Cancers,
Journal Year:
2022,
Volume and Issue:
15(1), P. 104 - 104
Published: Dec. 23, 2022
Triple-negative
breast
cancer
(TNBC)
is
characterized
by
a
high
rate
of
systemic
metastasis,
insensitivity
to
conventional
treatment
and
susceptibility
drug
resistance,
resulting
in
poor
patient
prognosis.
The
immune
checkpoint
inhibitors
(ICIs)
represented
antibodies
programmed
death
receptor
1
(PD-1)
ligand
(PD-L1)
have
provided
new
therapeutic
options
for
TNBC.
However,
the
efficacy
PD-1/PD-L1
blockade
monotherapy
suboptimal
response,
which
may
be
caused
reduced
antigen
presentation,
immunosuppressive
tumor
microenvironment,
interplay
with
other
checkpoints
aberrant
activation
oncological
signaling
cells.
Therefore,
improve
sensitivity
TNBC
ICIs,
suitable
patients
are
selected
based
on
reliable
predictive
markers
treated
combination
ICIs
therapies
such
as
chemotherapy,
radiotherapy,
targeted
therapy,
oncologic
virus
neoantigen-based
therapies.
This
review
discusses
current
mechanisms
underlying
resistance
inhibitors,
potential
biomarkers
predicting
anti-PD-1/PD-L1
immunotherapy
recent
advances
increase
response
rates,
depth
remission
durability
benefit
ICIs.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
Cancer
is
a
disease
caused
by
abnormal
cell
growth
that
spreads
through
other
parts
of
the
body
and
threatens
life
destroying
healthy
tissues.
Therefore,
numerous
techniques
have
been
employed
not
only
to
diagnose
monitor
progress
cancer
in
precise
manner
but
also
develop
appropriate
therapeutic
agents
with
enhanced
efficacy
safety
profiles.
In
this
regard,
molecularly
imprinted
polymers
(MIPs),
synthetic
receptors
recognize
targeted
molecules
high
affinity
selectivity,
intensively
investigated
as
one
most
attractive
biomaterials
for
theragnostic
approaches.
This
review
describes
diverse
synthesis
strategies
provide
rationale
behind
these
antibodies
provides
selective
overview
recent
vitro
vivo
targeting
biomarkers
diagnosis
applications.
Taken
together,
topics
discussed
concise
guidelines
development
novel
MIP-based
systems
more
precisely
promote
successful
treatment.
Molecularly
The
aim
Clinical and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 19, 2024
Abstract
Humanity
is
suffering
from
cancer
which
has
become
a
root
cause
of
untimely
deaths
individuals
around
the
globe
in
recent
past.
Nanotheranostics
integrates
therapeutics
and
diagnostics
to
monitor
treatment
response
enhance
drug
efficacy
safety.
We
hereby
propose
discuss
all
imaging
diagnostic
tools,
mechanism
targeting
tumor
cells,
current
nanotheranostic
platforms
available
for
cancer.
This
review
discusses
various
agents
novel
molecular
tools
like
MRI,
CT,
PET,
SPEC,
PAT
used
diagnostics.
Emphasis
given
gold
nanoparticles,
silica,
liposomes,
dendrimers,
metal-based
agents.
also
highlight
limitations
different
field
research
treatment.
Due
complexity
this
area,
multifunctional
hybrid
nanoparticles
functionalized
with
targeted
moieties
or
anti-cancer
drugs
show
best
feature
theranostics
that
enables
them
work
on
carrying
delivering
active
materials
desired
area
requirement
early
detection
diagnosis.
Non-invasive
techniques
have
specificity
receptor
binding
internalization
processes
nanosystems
within
cells.
may
provide
appropriate
medicine
at
dose
patient
time.
Graphical
abstract
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: March 16, 2024
Abstract
Conventional
cancer
treatments
can
cause
serious
side
effects
because
they
are
not
specific
to
cells
and
damage
healthy
cells.
Aptamers
often
single-stranded
oligonucleotides
arranged
in
a
unique
architecture,
allowing
them
bind
specifically
target
sites.
This
feature
makes
an
ideal
choice
for
targeted
therapeutics.
They
typically
produced
through
the
systematic
evolution
of
ligands
by
exponential
enrichment
(SELEX)
undergo
extensive
pharmacological
revision
modify
their
affinity,
specificity,
therapeutic
half-life.
act
as
drugs
themselves,
directly
inhibiting
tumor
Alternatively,
be
used
drug
delivery
systems
transport
cells,
minimizing
toxicity
In
this
review,
we
will
discuss
latest
most
advanced
approaches
using
aptamers
treatment,
particularly
therapy
overcoming
resistance
conventional
therapies.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116207 - 116207
Published: Jan. 31, 2024
Lung
cancer
ranks
among
the
most
prevalent
forms
of
and
remains
a
significant
factor
in
cancer-related
mortality
across
world.
It
poses
challenges
to
healthcare
systems
society
as
whole
due
its
high
incidence,
rates,
late-stage
diagnosis.
Resveratrol
(RV),
natural
compound
found
various
plants,
has
shown
potential
nanomedicine
for
lung
treatment.
RV
varied
effects
on
cells,
including
promoting
apoptosis
by
increasing
pro-apoptotic
proteins
(Bax
Bak)
decreasing
anti-apoptotic
(Bcl-2).
also
hinders
cell
proliferation
influencing
important
signaling
pathways
(MAPK,
mTOR,
PI3K/Akt,
Wnt/β-catenin)
that
govern
progression.
