RSC Advances, Journal Year: 2024, Volume and Issue: 14(6), P. 4005 - 4024
Published: Jan. 1, 2024
In the current study, we biosynthesized copper oxide NPs (CuO NPs) utilizing essential oils extracted from Boswellia carterii oleogum resin, which served as a bioreductant and capping agent with help of microwave energy.
Language: Английский
Catalysts, Journal Year: 2023, Volume and Issue: 13(2), P. 348 - 348
Published: Feb. 3, 2023
Herein, the aqueous extract of Portulaca oleracea has been used as a safe, cheap, eco-friendly, and applicable scale-up method to bio-fabricate copper oxide nanoparticles (CuO-NPs). The character CuO-NPs were determined using UV-vis spectroscopy, Fourier transform infrared (FT-IR), X-ray diffraction (XRD), Transmission electron microscopy (TEM), Energy dispersive X-ray(EDX), Dynamic light scattering (DLS), zeta potential. Spherical crystalline with size range 5–30 nm at maximum surface plasmon resonance 275 successfully fabricated. main components green-synthesized particles Cu O weight percentages 49.92 28.45%, respectively. A Zeta-potential value −24.6 mV was recorded for CuO-NPs, indicating their high stability. plant-based showed promising antimicrobial catalytic activity in dose-dependent manner. Results that synthesized had efficacy inhibit growth pathogens Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans low MIC values ranges 6.25–25 µg/mL. highest decolorization tanning wastewater attained under sunlight irradiation conditions concentration 2.0 mg/mL after 200 min 88.6 ± 1.5% compared those which dark (70.3 1.2%). physicochemical parameters including total suspended solids (TSS), dissolved (TDS), chemical oxygen demand (COD), biological (BOD), conductivity optimum significantly decreased 95.2, 86.7, 91.4, 87.2, 97.2%, Interestingly, heavy metals cobalt (Co), lead (Pb), nickel (Ni), cadmium (Cd), chromium (Cr (VI)) 73.2, 80.8, 72.4, 64.4, 91.4%, respectively, treatment conditions. Overall, plant-synthesized have activities are considered nano-catalyst environmentally beneficial treatment.
Language: Английский
Citations
66
Journal of Hazardous Materials Advances, Journal Year: 2024, Volume and Issue: 13, P. 100401 - 100401
Published: Jan. 13, 2024
Bio-synthesized metal oxide (MeO) nanoparticles (NPs) have triggered a huge global research interest owing to their advancement and various environmental remediation, personal care products, medical, energy, sensing, water treatment applications. They demonstrate developing assets in industries, remarkably with heightened physicochemical, optical, mechanical, electronic attributes. The physical chemical routes been sticking point the production of MeO NPs, natural risks linked utilizing these approaches. growth NPs via biologic method employing plants microorganisms as precursor material for metal-ions (MIs) reduction stabilization has focus scientists recent years. Hence, this review, comprehensive brief bio-synthesis approaches using plant extracts (PEs) microorganism components well factors affecting bio-production applications toxicity were considered.
Language: Английский
Citations
46
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 219 - 260
Published: Jan. 1, 2024
Language: Английский
Citations
19
Cells, Journal Year: 2022, Volume and Issue: 11(14), P. 2209 - 2209
Published: July 15, 2022
Natural products play a critical role in the discovery and development of numerous drugs for treatment various types cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with initiation, development, progression cancer through altering mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, metastasis. Treating multifactorial diseases, agents targeting single target, might lead to limited success and, many cases, unsatisfactory outcomes. Various epidemiological studies shown that steady consumption fruits vegetables is intensely associated reduced risk Since ancient period, plants, herbs, other natural been used healing agents. Likewise, most medicinal ingredients accessible today are originated from resources. Regardless achievements, developing bioactive compounds has remained challenging, part because problem large-scale sequestration mechanistic understanding. With significant progress landscape therapy rising use cutting-edge technologies, we may come crossroads review approaches identify potential investigate their therapeutic efficacy. In present review, summarize recent developments products-based research its application generating novel systemic strategies focus on underlying molecular solid
Language: Английский
Citations
64
Journal of Nanomaterials, Journal Year: 2022, Volume and Issue: 2022(1)
Published: Jan. 1, 2022
The present study evaluated the anticancer potential of copper oxide nanoparticles (CuO NPs) synthesized from pumpkin seed extract in human breast cancer cell line (MDA‐MB‐231) using a battery tests such as MTT [3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide] assay, morphological alteration, reactive oxygen species (ROS) generation, and changes mitochondrial membrane (MMP). biogenic CuO NPs showed dose‐dependent decline viability with 50% inhibitory concentration (IC50) at 20 μ g/ml. Treatment an IC50 dose resulted considerable morphology changes, shrinkage, detachment, blebbing, deformed shape MDA‐MB‐231 cells. We also observed significant increase ROS production MMP modulation due to NP treatment. Overall, line. However, further validation our data is required ex vivo models before this nanoformulation could be exploited for treatment/management cancer.
