Sleep Loss and the Socio-Emotional Brain

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(6), P. 435 - 450

Published: April 14, 2020

Language: Английский

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Causal dynamics of sleep, circadian rhythm, and mood symptoms in patients with major depression and bipolar disorder: insights from longitudinal wearable device data

EBioMedicine, Journal Year: 2024, Volume and Issue: 103, P. 105094 - 105094

Published: April 4, 2024

Sleep and circadian rhythm disruptions are common in patients with mood disorders. The intricate relationship between these has been investigated, but their causal dynamics remain unknown.

Language: Английский

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The Effects of Light and the Circadian System on Rhythmic Brain Function

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2778 - 2778

Published: March 3, 2022

Life on earth has evolved under the influence of regularly recurring changes in environment, such as 24 h light/dark cycle. Consequently, organisms have developed endogenous clocks, generating (circadian) rhythms that serve to anticipate these rhythmic changes. In addition circadian rhythms, which persist constant conditions and can be entrained environmental light drives behavior brain function, especially nocturnal laboratory rodents. recent decades, research made great advances elucidation molecular clockwork perception. This review summarizes role clock with a focus complex interaction between different components mammalian system. Furthermore, chronodisruption consequence at night, genetic manipulation, neurodegenerative diseases is briefly discussed.

Language: Английский

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Insights into the circadian rhythm alterations of the novel PFOS substitutes F-53B and OBS on adult zebrafish

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 448, P. 130959 - 130959

Published: Feb. 8, 2023

Language: Английский

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In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer's disease

Neurobiology of Aging, Journal Year: 2018, Volume and Issue: 72, P. 72 - 82

Published: Aug. 23, 2018

We assessed here functional connectivity changes in the locus coeruleus (LC) and ventral tegmental area (VTA) of patients with Alzheimer's disease (AD). recruited 169 either AD or amnestic mild cognitive impairment due to 37 elderly controls who underwent neuropsychiatric assessments resting-state magnetic resonance imaging at 3T. Connectivity was between LC VTA rest brain. In patients, disconnection predominant parietal regions, while it involved posterior nodes default-mode network. also looked association symptoms (assessed by inventory) connectivity. Symptoms such as agitation, irritability, disinhibition were associated parahippocampal gyrus cerebellar vermis, sleep eating disorders striatum insular cortex. This suggests a contribution degeneration pathophysiology occurrence symptoms. did not find evidence disconnection, but this could be explained size nucleus, which makes difficult isolate. These results are consistent animal findings have potential implications for prognosis therapies.

Language: Английский

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Outdoor daylight exposure and longer sleep promote wellbeing under COVID‐19 mandated restrictions

Journal of Sleep Research, Journal Year: 2021, Volume and Issue: 31(2)

Published: Sept. 21, 2021

Summary Light is an important regulator of daily human physiology in providing time‐of‐day information for the circadian clock to stay synchronised with 24‐hr day. The coronavirus disease 2019 (COVID‐19) pandemic led social restrictions many countries prevent virus spreading, that dramatically altered routines and limited outdoor daylight exposure. We previously reported sleep duration increased, jetlag decreased, mid‐sleep times delayed during (Global Chrono Corona Survey, N = 7,517). In present study, we investigated same dataset changes wellbeing their link exposure, sleep–wake behaviour. restrictions, median values quality, quality life, physical activity productivity deteriorated, while screen time exposure was reduced by ~58%. Yet, survey participants also no or even improvements. Larger reductions were linked deteriorations times. Notably, not associated loss. Longer decreased alarm‐clock use dose‐dependently correlated life. Regression analysis each aspect showed a model six predictors including both levels deltas timing explained 5%–10% variance scores (except productivity). As may extenuate negative effects restriction disruption, public strategies pandemics should actively foster spending more daytime outdoors.

Language: Английский

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Sleep loss leads to the withdrawal of human helping across individuals, groups, and large-scale societies

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(8), P. e3001733 - e3001733

Published: Aug. 23, 2022

Humans help each other. This fundamental feature of homo sapiens has been one the most powerful forces sculpting advent modern civilizations. But what determines whether humans choose to another? Across 3 replicating studies, here, we demonstrate that sleep loss represents previously unrecognized factor dictating other, observed at different scales (within individuals, across and societies). First, an individual level, 1 night triggers withdrawal from another. Moreover, fMRI findings revealed human helping is associated with deactivation key nodes within social cognition brain network facilitates prosociality. Second, a group ecological night-to-night reductions in several nights predict corresponding next-day choice others during day-to-day interactions. Third, large-scale national h lost opportunity, inflicted by transition Daylight Saving Time, reduces real-world altruistic through act donation giving, established analysis over million charitable donations. Therefore, inadequate significant influential force determining another, observable micro- macroscopic levels civilized interaction. The implications this effect may be non-trivial when considering essentiality maintenance cooperative, civil society, combined reported decline sufficient many first-world nations.

Language: Английский

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Effects of light and dark phase testing on the investigation of behavioural paradigms in mice: Relevance for behavioural neuroscience

Pharmacology Biochemistry and Behavior, Journal Year: 2018, Volume and Issue: 178, P. 19 - 29

Published: May 18, 2018

Language: Английский

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Drug repositioning for psychiatric and neurological disorders through a network medicine approach

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: May 12, 2020

Psychiatric and neurological disorders (PNDs) affect millions worldwide only a few drugs achieve complete therapeutic success in the treatment of these disorders. Due to high cost developing novel drugs, drug repositioning represents promising alternative method treatment. In this manuscript, we used network medicine approach investigate molecular characteristics PNDs identify candidates for repositioning. Using IBM Watson Drug Discovery, powerful machine learning text-mining application, built knowledge networks containing connections between genes or mentioned scientific literature published past 50 years. This revealed several that target key PND-related genes, which have never been treat date. We validate our framework by detecting undergoing clinical trial treating some PNDs, but no results their support. Our data provides comprehensive insights into pathology offers follow-up trials.

Language: Английский

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Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation

Neuroscience Bulletin, Journal Year: 2021, Volume and Issue: 37(7), P. 1010 - 1024

Published: June 15, 2021

Language: Английский

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