Pharmacology & Therapeutics, Journal Year: 2019, Volume and Issue: 205, P. 107423 - 107423
Published: Oct. 17, 2019
Language: Английский
Molecular Metabolism, Journal Year: 2021, Volume and Issue: 57, P. 101393 - 101393
Published: Nov. 14, 2021
Obesity develops due to an imbalance in energy homeostasis, wherein intake exceeds expenditure. Accumulating evidence shows that manipulations of dietary protein and their component amino acids affect the balance, resulting changes fat mass body weight. Amino are not only building blocks proteins but also serve as signals regulating multiple biological pathways.
Language: Английский
Citations
94
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(17), P. 9487 - 9487
Published: Aug. 31, 2021
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes wide range of functions. In the gastrointestinal tract, enterochromaffin cells are most important source for 5-HT production. Some intestinal bacterial species also able to produce 5-HT. Besides its role as neurotransmitter, acts on immune regulate their activation. Several lines evidence indicate that signaling altered patients inflammatory bowel disease. this review, we discuss current knowledge production, secretion, intestine. We present an inventory epithelial respond describe effects these processes homeostasis. Further, detail mechanisms by which could affect disease course interventions target signaling.
Language: Английский
Citations
65
Annual Review of Clinical Psychology, Journal Year: 2022, Volume and Issue: 18(1), P. 553 - 580
Published: May 9, 2022
The theory of constructed emotion is a systems neuroscience approach to understanding the nature emotion. It also general theoretical framework guide hypothesis generation for how actions and experiences are as brain continually anticipates metabolic needs attempts meet those before they arise (termed allostasis). In this review, we introduce hypothesize that allostatic dysregulation trans-disorder vulnerability mental physical illness. We then review published findings consistent with several symptoms in major depressive disorder (MDD), such fatigue, distress, context insensitivity, reward motor retardation, associated persistent problems energy regulation. Our transforms current MDD resulting from enhanced emotional reactivity combined reduced cognitive control and, doing so, offers novel hypotheses regarding development, progression, treatment, prevention MDD.
Language: Английский
Citations
51
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: Aug. 5, 2022
Objective: Long-term use of olanzapine can induce various side effects such as lipid metabolic disorders, but the mechanism remains to be elucidated. The gut microbiota-brain axis plays an important role in metabolism, and may related olanzapine. Therefore, we explored by which olanzapine-induced disturbances through axis. Methods: Sprague Dawley rats were randomly divided into two groups, underwent subphrenic vagotomy sham surgery. Then groups further subgroups, one was administered (10 mg/kg/day) intragastric administration, other normal saline administration (4 ml/kg/day) for 2 weeks. final changes parameters, microbes their metabolites, orexin-related neuropeptides hypothalamus investigated among different groups. Results: Olanzapine induced indicated increased weight gain, elevated ratio white adipose tissue brown tissue, well triglyceride total cholesterol. also Firmicutes/Bacteroides (F/B) gut, even aggravated vagotomy. In addition, reduced abundance short-chain fatty acids (SCFAs) metabolism microbiome 5-hydroxytryptamine (5-HT) levels rat cecum, gene protein expression appetite-related neuropeptide Y/agouti-related peptide (NPY/AgRP) hypothalamus. Conclusion: abnormal caused closely vagus nerve-mediated
Language: Английский
Citations
41
Humanities and Social Sciences Communications, Journal Year: 2022, Volume and Issue: 9(1)
Published: Jan. 11, 2022
Abstract Academic achievement and cognitive functions are influenced by sleep mood/emotion. In addition, several other factors affect learning. A coherent overview of the resultant interrelationships is essential but has not been presented till date. This unique interdisciplinary review sits at interface physiology, psychology, education. It compiles critically examines effects mood on cognition academic performance while including relevant conflicting observations. Moreover, it discusses impact regulatory learning, namely, age, gender, diet, hydration level, obesity, sex hormones, daytime nap, circadian rhythm, genetics. Core physiological mechanisms that mediate these described briefly simplistically. The bidirectional relationship between addressed. Contextual pictorial models hypothesise learning an emotion scale a have proposed. Essentially, convoluted associations psychological factors, determine recognised affirmed. emerged picture reveals far more complexity than perceived. questions currently adopted ‘one-size fits all’ approach in education urges to envisage formulating bespoke strategies optimise teaching-learning approaches retaining uniformity information here can help improvise provide better pastoral support students during their journey.
