Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(3), P. 167044 - 167044
Published: Jan. 30, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5556 - 5556
Published: May 20, 2024
The most common malignancy in women is breast cancer. During the development of cancer, oncogenic transcription factors facilitate overproduction inflammatory cytokines and cell adhesion molecules. Antiapoptotic proteins are markedly upregulated cancer cells, which promotes tumor development, metastasis, survival. Promising findings have been found studies on cycle-mediated apoptosis pathway for medication treatment. Dietary phytoconstituents studied great detail their potential to prevent by triggering body’s defense mechanisms. underlying mechanisms action may be clarified considering role polyphenols important signaling pathways. Phenolic acids, flavonoids, tannins, coumarins, lignans, lignins, naphthoquinones, anthraquinones, xanthones, stilbenes examples natural chemicals that being anticancer drugs. These substances also vital This review focuses innovations study polyphenol genistein’s effects cells presents integrated chemical biology methods harness therapeutic advances.
Language: Английский
Citations
23
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116685 - 116685
Published: May 5, 2024
Colorectal cancer (CRC), with its significant incidence and metastatic rates, profoundly affects human health. A common oncogenic event in CRC is the aberrant activation of Wnt/β-catenin signalling pathway, which drives both initiation progression disease. Persistent facilitates epithelial-mesenchymal transition (EMT), accelerates invasion metastasis. This review provides a summary recent molecular studies on role axis regulating EMT cells, triggers pathogenesis. We present comprehensive examination process transcriptional controllers, an emphasis crucial functions β-catenin, transcription factors (EMT-TFs). also evidences showing that hyperactive phenotypes via "Destruction complex" β-catenin mechanisms. Potential therapeutic challenges approache to suppress prevent cells metastasis by targeting are discussed. These include direct inhibitors novel targets Wnt finally highlight potential combinational treatment options based inhibition pathway.
Language: Английский
Citations
20
Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(2)
Published: Jan. 1, 2024
Cancer is the leading cause of morbidity and mortality worldwide an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally increasing numbers natural approved for clinical studies involving cancer recent years. To gain more insight into that have undergone trials treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website searched relevant product information up December 2022. terms included different types cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric haematologic. Then, PubMed Web Science were articles February 2024. Hence, we listed existing about used treatment cancers discussed preclinical some promising their targets, indications, underlying mechanisms action. Our intent provide basic readers who interested or majoring obtain deeper understanding progress actions
Language: Английский
Citations
19
Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32390 - e32390
Published: June 1, 2024
A form of cancer that affects the rectum or colon (large intestine) is called colorectal (CRC). The main risk factors for CRC include dietary, lifestyle, and environmental variables. Currently natural polyphenols have demonstrated impressive anticarcinogenic capabilities.
Language: Английский
Citations
12
Life, Journal Year: 2024, Volume and Issue: 14(5), P. 606 - 606
Published: May 9, 2024
Colorectal cancer (CRC) is a heterogenous pathology with high incidence and mortality rates globally, but it also preventable so finding the most promising candidates (natural compounds or repurposed drugs) to be chemopreventive alternatives has become topic of interest in recent years. The present work aims elucidate potential effects combination between genistein (GEN), an isoflavone natural origin, aspirin (ASA) CRC prevention/treatment by performing vitro evaluation human colorectal cells (HCT-116) ovo analysis using chick embryo chorioallantoic membrane (CAM) model. Cell viability was verified MTT (migratory scratch) assay, expressions MMP-2 MMP-9 were analyzed RT-qPCR. Our results indicated dose-dependent cytotoxic effect ASA (2.5 mM) + GEN (10–75 µM) characterized reduced cell morphological changes (actin skeleton reorganization nuclei deterioration), inhibition HCT-116 cells’ migratory down-regulating mRNA expressions, antiangiogenic modifying vascular network. These raise possibility future in-depth investigations regarding chemopreventive/therapeutical ASA+GEN combination.
