Rhythmic Bacteria as Biomarkers for Circadian-Related Diseases DOI Creative Commons

Pamela Karina Ubilla,

Evandro Ferrada, Pablo A. Marquet

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Recent studies suggest that the human circadian clock influences periodic changes in composition of gut microbiota, which is essential for maintaining host health. This connection has led researchers to hypothesize disruption may impact health via microbiota. Here, we rhythmic bacteria—those whose abundance fluctuates a pattern—are key drivers differences microbiota between healthy individuals and those with circadian-related diseases. Even absence causal relation, identifying bacteria associated diseases can reveal disease biomarkers as well intervention strategies. To test this, first conducted systematic review identify reported literature. Then, mapped these onto reference dataset nearly 4,800 from previously curated metagenomic database. We use this data assess prevalence bacteria. examine significant samples diseases, including type 2 diabetes, hypertension, atherosclerotic cardiovascular disease, colorectal cancer, metabolic syndrome, inflammatory bowel compared datasets several previous their respective controls. Of eight identified studies, seven were among top 100 most prevalent abundant species gut. found bacterium Roseburia faecis be strongly exclusively suggesting its biomarker possibly coadjuvant treatment Clinical trial number: not applicable.

Language: Английский

Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer DOI
Faraz Bishehsari, Robin M. Voigt, Ali Keshavarzian

et al.

Nature Reviews Endocrinology, Journal Year: 2020, Volume and Issue: 16(12), P. 731 - 739

Published: Oct. 26, 2020

Language: Английский

Citations

243
Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary DOI Creative Commons
Jeffrey A. Haspel, Ron C. Anafi,

Marishka Brown

et al.

JCI Insight, Journal Year: 2020, Volume and Issue: 5(1)

Published: Jan. 15, 2020

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate adaptive responses — ranging from leukocyte mobilization, trafficking, chemotaxis to cytokine release T cell differentiation —are mediated time of day–dependent manner. The National Institutes Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, the Immune Response,” highlight new research linking biology function identify areas high translational potential. This Review summarizes topics discussed highlights immediate opportunities delineating clinically relevant connections among biological rhythms, sleep, regulation.

Language: Английский

Citations

198
The microbiota-gut-brain axis in sleep disorders DOI
Zhe Wang, Zhong Wang,

Tangsheng Lu

et al.

Sleep Medicine Reviews, Journal Year: 2022, Volume and Issue: 65, P. 101691 - 101691

Published: Aug. 31, 2022

Language: Английский

Citations

142
Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease DOI Creative Commons
Simon Spichak, Thomaz F. S. Bastiaanssen,

Kirsten Berding

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 125, P. 698 - 761

Published: March 5, 2021

There is increasing knowledge regarding the role of microbiome in modulating brain and behaviour. Indeed, actions microbial metabolites are key for appropriate gut-brain communication humans. Among these metabolites, short-chain fatty acids, tryptophan, bile acid metabolites/pathways show strong preclinical evidence involvement various aspects function With identification neuroactive modules, new predictive tools can be applied to existing datasets. We identified 278 studies relating human microbiota-gut-brain axis which included sequencing data. This spanned across psychiatric neurological disorders with a small number also focused on normal behavioural development. consistent bioinformatics pipeline, thirty-five datasets were reanalysed from publicly available raw files remainder summarised collated. studies, we uncovered disease-related alterations metabolic pathways Alzheimer's Disease, schizophrenia, anxiety depression. Amongst that could not reanalysed, many technical limitations hindered discovery specific biomarkers microbes or conserved studies. Future warranted confirm our findings. propose guidelines future analysis increase reproducibility consistency within field.

Language: Английский

Citations

107
The Influence of Dietary Factors on the Gut Microbiota DOI Creative Commons
Esther Nova, Sonia Gómez‐Martínez, Rocío González-Soltero

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1368 - 1368

Published: July 7, 2022

There is increasing evidence that diet influences the relationship between gut microbiota and individual health outcomes. Nutrient intake affects composition of microbial community provides metabolites influence host physiology. Dietary patterns, including macronutrient balance feeding/fasting cycles which may be manipulated with dietary regimens based on caloric restriction periods, homeostasis through its impact ecosystem. Along same line, prebiotic probiotic ingredients additives in foods, as well degree food processing have consequences related immune metabolic response human host. Acquiring knowledge these aspects, especially an -omics-integral approach, might provide basis for personalized nutritional interventions directed to avoid dysbiosis contribute prevention major chronic degenerative diseases. Despite vast scientific supporting factors function, underlying mechanisms their potential are far from clear. a lack well-designed longitudinal studies performed target population groups whose patterns can particularly relevant future health, case infants, pregnant women, or athletes.

