Persistent COVID-19 symptoms in a community study of 606,434 people in England

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 12, 2022

Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3-5 the REACT-2 study (n = 508,707; September 2020 - February 2021), representative community survey adults in England, replication round 6 97,717; May 2021) to estimate identify predictors persistent symptoms lasting 12 weeks or more; unsupervised learning cluster individuals by reported symptoms. At 3-5, 37.7% experienced at least one symptom, falling 21.6% 6. Female sex, increasing age, obesity, smoking, vaping, hospitalisation COVID-19, deprivation, being healthcare worker are associated higher probability Asian ethnicity lower probability. Clustering analysis identifies subset participants predominantly respiratory Managing long-term sequelae COVID-19 will remain major challenge for affected their families health services.

Language: Английский

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Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 11, 2022

Abstract Infection with SARS-CoV-2 virus is associated a wide range of symptoms. The REal-time Assessment Community Transmission − 1 (REACT-1) study monitored the spread and clinical manifestation among random samples population in England from May 2020 to 31 March 2022. We show changing symptom profiles different variants over that period, lower reporting loss sense smell or taste for Omicron compared previous variants, higher cold-like influenza-like symptoms, controlling vaccination status. Contrary perception recent have become successively milder, BA.2 was more greater disruption daily activities, than BA.1. With restrictions lifted routine testing limited many countries, monitoring infection effects on activities will increasingly important.

Language: Английский

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Key Challenges for Respiratory Virus Surveillance while Transitioning out of Acute Phase of COVID-19 Pandemic

Emerging infectious diseases, Journal Year: 2024, Volume and Issue: 30(2)

Published: Jan. 12, 2024

Abstract To support the ongoing management of viral respiratory diseases while transitioning out acute phase COVID-19 pandemic, many countries are moving toward an integrated model surveillance for SARS-CoV-2, influenza virus, and other pathogens. Although approaches catalyzed by pandemic provide novel epidemiologic insight, continuing them as implemented during is unlikely to be feasible nonemergency surveillance, have already been scaled back. Furthermore, given anticipated cocirculation SARS-CoV-2 activities in place before require review adjustment ensure their value public health. In this report, we highlight key challenges development models surveillance. We discuss relative strengths limitations different practices studies well contribution assessment, forecasting, health decision-making.

Language: Английский

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Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

BMJ, Journal Year: 2021, Volume and Issue: unknown, P. n628 - n628

Published: March 18, 2021

Abstract Objective To investigate whether risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outcomes disease 2019 (covid-19) differed between adults living without children during the first two waves UK pandemic. Design Population based cohort study, on behalf NHS England. Setting Primary care data pseudonymously linked hospital intensive admissions death records from England, wave 1 (1 February to 31 August 2020) September 18 December 2020). Participants Two cohorts (18 years over) registered at a general practice 2020 2020. Main outcome measures Adjusted hazard ratios for SARS-CoV-2 infection, covid-19 related admission or care, covid-19, by presence in household. Results Among 9 334 392 aged 65 under, 1, was not associated materially increased risks recorded admission, covid-19. In 2, among any age an (hazard ratio 1.06 (95% confidence interval 1.05 1.08) 0-11 years; 1.22 (1.20 1.24) 12-18 years) (1.18 (1.06 1.31) 0-11; 1.26 (1.12 1.40) 12-18). Living reduced both non-covid-19 causes waves; also lower dying causes. For under absolute having 40-60 per 10 000 people, 810 850 870, increase number 1-5 160 161 165. 160-190 infections 2-6 admissions. Conclusions contrast evidence existed reported 2. However, this did translate into mortality, increases were small.

Language: Английский

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Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes

Viruses, Journal Year: 2022, Volume and Issue: 14(11), P. 2367 - 2367

Published: Oct. 27, 2022

COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as “long-COVID” or “post-COVID-19” syndrome. Despite an increasing body literature, long COVID remains poorly characterized. We retrospectively analysed data from electronic medical records patients admitted the post-COVID-19 outpatient service Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 2021, 4–12 weeks after hospital discharge. A total 428 patients, 41% women, median age 64 years, underwent follow-up visit 53 days Overall, 76% reported at least one persistent symptom, including dyspnoea (37%), chronic fatigue (36%), insomnia (16%), visual disorders (13%) brain fog (13%). Increasing oxygen support (OR 1.4, 95% CI 1.1–1.8), use immunosuppressants 6.4, 1.5–28) female sex 1.8, 1.1–2.9) were higher risk symptoms. Comparison symptomatic infected in period March–December (prevalent circulation wild-type SARS-CoV-2) those January–April 2021 B.1.1.7 Alpha variant) showed significant modification pattern symptoms belonging neurological cognitive/emotional categories. Our findings confirmed shortness breath most frequent manifestations, while severe course main factors for developing lingering SARS-CoV-2 variants may induce different phenotypes, possibly due changes cell tropism differences viral–host interaction.

