Efficacy and safety of acetazolamide in patients with NYHA class II-IV decompensated heart failure: protocol of an open-label prospective randomized multicenter study (ORION-A) DOI Creative Commons
О. А. Рубаненко, А. О. Рубаненко, S. Villevalde

et al.

Russian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 28(3S), P. 5477 - 5477

Published: Sept. 11, 2023

Aim. To study the efficacy and safety of acetazolamide administered orally to patients with decompensated heart failure (HF) at hospital stage within 72 hours from admission, compared standard therapy. Material methods. This open-label, prospective, randomized, multicenter is planned include 400 urgently admitted NYHA class II-IV HF: 200 each in therapy group additional (tablets) group. The primary endpoint includes number who achieved compensation accordance criteria for diuretic discontinuation. There are secondary endpoints: increase urine output first hospitalization (since randomization), weight loss, 24-hour natriuresis, length stay hospital, intensive care unit, 90-day any-cause death, cardiovascular death due chronic HF decompensation or acute HF, pleuro- pericardiocentesis episodes during hospitalization, scale clinical condition assessment patient (SHOKS) discharge 6-minute walk test hospital. follow-up duration a period an picture laboratory parameters. Telemedicine contact carried out after 14, 30 90 days using structured questionnaire. Conclusion. Analysis clinical, echocardiographic parameters tablets will make it possible determine effectiveness short long term.

Language: Английский

Chronic and acute decompensated heart failure: topical issues DOI Creative Commons
I. M. Okunev, А. М. Кочергина, В. В. Кашталап

et al.

Complex Issues of Cardiovascular Diseases, Journal Year: 2022, Volume and Issue: 11(2), P. 184 - 195

Published: June 26, 2022

Highlights. The article is a review of current literary data on the problem acute decompensated heart failure. highlights basic principles diagnosis and treatment, as well problems their implementation into clinical practice. Abstract Acute failure (ADHF) life-threatening condition that requires an emergency hospitalization for intensive treatment. Moreover, it event worsens patient's further prognosis. Frequent rehospitalizations decompensation reduce life expectancy quality, are also significant economic in practical health care. increasing number patients with leads to growing seeking medical help More than half re-hospitalized within year same reason. predicted increase prevalence CHF worldwide makes management such global social problem. Patients delay, low compliance insufficient ambulatory monitoring factors need be influenced order improve epidemiology ADHF, diagnosis, treatment outpatient observation compliance, prospects modern methods remote possibilities new drugs discussed article.

Language: Английский

Citations

8

Prospects for use of Vericiguat in HFrEF: Implications of VICTORIA Trial Results. Advisory Board Summary DOI
Yu. N. Belenkov, G. P. Arutyunov, Mareev VIu

et al.

Kardiologiia, Journal Year: 2023, Volume and Issue: 63(4), P. 3 - 10

Published: May 1, 2023

In September 2021, an online meeting of the Council Experts was held. The proposed focus discussion publishing results international prospective, randomized, double-blind, placebo-controlled study VICTORIA. objective VICTORIA evaluation efficacy and safety supplementing a standard therapy with vericiguat at target dose 10 mg twice day as compared to placebo for prevention cardiovascular death hospitalization heart failure (HF) in patients clinical manifestations chronic HF left ventricular ejection fraction <45% who have recently had episode decompensated HF. aim interpretation on potential use Russian population after recent reduced fraction.

Language: Английский

Citations

3

Decompensated heart failure: a reconceptualization in the light of updated consensus statement of the European Society of Cardiology DOI Creative Commons
В. Н. Ларина, Kokorin V.A. Kokorin, В. Г. Ларин

et al.

Russian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 28(12), P. 5581 - 5581

Published: Dec. 20, 2023

The article presents a brief analytical review of the European Society Cardiology consensus statement on definition and clinical features heart failure (HF) with summary latest results treatment prevention exacerbation. main viewpoints are compared existing approaches in Russian Federation. classification worsening HF (WHF), as well its manifestations, epidemiology, outcomes, pathophysiology, to early detection, patterns in- outpatient WHF discussed. Attention is paid terminology necessary identify cohort patients exacerbation previously established diagnosis order unify treatment.

Language: Английский

Citations

3

Hotspots and Global Trends of Nursing Research on Telehealth From 2012 to 2021 DOI
Şefika Tuğba Yangöz, Selma Turan Kavradım, Zeynep Özer

et al.