Language: Английский

Citations

77
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies DOI Open Access
Justyna Godos, Walter Currenti, Raffaele Ferri

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 529 - 529

Published: Jan. 31, 2025

Fasting-feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal underscores importance maintaining alignment order to avoid creating metabolic environment conducive carcinogenesis following molecular systemic disruption performance immune function. chronicity such condition may support initiation progression cancer through variety mechanisms, including increased oxidative stress, suppression, activation proliferative signaling pathways. This review aims summarize current evidence from human studies provide an overview potential mechanisms underscoring role chrononutrition (including time-restricted eating) on risk. Current shows that morning chronotype, suggesting physiological rhythms eating timing, associated with lower risk cancer. Also, early prolonged nighttime fasting were also suggests chronotype influences cell cycle regulation, modulation pathways inflammation, gut microbiota fluctuations. In conclusion, although there are no clear guidelines this matter, emerging supports hypothesis time-related (i.e., time/calorie-restricted feeding intermittent/periodic fasting) could potentially lead reduced

Language: Английский

Citations

3
The complexities of the diet-microbiome relationship: advances and perspectives DOI Creative Commons
Emily R. Leeming, Panayiotis Louca, Rachel Gibson

et al.

Genome Medicine, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 20, 2021

Personalised dietary modulation of the gut microbiota may be key to disease management. Current investigations provide a broad understanding impact diet on composition and activity microbiota, yet detailed knowledge in applying as an actionable tool remains limited. Further relative novelty field, approaches are standardised extremely heterogeneous research outcomes have ensued. This related confounders associated with complexities capturing accurate representation both microbiota. review discusses intricacies current methodologies diet-microbial relations, implications limitations these investigative approaches, future considerations that assist accelerating applications. New should consider improved collection data, further characterisation mechanistic interactions, increased focus -omic technologies such metabolomics describe bacterial metabolic food degradation, together its crosstalk host. Furthermore, clinical evidence health is required before therapeutic strategies for microbial amelioration can made. The potential reach diet-microbiota relations depend re-evaluation, progression, unification methodologies, which interactions.

Language: Английский

Citations

82
Hepatic sexual dimorphism — implications for non-alcoholic fatty liver disease DOI
Philippe Lefèbvre, Bart Staels

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(11), P. 662 - 670

Published: Aug. 20, 2021

Language: Английский

Citations

72
Light exposure mediates circadian rhythms of rhizosphere microbial communities DOI Creative Commons
Kankan Zhao, Bin Ma, Yan Xu

et al.

The ISME Journal, Journal Year: 2021, Volume and Issue: 15(9), P. 2655 - 2664

Published: March 21, 2021

Abstract Microbial community circadian rhythms have a broad influence on host health and even though light-induced environmental fluctuations could regulate microbial communities, the contribution of light to rhizosphere communities has received little attention. To address this gap, we monitored diel changes in rice (Oryza sativa L.) soil under light–dark constant dark regimes, identifying microbes with caused by exposure clocks, respectively. While displayed taxa possessing two conditions were dissimilar. Light concealed clocks as regulatory driver, leading fewer ecological niches versus communities. These findings disentangle regulation mechanisms for highlight role

Language: Английский

Citations

64
Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics DOI Creative Commons
Sharlize Pedroza Matute, Sasitaran Iyavoo

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 5, 2023

The gut microbiota is a rich and dynamic ecosystem that actively interacts with the human body, playing significant role in state of health disease host. Diet, exercise, mental health, other factors have exhibited ability to influence bacterial composition, leading changes can prevent improve, or favor worsen, both intestinal extra-intestinal conditions. Altered microbial states, ‘dysbiosis’, associated conditions diseases are often characterized by shifts abundance diversity, including an impaired Firmicutes Bacteroidetes ratio. By understanding effect lifestyle on microbiota, personalized advice be generated suit each individual profile foster adoption ameliorate dysbiosis. delivery effective reliable advice, however, depends not only available research current topic, but also methods used assess individuals discover associations, which introduce bias at multiple stages. aim this review summarize how variability defined what choices shown association composition. Furthermore, popular investigate outlined, focus possible caused lack use standardized methods. Finally, overview based testing presented, underlining its power limitations.

Language: Английский

Citations

42