Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7910 - 7910

Published: April 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Language: Английский

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Platelets, a Key Cell in Inflammation and Atherosclerosis Progression

Cells, Journal Year: 2022, Volume and Issue: 11(6), P. 1014 - 1014

Published: March 17, 2022

Platelets play important roles in thrombosis-dependent obstructive cardiovascular diseases. In addition, it has now become evident that platelets also participate the earliest stages of atherosclerosis, including genesis atherosclerotic lesion. Moreover, while link between platelet activity and hemostasis been well established, role as modulators inflammation only recently recognized. Thus, through their secretory activities, can chemically attract a diverse repertoire cells to inflammatory foci. Although monocytes lymphocytes act key progression an event central plaque formation progression, there is evidence traverse endothelium, therefore be direct mediator plaque. This review provides overview interactions regulation atherosclerosis.

Language: Английский

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Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 8 - 8

Published: Jan. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Language: Английский

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Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 21, 2024

Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with myocardial infarction (AMI). The intersection of COPD AMI is characterised by a considerable overlap in inflammatory mechanisms, which play crucial role development both conditions. Although extensive research has been conducted on individual pathways COPD, understanding thrombo-inflammatory crosstalk comorbid settings remains limited. effectiveness various components reducing infarct size or slowing progression shown promise, yet their efficacy context comorbidity not established. This review focuses critical importance local systemic inflammation, highlighting it as key pathophysiological connection between COPD/AE-COPD.

Language: Английский

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Preoperative Laboratory Values Predicting Periprosthetic Joint Infection in Morbidly Obese Patients Undergoing Total Hip or Knee Arthroplasty

Journal of Bone and Joint Surgery, Journal Year: 2024, Volume and Issue: 106(14), P. 1317 - 1327

Published: June 28, 2024

Morbidly obese patients are an ever-growing high-risk population undergoing total hip arthroplasty (THA) and knee (TKA) for end-stage osteoarthritis. This study sought to identify preoperative laboratory values that may serve as predictors of periprosthetic joint infection (PJI) in morbidly THA or TKA.

Language: Английский

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Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism

Cytokine & Growth Factor Reviews, Journal Year: 2021, Volume and Issue: 63, P. 58 - 68

Published: Oct. 25, 2021

Language: Английский

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The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(4), P. 1000 - 1000

Published: Feb. 14, 2022

Subjective tinnitus is the perception of sound without presence an external source. Increasing evidence suggests that associated with inflammation. In this systematic review, role inflammation in subjective was studied. Nine animal and twenty human studies reporting inflammatory markers both humans animals were included. It established TNF-α IL-1β are increased tinnitus, microglia astrocytes activated as well. Moreover, platelet activation may also play a tinnitus. addition, we elaborate on mechanisms discuss potential treatment options targeting pathways.

Language: Английский

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Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1282 - 1282

Published: Feb. 17, 2023

Platelets, the primary operatives of hemostasis that contribute to blood coagulation and wound healing after vessel injury, are also involved in pathological conditions, including cancer. Malignancy-associated thrombosis is common ovarian cancer patients associated with poor clinical outcomes. Platelets extravasate into tumor microenvironment interact cells non-cancerous elements. Ovarian activate platelets. The communication between activated platelets, cells, via various platelet membrane proteins or mediators released through degranulation secretion microvesicles from These interactions trigger signaling cascades tumors promote progression, metastasis, neoangiogenesis. This review discusses how stem stromal extracellular matrix influence progression. It presents novel potential therapeutic approaches toward this gynecological

Language: Английский

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Endothelial dysfunction of syphilis: Pathogenesis

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(8), P. 1478 - 1490

Published: Feb. 20, 2024

Abstract Treponema pallidum is the causative factor of syphilis, a sexually transmitted disease (STD) characterized by perivascular infiltration inflammatory cells, vascular leakage, swelling and proliferation endothelial cells (ECs). The endothelium lining blood lymphatic vessels key barrier separating body fluids from host tissues major target T. . In this review, we focus on how establish intimate interactions with ECs, triggering dysfunction such as inflammation, abnormal repairment damage ECs. addition, summarize that migration invasion across ECs may occur through two pathways. These mechanisms transendothelial are paracellular cholesterol‐dependent, respectively. Herein, clarifying relationship between great significance to provide novel strategies for diagnosis prevention has potential prospect clinical application.

Language: Английский

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Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation

The Pediatric Infectious Disease Journal, Journal Year: 2024, Volume and Issue: 43(12), P. e430 - e433

Published: July 15, 2024

We investigated if children with Long Covid (n=14) have activated platelets compared healthy controls (n=14). Platelet activation and secretion markers were by flow cytometry using MoAbs directed against P-selectin, CD63, PAC-1 in quiescent stimulated 10-µM adenosine diphosphate 25-µM protease receptor 1-activating peptide. Circulating of patients had significantly increased expression the marker P-selectin (P = 0.019).

Language: Английский

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