Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak

Annals of Intensive Care, Journal Year: 2020, Volume and Issue: 10(1)

Published: Aug. 8, 2020

Abstract Background The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress providers. We sought to document the burnout syndrome amongst intensivists facing outbreak. Methods Cross-sectional survey among part European Society Intensive Care Medicine. Symptoms severe burnout, anxiety and depression were collected. Factors independently associated assessed using Cox model. Results Response rate was 20% (1001 completed questionnaires returned, 45 years [39–53], 34% women, from 85 countries, 12 regions, 50% university-affiliated hospitals). symptoms or 46.5%, 30.2%, 51%, respectively, varied significantly across regions. Rating relationship between other ICU stakeholders differed according presence anxiety, depression, burnout. Similar figures reported for their rating ethical climate quality decision-making. female gender (HR 1.85 [1.33–2.55]), working hospital 0.58 [0.42–0.80]), living city > 1 million inhabitants 1.40 [1.01–1.94]), clinician’s 0.83 [0.77–0.90]). Independent determinants included 1.63 [1.15–2.31]) 0.84 [0.78–0.92]). age 0.98/year [0.97–0.99]) 0.76 [0.69–0.82]). Conclusions had overwhelming impact on intensivists. Follow-up, management are warranted assess long-term outcomes alleviate burden frontline personnel.

Language: Английский

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Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China

Critical Care, Journal Year: 2020, Volume and Issue: 24(1)

Published: July 6, 2020

The global numbers of confirmed cases and deceased critically ill patients with COVID-19 are increasing. However, the clinical course, 60-day mortality its predictors in have not been fully elucidated. aim this study is to identify COVID-19. Critically adult admitted intensive care units (ICUs) from 3 hospitals Wuhan, China, were included. Data on demographic information, preexisting comorbidities, laboratory findings at ICU admission, treatments, outcomes, results SARS-CoV-2 RNA tests serum IgM collected including duration between symptom onset negative conversion RNA. Of 1748 COVID-19, 239 (13.7%) Complications included acute respiratory distress syndrome (ARDS) 164 (68.6%) patients, coagulopathy 150 (62.7%) cardiac injury 103 (43.1%) kidney (AKI) 119 (49.8%) which occurred 15.5 days, 17 18.5 19 days after onset, respectively. median was 30 (range 6-81) 49 survivors that identified. A total 147 (61.5%) by 60 admission. admission decease 12 3-36). Cox proportional-hazards regression analysis revealed age older than 65 years, thrombocytopenia ARDS, AKI independently predicted mortality. Severe complications common considerably high. association severity should be seriously considered further studied.

Language: Английский

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Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 30, 2021

More than one year since its emergence, corona virus disease 2019 (COVID-19) is still looming large with a paucity of treatment options. To add to this burden, sizeable subset patients who have recovered from acute COVID-19 infection reported lingering symptoms, leading significant disability and impairment their daily life activities. These are considered suffer what has been termed as “chronic” or “long” form post-acute sequelae COVID-19, experiencing syndrome long-haulers. Despite recovery infection, the persistence atypical chronic including extreme fatigue, shortness breath, joint pains, brain fogs, anxiety depression, that could last for months implies an underlying pathology persist beyond presentation disease. As opposed direct effects itself, immune response severe respiratory coronavirus 2 (SARS-CoV-2) believed be largely responsible appearance these lasting possibly through facilitating ongoing inflammatory process. In review, we hypothesize potential immunological mechanisms persistent prolonged effects, describe multi-organ long-term manifestations COVID-19.

Language: Английский

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Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study

Critical Care, Journal Year: 2020, Volume and Issue: 24(1)

Published: May 14, 2020

A COVID-19 outbreak started in Wuhan, China, last December and now has become a global pandemic. The clinical information caring of critically ill patients with needs to be shared timely, especially under the situations that there is still largely ongoing spread many countries.A multicenter prospective observational study investigated all received 19 ICUs 16 hospitals over 24 h between 8 AM February 2h 27, 2020. demographic information, characteristics, vital signs, complications, laboratory values, managements were studied.A total 226 included. Their median (interquartile range, IQR) age was 64 (57-70) years, 139 (61.5%) male. duration from date ICU admission 11 (5-17) days, onset symptoms 31 (24-36) days. Among patients, 155 (68.6%) had at least one coexisting disease, their sequential organ failure assessment score 4 (2-8). Organ function damages found most patients: ARDS 161 (71.2%) septic shock 34 (15.0%) acute kidney injury occurred 57 (25.2%) cardiac 61 (27.0%) lymphocytopenia 160 (70.8%) patients. Of studied 85 (37.6%) invasive mechanical ventilation, including 14 (6.2%) treated extracorporeal membrane oxygenation (ECMO) same time, 20 (8.8%) noninvasive (10.6%) continuous renal replacement therapy. By April 9, 2020, 87 (38.5%) deceased 15 (6.7%) hospital.Critically are associated higher risk severe complications need receive an intensive level treatments. poses great strain on critical care resources hospitals.Chinese Clinical Trial Registry, ChiCTR2000030164. Registered 24, http://www.chictr.org.cn/edit.aspx?pid=49983&htm=4.

