AN UMBRELLA REVIEW ON TREATMENTS AND THERAPEUTIC OPTIONS FOR COVID-19 DOI Creative Commons
SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Ayoob Molla

et al.

Russian Journal of Infection and Immunity, Journal Year: 2023, Volume and Issue: 13(5), P. 885 - 898

Published: Oct. 20, 2023

Introduction. As the COVID-19 pandemic continues to pose a significant challenge global health, effective therapeutic options for preventing and treating disease have become increasingly important. We aimed provide an update on current treatments patients.Materials methods. The purpose of this umbrella review is explore patients. Keywords their combinations were searched across online databases in Embase, PubMed/MEDLINE, Web Science, Scopus spanning from July 1, 2020, through March 3, 2023. Publications selected data extraction two steps based study inclusion/exclusion criteria. adheres PRISMA checklist as well NIH bias risk quality assessment tool.Results. In review, 28 relevant articles final qualitative synthesis. majority included studies had reported efficacy Lopinavir/Ritonavir (n = 4), Ivermectin 3), Baricitinib 2), Tocilizumab Remdesivir ACEI/ARB Vitamin D Molnupiravir Traditional Chinese medicine (TCM) Convalescent plasma transfusion (CPT) 2) hydroxychloroquine COVID-19. It appeared that Baricitinib, Remdesivir, ACEI/ARB, TCM, CPT may beneficial effects reducing mortality, hospitalization duration, severity Other interventions, such Lopinavir/Ritonavir, Ivermectin, D, Hydroxychloroquine did not show clear benefits or inconclusive results.Conclusion. This provides comprehensive overview evidence effectiveness safety various pharmacological non-pharmacological interventions These results updated landscape treatments, highlighting potential avenues further research clinical practice. crucial continue monitoring emerging conducting rigorous guide development optimization strategies against

Language: Английский

Retracted: Prenatal and neonatal complications of COVID‐19: A systematic review DOI Creative Commons
Zahra Pashaei, SeyedAhmad SeyedAlinaghi, Kowsar Qaderi

et al.

Health Science Reports, Journal Year: 2022, Volume and Issue: 5(2)

Published: Feb. 15, 2022

Abstract Background and Aims The outbreak of coronavirus disease 2019 (COVID‐19) over the past year has affected public health worldwide. During pregnancy, maternal immune system inflammatory responses are widely suppressed. Pregnancy‐related suppression could make mother vulnerable to infectious diseases like SARS‐COV‐2. However, current data suggest little no possibility COVID‐19 transmission in pregnant women fetus during pregnancy or childbirth. This systematic review focused on possible complications infection newborn babies including evidence vertical by reviewing articles published first pandemic. Methods We conducted a search using keywords PubMed, Embase, Scopus databases. studies followed title/abstract full‐text screening process, eligible were included study. Results In total, 238 papers identified strategy (44 met inclusion criteria final review). all studies, total 2375 with signs symptoms COVID‐19, who second third trimester assessed mild moderate pneumonia was one most common symptoms. Seventy‐three percent did not present any comorbidity, 19% had fever, 17% cough as frequent clinical symptoms, 7.5% pulmonary changes chest scans, 8% increased C reactive protein, 9.4% decreased lymphocytes (lymphocytopenia). A 2716 newborns fetal assessed; delivery method 1725 them reported, 913 (53%) through C‐section delivery, 812 normal vaginal (47%). Of newborns, 13 died (five along mother), 1965 tested for SARS‐CoV‐2:118 positive. study, seven cases reported 145 assessed. Conclusion It appeared that COVID patients mildly ill, there is currently convincing support disease. Therefore, neonates do represent additional risk adverse outcomes neither prenatal period nor after birth.

Language: Английский

Citations

24

Incidence of congenital complications related to COVID-19 infection during pregnancy DOI Open Access
Marina L. Reppucci, Alexander Kaizer,

Connor Prendergast

et al.

Journal of Neonatal-Perinatal Medicine, Journal Year: 2023, Volume and Issue: 16(2), P. 227 - 234

Published: April 21, 2023

Infection with COVID-19 during pregnancy has been associated a hypercoagulable state. It is unknown if maternal infection results in congenital anomalies secondary to intrauterine vascular accidents. This study sought determine the rate of in-utero complications (intestinal atresia and limb abnormalities) that may be attributable states increased after onset pandemic.Pregnancy, neonatal, defect data from single academic medical center partner's children's hospital were collected compared period prior pandemic. A subanalysis including pregnant woman 18 years or greater documented gestation between March 2020-2021 was performed.Rates intestinal did not differ pandemic (3.78% vs 7.23%, p = 0.21) nor rates deficiency disorders (4.41% 9.65%, 0.09). On subanalysis, there 194 women included analysis: 135 (69.6%) positive delivery admission 59 (30.4%) earlier their pregnancy. There one infant born atresia.We report low incidence infants mothers infection. remains unclear impact on coagulative state augments normal pro-thrombotic pregnancy; ongoing surveillance warranted.

