Inhibitory effect of silver nanoparticles–conjugated PEG-nystatin against some resistance pathogenic bacteria

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112952 - 112952

Published: Aug. 7, 2024

Language: Английский

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Chrysin, The Flavonoid Molecule of Antioxidant Interest

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(48)

Published: Dec. 21, 2023

Abstract Chrysin, the natural bioactive flavone compound, has been identified in several edible materials such as honey, propolis, and passionflower with numerous biological potentials pharmaceutical effects including antitumor, anti‐inflammatory, antiviral antioxidant. The compound reported to have lower vitro antioxidant activity compared other flavone‐based structures quercetin, luteolin, myricetin, which is mostly attributed higher hydroxylation presence of conjugated en‐diol these flavonoids lack structural features chrysin. On contrary effect chrysin, exerted remarkable vivo activities models related liver, brain, heart, kidneys, soft tissues. current review includes a discussion chrysin common flavonoids. study also covers subjects linked antioxidants, its metabolism, bioavailability, formulations that aim increase impact overcome low bioavailability.

Language: Английский

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Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 666, P. 124800 - 124800

Published: Oct. 5, 2024

Language: Английский

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Chitosan‐Coated Gold Nanoparticles' Folic Acid Conjugates for Targeted Delivery of Papain Enzyme: An Extended Nanoplatform Approach for Cancer Therapy

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 3, 2025

ABSTRACT Cancer is a significant global public health concern, being the second leading cause of mortality, accounting for one in six cases worldwide. Researchers have employed various approaches cancer treatment, with nanobiotechnology emerging as standout technique developing anticancer agents. This study assessed activity chitosan (CS)‐coated gold nanoparticles (AuNPs) and combination AuNPs–papain (Pap)–folic acid (FA) nanomaterial platforms against Michigan Foundation‐7 (MCF‐7) cell lines. A range methods, including ultraviolet–visible (UV–Vis), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), transmission (TEM), X‐ray diffraction (XRD), energy‐dispersive spectroscopy (EDS), zeta potential, were used to characterize prepared nanomaterials. AuNPs AuNPs–Pap–FA exhibited UV–Vis absorption at 525 558 nm, respectively. In XRD test, peaks found 32°, 39°, 45°, 65°, 78.5°, AuNPs–CS–Pap–FA identified 29, 37°, 78.5°. SEM revealed irregularly dispensed oval shapes AuNPs. TEM images confirmed shape before after coating Pap FA. The mean diameter was 15 AuNPs–CS–Pap–FA, it 22.5 nm. Acridine orange–ethidium bromide (AO/EB) staining, flow cytometry assay, 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), vitro hemolysis assays conducted. maximum scavenging observed reaching up 90%. hemolytic rate low concentrations (3.12, 6.25, 12.5 μg mL −1 ) within permissible levels. concentration 100 reduced viability MCF‐7 cells 10% when compared nontreated cells. highest expression caspase‐8 achieved treating line AuNPs–CS–Pap–FA. nanopreparation remarkable holds promise potential candidate further development towards clinical applications an agent.

Language: Английский

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Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: March 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Language: Английский

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Solid lipid nanoparticles in colon targeting

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 195 - 219

Published: Jan. 1, 2025

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Antibacterial activity of green synthesized selenium nanoparticles using Vaccinium arctostaphylos (L.) fruit extract

Cogent Food & Agriculture, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 9, 2023

In recent years, there has been an increase in the acceptance of green synthesis as a viable method for producing nanoparticles active materials that can inhibit bacterial resistance to antibiotics. The current study aimed evaluate effect synthesized selenium (SeNPs) using Vaccinium arctostaphylos L. fruit extract on Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Corynebacterium diphtheriae (C. diphtheriae). SeNPs were characterized by Ultraviolet-visible (U-V), Fourier-transform infrared (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Dynamic Light Scattering (DLS), Zeta Potential (ZP) measurements. Minimum Inhibitory Concentration (MIC) Bactericidal (MBC) tested bacteria determined resazurin test, values used basis achieve antibacterial activity test detection viability (live/dead cell percentage) flow cytometry. this study, FESEM assay further shows Se NPs are precisely spherical uniform size (50 ± 1.23 nm) distribution. effectiveness against S. aureus, E. coli, C. diphtheria ranged from zero when MIC value was large (0.5 mg/ml) significant low (0.015625 mg/ml). high percentage death achieved diphtheria, 44.6%, 29.49%, 24.4% respectively. conclusion, V. desirable, safe, environmentally friendly options could be efficient agent prevent infections.