In
addition,
acts
potent
antioxidant,
diminishing
oxidative
stress
safeguarding
cells
against
DNA
damage.
However,
using
alone
treatment
drawbacks,
such
low
bioavailability,
lack
targeting
ability,
susceptibility
degradation.
contrast,
nanoparticle-based
delivery
address
these
limitations
hold
promise
improving
outcomes
cancer;
nanoparticle
formulations
offer
advantages
improved
drug
delivery,
increased
stability,
controlled
release,
targeted
cells.
This
article
will
provide
an
overview
cancer,
explore
therapeutic
agent,
discuss
benefits
highlight
nanoparticles
treatment,
cancer.
By
optimizing
clinical
application,
future
studies
aim
enhance
overall
improve
prognosis
patients.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(1), P. 126 - 126
Published: Jan. 18, 2024
Resveratrol
is
a
polyphenolic
compound
that
has
gained
considerable
attention
in
the
past
decade
due
to
its
multifaceted
therapeutic
potential,
including
anti-inflammatory
and
anticancer
properties.
However,
efficacy
impeded
by
low
water
solubility,
dose-limiting
toxicity,
bioavailability,
rapid
hepatic
metabolism.
To
overcome
these
hurdles,
various
nanoparticles
such
as
organic
inorganic
nanoparticles,
liposomes,
polymeric
dendrimers,
solid
lipid
gold
zinc
oxide
zeolitic
imidazolate
frameworks,
carbon
nanotubes,
bioactive
glass
mesoporous
were
employed
deliver
resveratrol,
enhancing
against
types
of
cancer.
Resveratrol-loaded
nanoparticle
or
resveratrol-conjugated
administration
exhibits
excellent
potency
compared
free
resveratrol.
This
review
highlights
latest
developments
nanoparticle-based
delivery
systems
for
focusing
on
potential
limitations
associated
with
compound’s
bioavailability
effectiveness.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(6), P. 1966 - 2006
Published: Jan. 1, 2024
Neoplasias
pose
a
significant
threat
to
aging
society,
underscoring
the
urgent
need
overcome
limitations
of
traditional
chemotherapy
through
pioneering
strategies.
Targeted
drug
delivery
is
an
evolving
frontier
in
cancer
therapy,
aiming
enhance
treatment
efficacy
while
mitigating
undesirable
side
effects.
One
promising
avenue
utilizes
cell
membrane
receptors
like
folate
receptor
guide
transporters
precisely
malignant
cells.
Based
on
cellular
as
hallmark,
targeted
nanocarriers
and
small
molecule-drug
conjugates
have
been
developed
that
comprise
different
(bio)
chemistries
and/or
mechanical
properties
with
individual
advantages
challenges.
Such
modern
folic
acid-conjugated
stimuli-responsive
provide
systemic
controlled
release,
enabling
reduced
dosages,
circumvention
resistance,
diminished
adverse
Since
transporters'
structure-based
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(7), P. 723 - 723
Published: July 4, 2024
Breast
cancer
remains
the
most
prevalent
among
women
worldwide,
driving
urgent
need
for
innovative
approaches
to
diagnosis
and
treatment.
This
review
highlights
pivotal
role
of
nanoparticles
in
revolutionizing
breast
management
through
advancements
interconnected
including
targeted
therapy,
imaging,
personalized
medicine.
Nanoparticles,
with
their
unique
physicochemical
properties,
have
shown
significant
promise
addressing
current
treatment
limitations
such
as
drug
resistance
nonspecific
systemic
distribution.
Applications
range
from
enhancing
delivery
systems
sustained
release
developing
diagnostic
tools
early
precise
detection
metastases.
Moreover,
integration
into
photothermal
therapy
synergistic
use
existing
treatments,
immunotherapy,
illustrate
transformative
potential
care.
However,
journey
towards
clinical
adoption
is
fraught
challenges,
chemical
feasibility,
biodistribution,
efficacy,
safety
concerns,
scalability,
regulatory
hurdles.
delves
state
nanoparticle
research,
applications
diagnosis,
obstacles
that
must
be
overcome
integration.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(9), P. 10030 - 10048
Published: Feb. 22, 2024
Skin
cancer
(SC)
poses
a
global
threat
to
the
healthcare
system
and
is
expected
increase
significantly
over
next
two
decades
if
not
diagnosed
at
an
early
stage.
Early
diagnosis
crucial
for
successful
treatment,
as
disease
becomes
more
challenging
cure
it
progresses.
However,
identifying
new
drugs,
achieving
clinical
success,
overcoming
drug
resistance
remain
significant
challenges.
To
overcome
these
obstacles
provide
effective
understand
causes
of
skin
cancer,
how
cells
grow
divide,
factors
that
affect
cell
growth,
occurs.
In
this
review,
we
have
explained
various
therapeutic
approaches
SC
treatment
via
ligands,
targeted
photosensitizers,
natural
synthetic
drugs
SC,
epigenetic
approach
management
melanoma,
photodynamic
therapy,
therapy
BRAF-mutated
melanoma.
This
article
also
provides
detailed
summary
are
in
managing
melanoma
reducing
occurrence
stages
focuses
on
current
status
future
prospects
therapies
available
cancer.
