The role of gut microbiota in anorexia induced by T-2 toxin DOI Creative Commons

Tingyu Huang,

Aoyun Li,

Shanshan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116612 - 116612

Published: June 18, 2024

T-2 toxin is one of trichothecene mycotoxins, which can impair appetite and decrease food intake. However, the specific mechanisms for toxin-induced anorexia are not fully clarified. Multiple research results had shown that gut microbiota have a significant effect on regulation. Hence, this study purposed to explore potential interactions regulate factors in induced by toxin. The divided mice into control group (CG, 0 mg/kg BW toxin) toxin-treated (TG, 1 toxin), oral gavage 4 weeks, construct subacute poisoning mouse model. This data proved was able induce an increased contents gastrointestinal hormones (CCK, GIP, GLP-1 PYY), neurotransmitters (5-HT SP), as well pro-inflammatory cytokines (IL-1β, IL-6 TNF-α) serum mice. disturbed composition microbiota, especially, Faecalibaculum Allobaculum, positively correlated with CCK, GLP-1, 5-HT, IL-1β, TNF-α, played certain role regulating host appetite. In conclusion, changes (especially increase abundance Allobaculum) promote upregulation hormones, neurotransmitters, cytokines, may be mechanism anorexia.

Language: Английский

Quercetin Alleviates Deoxynivalenol-Induced Intestinal Damage by Suppressing Inflammation and Ferroptosis in Mice DOI

Yingrong Ye,

Mingzhen Jiang,

Xinyao Hong

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(28), P. 10761 - 10772

Published: July 1, 2023

Deoxynivalenol (DON), one of the most prevalent mycotoxins found in food and feed, can cause gastrointestinal inflammation systemic immunosuppression, presenting a serious hazard to human animal health. Quercetin (QUE) is plant polyphenol with anti-inflammatory antioxidant properties. In this research, we investigated potential function QUE as treatment for DON-induced intestinal damage. Thirty male specific-pathogen-free BALB/c mice were randomly allocated (50 mg/kg) and/or DON (0, 0.5, 1, 2 mg/kg). We that attenuated damage by improving jejunal structural injury changing tight junction proteins (claudin-1, claudin-3, ZO-1, occludin) levels. also suppressed DON-triggered inhibiting TLR4/NF-κB signaling pathway. Meanwhile, decreased oxidative stress caused enhancing concentrations SOD GSH, while diminishing contents MDA. particular, reduced ferroptosis. elevated TfR 4HNE levels, along transcription levels ferroptosis-related genes (PTGS2, ACSL4, HAMP1) mRNA FTH1, SLC7A11, GPX4, FPN1, FSP1, all which reversed treatment. Our findings imply alleviates pathway study, elucidate toxicological mechanism DON, provide basic foundation or theory future prevention treatment, explore strategies prevent alleviate DON's hazardous effects.

Language: Английский

Citations

34
Resveratrol protects against deoxynivalenol-induced ferroptosis in HepG2 cells DOI
Pengju Wang, Qing Yao,

Dan Zhu

et al.

Toxicology, Journal Year: 2023, Volume and Issue: 494, P. 153589 - 153589

Published: July 6, 2023

Language: Английский

Citations

24
Translocation of gut microbes to epididymal white adipose tissue drives lipid metabolism disorder under heat stress DOI

Zhang‐Chao Deng,

Jiacheng Yang, Yuxuan Huang

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(12), P. 2877 - 2895

Published: July 17, 2023

Language: Английский

Citations

24
Pathological consequences, metabolism and toxic effects of trichothecene T-2 toxin in poultry DOI Creative Commons
Júlia Vörösházi, Zsuzsanna Neogrády, Gábor Mátis

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(3), P. 103471 - 103471

Published: Jan. 17, 2024

Contamination of feed with mycotoxins has become a severe issue worldwide. Among the most prevalent trichothecene mycotoxins, T-2 toxin is particular importance for livestock production, including poultry posing significant threat to animal health and productivity. This review article aims comprehensively analyze pathological consequences, metabolism, toxic effects in poultry. Trichothecene primarily produced by Fusarium species, are notorious their potent toxicity. exhibits broad spectrum negative on leading substantial economic losses as well concerns about welfare food safety modern agriculture. exposure easily results consequences gastrointestinal tract, parenchymal tissues like liver (as key organ its metabolism), kidneys, or reproductive organs. In addition, it also intensely damages immune system-related such spleen, bursa Fabricius, thymus causing immunosuppression increasing susceptibility animals infectious diseases, making immunization programs less effective. The cellular processes transcriptional translational levels induces apoptosis through activation numerous signaling cascades. Furthermore, according recent studies, besides direct abovementioned processes, production reactive molecules free radicals resulting oxidative distress concomitantly occurring damage. conclusion, this provides complex detailed overview mechanism action immunomodulatory stress-related toxin. Understanding these crucial developing strategies mitigate impact avian future.

