Polymers,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1187 - 1187
Published: April 24, 2024
Studying
cell
settlement
in
the
three-dimensional
structure
of
synthetic
biomaterials
over
time
is
great
interest
research
and
clinical
translation
for
development
artificial
tissues
organs.
Tracking
cells
as
physical
objects
improves
our
understanding
processes
migration,
homing,
division
during
colonisation
environment.
In
this
study,
3D
environment
had
a
direct
effect
on
behaviour
biological
objects.
Recently,
deep
learning-based
algorithms
have
shown
significant
benefits
segmentation
tasks
and,
furthermore,
biomaterial
design
optimisation.
We
analysed
primary
LHON
fibroblasts
an
after
adeno-associated
virus
transduction.
Application
these
tools
to
model
homing
monitor
morphology,
migration
proliferation
indirectly
demonstrated
restoration
normal
phenotype
gene
manipulation
by
AAV
Following
3Rs
principles
reducing
use
living
organisms
research,
modeling
formation
organs
reconstructing
different
types
materials
facilitates
drug
testing,
study
inherited
inflammatory
diseases,
wound
healing.
These
studies
composition
creating
layers
were
inspired
biomimicry.
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Feb. 18, 2024
Abstract
Scar
formation
resulting
from
burns
or
severe
trauma
can
significantly
compromise
the
structural
integrity
of
skin
and
lead
to
permanent
loss
appendages,
ultimately
impairing
its
normal
physiological
function.
Accumulating
evidence
underscores
potential
targeted
modulation
mechanical
cues
enhance
regeneration,
promoting
scarless
repair
by
influencing
extracellular
microenvironment
driving
phenotypic
transitions.
The
field
appendage
regeneration
has
witnessed
remarkable
advancements
in
utilization
biomaterials
with
distinct
physical
properties.
However,
a
comprehensive
understanding
underlying
mechanisms
remains
somewhat
elusive,
limiting
broader
application
these
innovations.
In
this
review,
we
present
two
promising
biomaterial-based
approaches
aimed
at
bolstering
regenerative
capacity
compromised
skin.
first
approach
involves
leveraging
specific
biophysical
properties
create
an
optimal
environment
that
supports
cellular
activities
essential
for
regeneration.
second
centers
on
harnessing
forces
exerted
plasticity,
facilitating
efficient
reprogramming
and,
consequently,
appendages.
summary,
manipulation
using
strategies
holds
significant
promise
as
supplementary
achieving
wound
healing,
coupled
restoration
multiple
functions.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 7, 2025
The
reconstruction
of
complex
skin
defects
challenges
clinical
practice,
with
autologous
grafts
(ASGs)
as
the
traditional
choice
due
to
their
high
graft
take
rate
and
patient
compatibility.
However,
ASGs
have
limitations
such
donor
site
morbidity,
limited
tissue
availability,
necessity
for
multiple
surgeries
in
severe
cases.
Bioengineered
(BSGs)
aim
address
these
drawbacks
through
advanced
engineering
biomaterial
science.
This
study
conducts
a
systematic
review
describe
benefits
shortcomings
BSGs
across
wound
healing
efficacy,
integration,
immunogenicity,
functional
outcomes
focusing
on
re-epithelialization,
survival,
overall
aesthetic
outcomes.
Preliminary
findings
suggest
show
superior
early
results,
while
demonstrate
comparable
long-term
reduced
morbidity.
comparative
analysis
enhances
understanding
bioengineered
alternatives
reconstruction,
potentially
redefining
best
practices
based
safety,
patient-centric
outcomes,
highlighting
need
further
innovation
solutions.
Biomaterials Research,
Journal Year:
2025,
Volume and Issue:
29
Published: Jan. 1, 2025
The
field
of
infected
wound
management
continues
to
face
challenges,
and
traditional
methods
used
cope
with
wounds
include
debridement,
gauze
coverage,
medication,
others.
Currently,
synthetic
natural
biomaterials
are
readily
available
today,
enabling
the
creation
new
dressings
that
substantially
enhance
healing.
Considerable
attention
is
being
paid
hydrogels
based
on
materials,
which
have
good
biocompatibility
degradability
properties,
while
exhibiting
higher
similarity
extracellular
matrix
as
compared
materials.
In
this
study,
we
extracted
active
ingredients
oxidized
konjac
glucomannan
(OKGM)
fresh
egg
white
(EW)
from
2
foods,
konjac,
egg,
respectively,
formed
a
self-repairing
hydrogel
cross-linking
Schiff
base.
