International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(9), P. 4998 - 4998
Published: April 30, 2022
The
atherosclerotic
vascular
disease
is
a
cardiovascular
continuum
in
which
the
main
role
attributed
to
atherosclerosis,
from
its
appearance
associated
complications.
increasing
prevalence
of
risk
factors,
population
ageing,
and
burden
on
both
economy
healthcare
system
have
led
development
new
diagnostic
therapeutic
strategies
field.
better
understanding
or
discovery
pathophysiological
mechanisms
molecules
modulating
various
signaling
pathways
involved
atherosclerosis
potential
biomarkers,
with
key
early,
subclinical
diagnosis.
evolution
technological
processes
medicine
has
shifted
attention
researchers
profiling
classical
factors
identification
biomarkers
such
as
midregional
pro-adrenomedullin,
midkine,
stromelysin-2,
pentraxin
3,
inflammasomes,
endothelial
cell-derived
extracellular
vesicles.
These
are
seen
future
targets
decreased
morbidity
mortality
through
early
diagnosis
lesions
research
directions.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(9), P. 2322 - 2322
Published: May 10, 2019
Elevated
pro-inflammatory
biomarkers
and
cytokines
are
associated
with
morbidity
mortality
in
heart
failure
(HF).
Preclinical
clinical
studies
have
shown
multiple
inflammatory
mechanisms
causing
cardiac
remodeling,
dysfunction
chronic
failure.
Therapeutics
trials
targeting
the
immune
response
its
effects
did
not
result
evident
benefits
regarding
endpoints
mortality.
This
review
elaborates
pathways
of
pathogenesis
worsening
cellular
settings.
Besides
well-known
activation
inflammation
atherosclerosis
ischemic
cardiomyopathy
or
myocarditis,
attention
is
focused
on
other
leading
to
such
as
transthyretin
(TTR)
amyloidosis
preserved
ejection
fraction.
The
knowledge
a
molecular
level
might
help
highlight
new
disease
defining
lead
way
therapeutic
targets.
Journal of Periodontal Research,
Journal Year:
2021,
Volume and Issue:
56(3), P. 597 - 605
Published: Feb. 28, 2021
Different
evidence
has
shown
that
Galectins
have
a
key
role
as
modulators
of
cell
surface
functions
and
signaling
in
wide
range
inflammatory
diseases
during
their
preclinical
stages.
The
aim
this
study
was
to
analyze
the
association
impact
periodontitis
coronary
heart
disease
(CHD)
on
salivary
serum
Galectin-3
patients
with
CHD.For
present
study,
healthy
controls
(n
=
38),
40),
CHD
39),
combination
+CHD
38)
were
enrolled
analyzed.
In
each
patient,
demographic
characteristics
full-mouth
clinical
periodontal
examination
achieved.
Moreover,
samples
collected
assess
Endothelin-1
(ET-1)
levels.
Jonckheere-Terpstra
p-trend
Spearman's
correlation
tests
well
uni-
linear
regression
analyses
used
data.Patients
(serum,
p
.003;
saliva,
<
.001)
+
groups
(serum
.004;
had
higher
median
concentrations
comparison
controls.
Serum
(p
.006)
.009)
levels
significantly
correlated
ET-1.
multivariate
analysis
highlighted
.047)
significant
predictor
while
ET-1
.028)
levels.The
results
showed
presented
subjects.
Periodontitis
predictors
levels,
respectively.
Journal of Cellular and Molecular Medicine,
Journal Year:
2019,
Volume and Issue:
23(9), P. 6005 - 6016
Published: June 26, 2019
Abstract
MicroRNAs
(miRNAs)
are
strongly
up‐regulated
under
pathological
stress
and
in
a
wide
range
of
diseases.
In
recent
years,
miRNAs
investigation
for
their
potential
use
as
biomarkers
cardiovascular
We
investigate
whether
specific
cardio‐miRNAs
overexpressed
heart
samples
from
subjects
deceased
acute
myocardial
infarction
(AMI)
or
sudden
cardiac
death
(SCD),
miRNA
could
help
differentiate
between
them.
Forty
four
cases
due
to
disease
were
selected,
respectively,
19
categorized
AMI
25
SCD.
Eighteen
traumatic
without
involvement
selected
control.
