Journal of Infectious Diseases and Epidemiology,
Journal Year:
2021,
Volume and Issue:
7(4)
Published: April 30, 2021
Coronavirus
infectious
disease
2019
(COVID-19)
pandemic
is
a
global
public
health
issue
due
to
new
coronavirus
called
severe
acute
respiratory
syndrome
virus
2
(SARS-Cov-2).
It
very
contagious
with
often
benign
symptoms.
However,
some
patients
present
clinical
signs
and
are
more
at
risk
die.
The
aim
of
this
study
was
assess
the
factors
associated
COVID-19
in
an
Epidemic
Treatment
Center
(ETC)
Dakar,
Senegal.
Frontiers in Molecular Biosciences,
Journal Year:
2021,
Volume and Issue:
8
Published: July 23, 2021
The
worldwide
pandemic
of
COVID-19
has
become
a
global
public
health
crisis.
Various
clinical
diagnosis
methods
have
been
developed
to
distinguish
COVID-19–infected
patients
from
healthy
people.
nucleic
acid
test
is
the
golden
standard
for
virus
detection
as
it
suitable
early
diagnosis.
However,
due
low
amount
viral
in
respiratory
tract,
sensitivity
unsatisfactory.
As
result,
serological
screening
began
be
widely
used
with
merits
simple
procedures,
lower
cost,
and
shorter
time.
Serological
tests
currently
include
enzyme-linked
immunosorbent
assay
(ELISA),
lateral
flow
immunoassay
(LFIA),
chemiluminescence
(CLIA).
This
review
describes
various
methods,
discusses
performance
diagnostic
effects
different
points
out
problems
direction
optimization,
improve
efficiency
These
increasingly
sophisticated
diverse
technologies
will
help
human
beings
control
spread
COVID-19.
Small Methods,
Journal Year:
2021,
Volume and Issue:
5(9)
Published: July 28, 2021
In
recent
years,
the
main
quest
of
science
has
been
pioneering
groundbreaking
biomedical
strategies
needed
for
achieving
a
personalized
medicine.
Ribonucleic
acids
(RNAs)
are
outstanding
bioactive
macromolecules
identified
as
pivotal
actors
in
regulating
wide
range
biochemical
pathways.
The
ability
to
intimately
control
cell
fate
and
tissue
activities
makes
RNA-based
drugs
most
fascinating
family
agents.
However,
widespread
application
RNA
therapeutics
humans
is
still
challenging
feat,
due
both
instability
naked
presence
biological
barriers
aimed
at
hindering
entrance
into
cells.
Recently,
material
scientists'
enormous
efforts
have
led
development
various
classes
nanostructured
carriers
customized
overcome
these
limitations.
This
work
systematically
reviews
current
advances
developing
next
generation
based
on
nanotechnology-assisted
delivery.
features
used
molecules
presented,
together
with
properties
vehicles.
Also
provided
an
in-depth
overview
therapeutic
applications
presented
systems,
including
coronavirus
disease
vaccines
newest
trends
field.
Lastly,
emerging
challenges
future
perspectives
nanotechnology-mediated
therapies
discussed.
Current Opinion in Neurology,
Journal Year:
2022,
Volume and Issue:
35(3), P. 392 - 398
Published: March 11, 2022
Purpose
of
review
As
January
8,
2022,
a
global
pandemic
caused
by
infection
with
severe
acute
respiratory
syndrome
coronavirus
(SARS-CoV)-2,
new
RNA
virus,
has
resulted
in
304,896,785
cases
over
222
countries
and
regions,
5,500,683
deaths
(www.worldometers.info/coronavirus/).
Reports
neurological
psychiatric
symptoms
the
context
infectious
disease
2019
(COVID-19)
range
from
headache,
anosmia,
dysgeusia,
to
depression,
fatigue,
psychosis,
seizures,
delirium,
suicide,
meningitis,
encephalitis,
inflammatory
demyelination,
infarction,
hemorrhagic
necrotizing
encephalopathy.
Moreover,
30–50%
COVID-19
survivors
develop
long-lasting
neurologic
symptoms,
including
dysexecutive
syndrome,
inattention
disorientation,
and/or
poor
movement
coordination.
Detection
SARS-CoV-2
within
central
nervous
system
(CNS)
patients
is
rare,
mechanisms
damage
ongoing
diseases
are
unknown.
