Influence of maternal obesity on the long-term health of offspring

The Lancet Diabetes & Endocrinology, Journal Year: 2016, Volume and Issue: 5(1), P. 53 - 64

Published: Oct. 16, 2016

Language: Английский

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Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

Science, Journal Year: 2018, Volume and Issue: 359(6381)

Published: Feb. 8, 2018

Daily transcription cycling in the baboon Much of our knowledge about important effects circadian rhythms physiology comes from studies mice, which are nocturnal. Mure et al. report transcriptional profiles many tissues and brain regions baboons over a 24-hour period (see Perspective by Millius Ueda). The results emphasize how extensive rhythmic expression is, with more than 80% protein-coding genes involved. They also highlight unanticipated differences between mouse transcripts various tissues. findings provide comprehensive analysis variation gene for diurnal animal closely related to humans. Science , this issue p. eaao0318 ; see 1210

Language: Английский

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The human stress response

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(9), P. 525 - 534

Published: June 27, 2019

Language: Английский

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Investigation of Cortisol Dynamics in Human Sweat Using a Graphene-Based Wireless mHealth System

Matter, Journal Year: 2020, Volume and Issue: 2(4), P. 921 - 937

Published: Feb. 26, 2020

Language: Английский

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Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

Stress, Journal Year: 2018, Volume and Issue: 21(5), P. 403 - 416

Published: May 15, 2018

The hypothalamic-pituitary-adrenal (HPA) axis is the major neuroendocrine regulating homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted from adrenal gland response to stress. In addition, under basal conditions glucocorticoids released rhythmically with both a circadian an ultradian (pulsatile) pattern. These rhythms important not only for normal function of glucocorticoid target organs, but also HPA responses Several studies have shown that disruption associated disease humans rodents. this review, we will discuss our knowledge negative feedback mechanisms regulate synthesis secretion glucocorticoids, including role mineralocorticoid receptors their chaperone protein FKBP51. Moreover, light recent findings, importance intra-adrenal receptor signaling synthesis.

Language: Английский

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The circadian regulation of food intake

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(7), P. 393 - 405

Published: May 9, 2019

Language: Английский

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Systems Chronotherapeutics

Pharmacological Reviews, Journal Year: 2017, Volume and Issue: 69(2), P. 161 - 199

Published: March 28, 2017

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms, which moderate xenobiotic metabolism and cellular drug response. The molecular clocks present in individual cells involve approximately fifteen clock genes interconnected regulatory feedback loops. They are coordinated by suprachiasmatic nuclei, a hypothalamic pacemaker, also adjusts circadian rhythms environmental cycles. As result, many mechanisms of diseases effects controlled timing system. Thus, tolerability nearly 500 medications varies up fivefold scheduling, both experimental models and/or patients. Moreover, treatment itself disrupted, maintained, or improved system as function timing. Improved patient outcomes on circadian-based treatments (chronotherapy) have been demonstrated randomized clinical trials, especially for cancer inflammatory diseases. However, recent technological advances highlighted large interpatient differences functions resulting significant variability chronotherapy Such findings advocate advancement personalized chronotherapeutics through interdisciplinary systems approaches. combination mathematical, statistical, technological, experimental, expertise is now shaping development dedicated devices diagnostic delivery algorithms enabling individualization. In particular, multiscale chronopharmacology approaches currently combine mathematical modeling based whole-body physiology preclinical investigations toward design patient-tailored chronotherapies. We review research works aiming individualization disease treatment, with emphasis management system–resetting strategies improving chronic control outcomes.

Language: Английский

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Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation

Frontiers in Neuroendocrinology, Journal Year: 2018, Volume and Issue: 49, P. 124 - 145

Published: Feb. 8, 2018

Bruce McEwen’s discovery of receptors for corticosterone in the rat hippocampus introduced higher brain circuits neuroendocrinology stress. Subsequently, these were identified as mineralocorticoid (MRs) that are involved appraisal processes, choice coping style, encoding and retrieval. The MR-mediated actions on cognition complemented by slower via glucocorticoid (GRs) contextualization, rationalization memory storage experience. These sequential phases cognitive performance depend synaptic metaplasticity is regulated coordinate MR- GR activation. receptor activation includes recruitment coregulators transcription factors determinants context-dependent specificity steroid action; they can be modulated genetic variation (early) Interestingly, inflammatory responses to damage seem governed a similarly balanced MR:GR-mediated action initiating, terminating priming mechanisms stress-adaptation. We conclude with five questions challenging MR:GR balance hypothesis.

Language: Английский

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Fracture Risk and Management of Discontinuation of Denosumab Therapy: A Systematic Review and Position Statement by ECTS

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2020, Volume and Issue: 106(1), P. 264 - 281

Published: Oct. 26, 2020

Abstract Context Denosumab discontinuation is characterized by an increase in bone turnover overriding pretreatment status, a rapid loss the majority and multiple vertebral fractures (VFx) some patients. Methods A working group of European Calcified Tissue Society performed updated systematic review existing literature on changes turnover, mineral density (BMD), fracture risk after denosumab provided advice management based expert opinion. Results Important factors for VFx following cessation are prevalent VFx, longer duration off therapy, greater gain hip BMD during therapy according to retrospective analysis FREEDOM Extension Study. Case series indicate that prior bisphosphonate mitigates biochemical rebound phenomenon discontinuation, but it uncertain whether this attenuation prevents fractures. Current evidence indicates partial efficacy subsequent antiresorptive treatment with results seemingly dependent treatment. Conclusions careful assessment indications start advised, especially younger case long-term can be made patients at high already given favorable safety profile. In alternative should initiated 6 months final injection. Assessment markers may help define optimal regimen, pending ongoing randomized controlled trials. Patients who have sustained offered prompt reduce turnover.

Language: Английский

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Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal

Frontiers in Neurology, Journal Year: 2018, Volume and Issue: 9

Published: Feb. 8, 2018

Light exerts a wide range of effects on mammalian physiology and behaviour. As well as synchronising circadian rhythms to the external environment, light has been shown modulate autonomic neuroendocrine responses regulating sleep influencing cognitive processes such attention, arousal performance. The last two decades have seen major advances in our understanding retinal photoreceptors that mediate these non-image forming light, neural pathways molecular mechanisms by which are generated entrained light/dark (LD) cycle. By contrast, lighting influences more equivocal. different complex. direct indirect may also occur due disrupted entrainment. Despite widespread use LD cycles study role cognition, experimental protocols used subtly function not comparable. Moreover, will disrupt alter physiological arousal, both known cognition. Studies behavioural assays dependent upon sensory processes, contribute their variable findings. Here we propose studies addressing conditions must account for rhythms, if fully understand basis effects.

Language: Английский

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