The Journal of Infectious Diseases,
Journal Year:
2021,
Volume and Issue:
225(5), P. 793 - 799
Published: Nov. 30, 2021
Abstract
Background
The
Delta
variant
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
was
the
predominant
worldwide
at
time
this
study.
However,
its
transmission
dynamics
were
unclear.
Methods
We
analyzed
405
local
cases
infected
with
SARS-CoV-2
and
temporal
patterns
viral
shedding
identified
between
22
June
31
July
2021
in
Daejeon,
South
Korea.
Results
Overall,
20%
presymptomatic
epidemiological
investigation.
6
clustered
outbreaks,
all
associated
indoor
facilities.
In
23
household
contacts,
secondary
attack
rate
63%.
estimated
mean
serial
interval
as
3.26
days
(95%
credible
interval,
2.92–3.60),
15%
confidence
13%–18%)
seeded
80%
transmission.
Analysis
nasopharyngeal
swab
samples
virus
from
highest
load
observed
after
symptom
onset.
Conclusions
Our
findings
suggest
that
is
highly
transmissible
settings
households.
Rapid
contact
tracing,
isolation
asymptomatic
strict
adherence
to
public
health
measures,
increased
uptake
disease
2019
(COVID-19)
vaccination,
including
booster
doses,
are
needed
reduce
community
variant.
Science,
Journal Year:
2020,
Volume and Issue:
370(6518), P. 811 - 818
Published: Sept. 21, 2020
The
future
trajectory
of
the
coronavirus
disease
2019
(COVID-19)
pandemic
hinges
on
dynamics
adaptive
immunity
against
severe
acute
respiratory
syndrome
2
(SARS-CoV-2);
however,
salient
features
immune
response
elicited
by
natural
infection
or
vaccination
are
still
uncertain.
We
use
simple
epidemiological
models
to
explore
estimates
for
magnitude
and
timing
COVID-19
cases,
given
different
assumptions
regarding
protective
efficacy
duration
SARS-CoV-2,
as
well
its
interaction
with
vaccines
nonpharmaceutical
interventions.
find
that
variations
in
primary
SARS-CoV-2
infections
a
potential
vaccine
can
lead
markedly
landscapes
burdens
critically
ranging
from
sustained
epidemics
near
elimination.
Our
findings
illustrate
likely
complexities
highlight
importance
immunological
characterization
beyond
measurement
active
adequately
projecting
landscape
generated
infections.
Proceedings of the National Academy of Sciences,
Journal Year:
2020,
Volume and Issue:
117(51), P. 32764 - 32771
Published: Dec. 1, 2020
Significance
In
contrast
to
predictions
of
conventional
epidemic
models,
COVID-19
outbreak
time
series
have
highly
asymmetric
shapes,
with
cases
and
fatalities
declining
much
more
slowly
than
they
rose.
Here,
we
investigate
how
awareness-driven
behavior
modulates
shape.
We
find
that
short-term
awareness
leads
emergent
plateaus,
persistent
shoulder-like
dynamics,
lag-driven
oscillations
in
an
SEIR-like
model.
However,
a
joint
analysis
mobility
data
suggests
populations
relaxed
restrictions
prior
fatality
peaks,
model
predictions.
show
incorporating
fatigue
long-term
change
can
explain
this
phenomenon,
shed
light
on
when
post-peak
dynamics
are
likely
lead
resurgence
or
sustained
declines,
inform
public
health
campaigns
control
COVID-19.
BMC Infectious Diseases,
Journal Year:
2021,
Volume and Issue:
21(1)
Published: July 27, 2021
Scientists
across
disciplines,
policymakers,
and
journalists
have
voiced
frustration
at
the
unprecedented
polarization
misinformation
around
coronavirus
disease
2019
(COVID-19)
pandemic.
Several
false
dichotomies
been
used
to
polarize
debates
while
oversimplifying
complex
issues.
In
this
comprehensive
narrative
review,
we
deconstruct
six
common
COVID-19
dichotomies,
address
evidence
on
these
topics,
identify
insights
relevant
effective
pandemic
responses,
highlight
knowledge
gaps
uncertainties.
The
topics
of
review
are:
1)
Health
lives
vs.
economy
livelihoods,
2)
Indefinite
lockdown
unlimited
reopening,
3)
Symptomatic
asymptomatic
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection,
4)
Droplet
aerosol
transmission
SARS-CoV-2,
5)
Masks
for
all
no
masking,
6)
SARS-CoV-2
reinfection
reinfection.
We
discuss
importance
multidisciplinary
integration
(health,
social,
physical
sciences),
multilayered
approaches
reducing
risk
("Emmentaler
cheese
model"),
harm
reduction,
smart
relaxation
interventions,
context-sensitive
policymaking
response
plans.
also
challenges
in
understanding
broad
clinical
presentation
COVID-19,
transmission,
These
key
issues
science
public
health
policy
presented
as
during
However,
they
are
hardly
binary,
simple,
or
uniform,
therefore
should
not
be
framed
polar
extremes.
urge
a
nuanced
caution
against
black-or-white
messaging,
all-or-nothing
guidance,
one-size-fits-all
approaches.
There
is
need
meaningful
communication
science-informed
policies
that
recognize
shades
gray,
uncertainties,
local
context,
social
determinants
health.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 7, 2025
Abstract
New
and
more
transmissible
variants
of
SARS-CoV-2
have
arisen
multiple
times
over
the
course
pandemic.
Rapidly
identifying
mutations
that
affect
transmission
could
improve
our
understanding
viral
biology
highlight
new
warrant
further
study.
Here
we
develop
a
generic,
analytical
epidemiological
model
to
infer
effects
from
genomic
surveillance
data.
Applying
data
across
many
regions,
find
substantially
rate,
both
within
outside
Spike
protein.
The
largest
on
are
strongly
supported
by
experimental
evidence
prior
studies.
Importantly,
detects
lineages
with
increased
even
at
low
frequencies.
As
an
example,
significant
advantages
for
Alpha,
Delta,
Omicron
shortly
after
their
appearances
in
regional
data,
when
they
comprised
only
around
1-2%
sample
sequences.
Our
thus
facilitates
rapid
identification