Language: Английский

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COVID-19 Symptoms and Duration of Rapid Antigen Test Positivity at a Community Testing and Surveillance Site During Pre-Delta, Delta, and Omicron BA.1 Periods

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(10), P. e2235844 - e2235844

Published: Oct. 10, 2022

Characterizing the clinical symptoms and evolution of community-based SARS-CoV-2 infections may inform health practitioners public officials in a rapidly changing landscape population immunity viral variants.To compare COVID-19 among people testing positive with rapid antigen test (RAT) during Omicron BA.1 variant period (December 1, 2021, to January 30, 2022) pre-Delta (January 10 May 31, 2021) Delta (June 1 November periods assess duration RAT positivity surge.This cross-sectional study was conducted from 10, 2022, at walk-up community site San Francisco, California. Participants included children adults seeking an RAT, regardless age, vaccine status, or symptoms.Fisher exact tests χ2 were used for vaccination status age group. Among returning repeated period, proportion between 4 14 days symptom onset since first if asymptomatic estimated.Among 63 277 persons tested (median [IQR] 32 [21-44] years, 12.0% younger than 12 years; 52.0% women; 68.5% Latinx), total 18 301 (28.9%) reported symptoms, whom 4565 (24.9%) COVID-19. During 3032 7283 symptomatic participants (41.6%) positive, numbers these reporting cough sore throat higher (cough: 2044 [67.4%] vs 546 [51.3%] 1065 participants, P < .001 pre-Delta, 281 [60.0%] 468 = .002, Delta; throat: 1316 [43.4%] 315 [29.6%] 136 [29.1%] .001, Delta). Compared patients results congestion more common (1177 [38.8%] 294 [27.6%] .001), loss taste smell (160 [5.3%] 183 [17.2%] .001) fever (921 [30.4%] 369 [34.7%] .01) less common. In addition, who had received booster compared those unvaccinated (97 [22.5%] 432 42 [36.2%] 116 .003), myalgia only primary series (fever: 97 559 [32.8%] 1705 .001; myalgia: 115 [26.6%] 580 [34.0%] .003). 5 after onset, 507 1613 (31.1%) stated that their similar, 95 (5.9%) worsening symptoms. 80.2% retested remained onset.In this study, upper respiratory tract commonly periods, differences by status. Rapid high supporting guidelines requiring negative length isolation period.

Language: Английский

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Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 28, 2022

Abstract The SARS-CoV-2 pandemic has been characterised by the regular emergence of genomic variants. With natural and vaccine-induced population immunity at high levels, evolutionary pressure favours variants better able to evade neutralising antibodies. Omicron variant (first detected in November 2021) exhibited a degree immune evasion, leading increased infection rates worldwide. However, estimates magnitude this wave have often relied on routine testing data, which are prone several biases. Using data from REal-time Assessment Community Transmission-1 (REACT-1) study, series cross-sectional surveys assessing prevalence England, we estimated dynamics England’s (from 9 September 2021 1 March 2022). We estimate an initial peak national 6.89% (5.34%, 10.61%) during January 2022, followed resurgence infections as more transmissible sub-lineage, BA.2 replaced BA.1 BA.1.1. Assuming further distinct variants, intermittent epidemics similar magnitudes may become ‘new normal’.

Language: Английский

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Research needs for optimising wastewater-based epidemiology monitoring for public health protection

Journal of Water and Health, Journal Year: 2022, Volume and Issue: 20(9), P. 1284 - 1313

Published: Aug. 12, 2022

Abstract Wastewater-based epidemiology (WBE) is an unobtrusive method used to observe patterns in illicit drug use, poliovirus, and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The pandemic need for surveillance measures have led the rapid acceleration of WBE research development globally. With infrastructure available monitor SARS-CoV-2 from wastewater 58 countries globally, there potential expand targets applications public health protection, such as other viral pathogens, antimicrobial resistance (AMR), pharmaceutical consumption, or exposure chemical pollutants. Some been explored academic but are not inform decision-making. We reflect on current knowledge these identify barriers opportunities expanding beyond SARS-CoV-2. This paper critically reviews identifies important gaps be a useful tool health. It considers possible uses pathogenic viruses, AMR, chemicals. summarises evidence following: (1) presence markers stool urine; (2) environmental factors influencing persistence wastewater; (3) methods sample collection storage; (4) prospective detection quantification; (5) reducing uncertainties; (6) further considerations use.

Language: Английский

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Variant-specific symptoms of COVID-19 among 1,542,510 people in England

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: May 23, 2022

Abstract Infection with SARS-CoV-2 virus is associated a wide range of symptoms. The REal-time Assessment Community Transmission -1 (REACT-1) study has been monitoring the spread and clinical manifestation among random samples population in England from 1 May 2020 to 31 March 2022. We show changing symptom profiles different variants over that period, lower reporting loss sense smell taste for Omicron compared previous variants, higher cold-like influenza-like symptoms, controlling vaccination status. Contrary perception recent have become successively milder, BA.2 was more greater disruption daily activities, than BA.1. With restrictions lifted routine testing limited many countries, infection induced changes activities will increasingly important.

Language: Английский

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The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 10, 2023

Abstract In late 2020, the JCVI (the Joint Committee on Vaccination and Immunisation, which provides advice to Department of Health Social Care, England) made two important recommendations for initial roll-out COVID-19 vaccine. The first was that vaccines should be targeted older vulnerable people, with aim maximally preventing disease rather than infection. second increase interval between doses from 3 12 weeks. Here, we re-examine these through a mathematical model SARS-CoV-2 infection in England. We show targeting most had biggest immediate impact (compared younger individuals who may more responsible transmission). 12-week delay also highly beneficial, estimated have averted 32-72 thousand hospital admissions 4-9 deaths over ten months campaign (December 2020–September 2021) depending assumed interaction dose efficacy.

Language: Английский

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