Language: Английский

Citations

9

Effect of COVID-19 on Pregnancy and Neonate’s Vital Parameters: A Systematic Review DOI Creative Commons
Anna Charuta, Monika Smuniewska,

Z Woźniak

et al.

Journal of Pregnancy, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 21

Published: May 13, 2023

Background. COVID-19 is a new pandemic, which was declared by the World Health Organization in 2019 as threat to public health. According numerous reports, it can have negative consequences for pregnant women, labour, and neonates born infected mothers. The aim of this paper gather evidence present summary results studies concerning women their neonates. Methods. Articles from prestigious journals covering period 2020 February 2023, relevant review papers, original research articles PubMed were analysed. In order analyse available literature, Web Science, Scopus, databases used, search conducted using terms (“pregnancy,” “coronavirus,” “SARS-CoV-2,” “newborn”) PRISMA (Preferred Reporting Items Systemic Reviews Meta-Analysis) guidelines clinical trials. Meta-analyses systematic reviews (2022–2023) on symptoms, neonatal course, risk infection been summarized. Summary meta-analyses effect adverse reaction vaccination presented. Results. As result conducted, confirmed that most no serious signs observed, although isolated cases death related reported. Several authors called attention more severe course with obesity. It seemed vertical transmission mother child occurring. Nevertheless, information not clinching. condition mothers described normal; however, some papers reported deaths Conclusions. Due insufficient data, further necessary. Further follow-up are recommended, would make possible an assessment remote effects pregnancy vital parameters newborn.

Language: Английский

Citations

7

Impact of COVID-19 on emotional and behavioral problems among preschool children: a meta-analysis DOI Creative Commons
Jia-Qi Jing,

Chang-Jiang Yang,

Yue Wang

et al.

BMC Pediatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 16, 2024

The impact of the Coronavirus Disease 2019 (COVID-19) on society is continuous, resulting in negative psychological consequences. Given vulnerability and sensitivity to environment among preschool children, their emotional behavioral problems deserve more attention. current study aimed explore epidemic children's mental health by determining pooled prevalence amidst pandemic reveal potential reasons for variations between studies. Published studies were searched Embase, PubMed, ProQuest, PsycINFO, Web Science, CNKI, Wanfang. Based inclusion criteria outlined this study, a total 10 encompassing 38,059 participants incorporated. Employing random-effect model estimating problems, results revealed rate 24.3% (95% CI, 0.15-0.38; I²=99.9%) children. This surpasses pre-outbreak observed different countries, signifying detrimental influence well-being preschoolers. Therefore, care recovery are essential vulnerable group during after public crisis. Specific children expected be researched future provide targeted guidance intervention.

Language: Английский

Citations

2

COVID-19 infection rate after urgent versus elective total hip replacement among unvaccinated individuals: A multicenter prospective cohort amid the COVID-19 pandemic DOI Open Access
Peyman Mirghaderi, Erfan Sheikhbahaei, Maryam Salimi

et al.

Annals of Medicine and Surgery, Journal Year: 2022, Volume and Issue: 80

Published: Aug. 1, 2022

Due to the COVID-19 pandemic, hospitals have become unsafe for patients as potential sources of virus transmission. This study aims determine infection rate after primary total hip arthroplasty (THA) among unvaccinated patients. THA undergoing elective or traumatic (urgent) were compared regarding contraction.Primary prospectively followed from three in *two great cities* country between April 2020 August 2021. If patient had suspected symptoms, a SARS-CoV-2 PCR test nasopharyngeal and oropharyngeal swabs and/or chest CT scan.Finally, information was received 436 patients, including 345 (79.1%) 91 (20.9%) THAs. Eight (1.8%) contracted within month discharge, two died due COVID-19. There no statistical difference disease type surgery (elective 1.4% versus 3.3%, P = 0.24). Women (Odds ratio (95% CI) 8.5 (2.1-35.2), 0.01) those who heart with Haldane-Anscombe correction ≈ 14.0, more likely contract postoperatively.In both urgent cases THA, researchers found that there is not high risk contracting during peri-surgery period. Urgent surgeries are comparable THA-with strict pre-elective protocols-in terms hospital stay if appropriate health protocols followed.

Language: Английский

Citations

9

Efficacy of kangaroo mother care combined with neonatal phototherapy in newborns with non-pathological jaundice: A meta-analysis DOI Creative Commons

Xiang Huang,

Mei‐Ling Chen,

Rongrong Fu

et al.

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 11

Published: Jan. 25, 2023

Background The kangaroo-mother care method (KMC) is a skin-to-skin contact-centered approach with numerous benefits for neonates, but its impact on the treatment of jaundiced neonates unknown. This study aimed to investigate efficacy KMC combined neonatal phototherapy (NNPT) in treating non-pathological jaundice. Methods Relevant articles were searched PubMed, Embase, Web Science, and Cochrane Library databases from database establishment April 2022. outcomes included, without limitation, serum bilirubin levels, duration phototherapy. Results meta-analysis included five studies (4 randomized controlled trials 1 observational study) involving four hundred eighty-two results showed that group receiving NNPT had lower at 72 h after intervention [weighted mean difference (WMD) = −1.51, p 0.03], shorter [standard (SMD) −1.45, < 0.001] hospitalization (SMD −1.32, 0.002) compared group. There was no peak both groups (WMD −0.12, 0.62). Conclusions helped treat jaundice newborns alone.