Language: Английский

Citations

17
Tannic acid extracted from gallnut improves intestinal health with regulation of redox homeostasis and gut microbiota of weaned piglets DOI Creative Commons

Zhang‐Chao Deng,

Jie Wang, Juan Wang

et al.

Animal Research and One Health, Journal Year: 2024, Volume and Issue: 2(1), P. 16 - 27

Published: Feb. 1, 2024

Abstract The objective of this study is to evaluate the effects tannic acid (TA) derived from gallnut supplementation on growth performance and health status weaned piglets. A total 432 weanling piglets (7.05 ± 1.05 kg) were randomly allocated into 4 treatment groups with 6 replicates 18 pigs/pen. Piglets fed either a basal diet (CON), or diets supplemented 1.5 kg/t TA, 3.0 1.8 zinc oxide (ZnO) for 21 days. results showed that, compared CON, dietary TA did not affect ( p > 0.05) serum biochemistry However, had higher SOD, GPX, CAT activities lower MDA concentration in jejunum than those CON ZnO group. Meanwhile, increased < villus height height/crypt depth, decreased crypt depth small intestine. Dietary also downregulated IL‐1β TNF‐α expression jejunum. Furthermore, reduced abundance Candidatus Brocadia Escherichia‐Shigella cecal digesta. Notably, both negative correlation antioxidant enzymes R −0.60, 0.01), but was positively correlated concentrations = 0.44, In conclusion, improved gut piglets, potentially by regulating redox homeostasis microbiota.

Language: Английский

Citations

17
AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken DOI

Jiang Deng,

Jiacheng Yang,

Yue Feng

et al.

Science China Life Sciences, Journal Year: 2024, Volume and Issue: 67(7), P. 1468 - 1478

Published: April 18, 2024

Language: Английский

Citations

16
18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control DOI
Junze Jiang,

Xintong Zhou,

Hao Chen

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134319 - 134319

Published: April 21, 2024

Language: Английский

Citations

12
AHR activation relieves deoxynivalenol-induced disruption of porcine intestinal epithelial barrier functions DOI

Zi-Yan Hu,

Shang-Jia Yang,

Yuan‐Hang Chang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136095 - 136095

Published: Oct. 8, 2024

Language: Английский

Citations

12
Recent advances in the degradation efficacy and mechanisms of mycotoxins in food by atmospheric cold plasma DOI Creative Commons
Mengjie Liu,

Junxia Feng,

Xudong Yang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 270, P. 115944 - 115944

Published: Jan. 1, 2024

Food contaminated by mycotoxins has become a worldwide public problem with political and economic implications. Although variety of traditional methods have been used to eliminate from agri-foods, the results somewhat less than satisfactory. As an emerging non-thermal processing technology, atmospheric cold plasma (ACP) great potential for food decontamination. Herein, this review mainly presents degradation efficiency ACP on in vitro agri-foods as well its possible mechanisms. Meanwhile, effects quality, factors affecting toxicity products are also discussed. According literatures, could efficiently degrade many (e.g., aflatoxin, deoxynivalenol, zearalenone, ochratoxin A, fumonisin, T-2 toxin) both various foods hazelnut, peanut, maize, rice, wheat, barley, oat flour, date palm fruit) little nutritional sensory properties food. The efficacy was dependent including treatment parameter, working gas, mycotoxin property, substrate. attributed reactive oxygen nitrogen species ACP, which can damage chemical bonds mycotoxins, consequently reducing mycotoxins.

Language: Английский

Citations

11
Nutrition strategies to control post-weaning diarrhea of piglets: From the perspective of feeds DOI Creative Commons

Qingsong Tang,

Tianyi Lan, Chengyu Zhou

et al.

Animal nutrition, Journal Year: 2024, Volume and Issue: 17, P. 297 - 311

Published: March 26, 2024

Post-weaning diarrhea (PWD) is a globally significant threat to the swine industry. Historically, antibiotics as well high doses of zinc oxide and copper sulfate have been commonly used control PWD. However, development bacterial resistance environmental pollution created an interest in alternative strategies. In recent years, research surrounding these strategies mechanisms piglet has continually updated. Mechanically, piglets result imbalance intestinal fluid electrolyte absorption secretion. general, enterotoxigenic

Language: Английский

Citations

10