EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

Endocrine Reviews, Journal Year: 2015, Volume and Issue: 36(6), P. E1 - E150

Published: Nov. 6, 2015

The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease. Five years later, substantially larger body of literature has solidified our understanding plausible mechanisms underlying EDC actions exposures animals humans—especially during development—may lay foundations for disease later life. At this point history, we have much stronger knowledge EDCs alter gene-environment interactions via physiological, cellular, molecular, epigenetic changes, thereby producing effects exposed individuals as well their descendants. Causal links between exposure manifestation are substantiated by experimental animal models consistent with correlative epidemiological data humans. There several caveats because differences work is conducted can lead difficulties drawing broad conclusions, must continue be cautious inferring causality In second Statement, reviewed on subset topics which translational evidence strongest: 1) obesity diabetes; 2) female reproduction; 3) male 4) hormone-sensitive cancers females; 5) prostate; 6) thyroid; 7) neurodevelopment neuroendocrine systems. Our inclusion criteria studies were those predominantly past 5 deemed high quality based appropriate negative positive control groups or populations, adequate sample size design, mammalian levels range that was relevant We also focused using developmental origins model. No report excluded effect exposure. bulk results across board strengthen endocrine health-related EDCs. Based more complete principles act, including nonmonotonic dose-responses, low-dose effects, vulnerability, these findings better translated human health. Armed information, researchers, physicians, other healthcare providers guide regulators policymakers they make responsible decisions.

Language: Английский

---

Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes

Environmental Health Perspectives, Journal Year: 2015, Volume and Issue: 123(7), P. 643 - 650

Published: March 16, 2015

Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some replacements, however, are also bisphenols may similar physiological in organisms. Bisphenol S (BPS) F (BPF) two such substitutes.This review was carried out to evaluate endocrine activities substitutes BPS BPF. Further, we compared hormonal potency BPF that BPA.We conducted a systematic based Office Health Assessment Translation (OHAT) protocol.We identified body literature date, consisting 32 studies (25 vitro only, 7 vivo). The majority these examined found their be same order magnitude action (estrogenic, antiestrogenic, androgenic, antiandrogenic) vivo. has potencies estradiol membrane-mediated pathways, which important for cellular actions proliferation, differentiation, death. showed other vivo, altered organ weights, reproductive end points, enzyme expression.Based current literature, hormonally active BPA, they effects.Rochester JR, Bolden AL. 2015. F: comparison activity substitutes.

Language: Английский

---

State-of-the-science of endocrine disrupting chemicals, 2012

Toxicology Letters, Journal Year: 2012, Volume and Issue: 211, P. S3 - S3

Published: May 11, 2012

Language: Английский

---

Metabolism disrupting chemicals and metabolic disorders

Reproductive Toxicology, Journal Year: 2016, Volume and Issue: 68, P. 3 - 33

Published: Oct. 19, 2016

The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and syndrome have largely been attributed to genetic background changes in diet, exercise aging. However, there is now considerable evidence that other environmental factors may contribute the rapid increase incidence these diseases. This review will examine T2D non-alcoholic fatty disease (NAFLD), contribution genetics describe role endocrine system disorders. It then specifically focus on disrupting chemicals (EDCs) etiology NAFLD while finally integrating information EDCs multiple could lead syndrome. We linking EDC exposures during critical periods development with diseases manifest later life across generations.

Language: Английский

---

Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement

Environmental Health, Journal Year: 2016, Volume and Issue: 15(1)

