The clinical outcomes of COVID‐19 in HIV‐positive patients: A systematic review of current evidence

Immunity Inflammation and Disease, Journal Year: 2021, Volume and Issue: 9(4), P. 1160 - 1185

Published: July 29, 2021

Patients with chronic underlying diseases are more susceptible to coronavirus disease 2019 (COVID-19) complications. Recent studies showed people living HIV (PLWH) not at greater risk than the general population. Few have reviewed impacts of COVID-19 on PLWH. The purpose this systematic review was investigate impact patients infected HIV.We executed a search using four databases PubMed, Scopus, Science Direct, and Web screened records in two steps based their title/abstract full text. This study follows Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) checklist elevate validity reliability its results.We 36 studies. patients' age above 20 years all In almost studies, inflammatory parameters were reported high. most completely recovered from COVID 19 infection. Although CD4 count recorded minimum level as 12 cells/µl.Based current review, we concluded that advanced stages (3 or 4) disease, whose counts low, may show less severe infection symptoms. Similarly, Interference can reduce severity immune reactions subsequent cytokine storms consequently mitigate Therefore, majority no symptoms

Language: Английский

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Retracted: Mucormycosis infection in patients with COVID‐19: A systematic review

Health Science Reports, Journal Year: 2022, Volume and Issue: 5(2)

Published: Feb. 28, 2022

Several reports previously described mucormycosis co-infection in patients with COVID-19. As and COVID-19 might adversely affect patients' outcomes, we aimed to systematically review the related evidence subsequent outcomes.

Language: Английский

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COVID-19 in Pediatrics: A Systematic Review of Current Knowledge and Practice

Infectious Disorders - Drug Targets, Journal Year: 2021, Volume and Issue: 22(5)

Published: Sept. 30, 2021

SARS-CoV-2 is the novel coronavirus that causes severe acute respiratory syndrome and could afflict individuals from all walks of life. Children are usually asymptomatic or represent non-specific mild to moderate symptoms; therefore, they often remain undiagnosed be potential reservoirs silent carriers virus. Despite global attention COVID-19 its importance in public health, some clinical paraclinical aspects this disease children still unclear. Thus, we conducted a comprehensive systematic review available literature reflect on current knowledge practice among children.This study was evidence October 2020. We performed search using keywords online databases. The investigation adheres Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) checklist ensure reliability validity extracted results.We selected reviewed 23 most related studies out 1744 identified papers an initial based inclusion exclusion criteria present review; whom 13 were original research studies, 10 letters editors, commentaries, viewpoints, consensus statements, perspectives. Although due origin pandemic, China country with publications (12 articles), data several countries have been included review.COVID-19 can also affect cause systemic internal organ involvements. However, prevalence, severity, diversity symptoms less than adults. Cough fever appear common symptoms, followed by other such as gastrointestinal manifestations. Comorbidities increase risk children, those without underlying conditions very unlikely suffer disease. Mental health issues anxiety depression isolated situation caused pandemics findings early ages should seriously considered practice.

Language: Английский

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Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations

Infection Genetics and Evolution, Journal Year: 2022, Volume and Issue: 98, P. 105206 - 105206

Published: Jan. 5, 2022

SARS-CoV-2, the causative agent for COVID-19, an ongoing pandemic, engages ACE2 receptor to enter host cell through S protein priming by a serine protease, TMPRSS2. Variation in TMPRSS2 gene may account disparity disease susceptibility between populations. Therefore, present study, we have used next-generation sequencing (NGS) data of world populations from 393 individuals and analyzed using haplotype-based approach with major focus on South Asia study its phylogenetic structure their haplotype sharing among various worldwide. Our analysis relatedness showed closer affinity Asians West Eurasian therefore, severity particularly context will be more akin instead East Eurasian. This is contrast our prior which shows Asian haplotypes strong towards Eurasians. Thus antagonistic genetic Asians. Considering significance SARS-CoV-2 pathogenicity, COVID-19 infection intensity trends could directly associated increased expression also tested SNPs frequencies this Indian state respect case fatality rate (CFR). Interestingly, found significant positive association rs2070788 SNP (G Allele) CFR Further cis eQTL that GG genotype tends significantly higher lung compared AG AA genotypes thus validating previous observation therefore it might play vital part determining differential vulnerability. We trust information useful understanding role variant as biomarker help predict at risk.

Language: Английский

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Retracted: Prenatal and neonatal complications of COVID‐19: A systematic review

Health Science Reports, Journal Year: 2022, Volume and Issue: 5(2)

Published: Feb. 15, 2022

Abstract Background and Aims The outbreak of coronavirus disease 2019 (COVID‐19) over the past year has affected public health worldwide. During pregnancy, maternal immune system inflammatory responses are widely suppressed. Pregnancy‐related suppression could make mother vulnerable to infectious diseases like SARS‐COV‐2. However, current data suggest little no possibility COVID‐19 transmission in pregnant women fetus during pregnancy or childbirth. This systematic review focused on possible complications infection newborn babies including evidence vertical by reviewing articles published first pandemic. Methods We conducted a search using keywords PubMed, Embase, Scopus databases. studies followed title/abstract full‐text screening process, eligible were included study. Results In total, 238 papers identified strategy (44 met inclusion criteria final review). all studies, total 2375 with signs symptoms COVID‐19, who second third trimester assessed mild moderate pneumonia was one most common symptoms. Seventy‐three percent did not present any comorbidity, 19% had fever, 17% cough as frequent clinical symptoms, 7.5% pulmonary changes chest scans, 8% increased C reactive protein, 9.4% decreased lymphocytes (lymphocytopenia). A 2716 newborns fetal assessed; delivery method 1725 them reported, 913 (53%) through C‐section delivery, 812 normal vaginal (47%). Of newborns, 13 died (five along mother), 1965 tested for SARS‐CoV‐2:118 positive. study, seven cases reported 145 assessed. Conclusion It appeared that COVID patients mildly ill, there is currently convincing support disease. Therefore, neonates do represent additional risk adverse outcomes neither prenatal period nor after birth.

