Stem Cell Reviews and Reports, Journal Year: 2021, Volume and Issue: 17(3), P. 1027 - 1038
Published: Jan. 6, 2021
Language: Английский
Trends in Pharmacological Sciences, Journal Year: 2020, Volume and Issue: 41(9), P. 653 - 664
Published: July 22, 2020
Language: Английский
Citations
665
Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)
Published: Sept. 3, 2021
Abstract Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested mimic their parental cells, possessing pro-tumor anti-tumor effects, inherent tropism. Therefore, can be a cell-free cancer treatment alternative. This review discusses insights regarding EVs' roles summarizes bioengineered EVs’ applications safe versatile agent delivery platforms. Meanwhile, current hurdles of moving from bench to bedside also discussed.
Language: Английский
Citations
260
Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)
Published: Sept. 13, 2022
Abstract Mesenchymal stem cells (MSCs) are multipotent stromal that can be obtained from various human tissues and organs. They differentiate into a wide range of cell types, including osteoblasts, adipocytes chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studies have indicated MSCs play critical roles cancer biology. The crosstalk between tumour has been found to regulate many behaviours, such as proliferation, metastasis epithelial-mesenchymal transition (EMT). Multiple lines evidence demonstrated secrete exosomes modulate the microenvironment important development. Notably, very recent works shown mesenchymal cell-derived (MSC-derived exosomes) critically involved resistance chemotherapy agents, targeted-therapy drugs, radiotherapy immunotherapy. In this review, we systematically summarized emerging detailed molecular mechanisms MSC-derived mediating therapy resistance, providing novel insights clinical applications management.
Language: Английский
Citations
170
Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 175, P. 113801 - 113801
Published: May 18, 2021
Language: Английский
Citations
159
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2020, Volume and Issue: 154, P. 259 - 269
Published: July 25, 2020
Language: Английский
Citations
148
Stem Cell Research & Therapy, Journal Year: 2021, Volume and Issue: 12(1)
Published: Oct. 30, 2021
Abstract Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number researchers have focused on the use exosomes for drug delivery. Targeted delivery in body is a promising method treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding suitable carrier has become popular research today. studies, mesenchymal stem cells (MSC-EXOs) been broadly researched due to their immune properties, tumor-homing elastic properties. While MSC-EXOs apparent advantages, some unresolved problems also exist. This article reviews studies delivery, summarizes characteristics MSC-EXOs, introduces primary production purification methods loading provide solutions existing suggestions future studies.
Language: Английский
Citations
127
Advanced Science, Journal Year: 2023, Volume and Issue: 10(20)
Published: May 10, 2023
Abstract Over the last decade, adipose‐derived stem cells (ADSCs) have attracted increasing attention in field of regenerative medicine. ADSCs appear to be most advantageous cell type for therapies owing their easy accessibility, multipotency, and active paracrine activity. This review highlights current challenges translating ADSC‐based into clinical settings discusses novel strategies overcome limitations ADSCs. To further establish as an emerging platform medicine, this also provides update on advancements field, including fat grafting, wound healing, bone regeneration, skeletal muscle repair, tendon reconstruction, cartilage cardiac nerve regeneration. are expected more tissue‐specific increasingly important
Language: Английский
Citations
102
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Oct. 1, 2022
Language: Английский
Citations
75
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 7923 - 7940
Published: Dec. 1, 2023
Exosomes are nano-sized membrane vesicles that transfer bioactive molecules between cells and modulate various biological processes under physiological pathological conditions. By applying bioengineering technologies, exosomes can be modified to express specific markers or carry therapeutic cargo emerge as novel platforms for the treatment of cancer, neurological, cardiovascular, immune, infectious diseases. However, there many challenges uncertainties in clinical translation exosomes. This review aims provide an overview recent advances engineered exosomes, with a special focus on methods strategies loading drugs into pros cons different methods, optimization exosome production based encapsulated. Moreover, we also summarize current applications prospects well potential risks limitations need addressed engineering, including standardization preparation engineering protocols, quality quantity control drug release, immunogenicity cytotoxicity Overall, represent exciting frontier nanomedicine, but they still face large-scale production, maintenance storage stability, translation. With continuous this field, exosome-based formulation could offer great promise targeted human
Language: Английский
Citations
56
Stem Cell Reviews and Reports, Journal Year: 2023, Volume and Issue: 19(5), P. 1214 - 1231
Published: April 14, 2023
Abstract Mesenchymal stem cells (MSCs) are regarded as highly promising for allogeneic cell therapy, owing to their multipotent nature and ability display potent varied functions in different diseases. The of MSCs, including native immunomodulation, high self-renewal characteristic, secretory trophic properties, can be employed improve the immune-modulatory MSCs impact most immune by directly contacting and/or secreting positive microenvironmental factors influence them. Previous studies have reported that immunomodulatory role is basically dependent on secretion from MSCs. This review discusses capabilities strategies successfully potential utilization clinical research. Graphical
Language: Английский
Citations
45