medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Dec. 30, 2022
Abstract
Background
Multiple
sclerosis
(MS)
is
a
chronic
autoimmune
and
neuroinflammatory
disease
of
the
central
nervous
system
characterized
by
peripheral
activation
immune-inflammatory
pathways
which
culminate
in
neurotoxicity
causing
demyelination
neurons.
Nonetheless,
pathophysiology
relapsing-remitting
MS
(RRMS)-related
fatigue,
depression,
anxiety,
cognitive
impairments,
autonomic
disturbances
not
well
understood.
Objectives
The
current
study
aims
to
delineate
whether
remitted
phase
RRMS
accompanied
activated
if
latter,
coupled
with
erythron
variables,
explain
fatigue
mood
symptoms
due
RRMS.
Material
Methods
We
recruited
63
patients,
55
8
secondary
progressive
MS,
30
healthy
controls
assessed
variables
used
bio-plex
assay
measure
27
serum
cytokines.
Results
A
significant
part
patients
(46%)
displayed
response
(IRS)
compensatory
immune
(CIRS)
systems,
T
helper
(Th)1
Th-17
cytokine
profiles.
Remitted
showed
increased
physiosomatic,
autonomic,
insomnia
scores,
could
partly
be
explained
M1
macrophage,
Th1,
Th-17,
growth
factor,
CIRS
activation,
as
aberrations
including
lowered
hematocrit
hemoglobin
levels.
Conclusions
Around
50%
show
association
chronic-fatigue-like
symptoms.
IRS
are
new
drug
targets
treat
affective
MS.
Neuropsychiatric Disease and Treatment,
Journal Year:
2023,
Volume and Issue:
Volume 19, P. 1597 - 1604
Published: July 1, 2023
Accumulating
evidence
suggested
that
immune
system
activation
might
be
involved
in
the
pathophysiology
of
schizophrenia.
The
neutrophil/lymphocyte
ratio
(NLR),
monocyte/lymphocyte
(MLR),
platelet/lymphocyte
(PLR)
and
systemic
immune-inflammation
index
(SII)
can
measure
inflammation.
This
study
aimed
to
investigate
inflammatory
state
patients
with
schizophrenia
by
using
these
indicators.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(22), P. 15281 - 15281
Published: Nov. 18, 2022
Schizophrenia
patients
show
increased
disabilities
and
lower
quality
of
life
(DisQoL).
Nevertheless,
there
are
no
data
on
whether
the
activation
interleukin
(IL)-6,
IL-23,
T
helper
(Th)-17
axis,
magnesium
calcium
levels
impact
DisQoL
scores.
This
study
recruited
90
with
schizophrenia
(including
40
deficit
schizophrenia)
healthy
controls
assessed
World
Health
Association
QoL
instrument-Abbreviated
version
Sheehan
Disability
scale,
Brief
Assessment
Cognition
in
(BACS),
IL-6,
IL-17,
IL-21,
IL-22,
tumor
necrosis
factor
(TNF)-α,
calcium.
Regression
analyses
showed
that
a
large
part
first
extracted
from
physical,
psychological,
social
environmental
HR-QoL
interference
school/work,
life,
home
responsibilities
was
predicted
by
generalized
cognitive
deterioration
(G-CoDe)
index
(a
latent
vector
BACs
scores),
various
symptom
domains
(“symptomatome”),
whereas
biomarkers
had
effects.
Partial
Least
Squares
analysis
IL6IL23Th17
axis
magnesium/calcium
highly
significant
total
(indirect
+
direct)
effects
HR-QoL/disabilities,
which
were
mediated
G-CoDe
symptomatome
negative
positive
symptoms).
The
explained
63.1%
variance
behavioral-cognitive-psycho-social
(BCPS)
worsening
single
trait
G-CoDe,
symptomatome,
disability
data.
In
summary,
BCPS
is
partly
caused
neuroimmunotoxic
subjects
lowered
antioxidant
defenses
(magnesium
calcium),
thereby
probably
damaging
neuronal
circuits
may
underpin
schizophrenia.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(7), P. 1073 - 1073
Published: July 14, 2023
Multiple
sclerosis
(MS)
is
a
chronic
autoimmune
and
neuroinflammatory
disease
of
the
central
nervous
system
characterized
by
peripheral
activation
immune-inflammatory
pathways
which
culminate
in
neurotoxicity
causing
demyelination
neurons.