Immunohistochemical
was
performed
CD15,
IL‐15,
Cx43,
MCP‐1,
tryptase,
troponin
C
I.
Reverse
transcription
quantitative
real‐time
PCR
miR‐1,
miR‐133,
miR‐208
miR‐499.
group,
stronger
immunoreaction
the
IL‐15
MCP‐1
antibodies
detectable
compared
with
SCD
Cx43
showed
negative
reaction
respect
other
groups.
Real‐time
results
down‐regulation
all
group
The
presented
high
accuracy
discriminating
(miR‐1
miR‐499)
control
(miR‐208)
representing
aid
both
clinicians
pathologists
differential
diagnosis.
Frontiers in Cardiovascular Medicine,
Journal Year:
2021,
Volume and Issue:
8
Published: Oct. 27, 2021
miR-21
is
a
22-nucleotide
long
microRNA
that
matches
target
mRNAs
in
complementary
base
pairing
fashion
and
regulates
gene
expression
by
repressing
or
degrading
mRNAs.
involved
various
cardiomyopathies,
including
heart
failure,
dilated
cardiomyopathy,
myocardial
infarction,
diabetic
cardiomyopathy.
Expression
levels
of
notably
change
both
circulation
provide
cardiac
protection
after
injury.
In
the
meantime,
also
tightly
links
to
dysfunctions
such
as
hypertrophy
fibrosis.
This
review
focuses
on
pattern
its
functions
diseased-heart
further
discusses
feasibility
biomarker
therapeutic
cardiomyopathies.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 15
Published: June 24, 2022
Cardiovascular
disease
(CVD)
is
a
broad
term
that
incorporated
group
of
conditions
affect
the
blood
vessels
and
heart.
CVD
foremost
cause
fatalities
around
world.
Multiple
pathophysiological
mechanisms
are
involved
in
CVD;
however,
oxidative
stress
plays
vital
role
generating
reactive
oxygen
species
(ROS).
Oxidative
occurs
when
concentration
oxidants
exceeds
potency
antioxidants
within
body
while
producing
nitrogen
(RNS).
ROS
generated
by
disrupts
cell
signaling,
DNA
damage,
lipids,
proteins,
thereby
resulting
inflammation
apoptosis.
Mitochondria
primary
source
production
cells.
Increased
reduces
nitric
oxide
(NO)
bioavailability,
which
elevates
vasoconstriction
arteries
contributes
to
development
hypertension.
has
also
been
linked
atherosclerotic
plaque.
Antioxidants
can
decrease
body;
various
therapeutic
drugs
have
designed
treat
damage
due
CVD.
The
present
review
provides
detailed
narrative
generation
with
focus
on
biomarker
its
association
We
discussed
complex
relationship
between
endothelial
dysfunction
as
well
stress-induced
obesity
Finally,
we
reducing
Frontiers in Cardiovascular Medicine,
Journal Year:
2021,
Volume and Issue:
7
Published: Feb. 3, 2021
The
incidence
of
myocardial
infarction
(MI)
increases
every
year
worldwide.
Better
diagnostic
and
prognostic
biomarkers
for
clinical
applications
are
the
consistent
pursuit
MI
research.
In
addition
to
electrocardiogram,
echocardiography,
coronary
angiography,
etc.,
circulating
essential
diagnosis,
prognosis,
treatment
effect
monitoring
patients.
this
review,
we
assessed
both
strength
weakness
including:
(1)
originated
from
damaged
tissues
including
current
golden
standard
cardiac
troponin,
(2)
released
non-myocardial
due
MI-induced
systems
reactions,
(3)
preexisted
in
blood
circulation
before
occurrence
event.
We
also
summarized
newly
reported
biomarkers.
proposed
that
preexisting
incidents
should
be
emphasized
research
development
prevention
near
future.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5089 - 5089
Published: March 7, 2023
Cardiorenal
syndrome
consists
in
the
coexistence
of
acute
or
chronic
dysfunction
heart
and
kidneys
resulting
a
cascade
feedback
mechanisms
causing
damage
to
both
organs
associated
with
high
morbidity
mortality.
