Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice DOI Creative Commons
Akito Tsuruta,

Yuki Shiiba,

Naoya Matsunaga

et al.

Molecular Cancer Research, Journal Year: 2022, Volume and Issue: 20(6), P. 972 - 982

Published: Feb. 21, 2022

Abstract Cancer cells have acquired several pathways to escape from host immunity in the tumor microenvironment. Programmed death 1 (PD-1) receptor and its ligand PD-L1 are involved key pathway of immune escape, checkpoint therapy targeting PD-1 has been approved for treatment patients with certain types malignancies. Although is a well-characterized on T cells, also expressed tumor-associated macrophages (TAM), major component In this study, we found significant diurnal oscillation number PD-1–expressing TAMs collected B16/BL6 melanoma-bearing mice. The levels Pdcd1 mRNA, encoding PD-1, fluctuated manner. Luciferase reporter bioluminescence imaging analyses revealed that NF-κB response element upstream region gene responsible expression. A circadian regulatory component, DEC2, whose expression exhibited oscillation, periodically suppressed NF-κB–induced transactivation gene, resulting TAMs. Furthermore, antitumor efficacy BMS-1, small molecule inhibitor PD-1/PD-L1, was enhanced by administering it at time day when increased These findings suggest identification useful selecting most appropriate administer PD-1/PD-L1 inhibitors. Implications: Selecting dosing inhibitors may aid developing cancer immunotherapy higher efficacy.

Language: Английский

Advances of Wnt Signalling Pathway in Colorectal Cancer DOI Creative Commons

Yaoyao Zhu,

Xia Li

Cells, Journal Year: 2023, Volume and Issue: 12(3), P. 447 - 447

Published: Jan. 30, 2023

Colorectal cancer (CRC) represents one of the most common cancers worldwide, with a high mortality rate despite decreasing incidence and new diagnostic therapeutic strategies. CRC arises from both epidemiologic molecular backgrounds. In addition to hereditary factor genetic mutations, strongly varying is closely linked chronic inflammatory disorders intestine terrible dietary habits. The Wnt signalling pathway complex regulatory network that implicated in many physiological processes, including occurrence, development, prognosis, invasion, metastasis. It currently believed include classical Wnt/β-catenin, Wnt/PCP, Wnt/Ca2+. this review, we summarise recent mechanisms potential regulators three branches CRC.

Language: Английский

Citations

54
Waking Up to the Importance of Sleep in Type 2 Diabetes Management: A Narrative Review DOI Open Access
Joseph Henson, Alix Covenant, Andrew P. Hall

et al.

Diabetes Care, Journal Year: 2024, Volume and Issue: 47(3), P. 331 - 343

Published: Feb. 23, 2024

For the first time, latest American Diabetes Association/European Association for Study of (ADA/EASD) consensus guidelines have incorporated a growing body evidence linking health outcomes associated with type 2 diabetes to movement behavior composition over whole 24-h day. Of particular note, importance sleep as key lifestyle component in management is promulgated and presented using three constructs: quantity, quality, timing (i.e., chronotype). In this narrative review we highlight some justifying inclusion by examining associations measures glycemia, cardiovascular disease risk, mortality. We also consider potential mechanisms implicated association between provide practical advice care professionals about initiating conversations pertaining clinical care. particular, emphasize measuring free-living environment summary different methodologies targets. summary, although ADA/EASD report highlights central diabetes, placing it, on level playing field other behaviors (e.g., physical activity diet), base improving (beyond disorders) those living limited. This should act timely reminder incorporate into consultations, ongoing education, future interventions.

Language: Английский

Citations

20
Circadian rhythms: pervasive, and often times evasive DOI
Luis Larrondo

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

Most circadian texts begin by stating that clocks are pervasive throughout the tree of life. Indeed, clock mechanisms have been described from cyanobacteria to humans, representing a notable example convergent evolution: yet, there several phyla in animals, protists or within fungi and bacteria, which homologs some-or all-known components seem be absent, posing inevitable questions about evolution systems. Moreover, as we move away model organisms, taxa core elements can identified at genomic levels. However, functional description those putative has hard achieve, rhythmicity is not observed unless defined abiotic nutritional cues provided. The 'conditioning' functionality remain uncertain, emphasizing need delve further into non-model As absence evidence absence, lack known core-clock observable rhythms given organism, cannot an priori criterion discard presence clock, may limited yet untested experimental conditions phenotypes. This article seeks reflect on these topics, highlighting some pressing awaiting addressed.This part Theo Murphy meeting issue 'Circadian infection immunity'.

Language: Английский

Citations

2
The Role of Daylight for Humans: Gaps in Current Knowledge DOI Creative Commons
Mirjam Münch, Anna Wirz‐Justice, Steven A. Brown

et al.

