A disturbed communication between hypothalamic-pituitary-ovary axis and gut microbiota in female infertility: is diet to blame?

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Female infertility is a multifactorial condition influenced by various genetic, environmental, and lifestyle factors. Recent research has investigated the significant impact of gut microbiome dysbiosis on systemic inflammation, metabolic dysfunction, hormonal imbalances, which can potentially impair fertility. The gut-brain axis, bidirectional communication system between brain, also plays role in regulating reproductive functions. Emerging evidence suggests that influence brain functions behavior, further emphasizing importance microbiota-gut-brain axis reproduction. Given their as major modulator microbiome, diet dietary factors, including patterns nutrient intake, have been implicated development management female infertility. Hence, this review aims to highlight patterns, such Western (WD) Mediterranean (MD), decipher modulatory action infertile women. By contrasting detrimental effects WD with therapeutic potential MD, we emphasize pivotal balanced rich nutrients promoting healthy microbiome. These insights underscore targeted interventions modifications promising strategies enhance outcomes subfertile

Language: Английский

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Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Dec. 16, 2022

Every year, millions of women are affected by genital tract disorders, such as bacterial vaginosis (BV), endometrial cancer, polycystic ovary syndrome (PCOS), endometriosis, and uterine fibroids (UFs). These disorders pose a significant economic burden on healthcare systems have serious implications for health fertility outcomes. This review explores the relationships between gut, vaginal, dysbiosis pathogenesis various diseases female tract. In recent years, reproductive clinicians scientists focused microbiome to investigate its role in prevention diseases. Recent studies microbiomes identified patterns composition changes across individuals' lives associated with specific healthy diseased states, particularly regarding effects estrogen-gut axis estrogen-driven (such UFs) estrogen deficiency PCOS). Furthermore, this discusses contribution vitamin D gut altered metabolism well how these play key roles UFs. More research influences is vital.

Language: Английский

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Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health

Human Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 36, P. 200256 - 200256

Published: March 8, 2024

Short chain fatty acids (SCFA) have been linked to women's reproductive health, though a lesser extent, alteration in the production of SCFA and SCFA-producing bacteria has associated significantly with pregnancy-related complications, unfavourable pregnancy outcomes, menstrual anomalies, gynaecological cancer. The female system is delicate, intricate, hormone-dependent group tissues required for continuity life species' survival. Reproductive health impacts ovarian function implantation foetal development. Several environmental physiological factors contribute mammalian infertility concerns caused by change status. lifestyle demonstrated affect including age, body weight, smoking, alcohol consumption, work stress, exercise, diet, nutrition. Nutrition influences puberty, cycle, ovulation, conception, early This review provides an overview how intestinal derived SCFAs maintains summarizing current knowledge future perspectives. Microbial improve human metabolism interfering with, glucose homeostasis, appetite regulation lipid metabolism. Also host immunity barrier integrity via primary inhibition Histone deacetylases (HDAC) mechanism. Therefore, exhibit anti-inflammatory, anti-obesity, immunoregulatory, anti-diabetes, anti-cancer, hepatoprotective, cardiovascular protective neuroprotective properties. highlights recent findings on pathologies such as preeclampsia, gestational diabetes, polycystic ovary syndrome, bacterial vaginosis, endometriosis describe relationship between disease women.

Language: Английский

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Developmental programming of reproduction in the female animal

Animal Reproduction Science, Journal Year: 2024, Volume and Issue: 263, P. 107456 - 107456

Published: March 16, 2024

Language: Английский

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Gut microbiota and female health

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(12), P. 1655 - 1662

Published: March 28, 2024

The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore critical role of microbial homeostasis in female health; dysbiosis potentially leading diseases among women such polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer etc. Despite this, there has been limited discussion on underlying mechanisms. This editorial explores three potential mechanisms through which may impact development women, namely, immune system, microbiota-estrogen axis, metabolite pathway. We focused approaches for treating by addressing imbalances probiotics, prebiotics supplementation, fecal transplantation (FMT). Future studies should focus determining molecular associations between realize precision medicine, FMT emerging a promising intervention.