Nonetheless,
pathophysiology
relapsing-remitting
MS
(RRMS)-related
fatigue,
depression,
anxiety,
cognitive
impairments,
autonomic
disturbances
not
well
understood.The
current
study
aims
to
delineate
whether
remitted
phase
RRMS
accompanied
activated
if
latter,
coupled
with
erythron
variables,
explain
fatigue
mood
symptoms
due
RRMS.We
recruited
63
patients,
55
8
secondary
progressive
MS,
30
healthy
controls
assessed
used
bio-plex
assay
measure
27
serum
cytokines.A
significant
proportion
patients
(46%)
displayed
response
(IRS)
compensatory
immune
(CIRS)
systems,
T
helper
(Th)1
Th17
cytokine
profiles.
Remitted
showed
increased
physiosomatic,
autonomic,
insomnia
scores,
could
partly
be
explained
M1
macrophage,
Th1,
Th-17,
growth
factor,
CIRS
activation,
as
aberrations
including
lowered
hematocrit
hemoglobin
levels.Around
50%
show
association
chronic-fatigue-like
symptoms.
IRS
are
new
drug
targets
treat
affective
MS.
BMC Psychiatry,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 11, 2024
Major
psychotic
disorders
(MPD),
including
schizophrenia
(SCZ)
and
schizoaffective
disorder
(SAD),
are
severe
neuropsychiatric
conditions
with
unclear
causes.
Understanding
their
pathophysiology
is
essential
for
better
diagnosis,
treatment,
prognosis.
Recent
research
highlights
the
role
of
inflammation
immune
system,
particularly
Interleukin
17
(IL-17)
family,
in
these
disorders.
Elevated
IL-17
levels
have
been
found
MPD,
human
A
antibodies
available.
Changes
chemokine
levels,
such
as
CCL20,
also
noted
SCZ.
This
study
investigates
relationship
between
serum
CCL20
MPD
patients
clinical
characteristics.
We
conducted
a
case-control
at
Ibn
Sina
Psychiatric
Hospital
(Mashhad,
Iran)
2023.
The
involved
101
participants,
which
71
were
30
healthy
controls
(HC).
Positive
Negative
Symptom
Scale
(PANSS)
was
utilized
to
assess
symptoms
patients.
Serum
measured
using
Enzyme-Linked
Immunosorbent
Assay
(ELISA)
kits.
gathered
data
on
lipid
profiles
Fasting
Blood
Glucose
(FBS).
mean
age
41.04
±
9.93
years.
median
significantly
elevated
compared
HC
(5.8
(4.1–15.3)
pg/mL
4.2
(3–5)
pg/mL,
respectively;
p
<
0.001).
Furthermore,
showed
positive
correlation
severity
MPD.
had
higher
FBS,
cholesterol,
Low-Density
Lipoprotein
(LDL)
lower
High-Density
(HDL)
HC.
No
significant
PANSS
components
blood
IL17
CCL20.
current
revealed
that
than
those
control
group.
Metabolic
factors
HDL,
LDL
differences
In
conclusion,
findings
suggest
two
inflammatory
could
serve
potential
therapeutic
targets
prognostic
biomarkers
schizophrenia.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Relapsing-remitting
multiple
sclerosis
(RRMS)
is
defined
by
elevated
IgG/IgA/IgM
responses
targeting
Epstein-Barr
Virus
(EBV)
nuclear
antigen
1
(EBNA)
and
deoxyuridine-triphosphatases
(dUTPases)
of
Human
herpsesvirus-6
(HHV-6)
EBV.
These
suggest
that
the
viruses
are
being
replicated
reactivated.
An
increased
prevalence
chronic
fatigue
syndrome,
depression,
anxiety
associated
with
signs
immune
activation
in
RRMS.
