Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1352 - 1352
Published: Oct. 10, 2024
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive forms of pancreatic cancer with a poor prognosis. YAP1 expression markedly elevated in PDAC, but how it works not clear. GL-V9, derivative natural compound wogonin, effectively fights variety tumors; however, its effect on PDAC has yet been studied.
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117084 - 117084
Published: Aug. 1, 2024
The accumulation of excess reactive oxygen species (ROS) can lead to oxidative stress (OS), which induce gene mutations, protein denaturation, and lipid peroxidation directly or indirectly. expression is reduced ATP level in cells, increased cytoplasmic Ca
Language: Английский
Citations
42
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 20, 2024
Language: Английский
Citations
21
The EMBO Journal, Journal Year: 2023, Volume and Issue: 42(13)
Published: May 23, 2023
Abstract Lipid droplets (LDs) form inter‐organelle contacts with the endoplasmic reticulum (ER) that promote their biogenesis, while LD mitochondria enhance β‐oxidation of contained fatty acids. Viruses have been shown to take advantage lipid viral production, but it remains unclear whether they also modulate interactions between LDs and other organelles. Here, we showed coronavirus ORF6 protein targets is localized mitochondria‐LD ER‐LD contact sites, where regulates biogenesis lipolysis. At molecular level, find inserts into monolayer via its two amphipathic helices. further interacts ER membrane proteins BAP31 USE1 mediate ER‐LDs formation. Additionally, SAM complex in mitochondrial outer link LDs. In doing so, promotes cellular lipolysis reprogram host cell flux facilitate production.
Language: Английский
Citations
26
FEBS Letters, Journal Year: 2024, Volume and Issue: 598(10), P. 1235 - 1251
Published: Jan. 24, 2024
Our body stores energy mostly in form of fatty acids (FAs) lipid droplets (LDs). From there the FAs can be mobilized and transferred to peroxisomes mitochondria. This transfer is dependent on close opposition LDs mitochondria happens at membrane contact sites. However, composition dynamics these sites not well understood, which part due dependence metabolic state cell cell- tissue-type. Here, we summarize current knowledge contacts between both mammals yeast Saccharomyces cerevisiae, various are studied. We discuss possible functions site their implication disease.
Language: Английский
Citations
14
Cell, Journal Year: 2024, Volume and Issue: 187(10), P. 2393 - 2410.e14
Published: April 22, 2024
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6878 - 6878
Published: June 22, 2024
The orchestration of cellular metabolism and redox balance is a complex, multifaceted process crucial for maintaining homeostasis. Lipid droplets (LDs), once considered inert storage depots neutral lipids, are now recognized as dynamic organelles critical in lipid energy regulation. Mitochondria, the powerhouses cell, play central role production, metabolic pathways, signaling. physical functional contacts between LDs mitochondria facilitate direct transfer primarily fatty acids, which mitochondrial β-oxidation, thus influencing homeostasis health. This review highlights recent advances understanding mechanisms governing LD-mitochondria interactions their regulation, drawing attention to proteins pathways that mediate these contacts. We discuss physiological relevance interactions, emphasizing within cells, how processes response demands stress conditions. Furthermore, we explore pathological implications dysregulated particularly context diseases such obesity, diabetes, non-alcoholic liver disease, potential links cardiovascular neurodegenerative diseases. Conclusively, this provides comprehensive overview current underscoring significance suggesting future research directions could unveil novel therapeutic targets degenerative
Language: Английский
Citations
7
FEBS Letters, Journal Year: 2024, Volume and Issue: 598(10), P. 1299 - 1300
Published: Feb. 13, 2024
Intracellular pathogens rely on host metabolic networks for multiplication. Enveloped viruses need lipids formation of the viral envelope and positive sense RNA that replicate in membranous inclusions require replication compartments. In addition, all intracellular energy their replicative cycle. As triglycerides lipid droplets are main storage unit cells major source membrane lipids, it is not surprising have evolved various strategies to exploit different aspects droplet biology.
Language: Английский
Citations
6
Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)
Published: May 2, 2024
Myocardial ischemia/reperfusion injury (MIRI) is the leading cause of irreversible myocardial damage. A pivotal pathogenic factor (I/R)-induced cardiomyocyte ferroptosis, marked by iron overload and lipid peroxidation. However, impact droplet (LD) changes on I/R-induced ferroptosis unclear. In this study, an aggregation-induced emission probe, TPABTBP developed that used for imaging dynamic in LD during ferroptosis. exhibits excellent LD-specificity, superior capability monitoring lipophagy, remarkable photostability. Molecular dynamics (MD) simulation super-resolution fluorescence demonstrate specifically localized to phospholipid monolayer membrane LDs. Imaging LDs cardiomyocytes tissue model mice with MIRI reveals accumulation level increase early reperfusion stage (0-9 h) but decrease late (>24 via lipophagy. The inhibition breakdown significantly reduces peroxidation cardiomyocytes. Furthermore, it demonstrated chloroquine (CQ), FDA-approved autophagy modulator, can inhibit thereby attenuating mice. This study describes ischemia suggests a potential therapeutic target intervention.
Language: Английский
Citations
6
PLoS Biology, Journal Year: 2024, Volume and Issue: 22(3), P. e3002529 - e3002529
Published: March 5, 2024
At the core of organelle functions lies their ability and need to form dynamic organelle–organelle networks that drive intracellular communication coordination cellular pathways. These are facilitated by membrane contact sites (MCSs) promote both intra-organelle inter-organelle communication. Given multiple functions, MCSs proteins them commonly co-opted viruses during infection viral replication. This Essay discusses mechanisms acquired diverse human regulate MCS in either proviral processes or host defense. It also examines techniques used for examining context infections.
Language: Английский
Citations
4
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: May 17, 2024
Autophagy is an evolutionarily conserved cellular recycling process that maintains homeostasis. Despite extensive research in endocrine contexts, the role of autophagy ovarian and testicular steroidogenesis remains elusive. The significant testosterone production suggests potential treatments for conditions like oligospermia azoospermia. Further, influence folliculogenesis, ovulation, luteal development emphasizes its importance improved fertility reproductive health. Thus, investigating gonadal cells clinically significant. Understanding these processes could transform disorders, enhancing health longevity. Herein, we provide functional to date, highlighting modulation impact on hormone synthesis, follicle development, therapies.
Language: Английский
Citations
4