Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

Endocrine Reviews, Journal Year: 2012, Volume and Issue: 33(3), P. 378 - 455

Published: March 14, 2012

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, particular the dogma “the dose makes poison,” because EDCs can effects at low doses that are not predicted by higher doses. Here, we review two major EDC studies: and nonmonotonicity. Low-dose were defined National Toxicology Program as those occur range human exposures or observed below used for toxicological studies. We mechanistic data low-dose use a weight-of-evidence approach to analyze five examples from literature. Additionally, explore nonmonotonic dose-response curves, nonlinear relationship between effect where slope curve changes sign somewhere within examined. provide detailed discussion mechanisms responsible generating these phenomena, plus hundreds cell culture, animal, epidemiology illustrate responses remarkably common natural hormones EDCs. Whether influence certain disorders is no longer conjecture, epidemiological show environmental associated with diseases disabilities. conclude when curves occur, cannot be high Thus, fundamental chemical testing safety determination needed protect health.

Language: Английский

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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

Endocrine Reviews, Journal Year: 2015, Volume and Issue: 36(6), P. E1 - E150

Published: Nov. 6, 2015

The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease. Five years later, substantially larger body of literature has solidified our understanding plausible mechanisms underlying EDC actions exposures animals humans—especially during development—may lay foundations for disease later life. At this point history, we have much stronger knowledge EDCs alter gene-environment interactions via physiological, cellular, molecular, epigenetic changes, thereby producing effects exposed individuals as well their descendants. Causal links between exposure manifestation are substantiated by experimental animal models consistent with correlative epidemiological data humans. There several caveats because differences work is conducted can lead difficulties drawing broad conclusions, must continue be cautious inferring causality In second Statement, reviewed on subset topics which translational evidence strongest: 1) obesity diabetes; 2) female reproduction; 3) male 4) hormone-sensitive cancers females; 5) prostate; 6) thyroid; 7) neurodevelopment neuroendocrine systems. Our inclusion criteria studies were those predominantly past 5 deemed high quality based appropriate negative positive control groups or populations, adequate sample size design, mammalian levels range that was relevant We also focused using developmental origins model. No report excluded effect exposure. bulk results across board strengthen endocrine health-related EDCs. Based more complete principles act, including nonmonotonic dose-responses, low-dose effects, vulnerability, these findings better translated human health. Armed information, researchers, physicians, other healthcare providers guide regulators policymakers they make responsible decisions.

Language: Английский

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Endometriosis

New England Journal of Medicine, Journal Year: 2010, Volume and Issue: 362(25), P. 2389 - 2398

Published: June 23, 2010

A healthy 25-year-old woman presents with worsening dysmenorrhea, new-onset left lower quadrant pain, and dyspareunia. She has regular menstrual cycles, her last period was 3 weeks before presentation. How should this patient be evaluated treated?

Language: Английский

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Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes

Environmental Health Perspectives, Journal Year: 2015, Volume and Issue: 123(7), P. 643 - 650

Published: March 16, 2015

Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some replacements, however, are also bisphenols may similar physiological in organisms. Bisphenol S (BPS) F (BPF) two such substitutes.This review was carried out to evaluate endocrine activities substitutes BPS BPF. Further, we compared hormonal potency BPF that BPA.We conducted a systematic based Office Health Assessment Translation (OHAT) protocol.We identified body literature date, consisting 32 studies (25 vitro only, 7 vivo). The majority these examined found their be same order magnitude action (estrogenic, antiestrogenic, androgenic, antiandrogenic) vivo. has potencies estradiol membrane-mediated pathways, which important for cellular actions proliferation, differentiation, death. showed other vivo, altered organ weights, reproductive end points, enzyme expression.Based current literature, hormonally active BPA, they effects.Rochester JR, Bolden AL. 2015. F: comparison activity substitutes.

Language: Английский

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Polycystic ovary syndrome: etiology, pathogenesis and diagnosis

Nature Reviews Endocrinology, Journal Year: 2011, Volume and Issue: 7(4), P. 219 - 231

Published: Jan. 25, 2011

Language: Английский

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State-of-the-science of endocrine disrupting chemicals, 2012

Toxicology Letters, Journal Year: 2012, Volume and Issue: 211, P. S3 - S3

Published: May 11, 2012

Language: Английский

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Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution

The ISME Journal, Journal Year: 2014, Volume and Issue: 9(6), P. 1269 - 1279

Published: Dec. 12, 2014

Abstract Around all human activity, there are zones of pollution with pesticides, heavy metals, pharmaceuticals, personal care products and the microorganisms associated waste streams agriculture. This diversity pollutants, whose concentration varies spatially temporally, is a major challenge for monitoring. Here, we suggest that relative abundance clinical class 1 integron-integrase gene, intI1, good proxy because: (1) intI1 linked to genes conferring resistance antibiotics, disinfectants metals; (2) it found in wide variety pathogenic nonpathogenic bacteria; (3) its can change rapidly because host cells have rapid generation times move between bacteria by horizontal gene transfer; (4) single DNA sequence variant now on xenogenetic elements, these being complex mosaic elements fixed through agency selection. Here review literature examining relationship anthropogenic impacts outline an approach which could serve as pollution.

Language: Английский

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Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society

Endocrinology, Journal Year: 2012, Volume and Issue: 153(9), P. 4097 - 4110

Published: June 27, 2012

An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect hormone action. The potential for deleterious effects EDC must be considered relative to the regulation synthesis, secretion, and actions variability in these events across life cycle. developmental age at which exposures occur a critical consideration understanding their effects. Because endocrine systems exhibit tissue-, cell-, receptor-specific during cycle, produce complex, mosaic This complexity causes difficulty when static approach toxicity through mechanisms driven by rigid guidelines used identify manage risk human wildlife populations. We propose principles taken from fundamental endocrinology employed exposed emphasize importance stage and, particular, realization exposure presumptive "safe" dose may impact there normally no endogenous exposure, thereby underscoring very low-dose have potent irreversible Finally, regard current program designed detect putative EDC, namely, Endocrine Disruptor Screening Program, we offer recommendations strengthening this incorporation basic promote further complex effects, especially due exposures.

Language: Английский

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Endocrine disrupting chemicals and disease susceptibility

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2011, Volume and Issue: 127(3-5), P. 204 - 215

Published: Aug. 29, 2011

Language: Английский

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Metabolism disrupting chemicals and metabolic disorders

Reproductive Toxicology, Journal Year: 2016, Volume and Issue: 68, P. 3 - 33

Published: Oct. 19, 2016

The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and syndrome have largely been attributed to genetic background changes in diet, exercise aging. However, there is now considerable evidence that other environmental factors may contribute the rapid increase incidence these diseases. This review will examine T2D non-alcoholic fatty disease (NAFLD), contribution genetics describe role endocrine system disorders. It then specifically focus on disrupting chemicals (EDCs) etiology NAFLD while finally integrating information EDCs multiple could lead syndrome. We linking EDC exposures during critical periods development with diseases manifest later life across generations.

Language: Английский

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