Language: Английский
Citations
59
Nanotechnology Reviews, Journal Year: 2022, Volume and Issue: 11(1), P. 2714 - 2725
Published: Jan. 1, 2022
Abstract The cost-effective and environmental friendly biosynthesis of metal nanoparticles is becoming increasingly important in biomedical science. This study biosynthesized zinc oxide (ZnO NPs) from pumpkin seed extract assessed its anticancer activity by using different molecular biology experiments human breast cancer (MDA-MB-231) cell lines. well-known analytical techniques, such as UV-visible spectrophotometry, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission microscopy (TEM), were used to confirm the synthesis characterize morphological structural features biogenic ZnO NPs. formation spherical with an average size 50–60 nm was recorded TEM. We observed dose-dependent increase cytotoxicity NPs MDA-MB-231 line a 50% inhibitory concentration 10 µg/mL. Moreover, also showed significant morphology changes, apoptosis induction, reactive oxygen species production at highest tested concentration. cellular adhesion migration assay indicated death inhibition cells response NPs’ treatment. These results clearly demonstrated potential against studied line. However, extension this recommended models and, based on results, vivo validation should be done.
Language: Английский
Citations
59
Applied Food Research, Journal Year: 2022, Volume and Issue: 2(2), P. 100241 - 100241
Published: Nov. 19, 2022
Language: Английский
Citations
48
Green Processing and Synthesis, Journal Year: 2022, Volume and Issue: 11(1), P. 931 - 950
Published: Jan. 1, 2022
Abstract The biomass filtrate containing various metabolites of endophytic bacterial strain, Brevibacillus brevis PI-5 was used as a biocatalyst for reducing and stabilizing copper oxide nanoparticles (CuO-NPs). UV-Vis spectroscopy, Fourier transform infrared, transmission electron microscopy, scanning microscopy with energy-dispersive X-ray (SEM-EDX), diffraction, photoelectron spectroscopy were CuO-NPs characterization. A spherical, well-dispersed, crystallographic structure sizes 2–28 nm formed. SEM-EDX confirmed the presence Cu O weight percentages 27.62% 48.88%, respectively. biological activities including antifungal, anticancer, larvicidal synthesized assessed using fungal radial growth inhibition, MTT assay method, mortality percentages, obtained data showed that exhibit high activity in dose-dependent manner. three phytopathogenic fungi, Fusarium oxysporum, Alternaria alternata , Aspergillus niger decreased by 64.5% ± 4.1%, 62.9% 0.3%, 70.2% 2.3%, respectively at 300 µg·mL –1 . Also, clinical Candida spp. successfully inhibited varied zones inhibition minimum inhibitory concentration values ranges 6.25–50 vitro cytotoxicity exhibits target-orientation to breast cancer cells (T47D) low compared normal (HFB4) IC 50 122.3 5.4 229.9 5.7 μg·mL I, II, III, IV instar larvae Culex antennatus 60% 1.4%, 43.1% 1.1%, 36.2% 1%, 32.1% 0.9%, 10 mg·L increased 86.9% 2.1%, 68.1% 1.7%, 64.4% 1.9%, 53.1% 1.4%
Language: Английский
Citations
46
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Feb. 24, 2023
The present study examined the anticancer capabilities of Bacillus coagulans supernatant-produced copper oxide nanoparticles (BC-CuONPs) on MCF-7 and SKBR3 cancer cells. X-ray diffraction, ultraviolet-visible spectroscopy, Fourier-transform infrared photoelectron transmission electron microscopy, field-emission scanning energy-dispersive X-ray, dynamic light scattering, zeta potential techniques were used to characterize BC-CuONPs. This also investigated cellular molecular processes NPs' anti-proliferative apoptotic properties human breast cells compared them commercial pharmaceutical tamoxifen. size spherical NP was from 5 47 nm with negative potential. MTT results showed great cytotoxic effect BC-CuONPs against inhibited growth in a time- dose-dependent manner. up-regulation BCL2-associated X (BAX), cyclin dependent kinase inhibitor 1A (P21), Caspase 3 (CASP3), 9 (CASP9), down-regulation BCL2 apoptosis regulator (BCL2), Annexin V-FITC/propidium iodide, reactive oxygen species (ROS) generation suggested that had significant impact when control. Scratch tests vascular endothelial factor receptor gene (VEGF) demonstrated anti-metastatic activity. cell cycle analysis Cyclin D1 (CCND1) 4 (CDK4) revealed arrested sub-G1 phase. Finally, secondary metabolites supernatant could form CuONPs, biogenic anti-metastasis while having less adverse effects normal Therefore, synthesized CuONPs using B. can be shown as candidate for new therapeutic strategy management.
Language: Английский
Citations
35
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Jan. 17, 2023
Abstract Copper oxide nanoparticles (CuONPs) have received tremendous attention as efficient adsorbents owing to their low cost, desirable surface area, abundant active sites, potent textural characteristics and high adsorption capacities. However, CuONPs not been employed decontaminate water laden with increasing environmental contaminants such thiazolyl blue paracetamol. Herein, the of paracetamol onto green synthesized prepared from aqueous leaf extract Platanus occidentalis was studied. The BET, SEM, FTIR, XRD, EDX pH point zero charge showed successful synthesis having properties a area 58.76 m 2 /g an average size 82.13 nm. maximum monolayer capacities 72.46 mg/g 64.52 were obtained for paracetamol, respectively. Freundlich, pseudo-second-order intraparticle diffusion models well fitted both pollutants. studies suggested predominance electrostatic weaker intermolecular interactions in Spontaneous, physical, endothermic random pollutants on thermodynamic consideration. biosynthesized found be highly reusable water.
Language: Английский
Citations
30