Lactobacillus plantarum CCFM405 against Rotenone-Induced Parkinson’s Disease Mice via Regulating Gut Microbiota and Branched-Chain Amino Acids Biosynthesis

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1737 - 1737

Published: April 1, 2023

Recent studies have demonstrated that disturbances in the gut microbiota and -derived metabolites contribute to pathogenesis of Parkinson's disease (PD), suggesting probiotic treatments restore them may delay progression. This study aimed examine attenuating efficacy L. plantarum CCFM405 potential mechanisms mice with rotenone-induced PD. Our results indicate ameliorated motor deficits constipation, decreased dopaminergic neuronal death, reduced intestinal inflammation neuroinflammation, raised dopamine levels, 5-HT, associated striatal region brain Sequencing 16S rRNA from fecal revealed normalized bacterial composition PD, as evidenced by increased relative abundance following genus, Bifidobacterium, Turicibacter, Faecalibaculum, Alistipes, Bilophila, Akkermansia, Escherichia-Shigella. The PICRUSt-predicted function enhanced biosynthesis amino acid pathways, particularly valine, leucine, isoleucine (branched-chain acids, BCAAs). A non-metabolomic analysis serum feces showed markedly levels BCAAs. Pathway enrichment based on KEGG database further suggested supplementation can promote BCAAs biosynthesis. Collectively, help prevent PD modulating microbiota-metabolite axis. play a dominant role CCFM405-associated neuroprotection mice. could be utilized food supplement management

Language: Английский

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Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(4), P. 833 - 845

Published: Aug. 14, 2023

A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.

Language: Английский

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Associations between gut microbiota and Parkinson disease: A bidirectional Mendelian randomization analysis

European Journal of Neurology, Journal Year: 2023, Volume and Issue: 30(11), P. 3471 - 3477

Published: May 10, 2023

Parkinson disease (PD)-associated alterations in the gut microbiome have been observed clinical and animal studies. However, it remains unclear whether this association reflects a causal effect humans.We performed two-sample bidirectional Mendelian randomization using summary statistics from international consortium MiBioGen (N = 18,340), Framingham Heart Study 2076), International Parkinson's Disease Genomics Consortium for PD (33,674 cases 449,056 controls) age at onset (17,996 cases).Twelve microbiota features presented suggestive associations with risk or onset. Genetically increased Bifidobacterium levels correlated decreased (odds ratio 0.77, 95% confidence interval [CI] 0.60-0.99, p 0.040). Conversely, high of five short-chain fatty acid (SCFA)-producing bacteria (LachnospiraceaeUCG010, RuminococcaceaeUCG002, Clostridium sensustricto1, Eubacterium hallii group, Bacillales) risk, three SCFA-producing (Roseburia, Erysipelatoclostridium) an earlier Gut production serotonin was associated (beta -0.64, CI -1.15 to -0.13, 0.013). In reverse direction, genetic predisposition related altered composition.These results support relationship between dysbiosis PD, highlight role elevated endogenous SCFAs pathogenesis. Future studies experimental evidence are needed explain suggest new therapeutic approaches, such as dietary probiotic supplementation.

Language: Английский

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Gut microbiota bridges the iron homeostasis and host health

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(9), P. 1952 - 1975

Published: July 27, 2023

Language: Английский

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Sodium butyrate ameliorates gut dysfunction and motor deficits in a mouse model of Parkinson’s disease by regulating gut microbiota

