Journal of Personalized Medicine,
Journal Year:
2022,
Volume and Issue:
12(6), P. 995 - 995
Published: June 18, 2022
Over
the
two
years
that
we
have
been
experiencing
Severe
Acute
Respiratory
Syndrome
Coronavirus-2
(SARS-CoV-2)
pandemic,
our
challenges
race
to
develop
vaccines
and
difficulties
in
fighting
against
new
variants
due
rapid
ability
of
virus
evolve.
In
this
sense,
different
organizations
identified
classified
emerging,
distinguishing
between
concern
(VOC),
interest
(VOI),
or
under
monitoring
(VUM).
The
following
review
aims
describe
latest
updates
focusing
on
VOC
already
de-escalated
variants,
as
well
impact
these
had
global
situation.
Understanding
intrinsic
properties
SARS-CoV-2
its
interaction
with
immune
system
vaccination
is
essential
make
out
underlying
mechanisms
led
appearance
helping
determine
next
steps
for
better
public
management
pandemic.
Viruses,
Journal Year:
2022,
Volume and Issue:
14(9), P. 1913 - 1913
Published: Aug. 30, 2022
The
association
between
mean
air
temperature
and
new
SARS-CoV-2
case
numbers
throughout
the
ongoing
coronavirus
disease
2019
(COVID-19)
pandemic
was
investigated
to
identify
whether
diverse
lineages
may
exhibit
environmental
behaviors.
number
of
COVID-19
daily
cases
in
province
Verona
obtained
from
Veneto
Regional
Healthcare
Service,
whilst
during
same
period
retrieved
Agency
for
Ambient
Prevention
Protection
Veneto.
A
significant
inverse
correlation
found
up
Omicron
BA.1/BA.2
predominance
(correlation
coefficients
-0.79
-0.41).
then
became
positive
when
BA.4/BA.5
were
prevalent
(r
=
0.32).
When
median
value
(and
interquartile
range;
IQR)
recorded
warmer
year
(June-July)
compared
across
three
years
pandemic,
a
gradual
increase
could
be
seen
over
time,
1
(IQR,
0-2)
2020,
22
11-113)
2021,
890
343-1345)
2022.
These
results
suggest
that
measures
preventing
infection
should
not
completely
abandoned
periods
year.
Journal of Translational Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Nov. 12, 2022
COVID-19
infections
could
be
complicated
by
acute
respiratory
distress
syndrome
(ARDS),
increasing
mortality
risk.
We
sought
to
assess
the
methylome
of
peripheral
blood
mononuclear
cells
in
with
ARDS.We
recruited
100
patients
ARDS
under
mechanical
ventilation
and
33
non-COVID-19
controls
between
April
July
2020.
were
followed
at
four
time
points
for
60
days.
DNA
methylation
immune
cell
populations
measured
each
point.
A
multivariate
cox
proportional
risk
regression
analysis
was
conducted
identify
predictive
signatures
according
survival.The
comparison
inclusion
revealed
presence
a
14.4%
difference
promoter-associated
CpGs
genes
that
control
immune-related
pathways
such
as
interferon-gamma
interferon-alpha
responses.
On
day
60,
24%
died.
The
inter-comparison
baseline
last
recorded
point
both
groups
or
intra-comparison
end
follow-up
every
group
showed
most
changes
occurred
disease
progressed,
mainly
AIM
gene,
which
is
associated
an
intensified
response
those
who
recovered.
Cox
higher
"Apoptotic
execution
Pathway"
(ROC1,
ZNF789,
H1F0)
increases
over
twofold.We
observed
epigenetic
signature
ARDS.
Further,
Hypermethylation
apoptotic
pathway
predicts
outcome.IMRPOVIE
study,
NCT04473131.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(7), P. 891 - 891
Published: July 4, 2024
Genomic
surveillance
based
on
sequencing
the
entire
genetic
code
of
SARS-CoV-2
involves
monitoring
and
studying
changes
variations
in
disease-causing
organisms
such
as
viruses
bacteria.
By
tracing
virus,
it
is
possible
to
prevent
epidemic
spread
community,
ensuring
a
‘precision
public
health’
strategy.
A
peptide-based
design
was
applied
provide
an
efficacious
strategy
that
able
counteract
any
emerging
viral
variant
concern
dynamically
promptly
affect
outcomes
pandemic
at
early
stage
while
waiting
for
production
anti-variant-specific
vaccine,
which
require
longer
times.
The
inhibition
interaction
between
receptor-binding
domain
(RBD)
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
one
cellular
receptors
(DPP4)
its
routinely
bind
infect
human
cells
intriguing
therapeutic
approach
virus
from
entering
cells.
Among
other
modalities
developed
this
purpose,
peptides
surely
offer
unique
advantages,
including
ease
synthesis,
serum
stability,
low
immunogenicity
toxicity,
small
distribution
chain
costs.
Here,
we
obtained
potent
new
inhibitor
rearrangement
previously
identified
peptide
has
been
rationally
designed
cell
dipeptidyl
peptidase
4
sequence,
ubiquitous
membrane
protein
known
RBD-SPIKE
virus.
This
novel
(named
DPP4-derived),
conceived
endogenous
“drug”,
capable
targeting
latest
tested
variants
with
high
affinity,
reducing
VSV*
DG-Fluc
pseudovirus
Omicron’s
infection
capacity
by
up
14%,
revealed
vitro
testing
Calu-3
Surface
plasmon
resonance
(SPR)
confirmed
binding
affinity
DPP4-derived
Omicron
RBD.
Journal of Personalized Medicine,
Journal Year:
2022,
Volume and Issue:
12(6), P. 995 - 995
Published: June 18, 2022
Over
the
two
years
that
we
have
been
experiencing
Severe
Acute
Respiratory
Syndrome
Coronavirus-2
(SARS-CoV-2)
pandemic,
our
challenges
race
to
develop
vaccines
and
difficulties
in
fighting
against
new
variants
due
rapid
ability
of
virus
evolve.
In
this
sense,
different
organizations
identified
classified
emerging,
distinguishing
between
concern
(VOC),
interest
(VOI),
or
under
monitoring
(VUM).
The
following
review
aims
describe
latest
updates
focusing
on
VOC
already
de-escalated
variants,
as
well
impact
these
had
global
situation.
Understanding
intrinsic
properties
SARS-CoV-2
its
interaction
with
immune
system
vaccination
is
essential
make
out
underlying
mechanisms
led
appearance
helping
determine
next
steps
for
better
public
management
pandemic.