Language: Английский

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Pharmacological and non-pharmacological interventions for improving endometrial receptivity in infertile patients with polycystic ovary syndrome: a comprehensive review of the available evidence

Reproductive BioMedicine Online, Journal Year: 2024, Volume and Issue: 49(6), P. 104381 - 104381

Published: July 20, 2024

Language: Английский

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Impact of Probiotics and Prebiotics on Gut Microbiome and Hormonal Regulation

Gastrointestinal Disorders, Journal Year: 2024, Volume and Issue: 6(4), P. 801 - 815

Published: Sept. 27, 2024

The gut microbiome plays a crucial role in human health by influencing various physiological functions through complex interactions with the endocrine system. These involve production of metabolites, signaling molecules, and direct communication cells, which modulate hormone secretion activity. As result, can exert neuroendocrine effects contribute to metabolic regulation, adiposity, appetite control. Additionally, influences reproductive altering levels sex hormones such as estrogen testosterone, potentially contributing conditions like polycystic ovary syndrome (PCOS) hypogonadism. Given these roles, targeting offers researchers clinicians novel opportunities improve overall well-being. Probiotics,

Language: Английский

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Possible Therapeutic Mechanisms and Future Perspectives of Vaginal Microbiota Transplantation

Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1427 - 1427

Published: May 29, 2023

Microbial communities inhabiting the human body play a crucial role in protecting host against pathogens and inflammation. Disruptions to microbial composition can lead various health issues. transfer therapy (MTT) has emerged as potential treatment option address such Fecal microbiota transplantation (FMT) is most widely used form of MTT been successful treating several diseases. Another vaginal (VMT), which involves transferring from healthy female donor diseased patient's cavity with goal restoring normal composition. However, VMT not extensively studied due safety concerns lack research. This paper explores therapeutic mechanisms discusses future perspectives. Further research necessary advance clinical applications techniques VMT.

Language: Английский

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Gut microbiome and reproductive endocrine diseases: a Mendelian randomization study

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Observation studies have confirmed the association between gut microbiome and reproductive endocrine diseases (REDs), namely, polycystic ovary syndrome (PCOS), endometriosis, female infertility. However, their has never been by a two-sample Mendelian randomization (MR) analysis.We conducted MR analysis to evaluate relationship three aforementioned REDs. In order get more comprehensive results, two different thresholds were adopted select instrumental variables (IVs): one was locus-wide significance threshold (P <1.0×10-5) other genome-wide level (P< 5×10-8). Summary-level statistics for REDs collected from public databases. Inverse-variance weighted (IVW) main method used estimate causality, sensitivity analyses validate results.At level, we identified that genera Streptococcus (OR=1.52, 95%CI: 1.13-2.06, P=0.006) RuminococcaceaeUCG005 (OR=1.39, 1.04-1.86, P=0.028) associated with high risk of PCOS, while Sellimonas (OR= 0.69, 0.58-0.83, P=0.0001) RuminococcaceaeUCG011(OR=0.76, 0.60-0.95, P=0.017) linked low PCOS risk. The genus Coprococcus2 (OR=1.20, 1.01-1.43, P=0.039) correlated an increased infertility, Ruminococcus torques (OR=0.69, 0.54-0.88, P=0.002) negatively Olsenella 1.11, 1.01-1.22, P=0.036), Anaerotruncus 1.25, 1.03-1.53, P=0.025), Oscillospira 1.21, 1.01-1.46, P=0.035) endometriosis. results showed did not possess causal link based on level. Sensitivity further robustness results.Our study provides evidence is closely related Subsequent should be promote microbiome-orientated therapeutic strategies managing

Language: Английский

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Developmental programming of production and reproduction in dairy cows: IV. Association of maternal milk fat and protein percentage and milk fat to protein ratio with offspring's birth weight, survival, productive and reproductive performance and AMH concentration from birth to the first lactation period

Theriogenology, Journal Year: 2024, Volume and Issue: 220, P. 12 - 25

Published: March 3, 2024

Language: Английский

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