Subsequently,
peptide,
glycyl-l-histidyl-l-lysine-Cu
(GHK-Cu),
was
loaded,
an
all-natural
composite
dressing,
EW/OKGM@GHK-Cu
(GEK),
developed.
GEK
hydrogel,
both
antibacterial
anti-inflammatory
plays
hemostatic
role
by
adhering
tissues
promoting
neovascularization
serves
optimal
dressing
for
skin
regeneration.
Taken
together,
derived
food
sources
therefore
constitute
efficient
cost-effective
strategy
managing
healing
significant
potential
clinical
application
transformation.
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
208, P. 115295 - 115295
Published: March 24, 2024
Melanoma,
the
deadliest
form
of
skin
cancer,
poses
a
significant
clinical
challenge
for
development
effective
treatments.
Conventional
in
vivo
animal
studies
have
shown
limited
translational
relevance
to
humans,
raising
strength
pre-clinical
models
melanoma
research.
This
review
provides
an
in-depth
analysis
alternative
including
vitro
and
ex
platforms
such
as
reconstructed
skin,
spheroids,
organoids,
organotypic
models,
skin-on-a-chip,
bioprinting.
Through
comprehensive
analysis,
specific
attributes,
advantages,
limitations
each
model
are
elucidated.
It
discusses
points
related
uniqueness
from
capturing
complex
interactions
between
cells
their
microenvironment
enabling
high-throughput
drug
screening
personalized
medicine
approaches.
is
structured
covering
firstly
roadmap
identify
co-occurrence
discovering
new
treatments
its
secondly
it
covers
comparative
most
used
followed
by
section
discussing
them:
models.
intends
serve
asset
researchers
field
clinicians
involved
therapy,
offering
insights
into
diverse
preclinical
available
optimizing
integration
pipeline.
Dermatological Reviews,
Journal Year:
2025,
Volume and Issue:
6(2)
Published: March 24, 2025
ABSTRACT
Aim
This
study
aims
to
provide
a
comprehensive
analysis
of
keratinocytes,
the
predominant
cell
type
in
epidermis,
by
examining
their
structural,
functional,
and
regulatory
roles
skin
biology.
The
explores
intricate
processes
keratinocyte
differentiation,
proliferation,
immune
interactions,
emphasizing
essential
contributions
homeostasis,
wound
healing,
barrier
integrity.
Additionally,
it
investigates
involvement
keratinocytes
dermatological
disorders
such
as
psoriasis,
atopic
dermatitis,
cancer,
highlighting
pathological
alterations
molecular
mechanisms.
Methods
review
covers
broad
range
studies,
including
vitro
vivo
research
on
biology,
interactions
with
growth
factors,
inflammatory
responses
skin.
It
also
discusses
therapeutic
advancements
biologics
gene
therapy
that
focus
restoring
function
diseases.
Results
highlights
play
pivotal
role
inflammation
regulation
factors
promote
healing
regeneration.
Dysregulation
is
linked
several
diseases,
need
for
targeted
approaches.
Recent
treatments,
biologics,
offer
promising
outcomes
managing
conditions
driven
dysfunction.
Conclusion
primary
aim
this
an
in‐depth
overview
functions
particularly
health,
inflammation,
disease
development.
highlight
latest
strategies
targeting
treatment
International Journal of Extreme Manufacturing,
Journal Year:
2024,
Volume and Issue:
7(1), P. 012009 - 012009
Published: Oct. 16, 2024
Abstract
This
comprehensive
review
explores
the
multifaceted
landscape
of
skin
bioprinting,
revolutionizing
dermatological
research.
The
applications
bioprinting
utilizing
techniques
like
extrusion-,
droplet-,
laser-
and
light-based
methods,
with
specialized
bioinks
for
biofabrication
have
been
critically
reviewed
along
intricate
aspects
hair
follicles,
sweat
glands,
achieving
pigmentation.
Challenges
remain
need
vascularization,
safety
concerns,
integration
automated
processes
effective
clinical
translation.
further
investigates
incorporation
biosensor
technologies,
emphasizing
their
role
in
monitoring
enhancing
wound
healing
process.
While
highlighting
remarkable
progress
field,
critical
limitations
concerns
are
examined
to
provide
a
balanced
perspective.
synthesis
aims
guide
scientists,
engineers,
healthcare
providers,
fostering
deeper
understanding
current
state,
challenges,
future
directions
transformative
tissue
engineering
regenerative
medicine.
