The rise of Parkinson’s disease is a global challenge, but efforts to tackle this must begin at a national level: a protocol for national digital screening and “eat, move, sleep” lifestyle interventions to prevent or slow the rise of non-communicable diseases in Thailand DOI Creative Commons
Roongroj Bhidayasiri, Jirada Sringean, Saisamorn Phumphid

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 13, 2024

The rising prevalence of Parkinson’s disease (PD) globally presents a significant public health challenge for national healthcare systems, particularly in low-to-middle income countries, such as Thailand, which may have insufficient resources to meet these escalating needs. There are also many undiagnosed cases early-stage PD, period when therapeutic interventions would the most value and least cost. traditional “passive” approach, whereby clinicians wait patients with symptomatic PD seek treatment, is inadequate. Proactive, early identification will allow timely interventions, digital technologies can be scaled up diagnosis cases. risk survey (TCTR20231025005) aims evaluate population screening platform identify Thai population. Recognizing long prodromal phase target demographic people aged ≥ 40 years, approximately 20 years before usual emergence motor symptoms. Thailand has highly rated system an established universal program citizens, making it ideal deploying using technology. Designed by multidisciplinary group experts, comprises 20-item questionnaire about symptoms along objective tests eight markers: voice vowel, sentences, resting postural tremor, alternate finger tapping, “pinch-to-size” test, gait balance, performance recorded mobile application smartphone’s sensors. Machine learning tools use collected data subjects at developing, or signs of, PD. This article describes selection validation items markers, results showing chosen parameters analysis methods robust, reliable, reproducible. could serve model similar strategies other non-communicable diseases Thailand.

Language: Английский

Epigenetic regulation of aging: implications for interventions of aging and diseases DOI Creative Commons
Wang Kang, Huicong Liu, Qinchao Hu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 7, 2022

Abstract Aging is accompanied by the decline of organismal functions and a series prominent hallmarks, including genetic epigenetic alterations. These aging-associated changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, all which participate in regulation aging process, hence contribute to aging-related diseases. Therefore, understanding mechanisms will provide new avenues develop strategies delay aging. Indeed, interventions based on manipulating have led alleviation or extension lifespan animal models. Small molecule-based therapies reprogramming that enable rejuvenation been developed for ameliorating reversing conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, calibrating circadian rhythm, has demonstrated Furthermore, various clinical trials intervention are ongoing, providing more evidence safety efficacy these therapies. Here, we review recent work outline advances age-associated A better critical roles epigenetics process lead prevention human therapy

Language: Английский

Citations

307
Biomarkers of aging for the identification and evaluation of longevity interventions DOI Creative Commons
Mahdi Moqri, Chiara Herzog, Jesse R. Poganik

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(18), P. 3758 - 3775

Published: Aug. 1, 2023

Language: Английский

Citations

262
A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking DOI
Albert Higgins‐Chen, Kyra Thrush, Yunzhang Wang

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 2(7), P. 644 - 661

Published: July 15, 2022

Language: Английский

Citations

238
Aging Hallmarks and the Role of Oxidative Stress DOI Creative Commons
Edio Maldonado, Sebastián Morales, Fabiola Urbina

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 651 - 651

Published: March 6, 2023

Aging is a complex biological process accompanied by progressive decline in the physical function of organism and an increased risk age-related chronic diseases such as cardiovascular diseases, cancer, neurodegenerative diseases. Studies have established that there exist nine hallmarks aging process, including (i) telomere shortening, (ii) genomic instability, (iii) epigenetic modifications, (iv) mitochondrial dysfunction, (v) loss proteostasis, (vi) dysregulated nutrient sensing, (vii) stem cell exhaustion, (viii) cellular senescence, (ix) altered communication. All these alterations been linked to sustained systemic inflammation, mechanisms contribute timing not clearly determined yet. Nevertheless, dysfunction one most important contributing process. Mitochondria primary endogenous source reactive oxygen species (ROS). During ATP production elevated ROS together with antioxidant defense. Elevated levels can cause oxidative stress severe damage cell, organelle membranes, DNA, lipids, proteins. This contributes phenotype. In this review, we summarize recent advances emphasis on production.