Language: Английский

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Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2020, Volume and Issue: 14(6), P. 1563 - 1569

Published: Aug. 18, 2020

Language: Английский

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One Year of Coronavirus Disease 2019 (COVID-19) in Brazil: A Political and Social Overview

Annals of Global Health, Journal Year: 2021, Volume and Issue: 87(1), P. 44 - 44

Published: May 18, 2021

Background: Coronavirus Disease 2019 (COVID-19) became the deadliest pandemic of new millennium. One year after it a pandemic, current COVID-19 situation in Brazil is an example how impacts are beyond health outcomes and health, social, political actions intertwined. Objectives: We aimed to provide overview first Brazil, from social point view, discuss perspectives now on. Methods: This narrative review using official, scientific (PubMed, Medline, SciELO databases) publicly available data. Press articles were also used that contain important information not found these databases. Findings: address different regions on indigenous populations, care workers, internal contrasts impacted pandemic's advance across country. key points culminated country's failed management spread, such as poor public system, disparities between private infrastructure, lack mass testing viral spread tracking, preparedness planning implement strict isolation distancing measures, and, most importantly, instability, deteriorating Health Ministry sabotaging attitudes president, including anti-scientific actions, underplaying severity, spreading powering fake news about promoting knowingly inefficient medications for treatment, interference collective policies, vaccination plan. Conclusions:After one disastrous disease, has more than 11 million cases, 270,000 deaths, highest number daily deaths due world, which could have been avoided can be credited negligence municipal, state, federal authorities, especially President Jair Messias Bolsonaro. Unfortunately, country what do setting. Key Points:

• One was declared had second higher cases disease.
• Lack massive testing, non-stringent ineffective instability main drivers flawed advancement.
• Anti-science by government pivotal role situation.
• Brazil large territory marked among states, showed contrasting data regarding impact caused COVID-19.
• COVID-19 databases sharing epidemiological aspects disease; however, lacks standardization datasets.

Language: Английский

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The incidence, clinical characteristics, and outcomes of pneumothorax in hospitalized COVID-19 patients: A systematic review

Heart & Lung, Journal Year: 2021, Volume and Issue: 50(5), P. 599 - 608

Published: May 1, 2021

Pneumothorax has been frequently described as a complication of COVID-19 infections.In this systematic review, we describe the incidence, clinical characteristics, and outcomes COVID-19-related pneumothorax.Studies were identified through MEDLINE, Pubmed, Google Scholar databases using keywords "COVID-19," "SARS-CoV-2," "pneumothorax," "pneumomediastinum," "barotrauma" from January 1st, 2020 to 30th, 2021.Among nine observational studies, incidence pneumothorax is low at 0.3% in hospitalized patients. However, increases 12.8-23.8% those requiring invasive mechanical ventilation (IMV) with high mortality rate up 100%. tends be unilateral right-sided. Age, pre-existing lung diseases, active smoking status are not shown risk factors. The time diagnosis around 9.0-19.6 days admission 5.4 after IMV initiation. pneumothoraces associated prolonged hospitalization, increased likelihood ICU death, especially among elderly.COVID-19-related likely signify greater disease severity. With variability described, well-designed study required better assess significance pneumothorax.

Language: Английский

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Role of hematological parameters in the stratification of COVID-19 disease severity

Annals of Medicine and Surgery, Journal Year: 2021, Volume and Issue: 62, P. 68 - 72

Published: Jan. 10, 2021

COVID-19 virus involves respiratory as well other body systems including cardiovascular, gastrointestinal, neurological, immunological and hematopoietic system. Patient of covid-19 pneumonia presents with wide range hemostatic abnormalities. These abnormalities in are related disease progression, severity mortality. The Objective our study is to evaluate the role hematological parameters determination severity.This was a retrospective study, conducted Department Pathology medicine, FMH college Medicine Dentistry from May 2020 July 2020. Total 101, confirmed cases disease, both genders between 17 75-year age were included. Hematological compared mild, moderate, severe critical group. Continuous variables analyzed by using non parametric, Kruskal Wallis test while categorical chi-square test.Out 101 patients, 20.8%, 51.8%,19.8% 7.9% group respectively. Median (IQR) values WBCs (p-value 0.004), ANC 0.002), NLR 0.001), D-dimer level ferritin (0.0001), LDH (0.0001) significantly increased patients disease. APTT 0.003) CRP (p- value 0.0001) suggestively higher Other like Hemoglobin, MCV, HCT, ALC, Platelet count, prothrombin time did not show statistically significant association disease.The concluded that Leukocytosis, neutrophilia, elevated Neutrophil lymphocyte ratio, APTT, D-dimer, serum associated

Language: Английский

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Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(4), P. e0249346 - e0249346

Published: April 16, 2021

Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in cases associated with distress (ARDS).To describe the clinical characteristics of patients ARDS-COVID-19.This study involved 197 male Egyptian participants, among them111 COVID-19 presented ARDS, 60 non-ARDS, 26 Non-COVID-19 patients. We reported analysis results laboratory information, including blood routine tests, biochemistry parameters [aspartate aminotransferase (AST), alanine (ALT), creatinine C-reactive protein (CRP)], thrombotic activity (D-dimer) serum ferritin lactate dehydrogenase (LDH).The levels hemoglobin, AST, creatinine, monocyte count, %, RBC TLC, platelet count were not significantly different groups. The lymphopenia increased CRP, ALT, D-dimer, ferritin, LDH observed ARDS-COVID-19.COVID-19 ARDS lymphopenia, activity, LDH, levels. revealed that levels, have significant association severity can be used as biomarkers to predict severity.

Language: Английский

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Kidney disease and COVID-19 disease severity—systematic review and meta-analysis

Clinical and Experimental Medicine, Journal Year: 2021, Volume and Issue: 22(1), P. 125 - 135

Published: April 23, 2021

Language: Английский

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