Language: Английский

Citations

5

Maternal Fever and Reduced Fetal Movement as Predictive Risk Factors for Adverse Neonatal Outcome in Cases of Congenital SARS-CoV-2 Infection: A Meta-Analysis of Individual Participant Data from Case Reports and Case Series DOI Creative Commons
Elena Bernad, Florentina Duică, Panagiotis Antoniadis

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(7), P. 1615 - 1615

Published: July 24, 2023

Objectives: To determine risk factors for primary and secondary adverse neonatal outcomes in newborns with congenital SARS-CoV-2 infection. Data sources: PubMed/MEDLINE Google Scholar from January 2020 to 2022. Study eligibility criteria: delivered after 24 weeks of gestation confirmed/possible infection, according standard classification criteria. Methods: Execution the IPD analyses followed PRISMA-IPD statement. Univariate non-parametric tests compared numerical data distributions. Fisher’s exact or Chi-square test determined categorical variables’ statistical significance. Multivariate logistic regression revealed outcome. Results: Maternal fever was associated symptomatic infection (OR: 4.55, 95% CI: 1.33–15.57). Two-thirds women that reported decreased fetal movements were diagnosed IUFD (p-value = 0.001). Reduced movement increased intrauterine death by 7.84 times 0.016, 2.23–27.5). The stillbirth gestational age at time maternal < 0.05, OR: 0.87, 0.79–0.97). Conclusions: perception reduced may be predictive pregnancy outcome cases

Language: Английский

Citations

2

COVID-19 Infection Risk Following Elective Arthroplasty and Surgical Complications in COVID-19-vaccinated Patients: A Multicenter Comparative Cohort Study DOI
Peyman Mirghaderi, Maryam Salimi, Alireza Moharrami

et al.

Arthroplasty Today, Journal Year: 2022, Volume and Issue: 18, P. 76 - 83

Published: Sept. 27, 2022

Language: Английский

Citations

4

Observational cohort study of perinatal outcomes of women with COVID-19 DOI Creative Commons
Sami Al-Hajjar, Lina Ibrahim, Wesam Kurdi

et al.

Journal of Infection and Public Health, Journal Year: 2022, Volume and Issue: 15(12), P. 1503 - 1507

Published: Nov. 11, 2022

Understanding the impact of SARS-CoV-2 infection on pregnancy outcomes and COVID-19 is critical for ensuring proper prenatal antenatal care. No similar studies have been published in Saudi Arabia. We performed a prospective cohort study pregnant women with confirmed who presented at King Faisal Specialist Hospital Research Center (KFSHRC) Riyadh, Kingdom staging was performed, pregnancy-related complications were assessed, neonatal evaluated. enrolled 81 patients (mean age 31.75 years, SD 5.25) which there 17 cases first trimester, 20 second 34 third trimester. The distribution severity 40 Stage A, 36 B, 4 C, 1 D. Complications loss 2 (one each trimester) fetal death after weeks pregnancy, 7 growth restriction, 8 pre-term delivery. did not observe an unusual frequency due to this high-risk obstetric population no evidence vertical transmission newborns from delivered while positive virus.

Language: Английский

Citations

3

Frequency of Maternal Anemia in Patients Presenting With Preterm Premature Rupture of Membranes DOI Open Access
Naila Zaman Khan,

Saima Khattak

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 26, 2024

Background: Preterm premature rupture of membranes (PPROM) is the fetal before 38 weeks gestation. The etiology multifactorial. Maternal anemia one factors leading to PPROM. This study aims determine frequency maternal in patients presenting with Materials and Methods: cross-sectional was carried out at Department Obstetrics Gynecology, Lady Reading Hospital, Peshawar. conducted from July 1 December 31, 2021. One hundred twenty two PPROM Gynecology were included. diagnosis made based on history PV leak, followed by confirmation nitrazine litmus test, microscopic fern ultrasonographic amniotic fluid index measurement. Anemia determined examination hemoglobin levels blood samples. Hb <11gm/dl labeled as anemia. IBM Corp. Released 2011. SPSS Statistics for Windows, Version 20.0. Armonk, NY: used statistical analysis. Results: age ranged 20 40 years. mean 29.14 ± 6.194 63 (51.6%) multiparous (parity 2 4). observed 39 (32.0%). A significant association (p = 0.005) between grand multiparity Conclusion: significantly contributes PPROM, especially multiple pregnancies. Meticulous family planning consistent obstetrical monitoring throughout pregnancy are key addressing this, potentially reducing both risk complications.

Language: Английский

Citations

0