Clocks & Sleep, Journal Year: 2020, Volume and Issue: 2(1), P. 61 - 85

Published: Feb. 28, 2020

Daylight stems solely from direct, scattered and reflected sunlight, undergoes dynamic changes in irradiance spectral power composition due to latitude, time of day, year the nature physical environment (reflections, buildings vegetation). Humans their ancestors evolved under these natural day/night cycles over millions years. Electric light, a relatively recent invention, interacts competes with light–dark cycle impact human biology. What are consequences living industrialised urban areas much less daylight more use electric throughout day (and at night), on general health quality life? In this workshop report, we have classified key gaps knowledge research into three main groups: (I) uncertainty as quantity needed for “optimal” physiological psychological functioning, (II) lack consensus practical measurement assessment methods tools monitoring real (day) light exposure across multiple scales, (III) insufficient integration exchange bases different disciplines. Crucial short long-term objectives fill proposed.

Language: Английский

Citations

132
Circadian rhythm influences induction of trained immunity by BCG vaccination DOI Open Access
L. Charlotte J. de Bree, Vera P. Mourits, Valerie A. C. M. Koeken

et al.

Journal of Clinical Investigation, Journal Year: 2020, Volume and Issue: 130(10), P. 5603 - 5617

Published: July 21, 2020

BACKGROUND. The antituberculosis vaccine bacillus Calmette-Guérin (BCG) reduces overall infant mortality. Induction of innate immune memory, also termed trained immunity, contributes toward protection against heterologous infections. Since cells display oscillations in numbers and function throughout the day, we investigated effect BCG administration time on induction immunity.

Language: Английский

Citations

119
Mechanisms of resistance to chemotherapy in non-small cell lung cancer DOI
Hye‐Young Min, Ho‐Young Lee

Archives of Pharmacal Research, Journal Year: 2021, Volume and Issue: 44(2), P. 146 - 164

Published: Feb. 1, 2021

Language: Английский

Citations

98
Coupled network of the circadian clocks: a driving force of rhythmic physiology DOI Creative Commons
Anna‐Marie Finger, Charna Dibner, Achim Kramer

et al.

FEBS Letters, Journal Year: 2020, Volume and Issue: 594(17), P. 2734 - 2769

Published: Aug. 4, 2020

The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt daily changes in their environment. In mammals, clocks form a hierarchically organized network with ‘master clock’ located the suprachiasmatic nucleus hypothalamus, which ensures entrainment subsidiary environmental cycles. Robust rhythmicity body indispensable for temporally coordinating organ functions, disruption or misalignment rhythms caused instance by modern lifestyle strongly associated various widespread diseases. This review aims provide comprehensive overview our current knowledge about molecular architecture system‐level organization mammalian oscillators. Furthermore, we discuss regulatory roles peripheral cell physiology implication temporal coordination metabolism human health disease. Finally, summarize methods assessing humans.

Language: Английский

Citations

87
Mammalian circadian systems: Organization and modern life challenges DOI
Anna‐Marie Finger, Achim Kramer

Acta Physiologica, Journal Year: 2020, Volume and Issue: 231(3)

Published: Sept. 1, 2020

Abstract Humans and other mammalian species possess an endogenous circadian clock system that has evolved in adaptation to periodically reoccurring environmental changes drives rhythmic biological functions, as well behavioural outputs with approximately 24‐hour period. In mammals, body clocks are hierarchically organized, encompassing a so‐called pacemaker the hypothalamic suprachiasmatic nucleus (SCN), non‐SCN brain peripheral clocks, cell‐autonomous oscillators within virtually every cell type. A functional machinery on molecular level, alignment among synchronization between exogenous cycles been shown be crucial for our health well‐being. Yet, modern life constantly poses widespread challenges internal example artificial lighting, shift work trans‐meridian travel, potentially leading disruption or misalignment emergence of associated diseases. For instance many us experience mismatch sleep timing free days (social jetlag) everyday lives without being aware consequences may arise from such chronic misalignment, Hence, this review provides overview organization built‐up system, its interactions outside world, pathologies arising misalignment.

Language: Английский

Citations

87
The malaria parasite has an intrinsic clock DOI
Filipa Rijo‐Ferreira, Victoria A. Acosta-Rodríguez, John H. Abel

et al.

Science, Journal Year: 2020, Volume and Issue: 368(6492), P. 746 - 753

Published: May 14, 2020

Malarial rhythmic fevers are the consequence of synchronous bursting red blood cells (RBCs) on completion malaria parasite asexual cell cycle. Here, we hypothesized that an intrinsic clock in

Language: Английский

Citations

83
Hydrogen: A Novel Option in Human Disease Treatment DOI Creative Commons
Mengling Yang, Yinmiao Dong, Qingnan He

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 17

Published: Sept. 8, 2020

H 2 has shown anti-inflammatory and antioxidant ability in many clinical trials, its application is recommended the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed surprising finding that gas may protect lungs extrapulmonary organs from pathological stimuli NCP patients. The potential mechanisms underlying action of are not clear. regulate activity, mitochondrial energy metabolism, endoplasmic reticulum stress, immune system, cell death (apoptosis, autophagy, pyroptosis, ferroptosis, circadian clock, among others) therapeutic for systemic diseases. This paper reviews basic research applications multiorgan system diseases to establish strategies various

Language: Английский

Citations

81