Published: Feb. 12, 2016

The broad-spectrum herbicide glyphosate (common trade name "Roundup") was first sold to farmers in 1974. Since the late 1970s, volume of glyphosate-based herbicides (GBHs) applied has increased approximately 100-fold. Further increases are likely due more and higher rates application response widespread emergence glyphosate-resistant weeds new, pre-harvest, dessicant use patterns. GBHs were developed replace or reduce reliance on causing well-documented problems associated with drift crop damage, slipping efficacy, human health risks. Initial industry toxicity testing suggested that posed relatively low risks non-target species, including mammals, leading regulatory authorities worldwide set high acceptable exposure limits. To accommodate changes GBH patterns genetically engineered, herbicide-tolerant crops, regulators have dramatically tolerance levels maize, oilseed (soybeans canola), alfalfa crops related livestock feeds. Animal epidemiology studies published last decade, however, point need for a fresh look at toxicity. Furthermore, World Health Organization's International Agency Research Cancer recently concluded is "probably carcinogenic humans." In changing advances scientific understanding their potential hazards, we produced Statement Concern drawing emerging science relevant safety GBHs. Our considers current literature describing uses, mechanisms action, laboratory animals, epidemiological studies. It also examines derivation standards. We conclude that: (1) most heavily world usage continues rise; (2) Worldwide, often contaminate drinking water sources, precipitation, air, especially agricultural regions; (3) half-life soil longer than previously recognized; (4) Glyphosate its metabolites widely present global soybean supply; (5) Human exposures rising; (6) now authoritatively classified as probable carcinogen; (7) Regulatory estimates tolerable daily intakes United States European Union based outdated science. offer series recommendations new investments studies, biomonitoring, toxicology draw principles endocrinology determine whether effects endocrine disrupting activities. suggest common commercial formulations should be prioritized inclusion government-led programs such U.S. National Toxicology Program, well biomonitoring conducted by Centers Disease Control Prevention.

Language: Английский

---

Early-life exposure to EDCs: role in childhood obesity and neurodevelopment

Nature Reviews Endocrinology, Journal Year: 2016, Volume and Issue: 13(3), P. 161 - 173

Published: Nov. 18, 2016

Language: Английский

---

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 16(1), P. 45 - 57

Published: Nov. 12, 2019

Abstract Endocrine-disrupting chemicals (EDCs) are exogenous that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature mechanistic studies provides evidence on hazards EDC exposure, yet there is no widely accepted systematic method to integrate these data help identify hazards. Inspired by work improve hazard identification carcinogens using key characteristics (KCs), we have developed ten KCs EDCs based our knowledge actions effects. In this Expert Consensus Statement, describe logic which identified assays could be used assess several KCs. We reflect how can identify, organize utilize when evaluating as EDCs, use diethylstilbestrol, bisphenol perchlorate examples illustrate approach.

Language: Английский

---

Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

Endocrine Reviews, Journal Year: 2015, Volume and Issue: 36(6), P. 593 - 602

Published: Sept. 28, 2015

This Executive Summary to the Endocrine Society's second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of key points complete statement. The full represents comprehensive review literature seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence endocrine disruption, namely: obesity diabetes, female reproduction, male hormone-sensitive cancers in females, prostate cancer, thyroid, neurodevelopment neuroendocrine systems. EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants polychlorinated biphenyls, polybrominated diethyl ethers, dioxins were emphasized because these had greatest depth breadth available information. also included thorough coverage studies developmental exposures EDCs, especially fetus infant, are critical life stages during perturbations hormones can increase probability disease or dysfunction later life. A conclusion that publications over past 5 years have led much fuller understanding principles by act, including nonmonotonic dose-responses, low-dose effects, vulnerability. These findings will prove useful researchers, physicians, other healthcare providers translating science disruption improved public health.

Language: Английский

---

Obesity Pathogenesis: An Endocrine Society Scientific Statement

Endocrine Reviews, Journal Year: 2017, Volume and Issue: 38(4), P. 267 - 296

Published: June 26, 2017

Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in United States obesity affects one-third of adults, accounts for up to total mortality, concentrated lower income groups, increasingly children as well adults. A lack effective options long-term weight reduction magnifies enormity this problem; individuals who successfully complete behavioral dietary weight-loss programs eventually regain lost weight. We included evidence from basic science, clinical, epidemiological literature assess current knowledge regarding mechanisms underlying excess body-fat accumulation, biological defense fat mass, tendency be regained. major area emphasis science energy homeostasis, process maintains stability by actively matching intake expenditure over time. Growing suggests a disorder homeostasis system, rather than simply arising passive accumulation need elucidate "upward setting" or "resetting" defended level whether inherited acquired. The ongoing study how genetic, developmental, environmental forces affect system will help us better understand these are therefore focus statement. scientific goal pathogenesis so inform treatment, public policy, advocacy, awareness ways ultimately diminish its health economic consequences.

Language: Английский

---

Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2019, Volume and Issue: 21(1), P. 127 - 147

Published: Dec. 3, 2019

Language: Английский

---