Language: Английский

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Chitosan-Coated Solid Lipid Nanoparticles as an Efficient Avenue for Boosted Biological Activities of Aloe perryi: Antioxidant, Antibacterial, and Anticancer Potential

Molecules, Journal Year: 2023, Volume and Issue: 28(8), P. 3569 - 3569

Published: April 19, 2023

Aloe perryi (ALP) is an herb that has several biological activities such as antioxidant, antibacterial, and antitumor effects frequently used to treat a wide range of illnesses. The activity many compounds augmented by loading them in nanocarriers. In this study, ALP-loaded nanosystems were developed improve their activity. Among different nanocarriers, solid lipid nanoparticles (ALP-SLNs), chitosan (ALP-CSNPs), CS-coated SLNs (C-ALP-SLNs) explored. particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, release profile evaluated. Scanning electron microscopy was see the nanoparticles’ morphology. Moreover, possible properties ALP assessed extract contained 187 mg GAE/g 33 QE/g terms total phenolic flavonoid content, respectively. ALP-SLNs-F1 ALP-SLNs-F2 showed sizes 168.7 ± 3.1 138.4 9.5 nm potential values −12.4 0.6, −15.8 2.4 mV, However, C-ALP-SLNs-F1 C-ALP-SLNs-F2 had 185.3 5.5 173.6 11.3 with 1.4 13.6 1.1 size ALP-CSNPs 214.8 6.6 27.8 3.4 All exhibited PDI < 0.3, indicating homogenous dispersions. obtained formulations EE% DL% ranges 65–82% 2.8–5.2%, After 48 h, vitro rates from ALP-SLNs-F1, ALP-SLNs-F2, C-ALP-SLNs-F1, C-ALP-SLNs-F2, 86%, 91%, 78%, 84%, 74%, They relatively stable minor increase after one month storage. greatest antioxidant against DPPH radicals at 73.27%. demonstrated higher antibacterial based on MIC 25, 50, 50 µg/mL for P. aeruginosa, S. aureus, E. coli, addition, anticancer A549, LoVo, MCF-7 cell lines IC50 11.42 1.16, 16.97 1.93, 8.25 0.44, results indicate may be promising nanocarriers enhancing ALP-based medicines.

Language: Английский

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Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases

ACS Nano, Journal Year: 2024, Volume and Issue: 18(50), P. 33792 - 33826

Published: Dec. 3, 2024

Alzheimer's disease (AD) is a neurodegenerative that causes memory loss and progressive permanent deterioration of cognitive function. The most challenging issue in combating AD its complicated pathogenesis, which includes the deposition amyloid β (Aβ) plaques, intracellular hyperphosphorylated tau protein, neurofibrillary tangles (NFT), etc. Despite rapid advancements mechanistic research drug development for AD, currently developed drugs only improve ability temporarily relieve symptoms but cannot prevent AD. Moreover, blood–brain barrier (BBB) creates huge to delivery brain. Therefore, effective diagnostic tools treatments are urgently needed. In recent years, nanomedicine has provided opportunities overcome challenges limitations associated with traditional diagnostics or treatments. Various types nanoparticles (NPs) play an essential role diagnosis treatment acting as carriers targeting bioavailability across/bypass BBB directly on lesions. This review categorizes different NPs summarizes their applications It also discusses clinical explores latest developments prospects

Language: Английский

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Enhancing Efficacy of Combretastatin A4 by Encapsulation in Solid Lipid Nanoparticles: Implications for Anti-Angiogenic Cancer Therapy

Published: Jan. 1, 2025

Language: Английский

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