However,
studies
demonstrating
viral
glycoprotein
effects
on
coagulation
cerebral
vasculature,
hypoxia-
cytokine-mediated
coagulopathy
CNS
immunopathology
suggest
both
virus-specific
neuroimmune
responses
may
be
involved.
This
explores
potential
mechanistic
insights
that
could
contribute
COVID-19-related
disease.
Recent
findings
While
development
during
rarely
associated
evidence
neuroinvasion,
suggests
Spike
(S)
protein
exhibits
direct
pro-coagulation
effects.
This,
conjunction
immune
dysregulation
resulting
cytokine
release
(CRS)
result
cerebrovascular
or
neuroinflammatory
diseases.
Additionally,
CRS-mediated
loss
blood-brain
barrier
integrity
specific
brain
regions
expression
proinflammatory
mediators
neural
cells
impact
function
long
after
resolution
infection.
Importantly,
host
co-morbid
affect
vascular,
pulmonary,
type
triggered
SARS-COV-2
Summary
Distinct
S
compartment-
region-specific
CRS
underlie
chronic
COVID-19.
Journal of Fungi,
Journal Year:
2022,
Volume and Issue:
8(5), P. 445 - 445
Published: April 25, 2022
The
ongoing
COVID-19
pandemic
has
quickly
become
a
health
threat
worldwide,
with
high
mortality
and
morbidity
among
patients
comorbidities.
This
viral
infection
promotes
the
perfect
setting
in
for
development
of
opportunistic
infections,
such
as
those
caused
by
fungi.
Mucormycosis,
rare
but
deadly
fungal
infection,
recently
increased
its
incidence,
especially
endemic
areas,
since
onset
pandemic.
COVID-19-associated
mucormycosis
is
an
important
complication
because
it
mycosis
hard
to
diagnose
treat,
causing
concern
COVID-19-infected
even
already
recovered
population.
risk
factors
these
are
related
damage
SARS-CoV-2
itself,
patient’s
overstimulated
immune
response,
therapy
used
treat
COVID-19,
alterations
hyperglycemia,
acidosis,
endothelial
lung
damage,
immunosuppression.
In
this
review,
molecular
aspects
main
explained
understand
virus–fungi–host
interaction
highlight
importance
neglected
mycosis.
Pharmacological Reviews,
Journal Year:
2023,
Volume and Issue:
76(1), P. 142 - 193
Published: Nov. 8, 2023
The
neutral
amino
acid
transporter
subfamily
that
consists
of
six
members,
consecutively
SLC6A15–SLC620,
also
called
orphan
transporters,
represents
membrane,
sodium-dependent
symporter
proteins
belong
to
the
family
solute
carrier
6
(SLC6).
Primarily,
they
mediate
transport
acids
from
extracellular
milieu
toward
cell
or
storage
vesicles
utilizing
an
electric
membrane
potential
as
driving
force.
Orphan
transporters
are
widely
distributed
throughout
body,
covering
many
systems;
for
instance,
central
nervous,
renal,
intestinal
system,
supplying
cells
into
molecules
used
in
biochemical,
signaling,
and
building
pathways
afterward.
They
responsible
absorption
renal
reabsorption
acids.
In
nervous
constitute
a
significant
medium
provision
neurotransmitter
precursors.
Diseases
related
with
aforementioned
highlight
their
significance;
SLC6A19
mutations
associated
metabolic
Hartnup
disorder,
whereas
altered
expression
SLC6A15
has
been
depression/stress-related
disorders.
Mutations
SLC6A18-SLCA20
cause
iminoglycinuria
and/or
hyperglycinuria.
SLC6A18-SLC6A20
reach
cellular
require
ancillary
unit
ACE2
is
molecular
target
spike
protein
SARS-CoV-2
virus.
proposed
treatment
disorders
resembling
gastric
surgery
bypass.
Inhibition
appears
have
promising
outcome
psychiatric
SLC6A20
suggested
targets
COVID-19.
this
review,
we
gathered
recent
advances
on
structure,
functions,
disorders,
diseases,
particular
relevance
therapeutic
targets.
Significance
Statement
following
review
systematizes
current
knowledge
about
SLC6A15-SLCA20
different
diseases.
The
spike
(S)
polypeptide
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
consists
the
S1
and
S2
subunits
is
processed
by
cellular
proteases
at
S1/S2
boundary
that
contains
a
furin
cleavage
site
(FCS),