CIN Computers Informatics Nursing, Journal Year: 2023, Volume and Issue: 41(10), P. 833 - 843

Published: June 5, 2023

Telehealth is commonly used in nursing recent years; however, there a lack of information on hotspots and global trends over time. This study aimed to analyze the bibliometric patterns telehealth research nursing. descriptive study. Data were obtained from Web Science Core Collection. CiteSpace version 6.1.R6 was perform analysis. The co-occurrence co-citation analyses conducted. A total 1365 articles analyzed. 354 authors 352 institutions 68 countries have contributed most productive author Kathryn H. Bowles with six articles. United States 688 University Pennsylvania 22 country institution, respectively. top 10 keywords this area care , intervention management health technology quality life outcome mobile application telemedicine experience . In addition, common themes nurse practitioner student perception, hemodialysis patients, heart failure. will help finding potential collaborators, countries, for future researchers. it guide researchers, practitioners, scholars further studies, policy development, evidence-based practice

Language: Английский

Citations

2

Adherence to treatment as an integral component of the management of patients with heart failure DOI Creative Commons
В. Н. Ларина,

K. A. Zamyatin,

E. N. Sheregova

et al.

Russian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 29(1), P. 5690 - 5690

Published: Dec. 28, 2023

The problem of rational management patients with heart failure (HF) remains extremely relevant due to its increasing incidence and poor prognosis. Based on current guidelines, therapy for HF involves systematic long-term use many medications, their effectiveness largely depends the quality patient’s compliance. Pharmacotherapy older is complicated by metabolism coexistence diseases associated polypharmacy, which significantly reduces response therapy. Insufficient adherence treatment has been proven reduce life patients. Currently, three phenotypes have identified, depending left ventricular ejection fraction. However, number studies examining characteristics patient in different limited, requires further research. article an analytical review devoted various aspects HF. terms concepts compliance, history research, main modern approaches pharmacotherapy are briefly covered. results a large clinical presented, including assessment relationship

Language: Английский

Citations

2

Experience of introducing a new form of organization of medical care for patients with heart failure in the Russian Federation DOI Creative Commons
И. В. Фомин, Н. Г. Виноградова, D. S. Polyakov

et al.

Kardiologiia, Journal Year: 2021, Volume and Issue: 61(3), P. 42 - 51

Published: March 30, 2021

Aim To present clinical characteristics of patients after hospitalization for acute decompensated heart failure (ADHF) and to analyze hemodynamic indexes compliance with the treatment at two years depending on conditions outpatient follow-up. Material methods The study included 942 chronic (CHF) older than 18 who had been hospitalized ADHF. Based patients’ decisions, groups were isolated: continued follow-up Center CHF (CCHF) (group 1, n=510) in multidisciplinary clinics (OMC) their place residence 2, n=432). portrait was evaluated ADHF, parameters discharge from hospital. Also, patient analyzed during Statistical analysis performed Statistica 7.0 Windows. Results leading causes arterial hypertension, ischemic disease, atrial fibrillation, type 2 diabetes mellitus. With mean duration 11 inpatient days, 88.1 % 88.4 1 discharged complaints shortness breath; 62 70.4 complained palpitations; 73.6 71.8 general weakness. On hospital, following obvious signs congestion remained: peripheral edema 54.3 57.9 %; pulmonary rales 28.8 32.4 orthopnea 21.4 26.2 cough 16,5 15.5 respectively. For time hospitalization, did not achieve targets systolic BP (SBP), diastolic (DBP) rate (HR). Patients group achieved recommended values SBP, DBP HR already one year CCHF. no significant changes indexes. At follow-up, showed a considerable impairment basis therapy compared 1. Conclusions During short period (11 days), retained pronounced symptoms HF targets. followed up long CCHF more compliant therapy, which resulted improvement indexes, managed OMS residence.

Language: Английский

Citations

5

Advanced heart failure DOI Creative Commons
V. V. Kalyuzhin, А. T. Teplyakov, И. Д. Беспалова

et al.

Bulletin of Siberian Medicine, Journal Year: 2021, Volume and Issue: 20(1), P. 129 - 146

Published: April 12, 2021

The authors of the article have analyzed problem advanced heart failure (AHF). Despite significant and, it is not an exaggeration to say, revolutionary achievements in clinical pharmacology, cardiac surgery and implantation arrhythmology, number patients with chronic (CHF) many countries decreasing, some, for example, Russia, increasing. At same time, unfortunately, often immediate longterm results so-called optimal therapy CHF are disappointing both patient doctor. In 2007, experts from Heart Failure Association European Society Cardiology proposed term AHF refer which drug therapy, as well resynchronization effective, causes repeated hospitalizations justifies need treatment methods such transplantation mechanical circulatory support, and/or transition palliative care. agreed positions established cardiological communities Old New Worlds on definition, diagnostic criteria been changing over time. Unfortunately, this evolution has yet arrived at a consensus. lecture consistently addresses issues terminology, diagnosis, prognostic stratification routing AHF, short- long-term strategies treating these patients.