Language: Английский
Citations
39
Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 12(2), P. 694 - 706
Published: Dec. 7, 2023
Modulatory effects of serotonin (5-Hydroxytryptamine [5-HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host. Recent research has suggested probiotics can promote signaling, a crucial pathway the regulation mood, cognition, other physiological processes. Reviewing literature, we find peripheral increases nutrient uptake storage, regulates composition gut microbiota, is involved mediating neuronal This review explores mechanisms underlying probiotic-mediated increase highlighting role microbiota production modulation neurotransmitter receptors. Additionally, this discusses potential clinical implications as therapeutic strategy for disorders associated with altered such GI neurological Overall, demonstrates promising avenue treatment serotonin-related signaling serotonin.
Language: Английский
Citations
38
Current Atherosclerosis Reports, Journal Year: 2023, Volume and Issue: 25(2), P. 55 - 65
Published: Jan. 3, 2023
Language: Английский
Citations
30
Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1416 - 1416
Published: March 15, 2023
Overweight and obesity in childhood adolescence represents one of the most challenging public health problems our century owing to its epidemic proportions associated significant morbidity, mortality, increase costs. The pathogenesis polygenic is multifactorial due interaction among genetic, epigenetic, environmental factors. More than 1100 independent genetic loci with traits have been currently identified, there great interest decoding their biological functions gene–environment interaction. present study aimed systematically review scientific evidence explore relation single-nucleotide polymorphisms (SNPs) copy number variants (CNVs) changes body mass index (BMI) other measures composition children adolescents obesity, as well response lifestyle interventions. Twenty-seven studies were included qualitative synthesis, which consisted 7928 overweight/obese at different stages pubertal development who underwent multidisciplinary management. effect 92 genes was assessed revealed SNPs 24 significantly BMI and/or change, contribute complex metabolic imbalance including regulation appetite energy balance, homeostasis glucose, lipid, adipose tissue, interactions. molecular/cellular pathophysiology interactions, alongside individual genotype, will enable us design targeted personalized preventive management interventions for early life.
Language: Английский
Citations
29
Annual Review of Microbiology, Journal Year: 2023, Volume and Issue: 77(1), P. 479 - 497
Published: June 20, 2023
Amino acids are indispensable substrates for protein synthesis in all organisms and incorporated into diverse aspects of metabolic physiology signaling. However, animals lack the ability to synthesize several them must acquire these essential amino from their diet or perhaps associated microbial communities. The therefore occupy a unique position health relationships with microbes. Here we review recent work connecting production metabolism host biology, reciprocal impacts on We focus roles branched-chain (valine, leucine, isoleucine) tryptophan host-microbe communication intestine humans other vertebrates. then conclude by highlighting research questions surrounding less-understood acid animal hosts.
Language: Английский
Citations
28
Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(31), P. 11321 - 11340
Published: Aug. 16, 2023
As far as health benefit is concerned, dark tea one of the best beverages in world. Theabrownins are major ingredient contributing to benefits and known "the soft gold tea." A growing body evidence indicated that theabrownins macromolecular pigments with reddish-brown color mellow taste, mainly derived from oxidative polymerization polyphenols. main active ingredients which brings multiple health-promoting effects modulating lipid metabolism, reducing weight gain, attenuating diabetes, mitigating NAFLD, scavenging ROS, preventing tumors. More importantly, it's their substantial generation microbial fermentation endows much stronger hypolipidemic effect compared other types tea. This review firstly summarizes most recent findings on preparation, structural characteristics, theabrownins, emphasizing underlying molecular mechanism, especially different mechanisms behind theabrownins-mediated gut microbiota host's benefits. Furthermore, this points out limitations current research potential future directions, hoping provide updated scientific for better theoretical industrial utilization.
Language: Английский
Citations
28