Language: Английский

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Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection

Diagnostics, Journal Year: 2022, Volume and Issue: 12(11), P. 2824 - 2824

Published: Nov. 16, 2022

Many factors may influence the risk of being infected by SARS-CoV-2, coronavirus responsible for disease 2019 (COVID-19). Exposure to virus cannot explain variety an individual’s responses and high differences effect that cause some. While a person’s preexisting condition their immune defenses have been confirmed play major role in progression, there is still much learn about hosts’ genetic makeup towards COVID-19 susceptibility risk. The host direct on grade predisposition outcomes COVID-19. In this study, we aimed investigate presence relevant single nucleotide polymorphisms (SNPs), peripheral blood level IL6, vitamin D arterial gas (ABG) markers (pH, oxygen-SpO2 carbon dioxide-SpCO2) two groups, (n = 41, study), healthy 43, control). We analyzed cytokine interleukin genes charge both pro-inflammatory immune-modulating those are considered involved progression complications. Thus, selected genes, such as IL1β, IL1RN (IL-1 β α receptor) IL6R (IL-6 receptor), IL10, IFNγ (interferon gamma), TNFα (tumor necrosis factor alpha), ACE2 (angiotensin converting enzyme), SERPINA3 (Alpha-1-Antiproteinase, Antitrypsin member Serpin 3 family), VDR (vitamin receptor Tak1, Bsm1 Fok1), CRP (c-reactive protein). Though more research needed, these findings give better representation pleiotropic activity its relation system.

Language: Английский

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Molybdenum Disulfide-Assisted Spontaneous Formation of Multistacked Gold Nanoparticles for Deep Learning-Integrated Surface-Enhanced Raman Scattering

ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17557 - 17569

Published: June 24, 2024

Several fabrication methods have been developed for label-free detection in various fields. However, fabricating high-density and highly ordered nanoscale architectures by using soluble processes remains a challenge. Herein, we report biosensing platform that integrates deep learning with surface-enhanced Raman scattering (SERS), featuring large-area, close-packed three-dimensional (3D) of molybdenum disulfide (MoS2)-assisted gold nanoparticles (AuNPs) the on-site screening coronavirus disease (COVID-19) human tears. Some AuNPs are spontaneously synthesized without reducing agent because electrons induced on semiconductor surface reduce ions when Fermi level MoS2 electrolyte reach equilibrium. With addition polyvinylpyrrolidone, two-dimensional large-area layer assisted formation 3D multistacked AuNP structures, resembling electroless plating. This platform, convolutional neural network-based model, achieved outstanding SERS performance at subterascale levels despite microlevel irradiation power millisecond-level acquisition time accurately assessed susceptibility to COVID-19. These results suggest our has potential rapid, low-damage, high-throughput exceedingly low analyte concentrations.

Language: Английский

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ABO blood group and risk of COVID‐19 infection and complications: A systematic review and meta‐analysis

Transfusion, Journal Year: 2021, Volume and Issue: 62(2), P. 493 - 505

Published: Nov. 13, 2021

The authors have disclosed no conflicts of interest. Appendix S1. Supporting Information. Please note: publisher is not responsible for the content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Language: Английский

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Will Host Genetics Affect the Response to SARS-CoV-2 Vaccines? Historical Precedents

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: March 11, 2022

Recent progress in genomics and bioinformatics technologies have allowed for the emergence of immunogenomics field. This intersection immunology genetics has broadened our understanding how immune system responds to infection vaccination. While immunogenetic basis huge clinical variability response severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently being extensively studied, host genetic determinants SARS-CoV-2 vaccines remain largely unknown. Previous reports evidenced that may not protect all populations or individuals equally, due multiple host- vaccine-specific factors. Several studies on vaccine measles, rubella, hepatitis B, smallpox, influenza highlighted contribution mutations polymorphisms modulating innate adaptive immunity following Specifically, variants genes encoding virus receptors, antigen presentation, cytokine production, related cells activation differentiation could influence an individual Although such knowledge be utilized generate personalized strategies optimize response, this filed are still scarce. Here, we briefly summarize scientific literature vaccine-induced immunity, highlighting possible role as well.

Language: Английский

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MEFV gene variations in COVID-19 pneumonia patients (Pilot study)

Journal of Genetic Engineering and Biotechnology, Journal Year: 2025, Volume and Issue: 23(1), P. 100473 - 100473

Published: March 1, 2025

The emergence of worldwide pandemic caused by coronavirus 2 (SARS-CoV-2) has a radical change in everyday life. Patients diseased with FMF show manifestations and labs highly similar to COVID infected patients. In the current study, we evaluate presence variants exon 10 MEFV gene relation severity symptoms patients COVID-19 pneumonia. Thirty-nine admitted Kasr Alainy medical school were divided into two groups moderate severe. Sanger sequencing MEVF was scanned 39 subjects. We identified out (26 %) heterozygous 9 (23 homozygous one patient (2.5 %). most frequent variant found silent p.(P706 = ) (12.9 followed missense p.(A744S) (7.7 p.(V726A) (5.1 Striking result that 90 % had without progression severe form Our results indicated (either benign or uncertain significance) could have role determination severity.

Language: Английский

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