Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent “Resting-State” Connectivity

Neuron, Journal Year: 2017, Volume and Issue: 96(4), P. 936 - 948.e3

Published: Oct. 26, 2017

Language: Английский

---

Global waves synchronize the brain’s functional systems with fluctuating arousal

Science Advances, Journal Year: 2021, Volume and Issue: 7(30)

Published: July 21, 2021

Traveling waves spatiotemporally organize brain-wide activity in synchrony with ongoing arousal fluctuations.

Language: Английский

---

Regional and cell-type-specific afferent and efferent projections of the mouse claustrum

Cell Reports, Journal Year: 2023, Volume and Issue: 42(2), P. 112118 - 112118

Published: Feb. 1, 2023

The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and regions. Its regional anatomy cell-type-specific connections in the mouse remain not fully determined. Using multimodal reference datasets, we confirmed delineation of CLA as single group neurons embedded agranular insular cortex. We quantitatively investigated brain-wide inputs outputs using bulk anterograde retrograde viral tracing data neuron data. found that prefrontal module has more cell types projecting to than other modules, layer 5 IT predominating. nine morphological principal topographically innervate functionally linked targets, preferentially midline areas, secondary motor area, entorhinal area. Together, this study provides detailed wiring diagram CLA, laying foundation for studying its functions at cellular level.

Language: Английский

---

Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 3, 2024

Abstract Large-scale functional networks have been characterized in both rodent and human brains, typically by analyzing fMRI-BOLD signals. However, the relationship between underlying neural activity is complex incompletely understood, which poses challenges to interpreting network organization obtained using this technique. Additionally, most work has assumed a disjoint (i.e., brain regions belong one only network). Here, we employ wide-field Ca 2+ imaging simultaneously with mice expressing GCaMP6f excitatory neurons. We determine cortical discovered each modality mixed-membership algorithm test hypothesis that exhibit overlapping organization. find there considerable overlap (both modalities) addition Our results show multiple BOLD are detected via signals, determined low-frequency signals modestly more similar networks. In addition, principal gradient of connectivity nearly identical for Despite similarities, important differences also across modalities, such as measures strength diversity. conclusion, uncovers mouse reflects several, but not all, properties observed

Language: Английский

---

Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds

Neuron, Journal Year: 2020, Volume and Issue: 107(5), P. 782 - 804

Published: Aug. 12, 2020

Language: Английский

---

Mesoscopic Imaging: Shining a Wide Light on Large-Scale Neural Dynamics

Neuron, Journal Year: 2020, Volume and Issue: 108(1), P. 33 - 43

Published: Oct. 1, 2020

Language: Английский

---

Sleep–Wake Cycle in Young and Older Mice

Frontiers in Systems Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: Sept. 24, 2019

Sleep plays a key role in multiple cognitive functions and sleep pattern changes with aging. Human studies revealed that aging decreases efficiency reduces the total time, time spent slow-wave (SWS), delta power (1-4 Hz) during sleep; however, some of mice reported opposing results. The aim our work is to estimate how features sleep-wake state could correspond age-dependent observed human. In this study, we investigated sleep/wake cycle young (3 months old) older (12 C57BL/6 using local-field potentials (LFPs). We found adult more than ones but only dark phase cycle. fragmentation active (dark cycle), homologous naps, were higher mice. Older show frontal cortex, which was accompanied similar trend for age differences slow wave density. also regional specificity electrographic activities globally posterior regions cortex rapid eye movement (REM) whereas somatosensory displays often SWS patterns. Our results indicate effects on occur mainly electrode location strongly influence detection. Despite between human mice, share similarity

Language: Английский

---

Low-Dimensional Spatiotemporal Dynamics Underlie Cortex-wide Neural Activity

Current Biology, Journal Year: 2020, Volume and Issue: 30(14), P. 2665 - 2680.e8

Published: May 28, 2020

Cognition arises from the dynamic flow of neural activity through brain. To capture these dynamics, we used mesoscale calcium imaging to record across dorsal cortex awake mice. We found that large majority variance in cortex-wide (∼75%) could be explained by a limited set ∼14 "motifs" activity. Each motif captured unique spatiotemporal pattern cortex. These motifs generalized animals and were seen multiple behavioral environments. Motif expression differed states, specific engaged sensory processing, suggesting reflect core cortical computations. Together, our results show is highly but dynamics are restricted low-dimensional motifs, potentially allowing for efficient control behavior.

Language: Английский

---

Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response

Neuron, Journal Year: 2021, Volume and Issue: 109(13), P. 2183 - 2201.e9

Published: June 1, 2021

The neuronal mechanisms generating a delayed motor response initiated by sensory cue remain elusive. Here, we tracked the precise sequence of cortical activity in mice transforming brief whisker stimulus into licking using wide-field calcium imaging, multiregion high-density electrophysiology, and time-resolved optogenetic manipulation. Rapid evoked deflection acquired two prominent features for task performance: (1) an enhanced excitation secondary cortex, suggesting its important role connecting processing to lick planning; (2) transient reduction orofacial sensorimotor which contributed suppressing premature licking. Subsequent widespread during delay period largely correlated with anticipatory movements, but when these were accounted for, focal sustained remained frontal was causally essential period. Our results demonstrate key nodes plan generation timely execution goal-directed

Language: Английский

---

BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals

Cell, Journal Year: 2020, Volume and Issue: 182(1), P. 177 - 188.e27

Published: July 1, 2020

Language: Английский

---