Brain Behavior and Immunity, Journal Year: 2020, Volume and Issue: 90, P. 364 - 380
Published: Sept. 3, 2020
Language: Английский
Endocrine Reviews, Journal Year: 2019, Volume and Issue: 41(2), P. 273 - 319
Published: Sept. 23, 2019
Abstract Neurodegenerative diseases (NDs) are a wide class of disorders the central nervous system (CNS) with unknown etiology. Several factors were hypothesized to be involved in pathogenesis these diseases, including genetic and environmental factors. Many show sex prevalence steroids shown have role progression specific forms neurodegeneration. Estrogens reported neuroprotective through their action on cognate nuclear membrane receptors, while adverse effects male hormones been described neuronal cells, although some data also suggest activities. The response CNS is complex integrated process that depends (i) type amount steroid receptor (ii) target cell type—either neurons, glia, or microglia. Moreover, levels fluctuate due gonadal activities local metabolism synthesis. Importantly, biochemical processes NDs increasingly being recognized as different between two sexes influenced by steroids. aim this review present current state-of-the-art understanding potential receptors onset major neurodegenerative disorders, namely, Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, peculiar motoneuron disease spinal bulbar muscular atrophy, which hormonal therapy potentially useful modifier.
Language: Английский
Citations
177
Acta Neuropathologica, Journal Year: 2019, Volume and Issue: 138(3), P. 363 - 387
Published: April 11, 2019
Language: Английский
Citations
175
Journal of Neuroinflammation, Journal Year: 2018, Volume and Issue: 15(1)
Published: July 12, 2018
The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection against cerebral ischemic injury by activating receptors. novel receptor G protein-coupled 30 (GPR30) is highly expressed in the brain and acute stroke. However, underlying mechanisms remain unclear.In this study, ovariectomized female mice were subjected to middle artery occlusion (MCAO), E2, G1, ICI182780 administered immediately upon reperfusion. infarction volume, neurological scores, neuronal injuries examined. Primary microglial cells oxygen-glucose deprivation (OGD), drugs reintroduction. pro-inflammatory cytokines TNF-α, IL-1β, IL-6 penumbra microglia assessed ELISA. cell viability lactose dehydrogenase (LDH) release of neurons co-cultured with analyzed using counting kit-8 (CCK8) LDH assays. Microglial activation as well GPR30, Iba1, Toll-like 4 (TLR4) protein expression TLR4 mRNA detected. Additionally, NF-κB activity was detected lipopolysaccharide (LPS)-activated after GPR30.GPR30 significantly increased injury. GPR30 reduced improved deficit, alleviated injuries. Moreover, from OGD CCK8 Finally, relieved activation, Iba1 levels, inhibited activity.Microglial exerts neuroprotective effects inhibiting TLR4-mediated inflammation, which indicates that may be a potential target for treatment
Language: Английский
Citations
172
Journal of Advanced Research, Journal Year: 2020, Volume and Issue: 28, P. 97 - 109
Published: Aug. 18, 2020
Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with pro-inflammatory mediators' release. However, pyroptosis recognized as new programmed cell death mechanism regulated by stimulation caspase-1 and/or caspase-11/-4/-5 signaling pathways series inflammatory responses. Our current review concisely summarizes potential role pyroptosis-regulated in SCI, according molecular and pathophysiological mechanisms. This also highlights targeting inflammasome components its therapeutic implications for treatment SCI. Multiple pieces evidence have illustrated plays significant roles swelling, plasma membrane lysis, chromatin fragmentation intracellular factors including IL-18 IL-1β In addition, directly mediated recently discovered family pore-forming protein known GSDMD. Current investigations documented critical pathogenesis multiple neurological disorders well narrative article suggests inhibiting could be promising approach SCI near future.
Language: Английский
Citations
164
Biomolecules, Journal Year: 2022, Volume and Issue: 12(3), P. 371 - 371
Published: Feb. 25, 2022
Alzheimer’s and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology these disorders is not well known; however, environmental, molecular, genetic influences play a major role in pathogenesis Using disease (AD) as archetype, pathological findings include aggregation Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), cerebrovascular dysregulation. This review highlights neuroinflammatory neuroprotective epigallocatechin-3-gallate (EGCG): medicinal component green tea, known nutraceutical that has shown promise modulating AD progression due to its antioxidant, anti-inflammatory, anti-aging abilities. report also re-examines current literature provides innovative approaches for EGCG be used preventive measure alleviate other disorders.
