A review of the pharmaceutical exposome in aquatic fauna

Environmental Pollution, Journal Year: 2018, Volume and Issue: 239, P. 129 - 146

Published: April 10, 2018

Pharmaceuticals have been considered 'contaminants of emerging concern' for more than 20 years. In that time, many laboratory studies sought to identify hazard and assess risk in the aquatic environment, whilst field searched targeted candidates occurrence trends using advanced analytical techniques. However, a lack systematic approach detection quantification pharmaceuticals has provided fragmented literature serendipitous approaches. Evaluation extent plethora human veterinary available requires reliable measurement trace levels contaminants across different environmental compartments (water, sediment, biota - which largely neglected). The focus on pharmaceutical concentrations surface waters other exposure media therefore limited both characterisation exposome wildlife understanding cause effect relationships. Here, we compile current approaches accumulation data review state research field. Our analysis provides evidence support 'Matthew Effect' raises critical questions about use analyte lists biomonitoring. We provide six recommendations stimulate improve future avenues.

Language: Английский

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Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area

Journal of Hazardous Materials, Journal Year: 2017, Volume and Issue: 343, P. 140 - 148

Published: Sept. 11, 2017

Language: Английский

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Pharmacology beyond the patient – The environmental risks of human drugs

Environment International, Journal Year: 2019, Volume and Issue: 129, P. 320 - 332

Published: May 28, 2019

The presence of pharmaceuticals in the environment is a growing global concern and although environmental risk assessment required for approval new drugs Europe USA, adequacy current triggers effects-based assessments has been questioned. To provide comprehensive analysis all regulatory compliant aquatic ecotoxicity data evaluate to facilitate development more efficient approaches toxicity testing. Publicly-available targeting human proteins was compiled together with pharmacological information including drug targets, Cmax lipophilicity. Possible links between these factors effects on, growth, mortality and/or reproduction, were evaluated. risks then assessed based on combined predicted concentrations European patient consumption data. For most (88%) 975 approved small molecule complete set public domain lacking, highlighting need both intelligent prioritize legacy tailored transparent database that captures We show presence/absence drug-target orthologues are predictive susceptible species potent drugs. Drugs target endocrine system represent highest potency greatest risk. However, (>80%) full data, quotients assuming worst-case exposure below one countries indicating low endpoints assessed. believe presented can guide improvements testing procedures, valuable prioritising (i.e. those registered before 2006) further where possible (e.g. behaviour) not captured tests, additional mechanistic may be confidence avoiding impacts.

Language: Английский

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(Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 795, P. 148776 - 148776

Published: July 1, 2021

Monitoring of chemicals in the aquatic environment by chemical analysis alone cannot completely assess and predict effects on species ecosystems. This is primarily because increasing number (unknown) stressors mixture present environment. In addition, ability ecological indices to identify underlying causing negative limited. Therefore, additional complementary methods are needed that can address biological a direct manner provide link exposure, i.e. (eco)toxicological tests. (Eco)toxicological tests defined as test systems expose components (cells, individuals, populations, communities) (environmental mixtures of) register effects. These measure responses at sub-organismal (biomarkers vitro bioassays), whole-organismal, population, or community level. We performed literature search obtain state-of-the-art overview ecotoxicological available for assessing impacts biota reveal datagaps. total, we included 509 biomarkers, 207 bioassays, 422 measuring whole-organismal level, 78 population- community- ecosystem-level. Tests level biomarkers were most abundant invertebrates fish, whilst bioassays mostly based mammalian cell lines. ecosystem-level almost missing organisms other than microorganisms algae. an various extrapolation challenges faced using data from these suggest some forward looking perspectives. Although extrapolating measured relevant protection goals remains challenging, combination experiments models key more comprehensive assessment

Language: Английский

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Photocatalytic degradation of tetracycline in aqueous systems under visible light irridiation using needle-like SnO2 nanoparticles anchored on exfoliated g-C3N4

Environmental Sciences Europe, Journal Year: 2022, Volume and Issue: 34(1)

Published: Jan. 10, 2022

Abstract Background Pharmaceuticals is one of the groups contaminants emerging concern that are resistant to decomposition or removal by most existing water and wastewater treatment procedures, hence need develop techniques facilitate removals this group organic from systems. In study, needle-like SnO 2 nanoparticles was synthesised loaded on exfoliated g-C 3 N 4 nanosheet through a hydrothermal method, for use as sensitive visible light induce-photocatalyst tetracycline in aqueous The composites characterized analysed nature heterojunction between nanoparticle using microscopic spectroscopic techniques. Results were improved surface properties enhanced visible-light absorption. /g-C nanocomposites with various amounts (10–50 mg), employed degradation under irradiation, good efficiency. efficiencies 1 wt.%, wt.% 5 photocatalyst 81.54%, 90.57%, 95.90% 92.15% compared 40.92% 51.32% efficiencies. synergistic interaction promoted separation photogenerated electron holes pairs, which their migration rate SnO2 g-C3N4 heterojunction, thereby facilitating tetracycline. · O − noted be major reactive species photocatalytic nanocomposite. Conclusion fabricated anchored showed performance water, possible application other pharmaceuticals having same moiety (similar chemical structures).