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Jan. 25, 2023

A growing body of evidence showed that gut microbiota dysbiosis might be associated with the pathogenesis Parkinson's disease (PD). Microbiota-targeted interventions could play a protective role in PD by regulating microbiota-gut-brain axis. Sodium butyrate (NaB) improve and other neuropsychiatric disorders. However, potential mechanism complex interaction between NaB communication needs further investigation.C57BL/6 mice were subjected to rotenone-induced model treated intragastrically for 4 weeks. The function motor evaluated. α-synuclein expression colon substantia nigra detected western blotting. Tyrosine hydroxylase (TH)-positive neurons measured immunofluorescence. Moreover, composition was analyzed 16S rRNA sequencing. Fecal short chain fatty acids (SCFAs) levels determined liquid chromatography tandem mass spectrometry (LC-MS). glucagon like peptide-1 (GLP-1) tissues serum evaluated using enzyme-linked immunosorbent assay (ELISA).NaB ameliorated dysfunction deficits mice. Meanwhile, protected against nigra, prevented loss TH-positive neurons. In addition, remodel composition, regulate SCFAs metabolism, restore GLP-1 colon, serum, mice.NaB ameliorate mice, regulation dysbiosis.

Language: Английский

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The gut microbiota–brain axis in neurological disorders

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Language: Английский

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Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 238 - 238

Published: Feb. 29, 2024

Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson’s disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to unknown. To answer this question, mice received MPTP intraperitoneally construct subacute model and were then supplemented with orally 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, neurogenesis examined. In addition, intestinal inflammation, serum fecal short-chain fatty acids (SCFAs) analyses, assessed. We found treatment effectively inhibited reduction neurons substantia nigra pars compacta (SNpc) partially improved motor function mice. Additionally, markedly alleviated neuroinflammation striatum hippocampus promoted hippocampal neurogenesis. It also level colon inflammation. Furthermore, these aforementioned changes are mainly accompanied by alterations isovaleric acid levels, lower permeability. strongly neuroprotective agent therapy.

Language: Английский

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Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway

Environment International, Journal Year: 2024, Volume and Issue: 184, P. 108479 - 108479

Published: Feb. 1, 2024

Lead is an environmentally widespread neurotoxic pollutant. Although the neurotoxicity of lead has been found to be closely associated with metabolic disorders, effects short-chain fatty acids on and its mechanisms have not yet explored. In this study, results open field tests Morris water maze demonstrated that chronic exposure caused learning memory deficits anxiety-like symptoms in mice. The serum butyric acid content lead-treated mice decreased a dose-dependent manner, oral administration butyrate significantly improved cognitive impairment anxiety lead-exposed Moreover, alleviated neuroinflammation by inhibiting STAT3 signaling microglia. Butyrate also promoted expression acetyl-CoA synthetase ACSS2 hippocampal neurons, thereby increasing restoring both histone H3K9ac downstream BDNF. We median concentration high-lead humans was remarkably lower than low-lead (45.16 μg/L vs. 60.92 μg/L, P < 0.01), mediated relationship Montreal assessment scores, contribution rate 27.57%. conclusion, our suggest supplementation possible therapeutic strategy for lead-induced neurotoxicity.

Language: Английский

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Good girl goes bad: Understanding how gut commensals cause disease

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 190, P. 106617 - 106617

Published: March 16, 2024

Language: Английский

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Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 21, 2024

Abstract We aimed to identify gut microbial features in Parkinson’s disease (PD) across countries by meta-analyzing our fecal shotgun sequencing dataset of 94 PD patients and 73 controls Japan with five previously reported datasets from USA, Germany, China1, China2, Taiwan. GC-MS LC-MS/MS assays were established quantify short-chain fatty acids (SCFAs) polyamines, respectively. α-Diversity was increased six datasets. Taxonomic analysis showed that species Akkermansia muciniphila PD, while Roseburia intestinalis Faecalibacterium prausnitzii decreased PD. Pathway genes the biosyntheses riboflavin biotin markedly after adjusting for confounding factors. Five out categories carbohydrate-active enzymes (CAZymes) Metabolomic samples revealed SCFAs polyamines significantly Genes positively correlated concentrations polyamines. Bacteria accounted biosynthesis Japan, Germany different those Similarly, bacteria two country groups. postulate reduce intestinal mucus layer, which subsequently facilitates formation abnormal α-synuclein fibrils neural plexus also cause neuroinflammation

Language: Английский

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