Language: Английский
Citations
109
Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14
Published: March 31, 2022
One area of microglial biology that has been relatively neglected until recently is sex differences and this in spite the fact a risk factor several diseases are characterized by neuroinflammation and, extension, activation. Why these exist not known but panoply extend to number, genotype phenotype. Significantly, sex-related also evident health change during life emphasizing dynamic plastic nature microglia. This review will consider how age impacts on microglia ask whether advancement personalized medicine demands greater focus placed studying Alzheimer’s disease, Parkinson’s disease models inflammatory stress trauma order make true progress dealing with conditions.
Language: Английский
Citations
89
BMJ, Journal Year: 2023, Volume and Issue: unknown, P. e072770 - e072770
Published: June 28, 2023
Abstract Objectives To assess the association between use of menopausal hormone therapy and development dementia according to type treatment, duration use, age at usage. Design Nationwide, nested case-control study. Setting Denmark through national registries. Participants 5589 incident cases 55 890 matched controls were identified 2000 2018 from a population all Danish women aged 50-60 years in with no history or contraindications for therapy. Main outcome measures Adjusted hazard ratios 95% confidence intervals cause defined by first time diagnosis specific medication. Results Compared people who had never used received oestrogen-progestin an increased rate (hazard ratio 1.24 (95% interval 1.17 1.33)). Increasing durations yielded higher ratios, ranging 1.21 (1.09 1.35) one year less 1.74 (1.45 2.10) more than 12 use. Oestrogen-progestin was positively associated both continuous (1.31 (1.18 1.46)) cyclic (1.24 (1.13 1.35)) regimens. Associations persisted treatment younger (1.11 1.40)). Findings when restricted late onset (1.21 (1.12 1.30)) Alzheimer’s disease (1.22 (1.07 1.39)). Conclusions Menopausal disease, even younger. The similar treatment. Further studies are warranted determine whether these findings represent actual effect on risk, they reflect underlying predisposition need treatments.
Language: Английский
Citations
49
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117207 - 117207
Published: July 26, 2024
Language: Английский
Citations
25
Annals of Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Objective Despite the overwhelming evidence for profound and longstanding effects of early‐life stress (ELS) on inflammation, brain structure, molecular aging, its impact human aging risk neurodegenerative disease is poorly understood. We examined ELS severity in interaction with age blood‐based markers neuroinflammation neurodegeneration, volumes, cognitive function middle‐aged women. Methods recruited 179 women (aged 30–60 years) without exposure before onset puberty. Using Simoa technology, we assessed including serum concentrations glial fibrillary acidic protein (GFAP) neurofilament light chain (NfL). further obtained T1‐weighted T2‐weighted magnetic resonance images to assess volumes performance sensitive early impairments associated development dementia, using Cambridge Neuropsychological Automated Test Battery. used generalized additive models examine nonlinear these outcomes. Results Analyses revealed significant NfL GFAP concentrations, total subcortical gray matter volume loss, increased third ventricular volume, impairment. Interpretation These findings suggest that profoundly exacerbates peripheral, neurostructural, aging. Our results are critical novel prevention strategies target developmental mitigate aging‐related neurological diseases. ANN NEUROL 2025
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 22(1), P. 373 - 373
Published: Dec. 31, 2020
Increasing evidence suggests estrogen and signaling pathway disturbances across psychiatric disorders. Estrogens are not only crucial in sexual maturation reproduction but also highly involved a wide range of brain functions, such as cognition, memory, neurodevelopment, neuroplasticity. To add more, the recent findings its neuroprotective anti-inflammatory effects have grown interested investigating potential therapeutic use to In this review, we analyze emerging literature on receptors disorders cellular, preclinical, clinical studies. Specifically, discuss contribution receptor cognition neuroprotection via mediating multiple neural systems, dopaminergic, serotonergic, glutamatergic systems. Then, assess their disruptions implications for pathophysiologies Further, current treatment strategies involving evaluated suggest future direction identifying novel
Language: Английский
Citations
129