Gene, Journal Year: 2022, Volume and Issue: 856, P. 147129 - 147129
Published: Dec. 20, 2022
Language: Английский
Life Sciences, Journal Year: 2021, Volume and Issue: 291, P. 120064 - 120064
Published: Oct. 21, 2021
Language: Английский
Citations
80
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(1), P. 92 - 92
Published: Jan. 8, 2023
Autophagy is an evolutionarily conserved self-degradation system that recycles cellular components and damaged organelles, which critical for the maintenance of homeostasis. Intracellular reactive oxygen species (ROS) are short-lived molecules containing unpaired electrons formed by partial reduction molecular oxygen. It widely known autophagy ROS can regulate each other to influence progression cancer. Recently, due wide potent anti-cancer effects with minimal side effects, phytochemicals, especially those modulate autophagy, have attracted great interest researchers. In this review, we afford overview complex regulatory relationship between in cancer, emphasis on phytochemicals cancer therapy. We also discuss ROS/autophagy inhibitors challenges associated harnessing regulation potential
Language: Английский
Citations
40
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2108 - 2108
Published: Feb. 9, 2024
Betulinic acid is a naturally occurring compound that can be obtained through methanolic or ethanolic extraction from plant sources, as well chemical synthesis microbial biotransformation. has been investigated for its potential therapeutic properties, and exhibits anti-inflammatory, antiviral, antimalarial, antioxidant activities. Notably, ability to cross the blood-brain barrier addresses significant challenge in treating neurological pathologies. This review aims compile information about impact of betulinic an antitumor agent, particularly context glioblastoma. Importantly, demonstrates selective activity against glioblastoma cells by inhibiting proliferation inducing apoptosis, consistent with observations other cancer types. Compelling evidence published highlights acid's action suppressing Akt/NFκB-p65 signaling cascade enhancing cytotoxic effects chemotherapeutic agent temozolomide. Interesting findings also suggest focus on researching reduction glioblastoma's invasiveness aggressiveness profile. involves modulation extracellular matrix components, remodeling cytoskeleton, secretion proteolytic proteins. Drawing comprehensive review, we conclude formulations nanoparticles and/or ionic liquids are promising drug delivery approaches translation into clinical applications treatment management
Language: Английский
Citations
13
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1488 - 1525
Published: Jan. 30, 2023
Abstract Regulated cell death (RCD) refers to programmed regulated by various protein molecules, such as apoptosis, autophagy‐dependent death, and necroptosis. Accumulating evidence has recently revealed that RCD subroutines have several links many types of human cancer; therefore, targeting with pharmacological small‐molecule compounds would be a promising therapeutic strategy. Moreover, plant natural compounds, synthesized from sources, their derivatives been widely reported regulate different improve potential cancer therapy. Thus, in this review, we focus on updating the intricate mechanisms necroptosis cancer. further discuss representative above‐mentioned three RCD, candidate drugs for future treatment.
Language: Английский
Citations
21
Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(3), P. 867 - 888
Published: Jan. 22, 2024
Language: Английский
Citations
8
Molecules, Journal Year: 2022, Volume and Issue: 27(2), P. 373 - 373
Published: Jan. 7, 2022
Osteosarcoma, a primary bone tumor, responds poorly to chemotherapy and radiation therapy in children young adults; hence, as the basis for an alternative treatment, this study investigated cytotoxic antiproliferative effects of naringenin on osteosarcoma cell lines, HOS U2OS, by using counting kit-8 colony formation assays. DNA fragmentation increase G2/M phase U2OS cells upon treatment with various concentrations were determined terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay Annexin V/propidium iodide double staining, respectively. Flow cytometry was performed, 2′,7′-dichlorodihydrofluorescein diacetate, JC-1, Fluo-4 AM ester probes examined reactive oxygen species (ROS) generation, mitochondrial membrane potential, intracellular calcium levels, Caspase activation, cycle, cytosolic mitochondrial, autophagy-related proteins western blotting. The results indicated that significantly inhibited viability proliferation dose-dependent manner. In addition, induced cycle arrest inhibiting cyclin B1 cyclin-dependent kinase 1 expression upregulating p21 expression. Furthermore, growth increasing ROS level. Naringenin endoplasmic reticulum (ER) stress-mediated apoptosis through upregulation ER stress markers, GRP78 GRP94. caused acidic vesicular organelle increased autophagolysosomes, microtubule-associated protein-light chain 3-II protein autophagy. findings suggest induction apoptosis, arrest, autophagy dysfunction, production, signaling pathways contribute effect cells.
Language: Английский
Citations
23
Respiratory Research, Journal Year: 2024, Volume and Issue: 25(1)
Published: May 20, 2024
Abstract Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of lung cancer patients with mutated EGFR. However, efficacy EGFR-TKIs in wild-type EGFR tumors has been shown to be marginal. Methods that can sensitize NSCLC remain rare. Hence, we determined whether combination maximize therapeutic EGFR-TKIs. We established a focused drug screening system investigate candidates for overcoming intrinsic resistance Molecular docking assays and western blotting were used identify binding mode blocking effect candidate compounds. Proliferation assays, analyses interactions, colony formation flow cytometry nude mice xenograft models determine effects molecular mechanism treatment. Results Betulinic acid (BA) is effective at targeting synergizes (gefitinib osimertinib) preferentially against BA showed inhibitory activity due its interaction ATP-binding pocket dramatically enhanced suppressive by modulating EGFR-ATK-mTOR axis. Mechanistic studies revealed strategy activated EGFR-induced autophagic cell death EGFR-AKT-mTOR signaling pathway was essential completing autophagy cycle arrest. Activation mTOR or blockade specific chemical agents markedly attenuated In vivo administration caused marked tumor regression A549 xenografts. Conclusions potential inhibitor plays critical role sensitizing EGFR-TKI activity. combined an effectively suppressed proliferation survival intrinsically resistant cells via inhibition as well induction autophagy-related death, indicating may primary EGFR-positive cancers. Graphical abstract
Language: Английский
Citations
6
Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155858 - 155858
Published: July 4, 2024
Language: Английский
Citations
6
Pharmacological Research, Journal Year: 2022, Volume and Issue: 185, P. 106475 - 106475
Published: Oct. 3, 2022
Language: Английский
Citations
21
Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 392, P. 110904 - 110904
Published: Feb. 13, 2024
Language: Английский
Citations
4