Language: Английский

Citations

207
Epigenetic clock: A promising biomarker and practical tool in aging DOI
Ran Duan,

Qiaoyu Fu,

Yu Sun

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101743 - 101743

Published: Oct. 4, 2022

Language: Английский

Citations

144
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application DOI
Sebastian J. Hofer, Didac Carmona‐Gutiérrez,

Melanie I. Mueller

et al.

EMBO Molecular Medicine, Journal Year: 2021, Volume and Issue: 14(1)

Published: Nov. 15, 2021

Language: Английский

Citations

141
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study DOI
Giovanni Fiorito, Saverio Caini, Domenico Palli

et al.

Aging Cell, Journal Year: 2021, Volume and Issue: 20(10)

Published: Sept. 18, 2021

Several biomarkers of healthy aging have been proposed in recent years, including the epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting increasingly accurate predicting individual biological age. The recently developed "next-generation clock" DNAmGrimAge outperforms "first-generation clocks" longevity and onset many age-related pathological conditions diseases. Additionally, total number stochastic mutations (SEMs), also known as mutation load (EML), has a complementary DNAm-based biomarker aging. A fundamental property epigenetic, particular DNAm modifications, is potential reversibility effect, raising questions about possible slowdown by modifying one's lifestyle. Here, we investigated whether improved dietary habits increased physical activity favorable effects postmenopausal women. study sample consists 219 women from "Diet, Physical Activity, Mammography" (DAMA) study: 24-month randomized factorial intervention trial with measured twice, at baseline end trial. Women who participated had significant slowing clock, whereas increasing led to reduction SEMs crucial cancer-related pathways. Our provides strong evidence causal association between lifestyle modification down biomarkers. This elucidates relationship aging-related mechanisms.

Language: Английский

Citations

119
Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain DOI Creative Commons

Matthew T. Buckley,

Eric Sun, Benson M. George

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 3(1), P. 121 - 137

Published: Dec. 19, 2022

Abstract The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop ‘aging clocks’ based on single-cell transcriptomics to characterize cell-type-specific rejuvenation. We generated transcriptomes from the subventricular zone neurogenic region 28 mice, tiling ages young old. trained single-cell-based regression models predict chronological age biological (neural stem proliferation capacity). These clocks are generalizable independent cohorts other regions brains, species. To determine if these could quantify transcriptomic rejuvenation, datasets two interventions—heterochronic parabiosis exercise. Aging revealed that heterochronic exercise reverse in regions, but different ways. This study represents first development high-resolution data demonstrates their application

Language: Английский

Citations

98
Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine? DOI
Charlotte Ling, Karl Bacos, Tina Rönn

et al.

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(7), P. 433 - 448

Published: May 5, 2022

Language: Английский

Citations

77
A pan-tissue DNA-methylation epigenetic clock based on deep learning DOI Creative Commons
Lucas Paulo de Lima Camillo, Louis R. Lapierre, Ritambhara Singh

et al.

npj Aging, Journal Year: 2022, Volume and Issue: 8(1)

Published: April 19, 2022

Abstract Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been created in recent years, with the vast majority regularized linear regression. This study explores improvement performance and interpretation of clocks using deep learning. First, we gathered 142 publicly available data sets from several human tissues to develop AltumAge, a neural network framework that is highly accurate precise predictor. Compared ElasticNet, AltumAge performs better for within-data set cross-data prediction, being particularly more generalizable older ages new tissue types. We then used learning methods learn which methylation sites contributed final model predictions. observe while most important CpG are linearly related age, some highly-interacting can influence relevance such relationships. Using chromatin annotations, show highest contribution predictions were gene regulatory regions genome, including proximity CTCF binding sites. also found age-related KEGG pathways genes containing these Lastly, performed downstream analyses explore its applicability compare acceleration Horvath’s 2013 model. our approach predicts higher tumors, cells exhibit changes vitro, as immune mitochondrial dysfunction, samples patients multiple sclerosis, type 2 diabetes, HIV, among other conditions. Altogether, provides significant flexibility compared current both interpretability.

Language: Английский

Citations

71