In
last
few
years,
different
biomarkers
have
been
investigated
aim
achieve
an
early
accurate
diagnosis
cardiorenal
syndrome,
provide
prognostic
role
guide
development
targeted
pharmacological
non-pharmacological
therapies.
such
context,
sodium-glucose
cotransporter
2
(SGLT2)
inhibitors,
recommended
as
first-line
choice
management
failure,
might
represent
promising
strategy
due
their
efficacy
reducing
cardiac
renal
outcomes.
this
review,
we
will
discuss
current
knowledge
on
pathophysiology
adults,
well
utility
kidney
potential
insights
into
novel
therapeutics.
Thrombosis and Haemostasis,
Journal Year:
2019,
Volume and Issue:
119(12), P. 1901 - 1919
Published: Sept. 9, 2019
Abstract
In
cardiovascular
disease
(CVD),
biomarkers
(i.e.,
“biological
markers”)
could
have
multiple
roles
in
understanding
the
complexity
of
(CV)
pathophysiology
and
to
offer
an
integrated
approach
management.
Biomarkers
help
daily
practice
as
a
diagnostic
tool,
monitor
therapy
response,
assess
prognosis
early
marker
CV
damage,
or
stratify
risk.
recent
years,
role
CVD
is
even
more
relevant
some
recently
been
included
clinical
management
guideline
recommendations.
The
aim
this
review
discuss
recommendations
guidelines
various
their
usefulness
practice.
Ultimately,
balance
needed
between
simplicity
practicality
for
decision-making.
Most
(whether
blood,
urine,
imaging-based)
will
improve
on
risk
stratification,
but
awaiting
biomarker
results
may
lead
delays
initiation
therapy,
example,
anticoagulation
stroke
prevention
atrial
fibrillation.
Many
are
nonspecific,
being
predictive
many
non-CV
outcomes,
so
would
be
better
“rule-out”
rather
than
“rule-in”
assessments.
Derivation
also
made
highly
selected
trial
cohorts,
where
measurement
at
baseline
outcomes
determined
years
later;
given
dynamic
nature
“real
world”
patients
get
older
develop
incident
factors,
give
false
impression
profile.
Finally,
laboratory
diurnal
variation
inter-/intravariability
(and
lower
limits
detection)
assays,
which
expensive,
added
considerations.
Journal of Clinical Medicine,
Journal Year:
2019,
Volume and Issue:
8(1), P. 118 - 118
Published: Jan. 18, 2019
Aim.
To
evaluate
by
meta-analysis
of
interventional
studies
the
effect
statin
therapy
on
arterial
wall
inflammation.
Background.
Arterial
exposure
to
low-density
lipoprotein
(LDL)
cholesterol
levels
is
responsible
for
initiation
and
progression
atherosclerosis
18F-fluorodeoxyglucose
Positron
Emission
Tomography-Computed
Tomography
(18F-FDG
PET/CT)
has
been
used
detect
inflammation
monitor
vascular
anti-inflammatory
effects
lipid-lowering
therapy.
Despite
a
number
statin-based
exploring
18F-FDG
uptake,
these
trials
have
produced
inconsistent
results.
Methods.
Trials
with
at
least
one
treatment
arm
were
searched
in
PubMed-Medline,
SCOPUS,
ISI
Web
Knowledge,
Google
Scholar
databases.
Target-to-background
ratio
(TBR),
an
indicator
blood-corrected
was
as
target
variable
activity.
Evaluation
biases,
random-effects
model
generic
inverse
variance
weighting,
sensitivity
analysis
performed
qualitative
quantitative
data
assessment
synthesis.
Subgroup
meta-regression
analyses
also
performed.
Results.
Meta-analysis
seven
eligible
studies,
comprising
10
arms
287
subjects
showed
significant
reduction
TBR
following
(Weighted
Mean
Difference
(WMD):
−0.104,
p
=
0.002),
which
consistent
both
high-intensity
(WMD:
−0.132,
0.019)
low-to-moderate
intensity
−0.069,
0.037).
Statin
dose/duration,
plasma
C-reactive
protein
level
changes,
baseline
did
not
affect
response
statins.
Conclusions.
Statins
effective
reducing
inflammation,
assessed
PET/CT
imaging.
Larger
clinical
should
clarify
whether
either
cholesterol-lowering
or
other
pleiotropic
mechanisms
this
effect.