Language: Английский
Citations
6
Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(12)
Published: May 30, 2024
Scope The current evidence between dietary flavonoids consumption and multiple health outcomes is inadequate inconclusive. To summarize evaluate the for outcomes, an umbrella review of meta‐analyses systematic reviews conducted. Methods results PubMed, Ovid‐EMBASE, Cochrane Database Systematic Reviews are searched up to January 2024. study includes a total 32 articles containing 24 unique in this review. Meta‐analyses recalculated by using random effects model. Separate analyses performed based on kind different flavonoid subclasses. finds some associations such as flavonol gastric cancer, isoflavone uterine fibroids endometrial lung ovarian prostate cancer. Overall, confirms negative type 2 diabetes mellitus, cardiovascular diseases, breast colorectal mortality, while positive observed cancer fibroids. Conclusion Although significantly associated with many firm generalizable conclusions about their beneficial or harmful cannot be drawn because low certainty most outcomes. More well‐designed primary studies needed.
Language: Английский
Citations
6
Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10
Published: June 30, 2023
Introduction Coronavirus disease 2019 (COVID-19) is a global pandemic and highly contagious, posing serious threat to human health. Colorectal cancer (CRC) risk factor for COVID-19 infection. Therefore, it vital investigate the intrinsic link between these two diseases. Methods In this work, bioinformatics systems biology techniques were used detect mutual pathways, molecular biomarkers, potential drugs CRC. Results A total of 161 common differentially expressed genes (DEGs) identified based on RNA sequencing datasets Functional analysis was performed using ontology keywords, pathway also performed. The DEGs further utilized create protein-protein interaction (PPI) network identify hub key modules. revealed transcription factors-gene interactions, co-regulatory networks with DEGs-miRNAs DEGs, predicted possible as well. ten include troglitazone, estradiol, progesterone, calcitriol, genistein, dexamethasone, lucanthone, resveratrol, retinoic acid, phorbol 12-myristate 13-acetate, some which have been investigated CRC therapies. Discussion By clarifying relationship CRC, we hope provide novel clues promising therapeutic treat illnesses.
Language: Английский
Citations
11
Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 815 - 815
Published: July 7, 2024
Colorectal cancer (CRC) is a leading cause of deaths worldwide. Despite significant advances in medical treatment, chemotherapy as monotherapy can lead to substantial side effects and chemoresistance. This underscores the need for therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize cells overcome resistance standard drugs. In recent years, scientists have been searching natural compounds be used chemosensitizers addition conventional medications synergistic treatment CRC. Polyphenols represent diverse group target induce anti-cancer effects. Additionally, polyphenols shown work synergistically with chemotherapeutics other cells. review aims provide comprehensive insight into mechanisms selected CRC Further research clinical trials warranted fully harness combined or improving outcomes.
Language: Английский
Citations
4
Bioengineering, Journal Year: 2025, Volume and Issue: 12(2), P. 126 - 126
Published: Jan. 29, 2025
Background: Sensorineural hearing loss (SNHL) is a major contributor to impairment, yet effective therapeutic options remain elusive. Mendelian randomization (MR) has proven valuable for drug repurposing and identifying new targets. This study aims pinpoint novel treatment targets SNHL, exploring their pathophysiological roles potential adverse effects. Methods: research utilized the UKB-PPP database access cis-protein quantitative trait locus (cis-pQTL) data, with SNHL data sourced from FinnGen as endpoint MR causal analysis of Colocalization was employed determine whether risk protein expression share common SNPs. A phenotype-wide association conducted assess side effects these Drug prediction molecular docking were subsequently used evaluate identified Results: Four target proteins significantly associated sensorineural determined by co-localization analysis. These include LATS1, TEF, LMNB2, OGFR shown have fewer when acting on Genes are primarily implicated in Hippo signaling pathway, cell–cell adhesion, various binding regulatory activities involved regulation cell proliferation apoptosis. Next, drugs screened DsigDB docking, top 10 selected based p-value. Among them, atrazine CTD 00005450 most likely target, followed ampyrone HL60 DOWN genistein 00007324. In addition, could be intervened multiple drugs; however, TEF. Conclusion: successfully four promising which clinical trials minimal findings streamline development potentially reducing costs time pharmaceutical development.
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(3), P. 167044 - 167044
Published: Jan. 30, 2024
Language: Английский
Citations
1