Nevertheless,
there
a
lack
data
regarding
association
between
viral
reactivation
neuropsychiatric
symptoms
This
study
investigated
to
EBNA,
EBV
HHV-6-dUTPases,
58
remitted
RRMS
patients
63
normal
controls.
The
McDonald
criteria
were
employed
establish
diagnosis
MS.
Expanded
Disability
Status
Scale
(EDSS)
Multiple
Sclerosis
Severity
Score
evaluate
disabilities
caused
We
evaluated
scores
Hamilton
Depression
(HAMD)
Anxiety
(HAMA)
Rating
Scales,
Fibro-Fatigue
(FF)
scale.
One
latent
construct
was
extracted
from
EDSS,
MSSS,
FF,
HAMD,
HAMA
scores.
discovered
combined
effects
IgG
IgM-HHV-6-dUTPAses
accounted
for
63.7%
variance
this
construct.
Furthermore,
total
HAMA,
HAMD
substantially
IgM-HHV-6-dUTPAses,
accounting
approximately
38.7%
51.0%
variance.
three
rating
scale
also
significantly
correlated
IgA
reactivity
directed
both
dUTPases
EBNA.
replication
HHV-6
contributes
as
well
depression
due
Cells,
Journal Year:
2022,
Volume and Issue:
11(22), P. 3694 - 3694
Published: Nov. 21, 2022
Background:
a
significant
percentage
of
methamphetamine
(MA)
dependent
patients
develop
psychosis.
The
associations
between
oxidative
pathways
and
MA-induced
psychosis
(MIP)
are
not
well
delineated.
Objective:
the
aim
this
study
is
to
delineate
whether
acute
MA
intoxication
in
accompanied
by
increased
nitro-oxidative
stress
latter
associated
with
MIP.
Method:
we
recruited
30
healthy
younger
males
60
acutely
intoxicated
dependence
assessed
severity
use
psychotic
symptoms
during
intoxication,
serum
toxicity
(OSTOX)
biomarkers
including
oxidized
high
(oxHDL)
low
(oxLDL)-density
lipoprotein,
myeloperoxidase
(MPO),
malondialdehyde
(MDA),
nitric
oxide
(NO),
antioxidant
defenses
(ANTIOX)
HDL-cholesterol,
zinc,
glutathione
peroxidase
(GPx),
total
capacity
(TAC),
catalase-1.
Results:
large
part
(50%,
n
=
30)
could
be
allocated
cluster
characterized
ratings
delusions,
suspiciousness,
conceptual
disorganization
difficulties
abstract
thinking
an
OSTOX/ANTIOX
ratio.
Partial
Least
Squares
analysis
showed
that
29.9%
variance
MIP
(a
first
factor
extracted
from
psychosis,
hostility,
excitation,
mannerism,
formal
thought
disorder
scores)
was
explained
HDL,
TAC
zinc
(all
inversely)
oxLDL
(positively).
dosing
together
44.7%
Conclusions:
lowered
defenses,
both
which
increase
risk
intoxication.
atherogenicity
due
HDL
oxHDL.
Psychiatria Danubina,
Journal Year:
2023,
Volume and Issue:
35(1), P. 8 - 15
Published: April 13, 2023
Neural
cell-surface
autoantibody-associated
psychiatric
disease
and
a
subgroup
of
psychotic
disorders
are
probably
caused
by
an
immune
dysregulation
such
as
B-cell
related
autoantibody
production.In
this
review
we
describe
past
current
randomized
placebo-controlled
trials
investigating
monoclonal
antibodies
therapy
for
disorders,
aiming
to
delineate
the
landscape
in
well
perspectives
future
trials.Rituximab
ocrelizumab
now
being
tested
clinical
trials,
whereas
initial
results
on
tocilizumab
controversial,
they
demonstrated
cognitive-function
benefit
open
label
study
schizophrenic
patients
-results
that
were
not
replicated
trial.Adalinumab
TNFalpha
blockage
was
effective
treating
positive
negative
symptoms
schizophrenia.These
findings
demonstrate
antibody
is
potentially
promising
option
treat
subgroups
schizophrenia
patients,
but
it
should
be
investigated
more
placebo-controlled,
double-blind
with
large
cohorts.