Language: Английский

Citations

4

Results of Five-Year Outpatient Follow-Up of Patients With Heart Failure in a Specialized Center DOI Creative Commons
Н. Г. Виноградова, D. S. Polyakov, И. В. Фомин

et al.

Kardiologiia, Journal Year: 2024, Volume and Issue: 64(11), P. 84 - 95

Published: Nov. 30, 2024

Aim To evaluate the risks of all-cause death (ACD), cardiovascular (CVD), from recurrent acute decompensated heart failure (ADHF), and a composite index CVD ADHF in patients with chronic (CHF) after first hospitalization for during long-term, five-year follow-up conditions specialized medical care real clinical practice. Material methods This prospective cohort observational study included 942 ADHF. Group 1 consisted 510 who continued outpatient at center treatment CHF (cCHF); group 2 432 followed up polyclinic institutions (OPI) place residence. During follow-up, causes were determined based on records inpatients, postmortem examinations, or conclusion outpatients. Rates ACD, CVD, ADHF, (CVD ADHF) analyzed. Statistical analysis was performed R statistical package. Results ACD 32.3% 53.5% groups 2, respectively (p<0.001). Based results Cox proportional hazards models, it shown that 1, regardless other factors, associated decrease risk (HR 2.07; 95% CI 1.68-2.54; p<0.001), 1.94; 1.26-2.97; p=0.002), 2.4; 1.66–3.42; p<0.001) mortality 2.2; 1.65-2.85; compared to 2. The moderately reduced left ventricular ejection fraction (LVEF) (HFmrEF) consistent rates low LVEF (HFrEF) significantly higher than preserved (HFpEF). prognosis life worsened an increase Clinical Condition Assessment Scale score age. better women, as well values systolic blood pressure (BP) 6-minute walk test. In structure both groups, sudden cardiac (SCD) prevailed. Conclusion absence increases endpoint depth observation. leading SCD.

Language: Английский

Citations

0

Patient With Chronic Heart Failure as a Participant in the Treatment Process: the Role of Structured Training And Outpatient Observation (on the Anniversary of the Study Chance) DOI Creative Commons
Yu. N. Belenkov, Mareev VIu, Ф. Т. Агеев

et al.

Kardiologiia, Journal Year: 2024, Volume and Issue: 64(11), P. 37 - 47

Published: Nov. 30, 2024

Aim The article presents the principal results and conclusions of study “SCHool outpAtient moNitoring patients with Cardiac failurE (CHANCE)”, organized by Society Experts in Heart Failure. Material methods CHANCE was a multicenter randomized study. Patients intervention group (IG) received Structured Education Flexible Outpatient Control Model, that included telephone contacts plus an additional visit if necessary. planned visits for IG control (CG) were scheduled at 3, 6, 12 months. 360 385 CG analysis. In main analysis study, efficacy assessed impact on hard endpoints (mortality rehospitalizations), clinical condition, functional capabilities, quality life, anxiety depressive symptoms, cost-effectiveness. Also, comprehensive assessment performed prevalence, structure, dynamics symptoms depending changes condition. Results Mortality significantly differed between groups: 30 (8.3%) died 50 (13.0%) CG. relative risk death 0.68, 95% confidence interval 0.42-0.99, p = 0.044. To prevent one death, it necessary to educate monitor 21 clinically evident chronic heart failure (CHF) according principles program. According Clinical Condition Assessment Scale (SCAS), score difference groups 1.7 (p<0.001) after months follow-up favor group. months, increase 6-minute walk test distance 98.7 m 42.9 (p<0.001). change from baseline Minnesota questionnaire total 15.3 ± 16.3 6.2 odds developing increased each SCAS point 19% (p 0.0002). 12% 0.02). most unfavorable combination 41% 0.000002). participation reducing CHF 2.35 times (p<0.0001), greater extent women. Conclusion 42 centers 23 cities Russia became forerunner first initiatives organizing outpatient real practice serves as vivid example importance national research programs. Their implementation allows obtaining can be scaled up throughout country make important contribution improvement medical care CHF.

Language: Английский

Citations

0

Principles of Outpatient Care of Patients With Heart Failure DOI Creative Commons
О. М. Драпкина, А. И. Чесникова

Kardiologiia, Journal Year: 2024, Volume and Issue: 64(11), P. 148 - 156

Published: Nov. 30, 2024

These guidelines combine the key provisions for management of patients with chronic heart failure (CHF) at outpatient stage based on current data from clinical studies, new 2024 Russian Society Cardiology CHF patients, and order Ministry Health Federation procedure conducting dispensary observation. is a progressive disease characterized by high risk death, rehospitalizations, disability. Reducing decompensation improving prognosis possible only regular monitoring patient's condition timely correction therapy. The priority task unit to expand coverage follow-up preventive counseling, telemedicine identification progression, their quality life, prolonging life duration.

Language: Английский

Citations

0