Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(32), P. 16095 - 16104

Published: July 24, 2019

Significance Prevalence and temporal dynamics of transient oscillations in the beta frequency band (15 to 35 Hz), referred as β bursts, are correlated with motor performance. Disturbance these activities is a candidate mechanism for impairment Parkinson’s disease (PD), where excessively long bursts correlate symptom severity reduced by pharmacological surgical treatments. Here we describe changes action potential firing that take place across multiple nodes cortical basal ganglia circuit evolve. These analyses provide fresh insights into network can guide novel strategies interfere their generation maintenance PD.

Language: Английский

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Cortical representation of group social communication in bats

Science, Journal Year: 2021, Volume and Issue: 374(6566)

Published: Oct. 22, 2021

Social interactions occur in group settings and are mediated by communication signals that exchanged between individuals, often using vocalizations. The neural representation of social remains largely unexplored. We conducted simultaneous wireless electrophysiological recordings from the frontal cortices groups Egyptian fruit bats engaged both spontaneous task-induced vocal interactions. found activity single neurons distinguished vocalizations produced self others, as well among specific individuals. Coordinated members exhibited stable bidirectional interbrain correlation patterns to communicative Tracking spatial arrangements within a revealed relationship preferences intra- patterns. Combined, these findings reveal dedicated repertoire for across brains freely communicating bats.

Language: Английский

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Distributed cell assemblies spanning prefrontal cortex and striatum

Current Biology, Journal Year: 2021, Volume and Issue: 32(1), P. 1 - 13.e6

Published: Oct. 25, 2021

Highly synchronous neuronal assembly activity is deemed essential for cognitive brain function. In theory, such synchrony could coordinate multiple areas performing complementary processes. However, cell assemblies have been observed only in single structures, typically cortical areas, and little known about their with downstream subcortical as the striatum. Here, we demonstrate distributed activated at high (∼10 ms) spanning prefrontal cortex addition to including neurons different hierarchical levels, surprisingly, they synchronized functionally distinct limbic associative sub-regions. These activations occurred when members shifted firing phase relative ongoing 4 Hz theta rhythms, association gamma oscillations. This suggests that these rhythms mediate emergence of cross-structural assemblies. To test role behavior, trained rats perform a task requiring flexibility, alternating between two rules T-maze. Overall, were correlated task-relevant parameters, impending choice, reward, rule, or rule order. Moreover, behavioral correlates more robustly expressed by than individual member neurons. Finally, verify whether can be endogenously generated, found indeed spontaneously reactivated during sleep quiet immobility. Thus, are general coding mechanism previously envisioned, linking neocortical synchrony.

Language: Английский

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Filtering properties of Hodgkin–Huxley neuron on different time-scale signals

Communications in Nonlinear Science and Numerical Simulation, Journal Year: 2022, Volume and Issue: 117, P. 106894 - 106894

Published: Sept. 20, 2022

Language: Английский

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Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(19)

Published: May 2, 2022

Significance Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is highly effective for treating motor symptoms of Parkinson’s disease (PD). However, neural mechanisms by which DBS acts are unknown. PD tied to altered rhythms basal ganglia (BG) and particularly striatum. We develop a biophysical model BG pathway show how beta oscillations can emerge throughout PD. then establish mechanism STN interrupt these abnormal restore brain’s capability produce regulate normal lost with dopamine depletion. Our research suggests leverage striatal gamma theta counter aberrant dynamics enhance therapeutic effects DBS.

Language: Английский

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Echolocation-related reversal of information flow in a cortical vocalization network

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 25, 2022

Abstract The mammalian frontal and auditory cortices are important for vocal behavior. Here, using local-field potential recordings, we demonstrate that the timing spatial patterns of oscillations in fronto-auditory network vocalizing bats ( Carollia perspicillata ) predict purpose vocalization: echolocation or communication. Transfer entropy analyses revealed predominant top-down (frontal-to-auditory cortex) information flow during spontaneous activity pre-vocal periods. dynamics depend on behavioral role vocalization relative to onset. We observed emergence bottom-up (auditory-to-frontal) transfer post-vocal period specific pulse emission, leading self-directed acoustic feedback. Electrical stimulation areas selectively enhanced responses sounds cortex. These results reveal unique changes across sensory cortices, potentially driven by a highly model.

