles (mPer1, mPer2, mPer3), two cryptochromes (Cry1 Cry2). development early mammalian embryos an ordered complex biological process that includes stages from fertilized eggs to blastocysts undergoes important morphological changes, such as blastocyst formation, cell multiplication, compaction. affects onset timing embryonic development. many processes, including eating time, immune function, sleep, energy metabolism, endocrinology, therefore, it also for overall health, growth after birth. This review summarized effects body's activities. A new strategy proposed prevention malformations or diseases regulating changing

Language: Английский

Citations

5
Circadian rhythm disruption and endocrine-related tumors DOI Open Access
Christos Savvidis,

Efthymia Kallistrou,

Eleni Kouroglou

et al.

World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(7), P. 818 - 834

Published: July 16, 2024

This review delved into the intricate relationship between circadian clocks and physiological processes, emphasizing their critical role in maintaining homeostasis. Orchestrated by interlocked clock genes, timekeeping system regulates fundamental processes like sleep-wake cycle, energy metabolism, immune function, cell proliferation. The central oscillator hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles, while peripheral tissue are influenced cues such as feeding times. Circadian disruption, linked to modern lifestyle factors night shift work, correlates adverse health outcomes, including metabolic syndrome, cardiovascular diseases, infections, cancer. We explored molecular mechanisms of genes impact on disorders cancer pathogenesis. Specific associations disruption endocrine tumors, spanning breast, ovarian, testicular, prostate, thyroid, pituitary, adrenal gland cancers, highlighted. Shift work is associated increased breast risk,

Language: Английский

Citations

5
Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets DOI
Yu Wang, Hai-dong Guo, Feng He

et al.

Cancer and Metastasis Reviews, Journal Year: 2022, Volume and Issue: 42(1), P. 297 - 322

Published: Dec. 14, 2022

Language: Английский

Citations

20
Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals DOI Creative Commons
Xianhui Liu, Yao D. Cai, Joanna C. Chiu

et al.

Journal of Biological Chemistry, Journal Year: 2023, Volume and Issue: 300(2), P. 105616 - 105616

Published: Dec. 29, 2023

O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a dynamic post-translational modification that regulates thousands of proteins and almost all cellular processes. Aberrant O-GlcNAcylation has been associated with numerous diseases, including cancer, neurodegenerative cardiovascular type 2 diabetes. highly nutrient-sensitive since it dependent on UDP-GlcNAc, the end product hexosamine biosynthetic pathway (HBP). We previously observed daily rhythmicity protein in Drosophila model sensitive to timing food consumption. showed circadian clock pivotal regulating rhythms given its control feeding-fasting cycle hence nutrient availability. Interestingly, we reported also modulates rhythm by molecular mechanisms beyond regulation consumption time. A large body work now indicates likely generalized status effector as responds various signals conditions, such ER stress, apoptosis, infection. In this review, summarize metabolic through availability, HBP enzymes, O-GlcNAc processing enzymes. discuss emerging roles clocks rhythm. Finally, provide an overview other or conditions impact O-GlcNAcylation. Many these pathways are themselves regulated and/or metabolism. Our review highlights importance maintaining optimal restricting eating activity active period under physiological provides insights into potential therapeutic targets homeostasis pathological conditions.

Language: Английский

Citations

11
Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment DOI Creative Commons
Janina Hesse, Nina Nelson, Angela Relógio

et al.

Current Opinion in Systems Biology, Journal Year: 2024, Volume and Issue: 37, P. 100506 - 100506

Published: Feb. 29, 2024

The growing numbers of cancer cases represent a medical and societal burden worldwide. More than half all patients are treated with chemotherapy. Yet, chemotherapeutic drugs kill not only cells, but also healthy tissue, causing massive adverse side effects. Recent research on circadian medicine suggests that side-effects can be reduced, treatment efficacy increased, by considering the biological clock patients. Integrating profiles molecular markers in personalized mathematical models simulate individual dynamics drug uptake, action cellular response to This requires advanced computational tools balance prediction quality overfitting. Personalized will eventually lead an optimal alignment timing inner patient, reducing effects, increasing enhancing patient well-being.

Language: Английский

Citations

4