Language: Английский

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Uptake and Tissue Distribution of Pharmaceuticals and Personal Care Products in Wild Fish from Treated-Wastewater-Impacted Streams

Environmental Science & Technology, Journal Year: 2015, Volume and Issue: 49(19), P. 11649 - 11658

Published: Sept. 8, 2015

A fish plasma model (FPM) has been proposed as a screening technique to prioritize potential hazardous pharmaceuticals wild fish. However, this approach does not account for inter- or intraspecies variability of pharmacokinetic and pharmacodynamic parameters. The present study elucidated the uptake potency (from ambient water), tissue distribution, biological risk 20 pharmaceutical personal care product (PPCP) residues in cyprinoid inhabiting treated-wastewater-impacted streams. In order clarify uncertainty FPM PPCPs, we compared bioaccumulation factor field (BAFplasma = measured plasma/ambient water concentration ratio) with predicted bioconcentration (BCFplasma by use theoretical partition coefficients/ambient actual environment. As result, maximum BAFplasma inflammatory agents was up 17 times higher than BCFplasma values, leading possible underestimation toxicological on When tissue–blood coefficients (tissue/blood ratios) PPCPs were estimated, transportability into tissues, especially brain, found psychotropic agents, but brain/plasma ratios widely varied among individual (up 28-fold). study, provide valuable data set PPCP pharmacokinetics, our results emphasize importance determining concentrations target organs well blood assess

Language: Английский

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Determination of a broad spectrum of pharmaceuticals and endocrine disruptors in biofilm from a waste water treatment plant-impacted river

The Science of The Total Environment, Journal Year: 2015, Volume and Issue: 540, P. 241 - 249

Published: June 15, 2015

Wastewater treatment plants (WWTPs) are one of the main sources pharmaceuticals and endocrine disrupting compounds in freshwater ecosystems, several studies have reported bioaccumulation these different organisms those ecosystems. River biofilms exceptional indicators pollution, but very few focused on accumulation emerging contaminants. The objectives this study were first to develop an efficient analytical methodology for simultaneous analysis 44 13 biofilm, second, assess persistence, distribution, contaminants natural inhabiting a WWTP-impacted river. method is based pressurized liquid extraction, purification by solid-phase ultra performance chromatography coupled mass spectrometer (UPLC-MS/MS) tandem. Recoveries 31-137%, disruptors 32-93%. Method detection limits range 0.2-2.4 ng g(-1), pharmaceuticals, 0.07-6.7 g(-1). A total five seven detected field samples at concentrations up 100

Language: Английский

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Fluoxetine and diazepam acutely modulate stress induced-behavior

Behavioural Brain Research, Journal Year: 2015, Volume and Issue: 296, P. 301 - 310

Published: Sept. 25, 2015

Language: Английский

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Global scanning of selective serotonin reuptake inhibitors: occurrence, wastewater treatment and hazards in aquatic systems

Environmental Pollution, Journal Year: 2019, Volume and Issue: 250, P. 1019 - 1031

Published: April 27, 2019

Language: Английский

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Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities

Environmental Toxicology and Chemistry, Journal Year: 2016, Volume and Issue: 36(4), P. 882 - 897

Published: Nov. 7, 2016

Abstract The objective of the present study was to review current knowledge regarding bioaccumulation potential ionizable organic compounds (IOCs), with a focus on availability empirical data for fish. Aspects IOCs in fish that can be characterized relatively well include pH dependence gill uptake and elimination, gut, sorption phospholipids (membrane–water partitioning). Key challenges lack biotransformation binding plasma. Fish possess diverse array proteins may transport across cell membranes. Except few cases, however, significance this accumulation environmental contaminants is unknown. Two case studies are presented. first describes modeled effects bioconcentration acids bases, while second employs an updated model investigate factors responsible perfluorinated alkyl acids. acid notable insofar as it illustrates likely importance membrane transporters kidney highlights value read‐across approaches. Recognizing need perform hazard assessments ecological exposure risk assessment IOCs, authors provide tiered strategy progresses (as needed) from conservative assumptions (models associated data) more sophisticated models requiring chemical‐specific information. Environ Toxicol Chem 2017;36:882–897. © 2016 SETAC

Language: Английский

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