Language: Английский

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Proposing a neural framework for the evolution of elaborate courtship displays

eLife, Journal Year: 2022, Volume and Issue: 11

Published: May 27, 2022

In many vertebrates, courtship occurs through the performance of elaborate behavioral displays that are as spectacular they complex. The question how sexual selection acts upon these animals' neuromuscular systems to transform a repertoire pre-existing movements into such remarkable (if not unusual) display routines has received relatively little research attention. This is surprising gap in knowledge, given unraveling this extraordinary process central understanding evolution diversity and its neural control. often push limits performance, ritualized manner. These can range from songs require rapid switching between two independently controlled 'voice boxes' precisely choreographed acrobatics. Here, we propose framework for thinking about brain might only control displays, but also shape their evolution. Our focuses specifically on major midbrain area, which view likely important node orchestration complex behavior used process. area periaqueductal grey (PAG), studies suggest it both necessary sufficient production instinctive survival behaviors, including vocalizations. Thus, speculate why PAG, well key inputs, serve targets behavior. doing so, attempt combine core ideas with principles intent spur bring together neurobiologists ecologists more fully understand role play innovation diversification.

Language: Английский

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Oscillatory Waveform Shape and Temporal Spike Correlations Differ across Bat Frontal and Auditory Cortex

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(10), P. e1236232023 - e1236232023

Published: Jan. 23, 2024

Neural oscillations are associated with diverse computations in the mammalian brain. The waveform shape of oscillatory activity measured cortex relates to local physiology and can be informative about aberrant or dynamically changing states. However, how differs across distant yet functionally anatomically related cortical regions is largely unknown. In this study, we capitalize on simultaneous recordings field potentials (LFPs) auditory frontal cortices awake, male

Language: Английский

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Acoustic Context Modulates Natural Sound Discrimination in Auditory Cortex through Frequency-Specific Adaptation

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(50), P. 10261 - 10277

Published: Nov. 8, 2021

Sound discrimination is essential in many species for communicating and foraging. Bats, example, use sounds echolocation communication. In the bat auditory cortex there are neurons that process both sound categories, but how these respond to acoustic transitions, is, streams followed by a communication sound, remains unknown. Here, we show context, leading sequence target changes neuronal discriminability of versus calls awake bats sexes. Nonselective fire equally well absence context become category selective when present. On contrary, prefer turn into nonselective ones added. The presence leads an overall response suppression, strength this suppression stimulus specific. Suppression strongest belong same category, e.g.,echolocation echolocation. A neuron model stimulus-specific adaptation replicated our results silico . predicts selectivity inputs arriving cortex, as two forms adaptation, presynaptic frequency-specific acting cortical stimulus-unspecific postsynaptic adaptation. addition, predicted effects can last up 1.5 s after offset synaptic tuned low-frequency (communication signals) have shortest decay constant SIGNIFICANCE STATEMENT We studied responses isolated call mixtures (1) populations coexist including discriminate social from driven ethologically different types; (2) (i.e., other natural preceding sound) affects manner could not be based on sounds; (3) computational similar those used explaining rodents account observed sounds. This depends segregated feedforward inputs, depression,

Language: Английский

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Cerebellar activity predicts vocalization in fruit bats

Current Biology, Journal Year: 2024, Volume and Issue: 34(21), P. 5112 - 5119.e3

Published: Oct. 9, 2024

Echolocating bats exhibit remarkable auditory behaviors, enabled by adaptations both within and outside their system. Yet research on echolocating has focused mostly brain areas that belong to the classic ascending pathway. This study provides direct evidence linking cerebellum, an evolutionarily ancient non-classic structure, vocalization hearing. We report in fruit-eating bat Carollia perspicillata, external sounds can evoke cerebellar responses with latencies below 20 ms. Such fast are indicative of early inputs cerebellum. After establishing as a good model responses, we searched for neural correlate vocal production investigated spike trains field potentials occurring before after found type sound produced (echolocation pulses or communication calls) be decoded from pre-vocal post-vocal signals, prediction accuracies reach above 85%. The latter motor-coordination structure lies Taken together, our findings provide specializations hearing cerebellum specialist.

Language: Английский

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